LeonP.McLeanMDPhD, MPH

PubMed

• 69 citations
  Adverse events in IBD: to stop or continue immune suppressant and biologic treatment
  Leon P. McLean, Raymond K. Cross
  Expert Review of Gastroenterology & Hepatology. 2014-02-12
• 31 citations
  Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of Nippostrongylus brasiliensis through induction of TH2 cytokines
  Leon P. McLean, Allen Smith, Lumei Cheung, Joseph F. Urban, Rex Sun
  American Journal of Physiology. Gastrointestinal and Liver Physiology. 2016-07-01
• 33 citations
  Role of macrophages in the altered epithelial function during a type 2 immune response induced by enteric nematode infection
  Luigi Notari, Diana C. Riera, Rex Sun, Jennifer A. Bohl, Leon P. McLean
  Plos One. 2014-01-23

Journal Articles

• Adverse Events in IBD: To Stop or Continue Immune Suppressant and Biologic Therapy  
  McLean LP, Cross RK, Expert Rev Gastroenterol Hepatol, 1/1/2014
• Right Lower Quadrant Pain in a Patient with IBD of Undetermined Type  
  McLean LP, Chun JS, Cross RK, Clin Gastroenterol Hepatol, 1/1/2014
• M1 Muscarinic Receptors Modify the Oxidative Stress Response to Acetaminophen-Induced Acute Liver Injury  
  Urrunaga NH, Jadeja RN, Rachakonda V, Ahmad D, McLean LP, Chen K, Shah V, Twaddell WS, Raufman JP, Khurana S, Free Radic Biol Med, 1/1/2014
• Dependence of IL-33-induced Alterations in Intestinal Function and Cytokine Response on MyD88, STAT6, and IL-13 in Mice  
  Yang Z, Sun R, Grinchuk V, Notari L, Stiltz J, McLean LP, Ramalingam TR, Wynn TA, Urban JF, Vogel SM, Shea-Donohue T, Zhao A, Am J Physiol Gastrointest Liver Physiol, 1/1/2013
• Vedolizumab for the Treatment of Ulcerative Colitis and Crohn's Disease  
  McLean LP, Shea-Donohue T, Cross RK, Immunotherapy, 1/1/2012
• Hoxa4 Expression in Developing Mouse Hair Follicles and Skin  
  Packer AI, Jane-Wit D, McLean L, Panteleyev AA, Christiano AM and Wolgemuth DJ, Mech Dev, 1/1/2000
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Books/Book Chapters

• Gastroenterology Pocket 
  Chapter: Diarrhea and Constipation 
  McLean LP and Greenwald BDEditors: Nichita D and Ghugari R.Borm Bruckmeier Publishing, El Segundo, CA2014
• Gastroenterology Pocket 
  Chapter: Gastrointestinal Bleeding 
  McLean LP and Patil SAEditors: Nichita D and Ghugari R.Borm Bruckmeier Publishing, El Segundo, CA2014

Abstracts/Posters

• Type 3 Muscarinic Receptors (M3R) Contribute to Expulsion of Nippostrongylus brasliensis Through Induction of Th2 Cytokines
  McLean LP, Smith A, Cheung L, Desai N, Grinchuk V, Zhao A, Sun R, Raufman JP, Shea-Donohue T, American College of Gastroenterology Annual Scientific Meeting, Am J Gastroenterol, Philadelphia, PA, 1/1/2014
• Type 3 Muscarinic Receptor Activity Facilitates Clearance of Citrobacter rodentium
  McLean LP, Smith A, Cheung L, Sun R, Grinchuk V, Zhao A, Raufman JP, Shea-Donohue T, Digestive Disease Week, Gastroenterology, Chicago, IL, 1/1/2014
• Mechanisms Underlying Attenuated Acetaminophen (APAP)-Induced Liver Injury in M1R-Deficient (M1R-/-) Mice
  Urrunaga NH, Jadeja R, Rachakonda V, Ahmad D, McLean L, Saxena NK, Cheng K, Raufman J, Khurana S, The 64th Annual Meeting of the American Association for the Study of Liver Diseases, Hepatology, Washington, DC, 1/1/2013
• Genetic Ablation of M1 Muscarinic Receptors (M1R) Attenuates Azoxymethane (AOM)-Induced Murine Liver Injury by TRAIL-R2-Mediated Hepatic Stellate Cell (HSC) Apoptosis
  Rachakonda V, Urrunaga NH, Jadeja R, Ahmad D, McLean L, Cheng K, Saxena NK, Raufman J, Khurana S, The 64th Annual Meeting of the American Association for the Study of Liver Diseases, Hepatology, Washington, DC, 1/1/2013
• Crohn's Disease: An Uncommon Cause of Appendicitis
  McLean LP, Chun J, Cross RK, American College of Gastroenterology Annual Scientific Meeting, Am J Gastroenterol, San Diego, CA, 1/1/2013
• Type 3 Muscarinic Receptor Deficiency is Associated with Impaired Paracellular Permeability and Activation of Myosin Light Chain (MLC) 2
  McLean LP, Notari L, Sun R, Bohl J, Yan S, Grinchuk V, Zhao A, Raufman JP, Shea-Donohue T, Digestive Disease Week, Gastroenterology, Orlando, FL, 1/1/2013
• Type 3 Muscarinic Receptors Modulate Macrophage Phenotype in the Presence of Th2 Cytokines
  McLean L, Grinchuk V, Zhao A, Sun R, Raufman JP, Shea-Donohue T, American College of Gastroenterology Annual Scientific Meeting, Am J Gastroenterol, Las Vegas, NV, 1/1/2012
• In Mice, Genetic Ablation of M1 Subtype Muscarinic Receptors (Chrm1-/-) Attenuates Acetaminophen (APAP)-Induced Liver Injury
  Urrunaga N, Rachakonda V, Ahmad D, McLean L, Twadell W, Saxena N, Cheng K, Raufman JP, Khurana S, The 63rd Annual Meeting of the American Association for the Study of Liver Diseases, Hepatology, Boston, MA, 1/1/2012
• Genetic Ablation of M1 Subtype Muscarinic Receptor (M1R) Attenuates Azoxymethane (AOM)-Induced Liver Injury by Altering Expression of Fibrogenic Mediators and Inflamma...
  Rachakonda V, Urrunaga N, Ahmad D, Twadell W, Saxena N, Cheng K, McLean L, Raufman JP, Khurana S, The 63rd Annual Meeting of the American Association for the Study of Liver Diseases, Hepatology, Boston, MA, 1/1/2012
• Nematode Generated Protease Activation of PAR2 Plays a Key Role in the Th2 Protective Immune Response
  Bohl J, Urban J, Notari L, Sun R, Zhao A, Yan S, Grinchuk V, Vanuytsel T, McLean L, Yang Z, Shea-Donohue T, Digestive Disease Week, Gastroenterology, San Diego, CA, 1/1/2012
• Immune Regulation of the Intestinal Progenitor Cell Microenvironment
  Vanuytsel T, Notari L, Yan S, Zhao A, Bohl J, McLean L, Sun R, Urban J, Smith A, Tack J, Shea-Donohue T, Digestive Disease Week, Gastroenterology, San Diego, CA, 1/1/2012
• Type 3 Muscarinic Receptors Modulate Macrophage Phenotype in the Presence of Th1 Cytokines
  McLean L, Grinchuk V, Zhao A, Sun R, Raufman JP, Shea-Donohue T, Digestive Disease Week, Gastroenterology, San Diego, CA, 1/1/2012
• Type 1 and Type 3 Muscarinic Receptors Modulate Intestinal Barrier Function
  McLean LP, Notari L, Sun R, Stiltz JA, Grinchuk V, Yan S, Zhao A, Raufman JP, Shea-Donohue T, Digestive Disease Week, Gastroenterology, Chicago, IL, 1/1/2011
• Role of Muscarinic 3 Receptors in the Immune, Epithelial, and Smooth Muscle Responses to Enteric Nematode Infection
  McLean LP, Zhao A, Sun R, Stiltz JA, Riera DC, Urban JF, Raufman JP, Shea-Donohue T, Digestive Disease Week, Gastroenterology, San Diego, CA, 1/1/2008
• Muscarinic Type 3 Receptors (M3R) Contribute to Ileal Mucosal Barrier Function
  McLean LP, Sun R, Stiltz J, Zhao A, Raufman JP, Shea-Donohue T, Digestive Disease Week, Gastroenterology, Washington, DC, 1/1/2007
• Compliance with Dyspepsia Guidelines: Experience in a Primary Care General Medicine Setting
  McLean LP and Fairchild DG, American College of Gastroenterology Annual Scientific Meeting and Postgraduate Course, Am J Gastroenterol, Las Vegas, NV, 1/1/2006
• Attitudes of Healthcare Workers Towards Smallpox Vaccination
  McLean LP, Salas FL, Lazar JD, McCarthy TA, Hamer DH, 42nd Annual Meeting of the Infectious Diseases Society of America, Boston, MA, 1/1/2004
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Lectures

• Type 3 Muscarinic Receptors Contribute to Host Defense within the GI Tract 
  The Johns Hopkins Hospital, Baltimore, MD - 1/1/2014
• The Science of Medical Therapy for Inflammatory Bowel Disease 
  University of Maryland Medical Center, Baltimore, MD - 1/1/2014
• Type 3 Muscarinic Receptor Deficiency is Associated with Impaired Paracellular Permeability and Activation of Myosin Light Chain (MLC) 2 
  Orlando, FL - 1/1/2013
• Type 3 Muscarinic Receptors Modulate Macrophage Phenotype in the Presence of Th1 Cytokines 
  San Diego, CA - 1/1/2012
• The Aberrant Right Subclavian Artery 
  Maryland Chapter of the American College of Physicians, Baltimore, MD - 1/1/2008
• Advanced Lupus Nephritis as an Uncommon Initial Presentation of Systemic Lupus Erythematosus 
  Maryland Chapter of the American College of Physicians, Baltimore, MD - 1/1/2008
• Comparing the Automated and Non-Automated Sign-Out Systems Used by Medicine Interns in Transfers of Patient Care 
  Maryland Chapter of the American College of Physicians, Baltimore, MD - 1/1/2008
• Muscarinic Type 3 Receptors and Ileal Mucosal Barrier Function 
  Maryland Chapter of the American College of Physicians, Baltimore, MD - 1/1/2007
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Other

• Type 3 Muscarinic Receptors Contribute to Homeostasis and Host Defense within the Gastrointestinal Tract, Doctor of Philosophy Thesis Defense 
  McLean LP
  University of Maryland, Baltimore, Baltimore, MD - 1/1/2014