LeciaVSequistMD

Oncology • Boston, MA

Assistant Professor of Medicine, Massachusetts General Hospital

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Office
55 Fruit Street Yaw 7b
Hematology/Oncology
Boston, MA 02114
Phone+1 617-724-4000

Fax+1 617-726-0453

Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer InstituteFellowship, Hematology and Medical Oncology, 2002 - 2005
Brigham and Women's HospitalResidency, Internal Medicine, 1999 - 2002
Harvard Medical SchoolClass of 1999

Certifications & Licensure

MA State Medical License 2001 - 2026
NH State Medical License 2024 - 2024
ME State Medical License 2020 - 2021
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014

Clinical Trials

Gefitinib in Treating Patients With Previously Untreated Stage IIIB or Stage IV Non-Small Cell Lung Cancer Start of enrollment: 2005 Sep 01
Completed
Phase 2
Phase I/II Safety Study of IPI-504 in Relapsed/Refractory Stage IIIb, or Stage IV Non-small Cell Lung Cancer (NSCLC) Start of enrollment: 2007 Jan 01
Completed
Phase 1, Phase 2
Erlotinib in Patients With Resected, Early Stage NSCLC With Confirmed Mutations in the EGFR Start of enrollment: 2007 Dec 01
Completed
Phase 2
Cetuximab as Therapy for Recurrent Non-Small Cell Lung Cancer Patients Who Have Received Prior Therapy Start of enrollment: 2006 Sep 01
Terminated
Phase 2
Erlotinib With or Without Hydroxychloroquine in Chemo-Naive Advanced NSCLC and (EGFR) Mutations Start of enrollment: 2009 Oct 01
Active, not recruiting
Phase 2
Hydroxychloroquine With or Without Erlotinib in Advanced Non-small Cell Lung Cancer (NSCLC) Start of enrollment: 2007 Jul 01
Terminated
Phase 1
Biopsies of Cancer Patients for Tumor Molecular Characterization Start of enrollment: 2010 Feb 01
Completed
Understanding Mechanisms of Acquired Resistance to BIBW2992 Start of enrollment: 2011 Feb 01
Completed
Not Applicable
IPI-504 in NSCLC Patients With ALK Translocations Start of enrollment: 2010 Oct 01
Terminated
Phase 2
Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer Start of enrollment: 2011 Jan 11
Terminated
Phase 3
Afatinib With CT and RT for EGFR-Mutant NSCLC Start of enrollment: 2012 Apr 01
Recruiting
Phase 2
Adjuvant Afatinib in Stage I-III NSCLC With EGFR Mutation Start of enrollment: 2013 Jan 01
Active, not recruiting
Phase 2
Phase 2 Study of AUY922 in NSCLC Patients With Exon 20 Insertion Mutations in EGFR Start of enrollment: 2013 Jul 01
Completed
Phase 2
A Study of Emibetuzumab in Non Small Cell Lung Cancer (NSCLC) Participants Start of enrollment: 2013 Aug 01
Completed
Phase 2
A Study of TAS-120 in Patients With Advanced Solid Tumors Start of enrollment: 2014 Jul 21
Completed
Phase 1, Phase 2
A Phase I/II, Multicenter, Open-label Study of EGFRmut-TKI EGF816, Administered Orally in Adult Patients With EGFRmut Solid Malignancies Start of enrollment: 2014 Jun 06
Completed
Phase 1, Phase 2
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Publications & Presentations

PubMed

Phase II trial of consolidative stereotactic body radiation therapy in patients with metastatic oncogene-driven non-small cell lung carcinoma treated with tyrosine kin...
Florence K Keane, Beow Y Yeap, Melin J Khandekar, Jessica J Lin, Ibiayi Dagogo-Jack
International Journal of Radiation Oncology, Biology, Physics. 2024-11-20
2 citations
Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection.
Peter J Mazzone, Peter B Bach, Jacob Carey, Caitlin A Schonewolf, Katalin Bognar
Cancer Discovery. 2024-11-01
1 citations
Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors.
Risa Burr, Ignaty Leshchiner, Christina L Costantino, Martin Blohmer, Tilak Sundaresan
Nature Cancer. 2024-11-01

Journal Articles

Oxford University Press Has Registered This DOI Pre-Publication
R S Heist, Z Piotrowska, C G Azzoli, A T Shaw, I T Lennes, L V Sequist, J F Gainor, Oxford University Press
EGFR Exon 20 Insertion Mutations Display Sensitivity to Hsp90 Inhibition in Preclinical Models and Lung Adenocarcinomas
Lecia V Sequist, Zofia Piotrowska, Clinical Cancer Research
A Digital RNA Signature of Circulating Tumor Cells Predicting Early Therapeutic Response in Localized and Metastatic Breast Cancer
David T Miyamoto, Aditya Bardia, Lecia V Sequist, Laura M Spring, Daniel A Haber, Mark Kalinich, Clinical Cancer Research
Stress Hormones Promote EGFR Inhibitor Resistance in NSCLC: Implications for Combinations with Β-blockers
Hai Tran, Anil K Sood, John V Heymach, Roy Herbst, Lecia V Sequist, Edward S Kim, Science Magazine
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Lectures

SHERLOC: A phase 2 study of MM-121 plus with docetaxel versus docetaxel alone in patients with heregulin (HRG) positive advanced non-small cell lung cancer (NSCLC).
2019 ASCO Annual Meeting - 6/1/2019
The ASCENT trial: A phase II study of neoadjuvant afatinib, chemoradiation and surgery for stage III EGFR mutation-positive NSCLC.
2018 ASCO Annual Meeting - Chicago, Illinois - 06/3/2018

Other