Lawrence Edgar Flaherty MD

Oncology•Detroit, MI

Professor, Internal Medicine, Wayne State University School of Medicine

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Karmanos Cancer Center4100 John R Hwcrc 4th FlDetroit, MI 48201
Phone+1 313-576-8779
Fax+1 313-576-8726

Education & Training

University of Pennsylvania Health SystemFellowship, Hematology and Medical Oncology, 1983 - 1986
Medical College of Wisconsin Affiliated HospitalsResidency, Internal Medicine, 1978 - 1981
Saint Louis University School of MedicineClass of 1978

Certifications & Licensure

MI State Medical License 1986 - 2026
PA State Medical License 1984 - 1988
WI State Medical License 1979 - 1983
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Super Doctor SuperDoctors.com
Top MD Consumers Checkbook

Clinical Trials

Combination Chemotherapy With or Without Interleukin-2 and Interferon Alfa in Treating Patients With Metastatic Melanoma Start of enrollment: 1997 Nov 13
Completed
Phase 3
High-Dose Interferon Alfa in Treating Patients With Stage II or Stage III Melanoma Start of enrollment: 1999 Mar 25
ACTIVE_NOT_RECRUITING
PHASE3
S0008: Chemotherapy Plus Biological Therapy in Treating Patients With Melanoma Start of enrollment: 2000 Aug 01
Completed
Phase 3
Radiation Therapy With or Without Trastuzumab in Treating Women With Ductal Carcinoma In Situ Who Have Undergone Lumpectomy Start of enrollment: 2008 Nov 10
ACTIVE_NOT_RECRUITING
PHASE3
Laboratory-Treated T Cells After Second-Line Chemotherapy in Treating Patients With HER2/Neu-Negative Metastatic Breast Cancer Start of enrollment: 2010 Mar 08
Terminated
Phase 2
A Phase III Randomized Trial of Metformin vs Placebo in Early Stage Breast Cancer Start of enrollment: 2010 Aug 13
Completed
Phase 3
Targeted T Cells After Neoadjuvant Chemotherapy in Treating Women With Stage II or III Breast Cancer Undergoing Surgery Start of enrollment: 2010 Jul 01
Terminated
Phase 2
Aldesleukin With or Without Ziv-Aflibercept in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery Start of enrollment: 2011 Jan 18
Completed
Phase 2
Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer Start of enrollment: 2011 Jan 15
ACTIVE_NOT_RECRUITING
PHASE3
Chemotherapy With or Without Trastuzumab After Surgery in Treating Women With Invasive Breast Cancer Start of enrollment: 2011 Jan 06
ACTIVE_NOT_RECRUITING
PHASE3
A Multi-National, Prospective, Observational Study in Patients With Unresectable or Metastatic Melanoma Start of enrollment: 2012 Jun 03
Completed
S1207 Hormone Therapy With or Without Everolimus in Treating Patients With Breast Cancer Start of enrollment: 2013 Sep 12
ACTIVE_NOT_RECRUITING
PHASE3
HD IL-2 + Vemurafenib in Patients With BRAF Mutation Positive Metastatic Melanoma Start of enrollment: 2012 Aug 01
Terminated
Phase 4
Study Comparing the Efficacy of MEK162 Versus Dacarbazine in Unresectable or Metastatic NRAS Mutation-positive Melanoma Start of enrollment: 2013 Jul 12
Completed
Phase 3
HD IL-2 + Ipilimumab in Patients With Metastatic Melanoma Start of enrollment: 2013 May 01
Terminated
Phase 4
Molecularly Targeted Therapy in Treating Patients With BRAF Wild-type Melanoma That is Metastatic Start of enrollment: 2014 May 01
Completed
Phase 2
Dabrafenib and Trametinib for the Treatment of Patients With Stage III-IV BRAF Mutant Melanoma That Cannot Be Removed by Surgery Start of enrollment: 2014 Sep 19
ACTIVE_NOT_RECRUITING
PHASE2
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Publications & Presentations

PubMed

1 citations
Southwest Oncology Group S0826: A phase 2 trial of SCH 727965 (NSC 727135, dinaciclib) in patients with stage IV melanoma.
Christopher D Lao, James Moon, Vincent T Ma, John P Fruehauf, Lawrence E Flaherty
Cancer. 2025-01-01
3 citations
An Open–Label, Randomized, Multi–Center Study Comparing the Sequence of High Dose Aldesleukin (Interleukin–2) and Ipilimumab (Yervoy) in Patients with Metastatic Melanoma
Merve Hasanov, Denái R. Milton, William H. Sharfman, Bret Taback, Lee D. Cranmer
Oncoimmunology. 2021-10-09
21 citations
Phase II clinical trial using anti-CD3 × anti-HER2 bispecific antibody armed activated T cells (HER2 BATs) consolidation therapy for HER2 negative (0-2+) metastatic br...
Lawrence G. Lum, Zaid S. Al-Kadhimi, Abhinav Deol, Vidya Kondadasula, Dana L Schalk
Journal for Immunotherapy of Cancer. 2021-06-01

Press Mentions

Karmanos Cancer Institute Presents Its 2017 Heroes of CancerNovember 16th, 2017

Grant Support

National Clinical Trials Network (NCTN) - Lead Academic Participating Site (LAPS)WAYNE STATE UNIVERSITY2019–2026
Clinical Trials OfficeNational Cancer Institute2011–2012
Southwest Oncology Group U10 Member SiteNational Cancer Institute2010–2012
Southwest Oncology GroupNational Cancer Institute1996–2009

Professional Memberships

American College of Physicians - ACP
Member
American Society of Clinical Oncology - ASCO
Member