Laurence Herbert Kedes MD

PubMed

• 161 citations
  Research ethics recommendations for whole-genome research: consensus statement.
  Timothy Caulfield, Amy L. McGuire, Mildred K. Cho, Janet A. Buchanan, Michael M. Burgess
  Plos Biology. 2008-03-25
• New cellular and molecular approaches for the treatment of cardiac disease.
  Laurence Kedes, Robert A. Kloner, Kimi Y. Kong, Coralie Poizat, Boris Z. Simkhovich
  Seminars in Nephrology. 2004-09-01
• 901 citations
  Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution.
  Israel M. Barbash, Pierre Chouraqui, Jack Baron, Micha S. Feinberg, Sharon Etzion
  Circulation. 2003-08-19

Journal Articles

• A high-titer lentiviral production system mediates efficient transduction of differentiated cells including beating cardiac myocytes.  
  Sakoda T, Kasahara N, Hamamori Y, Kedes L., J Mol Cell Cardiol
• Evaluation of the effects of intramyocardial injection of DNA expressing vascular endothelial growth factor (VEGF) in a myocardial infarction model in the rat--angioge...  
  Schwarz ER, Speakman MT, Patterson M, Hale SS, Isner JM, Kedes LH, Kloner RA, J Am Coll Cardiol
• Intramyocardial injection of DNA encoding vascular endothelial growth factor in a myocardial infarction model.  
  Kloner RA, Dow J, Chung G, Kedes LH, J Thromb Thrombolysis
• Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium.  
  Muller-Ehmsen J, Whittaker P, Kloner RA, Dow JS, Sakoda T, Long TI, Laird PW, Kedes L., J Mol Cell
• HERP1 is a cell type-specific primary target of Notch.  
  Iso T, Chung G, Hamamori Y, Kedes L., J Biol Chem
• HES and HERP families: multiple effectors of the Notch signaling pathway.  
  Iso T, Kedes L, and Hamamori Y., J Cell Physiol
• Long-term outcome of fetal cell transplantation on postinfarction ventricular remodeling and function.  
  Yao M, Dieterle T, Hale SL, Dow JS, Kedes LH, Peterson KL, Kloner RA., . J Mol Cell Cardiol.
• Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells.  
  Itoh F, Itoh S, Goumans MJ, Valdimarsdottir G, Iso T, Dotto GP, Hamamori Y, Kedes L, Kato M, Dijke Pt P., EMBO J.
• Cytoplasmic nuclear transfer of the actin-capping protein tropomodulin.  
  Kong KY, Kedes L., J Biol Chem.
• Leucine 135 of tropomodulin-1 regulates its association with tropomyosin, its cellular localization, and the integrity of sarcomeres.  
  Kong, K. Y., and Kedes, L., J Biol Chem 281
• Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase.  
  Tanaka, T., Nishimura, D., Wu, R. C., Amano, M., Iso, T., Kedes, L., Nishida, H., Kaibuchi, K., and Hamamori, Y., J Biol Chem 281
• Critical Role of Nuclear Calcium/Calmodulin-dependent Protein Kinase II{delta}B in Cardiomyocyte Survival in Cardiomyopathy.  
  Little GH, Saw A, Bai Y, Dow J, Marjoram P, Simkhovich B, Leeka J, Kedes L, Kloner RA, Poizat C., J Biol Chem.
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Abstracts/Posters

• Rebuilding a damaged heart: long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function.
  Muller-Ehmsen J, Peterson KL, Kedes L, Whittaker P, Dow JS, Long TI, Laird PW, Kloner RA., Circulation
• The new date, new format, new goals and new sponsor of the Archon Genomics X PRIZE competition.
  Kedes L, Campany G., Nat Genet.
• Judging the Archon Genomics X PRIZE for whole human genome sequencing.
  Kedes L, Liu E, Jongeneel CV, Sutton G., Nat Genet.
• The Archon Genomics X PRIZE for whole human genome sequencing.
  Kedes L, Liu ET., Nat Genet.
• Research ethics recommendations for whole-genome research: consensus statement.
  Caulfield T, McGuire AL, Cho M, Buchanan JA, Burgess MM, Danilczyk U, Diaz CM, Fryer-Edwards K, Green SK, Hodosh MA, Juengst ET, Kaye J, Kedes L, Knoppers BM, Lemmens ..., PLoS Biol.
• Calcium phosphate coprecipitation greatly enhances transduction of cardiac myocytes and vascular smooth muscle cells by lentivirus vectors.
  Sakoda T, Kasahara N, Kedes L, Ohyanagi M., Exp Clin Cardiol.
• Nuclear hormone receptor coregulator GRIP1 suppresses, whereas SRC1A and p/CIP coactivate, by domain-specific binding of MyoD.
  Wu, H. Y., Hamamori, Y., Xu, J., Chang, S. C., Saluna, T., Chang, M. F., O'Malley, B. W., and Kedes, L., J Biol Chem 280
• Lentiviral vector-mediated gene transfer to endothelial cells compared with adenoviral and retroviral vectors.
  Sakoda, T., Kasahara, N., Kedes, L., and Ohyanagi, M., Prep Biochem Biotechnol 37
• The Ad5 fiber mediates nonviral gene transfer in the absence of the whole virus, utilizing a novel cell entry pathway.
  Rentsendorj, A., Agadjanian, H., Chen, X., Cirivello, M., Macveigh, M., Kedes, L., Hamm-Alvarez, S., and Medina-Kauwe, L. K., Gene Ther
• Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells.
  Poizat, C., Puri, P. L., Bai, Y., and Kedes, L., Mol Cell Biol 25
• Washout of transplanted cells from the heart: a potential new hurdle for cell transplantation therapy.
  Dow, J., Simkhovich, B. Z., Kedes, L., and Kloner, and R. A., Cardiovasc Res 67
• HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box.
  Doi, H., Iso, T., Yamazaki, M., Akiyama, H., Kanai, H., Sato, H., Kawai-Kowase, K., Tanaka, T., Maeno, T., Okamoto, E., and et al., Arterioscler Thromb Vasc Biol 25
• Age-related changes of cardiac gene expression following myocardial ischemia/reperfusion.
  Simkhovich BZ, Marjoram P, Poizat C, Kedes L, Kloner RA., Arch Biochem Biophys.
• Notch signaling in vascular development.
  Iso T, Hamamori Y, Kedes L., Arterioscler Thromb Vasc Biol.
• Development of abnormal tissue architecture in transplanted neonatal rat myocytes.
  Whittaker P, Muller-Ehmsen J, Dow JS, Kedes LH, Kloner RA., Ann Thorac Surg.
• Cardiomyocyte transplantation into the failing heart-new therapeutic approach for heart failure?
  Reffelmann T, Leor J, Muller-Ehmsen J, Kedes L, Kloner RA., Heart Fail Rev.
• Nonviral gene delivery to human breast cancer cells by targeted Ad5 penton proteins.
  Medina-Kauwe LK, Maguire M, Kasahara N, Kedes L., Gene Ther
• Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis.
  Puri PL, Iezzi S, Stiegler P, Chen TT, Schiltz RL, Muscat GE, Giordano A, Kedes L, Wang JY, Sartorelli V., Mol Cell
• HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling.
  Iso T, Sartorelli V, Poizat C, Iezzi S, Wu HY, Chung G, Kedes L, Hamamori Y., Mol Cell Biol
• HERP, a new primary target of Notch regulated by ligand binding.
  Iso T, Sartorelli V, Chung G, Shichinohe T, Kedes L, Hamamori Y., Mol Cell Biol
• 3PO, a novel nonviral gene delivery system using engineered Ad5 penton proteins.
  Medina-Kauwe LK, Kasahara N, Kedes L., Gene Ther
• Proteasome-mediated degradation of the coactivator p300 impairs cardiac transcription.
  Poizat C, Sartorelli V, Chung G, Kloner RA, Kedes L., Mol Cell Biol
• Assessing the binding and endocytosis activity of cellular receptors using GFP-ligand fusions.
  Medina-Kauwe LK, Leung V, Wu L, Kedes L., Biotechniques
• The myogenic regulatory circuit that controls cardiac/slow twitch troponin C gene transcription in skeletal muscle involves E-box, MEF-2, and MEF-3 motifs.
  Christensen TH, Kedes L., Gene Expr
• Twist is a potential oncogene that inhibits apoptosis.
  Maestro R, Dei Tos AP, Hamamori Y, Krasnokutsky S, Sartorelli V, Kedes L, Doglioni C, Beach DH, Hannon GJ., Genes Dev
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Lectures

• Genomics prize—the X PRIZE Foundation. 
  Rejuvenation Res.