Laura E. Crotty Alexander MD

PubMed

• E-cigarette-induced changes in cell stress and mitochondrial function.
  Ramamurthy Chitteti, Juan Pablo Zuniga-Hertz, Jorge A Masso-Silva, John Shin, Ingrid Niesman
  Free Radical Biology & Medicine. 2025-02-16
• E-cigarette vapor extract alters human eosinophil gene expression in an effect mediated by propylene glycol, glycerin, and nicotine.
  Nicholas T Hogan, Francisco Emmanuel Castaneda-Castro, Ashmitaa Logandha Ramamoorthy Premlal, Howard Brickner, Monalisa Mondal
  Journal of Leukocyte Biology. 2024-11-27
• 2 citations
  Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells.
  Le Xu, Chunting Tan, Justinn Barr, Nicole Talaba, Jamie Verheyden
  Cell Stem Cell. 2024-10-03

Journal Articles

• Epidermal deletion of HIF-2alpha stimulates wound closure  
  Cowburn AS, Alexander LE, Nizet V, Chilvers ER, and Johnson RS, Journal of Investigative Dermatology, 3/1/2014
• Activation of the stress response in macrophages alters the M1/M2 balance by enhancing bacterial killing and IL-10 expression  
  Vega VL, Crotty Alexander LE, Charles W, Nizet V, De Maio A, J Mol Med, 1/1/2014
• Hypoxia potentiates allergen induction of HIF-1a, chemokines, airway inflammation, TGF-b1, and airway remodeling a mouse model  
  Baek KJ, Cho JY, Rosenthal P, Alexander LE, Nizet V, and Broide DH, Clinical Immunology, 2/21/2013
• Myeloid cell HIF-1alpha regulates asthma airway resistance and eosinophil function  
  Crotty Alexander LE, Akong K, Feldstein S, Johansson P, Nyugen A, McEachern EK, Nicatia S, Cowburn A, Olson J, Cho JY, Isaacs Jr H, Johnson RS, Broide DH, Nizet V, Journal of Molecular Medicine, 12/19/2012
• Rescuing of deficient killing and phagocytic activities of macrophages derived from non-obese diabetic mice by treatment with geldanamycin or heat shock: potential cli...  
  Vega VL, Charles W, Crotty Alexander LE, Cell Stress Chaperones, 5/29/2011
• Staphylococcus epidermidis antimicrobial phenol soluble modulins cooperate with host antimicrobial peptides to kill Group A Streptococcus  
  Cogen AL, Yamasaki K, Muto J, Sanchez KM, Crotty Alexander L, Tanios J, Lai Y, Kim JE, Nizet V, Gallo RL, PLoS ONE, 1/5/2010
• M1T1 Group A Streptococcal Pili Promote Epithelial Colonization but Diminish Systemic Virulence Through Neutrophil Extracellular Entrapment  
  Crotty Alexander LE, Maisey HC, Timmer AM, Rooijakkers SHM, Gallo RL, von Kockritz-Blickwede M, Nizet V, Journal of Molecular Medicine, 12/4/2009
• Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition  
  Laugel B, Boulter JM, Lissin N, Vuidepot A, Li Y, Gostrick E, Crotty LE, Douek DC, Hemelaar J, Price DA, Jakobsen BK, Sewell AK, Journal of Biological Chemistry, 1/21/2005
• Epidermal growth factor receptor VIII peptide vaccination is efficacious against established intracerebral tumors  
  Crotty LE, Heimberger AB, Archer GE, Hess KR, Wikstrand CJ, Friedman AH, Friedman HS, Bigner DD, Sampson JH, Clinical Cancer Research, 9/15/2003
• Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells  
  Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE, Casazza JP, Kuruppu J, Migueles SA, Connors M, Roederer M, Douek DC, Koup RA, Blood, 4/1/2003
• Generation of anti-idiotypic reagents in the EGFRvIII tumor-associated antigen system  
  Wikstrand CJ, Cole VR, Crotty LE, Sampson JH, Bigner DD, Cancer Immunology & Immunotherapy, 2/1/2002
• Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma  
  Heimberger AB, Archer GE, Crotty LE, McLendon RE, Friedman AH, Friedman HS, Bigner DD, Sampson JH, Neurosurgery, 1/1/2002
• Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors  
  Crotty LE, Sampson JH, Lee S, Archer GE, Ashley DM, Wikstrand CJ, Hale LP, Small C, Dranoff G, Friedman AH, Friedman HS, Bigner DD, Proceedings of the National Academy of Sciences of the United States of America, 6/20/2000
• Bone marrow-derived dendritic cells pulsed with tumor homogenate induce immunity against syngeneic intracerebral glioma  
  Heimberger AB, Crotty LE, Archer GE, McLendon RE, Friedman A, Dranoff G, Bigner DD, Sampson JH, Journal of Neuroimmunology, 2/1/2000
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Books/Book Chapters

• Manual of Clinical Problems in Pulmonary Medicine 
  Chapter: Anaerobic Lung Infections. 
  Page 279 - 284Crotty Alexander LEEditors: Morris TA, Ries AL, and Bordow RA.Wolters Kluwer Health, Philadelphia2014
• Manual of Clinical Problems in Pulmonary Medicine 
  Chapter: Staphylococcal and Streptococcal Pneumonias. 
  Page 263 - 266Mohamedaly OH and Crotty Alexander LEEditors: Morris TA, Ries AL, and Bordow RA.Wolters Kluwer Health, Philadelphia2014
• The Cancer Handbook 
  Chapter: Models for CNS malignancies. 
  Page 1123 - 1138Crotty LE. Sampson JH. Archer GE, and Bigner DDEditors: Alison MR.Nature Publishing Group, London2004

Other

• "Here's Why Bacteria Like E-Cigs." 
  Laura Elise Crotty Alexander, MD, TIME Magazine, Alice Park
• "Study finds e-cigarettes increase superbug resistance." 
  Laura Elise Crotty Alexander, MD, NPR/KPCC
• "The Conversation" 
  Laura Elise Crotty Alexander, MD