Kristine Yaffe MD

Professor of Psychiatry, Neurology and Epidemiology; and the Roy and Marie Scola Endowed Chair and Vice Chair of Research in Psychiatry, UCSF. Chief of Geriatric Psychiatry and Director of the Memory Evaluation Clinic, San Francisco Veterans Affairs Medical Center.

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4150 Clement St # 181gSan Francisco, CA 94121
Phone+1 415-221-4810
Fax+1 415-750-6641

Education & Training

University of California (San Francisco)Residency, Psychiatry, 1993 - 1995
University of California (San Francisco)Residency, Neurology, 1990 - 1993
University of Pennsylvania Health SystemInternship, Internal Medicine, 1989 - 1990
Perelman School of Medicine at the University of PennsylvaniaClass of 1989

Certifications & Licensure

CA State Medical License 1990 - 2026
PA State Medical License 1989 - 1990

Clinical Trials

Metabolic Syndrome, Inflammation, and Risk of Cognitive Decline Start of enrollment: 1997 Jan 01
Completed
Computer-Based Training for Mild Alzheimer's Disease Start of enrollment: 2004 Sep 01
Completed
Phase 1
Clinical Characteristics of Dementias That Occur Remotely After Traumatic Brain Injury in Retired Military Personnel Start of enrollment: 2013 Jul 01
Withdrawn
Systematic Multi-domain Alzheimer's Risk Reduction Trial Start of enrollment: 2018 Aug 30
Completed
Not Applicable
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Publications & Presentations

PubMed

Five-Year Changes in 24-Hour Sleep-Wake Activity and Dementia Risk in Oldest Old Women.
Sasha Milton, Clémence Cavaillès, Sonia Ancoli-Israel, Katie L Stone, Kristine Yaffe
Neurology. 2025-04-22
Effects of Continuous Positive Airway Pressure on Neuroimaging Biomarkers and Cognition in Adult Obstructive Sleep Apnea: A Randomized Controlled Trial.
Huajun Xu, Yupu Liu, Chenyang Li, Xinyi Li, Li Shen
American Journal of Respiratory and Critical Care Medicine. 2025-04-01
Sleep health profiles across six population-based cohorts and recommendations for validating clustering models.
Sanne J W Hoepel, Nina Oryshkewych MSc, Lisa L Barnes PhD, Meryl A Butters PhD, Daniel J Buysse MD
Sleep Health. 2025-03-20

Journal Articles

Risk of Suicide Attempt in Patients with Recent Diagnosis of Mild Cognitive Impairment or Dementia
Kristine Yaffe, MD, JAMA Psychiatry
Sex Differences in Cognitive Decline Among US Adults
Deborah A Levine, Jeremy B Sussman, Rodney A Hayward, Rebecca F Gottesman, Ralph L Sacco, Kristine Yaffe, JAMA Network Open
Agent Orange Exposure and Dementia Diagnosis in US Veterans of the Vietnam Era
Kristine Yaffe, MD, JAMA Neurology
Association of Racial Residential Segregation Throughout Young Adulthood and Cognitive Performance in Middle-Aged Participants in the CARDIA Study
Kristine Yaffe, MD, JAMA Neurology
Assessing Risk for Adverse Outcomes in Older Adults: The Need to Include Both Physical Frailty and Cognition
Kristine Yaffe, Kenneth E Covinsky, Sei J Lee, Journal of the American Geriatrics Society
Multiple Sensory Impairment Is Associated with Increased Risk of Dementia Among Black and White Older Adults
Kristine Yaffe, Allison R Kaup, The Journals of Gerontology
Dissecting the Genetic Relationship Between Cardiovascular Risk Factors and Alzheimer’s Disease
Christine M Glastonbury, Fanny M Elahi, Reisa A Sperling, William P Dillon, Lindsay A Farrer, Rahul S Desikan, Christopher P Hess, James B Brewer, Bradley T Hyman, Kri..., Acta Neuropathologica
Vision Impairment and Cognitive Outcomes in Older Adults: The Health ABC Study
Marilyn Albert, Kristine Yaffe, The Journals of Gerontology
Fasting Glucose Variability in Young Adulthood and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Stephen Sidney, Kristine Yaffe, Diabetes Care
American Geriatrics Society and National Institute on Aging Bench‐to‐Bedside Conference: Sensory Impairment and Cognitive Decline in Older Adults
Kristine Yaffe, Heather E Whitson, Frank R Lin, Journal of the American Geriatrics Society
Rest‐Activity Rhythms and Cognitive Decline in Older Men: The Osteoporotic Fractures in Men Sleep Study
Nancy E Lane, Kristine Yaffe, Susan Redline, Kristine E Ensrud, Erin LeBlanc, Journal of the American Geriatrics Society
Excessive Daytime Sleepiness, Objective Napping and 11-Year Risk of Parkinson’s Disease in Older Men
Kristine Yaffe, MD, International Journal of Epidemiology
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Authored Content

Blood-Based Biomarkers for Alzheimer’s Present Complex Challenges to Health Care SystemOctober 2024
Association of Rapid Eye Movement Sleep with Mortality in Middle-Aged and Older AdultsJuly 2020
Association of Rapid Eye Movement Sleep with Mortality in Middle-Aged and Older AdultsJuly 2020
Association of Circadian Abnormalities in Older Adults with an Increased Risk of Developing Parkinson DiseaseJune 2020
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Press Mentions

These Sleep Habits Might Make Your Brain Age FasterFebruary 17th, 2025
MRI Shows Poor Sleep Translates to Poor Brain HealthOctober 30th, 2024
Study of Chemical Exposure, Dementia Risk Funded by $11M NIH GrantOctober 30th, 2024
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Grant Support

Lifecourse Predictors and Mechanisms of Early Clinical ADRD among Black and White Adults in their SixtiesUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2025–2029
Lifecourse Predictors and Mechanisms of Early Clinical ADRD among Black and White Adults in their SixtiesUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2025–2029
Early mid-life environmental toxicant exposures and AD/ADRD risk in CARDIAUNIVERSITY OF PENNSYLVANIA2024–2029
Early mid-life environmental toxicant exposures and AD/ADRD risk in CARDIAUNIVERSITY OF PENNSYLVANIA2024–2029
Hypertension, Blood Pressure Targets, and Alzheimer’s Disease and Dementia Risk and Disparities among Nationally Representative US VeteransUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2024–2029
Early mid-life environmental toxicant exposures and AD/ADRD risk in CARDIAUNIVERSITY OF PENNSYLVANIA2024–2029
Hypertension, Blood Pressure Targets, and Alzheimer’s Disease and Dementia Risk and Disparities among Nationally Representative US VeteransUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2024–2029
Hypertension, Blood Pressure Targets, and Alzheimer’s Disease and Dementia Risk and Disparities among Nationally Representative US VeteransUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2024–2029
Hypertension, Blood Pressure Targets, and Alzheimer’s Disease and Dementia Risk and Disparities among Nationally Representative US VeteransUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2024–2029
Hypertension, Blood Pressure Targets, and Alzheimer’s Disease and Dementia Risk and Disparities among Nationally Representative US VeteransUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2024–2029
Hypertension, Blood Pressure Targets, and Alzheimer’s Disease and Dementia Risk and Disparities among Nationally Representative US VeteransUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2024–2029
Early mid-life environmental toxicant exposures and AD/ADRD risk in CARDIAUNIVERSITY OF PENNSYLVANIA2024–2029
Early mid-life environmental toxicant exposures and AD/ADRD risk in CARDIAUNIVERSITY OF PENNSYLVANIA2024–2029
Hypertension, Blood Pressure Targets, and Alzheimer’s Disease and Dementia Risk and Disparities among Nationally Representative US VeteransUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2024–2029
Early mid-life environmental toxicant exposures and AD/ADRD risk in CARDIAUNIVERSITY OF PENNSYLVANIA2024–2029
Early mid-life environmental toxicant exposures and AD/ADRD risk in CARDIAUNIVERSITY OF PENNSYLVANIA2024–2029
Paul B. Beeson Emerging Leaders Career Development Awards in Aging Annual MeetingAMERICAN FEDERATION FOR AGING RESEARCH2017–2029
The Health & Aging Brain Study - Health Disparities (HABS-HD)UNIVERSITY OF NORTH TEXAS HLTH SCI CTR2022–2027
The Health & Aging Brain Study - Health Disparities (HABS-HD)UNIVERSITY OF NORTH TEXAS HLTH SCI CTR2022–2027
The Health & Aging Brain Study - Health Disparities (HABS-HD)UNIVERSITY OF NORTH TEXAS HLTH SCI CTR2022–2027
The Health & Aging Brain Study - Health Disparities (HABS-HD)UNIVERSITY OF NORTH TEXAS HLTH SCI CTR2022–2027
The Health & Aging Brain Study - Health Disparities (HABS-HD)UNIVERSITY OF NORTH TEXAS HLTH SCI CTR2022–2027
The Health & Aging Brain Study - Health Disparities (HABS-HD)UNIVERSITY OF NORTH TEXAS HLTH SCI CTR2022–2027
The Health & Aging Brain Study - Health Disparities (HABS-HD)UNIVERSITY OF NORTH TEXAS HLTH SCI CTR2022–2027
Population Based Research for Alzheimer's Innovation (POP BRAIN)UNIVERSITY OF CALIFORNIA, SAN FRANCISCO2021–2026
Population Based Research for Alzheimer's Innovation (POP BRAIN)UNIVERSITY OF CALIFORNIA, SAN FRANCISCO2021–2026
Population Based Research for Alzheimer's Innovation (POP BRAIN)UNIVERSITY OF CALIFORNIA, SAN FRANCISCO2021–2026
Population Based Research for Alzheimer's Innovation (POP BRAIN)UNIVERSITY OF CALIFORNIA, SAN FRANCISCO2021–2026
Population Based Research for Alzheimer's Innovation (POP BRAIN)UNIVERSITY OF CALIFORNIA, SAN FRANCISCO2021–2026
Population Based Research for Alzheimer's Innovation (POP BRAIN)UNIVERSITY OF CALIFORNIA, SAN FRANCISCO2021–2026
Population Based Research for Alzheimer's Innovation (POP BRAIN)UNIVERSITY OF CALIFORNIA, SAN FRANCISCO2021–2026
Clin-STAR Coordinating CenterAMERICAN FEDERATION FOR AGING RESEARCH2019–2026
Blood mitochondrial DNA biomarkers of midlife cognitive decline and adverse brain imaging changes - A longitudinal investigation in the CARDIA population-based cohort studyNORTHWESTERN UNIVERSITY AT CHICAGO2020–2025
Blood mitochondrial DNA biomarkers of midlife cognitive decline and adverse brain imaging changes - A longitudinal investigation in the CARDIA population-based cohort studyNORTHWESTERN UNIVERSITY AT CHICAGO2020–2025
Sleep Quality and Mechanistic Links to Alzheimer Disease and Related Disorders among older Mexican Americans and Non-Hispanic WhitesUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2019–2025
Lifecourse CVD Risk and Midlife Cognitive Trajectories and Brain Aging: Implications for Alzheimer's and Dementia PreventionNORTHERN CALIFORNIA INSTITUTE/RES/EDU2019–2025