KirkUKnowltonMDFACC, FAHA
Cardiology • Murray, UTNon-Invasive Cardiology, Preventive Cardiology, Cardiovascular Disease Genetics
Director of Cardiovascular Research Intermountain Health. Professor, Clinical Investigation, Intermountain Health. Adjunct Professor of Medicine, University of Utah
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Office
5121 S Cottonwood St
Murray, UT 84107Phone+1 801-507-4000
Summary
- I have a strong interest in understanding how and why patients develop heart failure, including abnormalities in DNA, infections of the heart like viral myocarditis, and the role of immune function in heart cells that affect cardiac performance. I've also made discoveries related to how heart cells communicate with each other to establish normal conduction. Clinically, I practice as a general cardiologist with a focus on heart failure and pulmonary hypertension, where I apply my research efforts to preventing the development of heart disease, promoting optimal recovery, and advancing the use of a person’s own biological characteristics to provide precision medicine.
Education & Training
UC San Diego Medical Center Molecular Cardiology Research Fellowship, 1989 - 1991
University of California (San Diego) Medical CenterFellowship, Cardiovascular Disease, 1987 - 1989
Duke University HospitalResidency, Internal Medicine, 1984 - 1987
University of Utah School of MedicineClass of 1984- Brigham Young UniversityBA, Chemistry, 1977 - 1980
Certifications & Licensure
UT State Medical License 2015 - 2026
CA State Medical License 1987 - 2025- American Board of Internal Medicine Internal Medicine
- American Board of Internal Medicine Cardiovascular Disease
Awards, Honors, & Recognition
- Fellow American Heart Association
- American Heart Association "Heart of Gold" Physician Honoree Utah Heart Association Gala, 2017
- Inaugural Frederic C. Shean Endowed Lecturer University of Utah Grand Rounds, 2016
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Clinical Trials
- Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-term Start of enrollment: 2016 Apr 01
- Pilot and Feasibility Study of a MAWDS (Medications, Activity, Weight, Diet and Symptoms) Heart Failure Mobile Platform Start of enrollment: 2017 Sep 28
- Effectiveness of a Proactive Cardiovascular Primary Prevention Strategy, With or Without the Use of Coronary Calcium Screening, in Preventing Future Major Adverse Cardiac Events Start of enrollment: 2018 Mar 26
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Publications & Presentations
PubMed
- 392 citationsEnteroviral protease 2A cleaves dystrophin: Evidence of cytoskeletal disruption in an acquired cardiomyopathyCornel Badorff, Gil-Hwan Lee, Barry J. Lamphear, Maryann E. Martone, Kevin P. Campbell
Nature Medicine. 1999-03-01 - 77 citationsMultiomics study of nonalcoholic fatty liver disease.Gardar Sveinbjornsson, Magnus O Ulfarsson, Rosa B Thorolfsdottir, Benedikt A Jonsson, Eythor Einarsson
Nature Genetics. 2022-11-01 - 636 citationsSegregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophyHoward A. Rockman, Robert S. Ross, Adrienne N. Harris, Kirk U. Knowlton, Mark E. Steinhelper
Proceedings of the National Academy of Sciences of the United States of America. 1991-09-15
Press Mentions
Reduction in BP Drives Treatment Preference for Hypertensive PatientsDecember 20th, 2022- Gout Flares Linked to Temporary Increase in Cardiovascular RiskApril 8th, 2022
- Can a Simple Technique During Vaccination Stop Myocarditis?October 2nd, 2021
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Grant Support
- Training In Cardiovascular Physiology And PharmacologyNational Heart, Lung, And Blood Institute2007–2011
- Administative CoreNational Heart, Lung, And Blood Institute2007–2011
- Adhesion Molecules Of The Intercalated DISC In CardiomyopathyNational Heart, Lung, And Blood Institute2007–2011
- Molecular Pathways For Hypertrophy And CardiomyopathyNational Heart, Lung, And Blood Institute2005–2011
- Cardiac SOCS Proteins: A Role In Enterovirus InfectionNational Heart, Lung, And Blood Institute2004–2007
- Biomechanical Stress Pathways And CardiomyopathyNational Heart, Lung, And Blood Institute2005–2006
- Core--Myocardial Cell Biology And Viral Vector FacilityNational Heart, Lung, And Blood Institute2005
- Administrative CoreNational Heart, Lung, And Blood Institute2005
- Dystrophin-Glycoprotein Complex In Viral CardiomyopathyNational Heart, Lung, And Blood Institute2001–2004
- Core--Cell Biology And Viral Vector FacilityNational Heart, Lung, And Blood Institute2002
- Dystrophin-Glyoprotein Complex And Dilated CardiomyopathyNational Heart, Lung, And Blood Institute2000–2002
- Pathogenesis Of Viral Heart DiseaseNational Center For Research Resources2001
- Myocyte Apoptosis And A Transgenic Heart Failure ModelNational Heart, Lung, And Blood Institute1999–2001
- Regulation Of ANF Gene During Ventricular HypertrophyNational Heart, Lung, And Blood Institute1991–1995
Committees
- Committee Member, Chair Nominating Committee, American Heart Association, Western States Affiliate 2017 - Present
- Chair, Scientific Advisory Committee, The Medical Heart and Lung Foundation, Intermountain 2017 - Present
- Member, Research Guidance Council, Intermountain Healthcare 2017 - Present
- Member, National Research Committee, American Heart Association 2015 - 2016
- President, American Heart Association, Western States Affiliate 2014 - 2016
Professional Memberships
- Member
- Immediate Past President of the Board of Directors, Western States Affiliate; Member, Precision Medicine Task Force
- American Society of Clinical InvestigationMember
- International Society for Heart Research - ISHRMember
- Association of Professors of CardiologyPresident 2015-2016
- Association of University CardiologistsMember
- Heart Failure Society of AmericaMember
Other Languages
- Spanish
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