Kevin N Sheth MD

PubMed

• Outcomes Following Minimally Invasive Surgery for Intracerebral Hemorrhage in the AHA Get With The Guidelines Registry.
  Santosh B Murthy, Cenai Zhang, Andrew L A Garton, Brian Mac Grory, Shreyansh Shah
  Stroke. 2025-04-03
• Voxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes.
  Gaby Abou Karam, Min-Chiun Chen, Dorin Zeevi, Bendix C Harms, Elisa Berson
  Stroke. 2025-04-01
• A failure to launch: blood pressure control after stroke in a regional health system.
  Rachel Forman, Xin Xin, Chungsoo Kim, Walter N Kernan, Kevin N Sheth
  Journal of Hypertension. 2025-04-01

Journal Articles

• Holding Out Hope After Traumatic Brain Injury  
  Kevin Sheth, MD, JAMA Neurology
• Clinical Characteristics and Outcomes Associated with Oral Anticoagulant Use Among Patients Hospitalized with Intracerebral Hemorrhage  
  Eric E Smith, Kevin N Sheth, Lee H Schwamm, JAMA Network Open
• Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients  
  Kevin N Sheth, Emily J Gilmore, Guido J Falcone, Nils Petersen, Firas Kaddouh, David Y Hwang, Joseph Schindler, Lauren Sansing, Charles Matouk, Gordon Sze, Jonathan Si..., JAMA Neurology
• A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients with Acute Intracerebral Hemorrhage  
  Santosh B Murthy, Babak B Navi, Pitchaiah Mandava, Guido J Falcone, Kevin N Sheth, Jonathan Rosand, Adnan I Qureshi, Joshua N Goldstein, Magdy Selim, Daniel F Hanley, ..., JAMA Neurology
• Fingolimod Enhances the Efficacy of Delayed Alteplase Administration in Acute Ischemic Stroke by Promoting Anterograde Reperfusion and Retrograde Collateral Flow  
  Kevin N Sheth, DeRen Huang, Andrew F Ducruet, Michael F Waters, Qiang Liu, Annals of Neurology
• Novel Imaging Markers of Ischemic Cerebral Edema and its Association with Neurological Outcomes  
  Kimberly WT, Battey TW, Wu O, Singhal AB, Campbell BC, Davis SM, Donnan GA, Sheth KN, Acta Neurochir Supp, 1/1/2016
• Human data supporting glyburide in ischemic stroke  
  Sheth KN, Simard JM, Elm J, Kronenberg G, Kunte H, Kimberly WT, Acta Neurochir Supp, 1/1/2016
• Monocyte Count and 30 Day Case Fatality in Intracerebral Hemorrhage  
  Walsh KB, Sekar P, Langefeld CD, Moomaw CJ, Elkind MS, Boehme AK, James ML, Osborne J, Sheth KN, Woo D, Adeoye O, Stroke, 1/1/2015
• Prophylactic Antiepileptic Drug Use and Outcome in the Ethnic/Racial Variations of Intracerebral Hemorrhage Study  
  Sheth KN, Martini SR, Moomaw CJ, Koch S, Elkind MS, Sung G, Kittner SJ, Frankel M, Rosand J, Langefeld CD, Comeau ME, Waddy SP, Osborne J, Woo D, Stroke, 1/1/2015
• Management of Hemispheric Infarction and Ischemic Swelling  
  Sheth KN, Continuum, 1/1/2015
• TURN Score Predicts 24-Hour Cerebral Edema After IV Thrombolysis  
  Asuzu D, Nystrom K, Sreekrishnan A, Schindler J, Wira C, Greer D, Halliday J, Kimberly WT, Sheth KN, Neurocrit Care, 1/1/2015
• Glyburide Advantage in Malignant Edema and Stroke (GAMES-RP) Trial: Rationale and Design  
  Sheth KN, Elm JJ, Beslow LA, Sze GK, Kimberly WT, Neurocrit Care, 1/1/2015
• Sulfonylureas: a novel treatment to reduce tissue damage after acute spinal cord injury  
  Kunte H, Fahardi HF, Sheth KN, Simard JM, Kronenberg G, Lancet Neurol, 1/1/2015
• Perihematoma Edema: A Potential Translational Target in Intracerebral Hemorrhage?  
  Selim M, Sheth KN, Transl Stroke Res, 1/1/2015
• Is Glibenclamide the New Cool in Cardiopulmonary Resuscitation?  
  Simard JM, Sheth KN, Crit Care Med, 1/1/2015
• Update on the Global Burden of Ischemic and Hemorrhagic Stroke in 1990-2013: The GBD 2013 Study  
  Sheth KN, et el, Neuroepidemiology, 1/1/2015
• Stroke Prevalence, Mortality and Disability-Adjusted Life Years in Children and Youth Aged 0-19 Years: Data from the Global and Regional Burden of Stroke 2013  
  Sheth KN, et el, Neuroepidemiology, 1/1/2015
• Stroke Prevalence, Mortality, and Disability-Adjusted Life Years in Children and Youth Aged 20-64 Years: Data from the Global and Regional Burden of Stroke 2013  
  Sheth KN, et el, Neuroepidemiology, 1/1/2015
• Sex Differences in Stroke Incidence, Prevalence, Mortality and Disability-Adjusted Life Years: Data from the Global and Regional Burden of Stroke 2013  
  Sheth KN, et el, Neuroepidemiology, 1/1/2015
• Atlas of the Global Burden of Stroke (1190-2013): The GBD 2013 Study  
  Sheth KN, et el, Neuroepidemiology, 1/1/2015
• Adverse Outcomes After Initial Non-Surgical Management of Subdural Hematoma: A Population-Based Study  
  Morris NA, Merkler AE, Parker WE, Claassen J, Connolly ES, Sheth KN, Kamel H, Neurocrit Care, 1/1/2015
• Evidenced based guidelines for the management of large hemispheric infarction: A statement for healthcare professionals from the Neurocritical Care Society and the Ger...  
  Torbey MT, Bosel J, Rhoney DH, Staykov D, Amar AP, Varelas PN, Juttler E, Olson D, Huttner HB, Zweckberger K, Sheth KN, Dohmen C, Brambrink AM, Mayer SA, Zaidat OO, Ha..., Neurocrit Care, 1/1/2015
• TURN Score Predicts 90-Day Outcome in Acute Ischemic Stroke Patients After IV Thrombolysis  
  Asuzu D, Nystrom K, Amin H, Schindler J, Wira C, Greer D, Chi NF, Halliday J, Sheth KN, Neurocrit Care, 1/1/2015
• Targeting secondary injury in intracerebral hemorrhage-perihaematomal edema  
  Urday S, Kimberly WT, Beslow LA, Vortmeyer AO, Selim MH, Rosand J, Simard JM, Sheth KN, Nat Rev Neurol, 1/1/2015
• Management of acute spinal cord injury  
  Stein DM, Sheth KN, Continuum (Minneapolis), 1/1/2015
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Books/Book Chapters

• Critical Care Handbook of the Massachusetts General Hospital 
  Chapter: Critical Care of the Neurologic Patient. 
  Sheth KN, Schwamm LHLippincott Williams & WilkinsEdition 5th,2010
• Acute Ischemic Stroke: An Evidence-based Approach 
  Chapter: Intensive Care Management of Acute Stroke. 
  Sheth KN, Greer DMWiley2007
• Blueprints: Clinical Cases in Neurology 
  Sheth KN, Harris OA, Cho TA, Caughey ABLippincott Williams & WilkinsEdition 2nd,2006

Abstracts/Posters

• Predictors of Survival After Civilian Penetrating Brain Injuries: A Two Center Cohort Study.
  Ahlawat A, Muehlschlegel S, Izzy S, Ayturk D, Scalea TM, Stein DM, Emhoff T, Sheth KN, Neurocritical Care Society, 1/1/2015
• Main results of the GAMES-RP Study.
  Sheth KN, Kimberly WT, Neurocritical Care Society, 1/1/2015
• Neuroimaging Markers of Swelling Predict Outcome After Acute Ischemic Stroke.
  Battey TW, Karki M, Singhal AB, Wu O, Sadaghiani S, Campbell BC, Davis SM, Donnan GA, Sheth KN, Kimberly WT, International Stroke Conference, 1/1/2015
• GAMES (Glyburide Against Malignant Edema and Stroke) RP.
  Sheth KN, Elm J, Jacobson S, Kimberly WT, GAMES Investigators, International Stroke Conference, 1/1/2015
• The Important Role of Drip and Ship Administration in Expanded Use of Thrombolytic Therapy in the United States.
  Sheth KN, Smith EE, Grau-Sepulveda M, Kleindorfer D, Fonarow GC, Schwamm L, International Stroke Conference, 1/1/2015
• Discharge Disposition After Intracerebral Hemorrhage.
  Osborne J, Langefeld C, Moomaw CJ, Sheth KN, Hwang DY, Flaherty ML, Vashkevich A, Gohs J, Woo D, International Stroke Conference, 1/1/2015
• Rate of Peri-Hematomal Edema Expansion Predicts Outcome After Intracerebral Hemorrhage.
  Urday S, Beslow LA, Goldstein D, Dai F, Zhang F, Vashkevich A, Ayres A, Battey A, Simard JM, Rosand J, Kimberly WT, Sheth KN, International Stroke Conference, 1/1/2015
• Accurate Outcome Predictors for Intracerebral Hemorrhage Patients are More Likely Than Inaccurate Predictions to be Influenced by Co-Morbidities Not Included in Clinic...
  Hwang DY, Dell CA, Sparks MJ, Watson TD, Langefeld C, Comeau ME, Rosand J, Battey TW, Koch S, Perez ML, James ML, McFarlin JM, Osborne JL, Woo D, Kittner SJ, Sheth KN, International Stroke Conference, 1/1/2015
• Variation of Blood Pressure Response of Antihypertensive Agents in Acute Intracerebral Hemorrhage.
  Lin WC, Langefeld C, Koch S, Moomaw CJ, Sheth KN, Sekar P, Osborne J, Woo D, International Stroke Conference, 1/1/2015
• A Mobile Application for Predicting 90-day Outcomes after IV Thrombolysis in Ischemic Stroke.
  Nystrom, KV; Asuzu, DT; Schindler, JL; Halliday, JR; Wira, C; Greer, DM; Sheth, KN, American Academy of Neurology, 1/1/2015
• Comparison of On-hour vs Off-hour Patient Cohorts at a Primary Stroke Center: Onset-To-Treatment Duration and Clinical Outcomes after IV Thrombolysi.
  Nystrom K, Asuzu D, Schindler J, Halliday J, Wira C, Greer D, Sheth KN, American Academy of Neurology, 1/1/2015
• Accurate outcome predictions for intracerebral hemorrhage patients are more likely than inaccurate predictions to be influenced by co-morbidities not included in clini...
  Hwang D, Dell C, Sparks M, Watson T, Langefeld C, Comeau, ME Rosand J, Battey T, Koch S, Perez ML, James M, McFarlin J, Osborne J, Woo D, Kittner S, Sheth KN, American Academy of Neurology, 1/1/2015
• Rate of Peri-Hematomal Edema Expansion Predicts Outcome after Intracerebral Hemorrhage.
  Urday S, Beslow LA, Goldstein D, Dai F, Zhang F, Vashkevich A, Ayres A, Battey T, Selim M, Simard JM, Rosand J, Kimberly WT, Sheth KN, American Academy of Neurology, 1/1/2015
• Practice variability in feeding tube placement for ICH inpatients across US hospitals is large.
  Hwang DY, George BP, Kelly AG, Schneider EB, Sheth KN, Holloway RG, Neurocritical Care Society, 1/1/2015
• Validating the Association of Peripheral Monocyte Count with 30 Day Case Fatality in Intracerebral Hemorrhage.
  Walsh KB, Sekar P, Langefeld C, Moomaw CJ, Elkind M, James ML, Osborne J, Sheth KN, International Stroke Conference, 1/1/2015
• "GAMES (Glyburide Advantage in Malignant Edema and Stroke) RP: A Phase II Study Aimed at Preventing Brain Swelling After Ischemia"
  Sheth KN, Elm J, Jacobson S, Kimberly WT for the GAMES Investigators, 16th International Conference on Brain Edema and Cellular Injury, Huntington Beach, CA, 1/28/2014
• Predictors of Platelet Transfusion in Patients with Intracerebral Hemorrhage.
  Guerrero WR, Gonzales NR, Sekar P, Castillo J, Moomaw CJ, Worrall BB, Langefeld C, Martini SR, Flaherty M, Sheth KN, Osborne J, Woo D, International Stroke Conference, 1/1/2014
• Lower Apparent Diffusion Coefficient Ratio Predicts Increased Swelling After Ischemic Stroke.
  Battey TW, Karki M, Wu O, Singhal AB, Sheth KN, Kimberly WT, International Stroke Conference, 1/1/2014
• Delays in Seeking Medical Attention in Intracerebral Hemorrhage.
  Testai F, Langefeld C, Mukarram F, Castillo NK, Hillmann M, Sheth KN, Smith S, Ali LK, Gilda R, Moomaw CJ, Osborne J, Woo D, International Stroke Conference, 1/1/2014
• GENEtic Determinants of Collateral Status in Stroke-The GENEDCSS Study.
  Faber JE, Lee YZ, Menon BK, Huang DY, Wilhelmsen KC, Powers WJ, Liebeskind D, Demchuk AM, Al-Ali F, Jovin TG, Marshall RS, Parsons MW, Ribo M, Selim MH, Sheth KN, Shua..., International Stroke Conference, 1/1/2014
• GAMES (Glyburide Against Malignant Edema and Stroke) RP: Initial Design and Enrollment.
  Sheth KN, Elm J, Jacobson S, Kimberly WT, GAMES Investigators, International Stroke Conference, 1/1/2014
• Racial-ethnic Blood Pressure Differences in Acute Intracerebral Hemorrhage.
  Koch S, Sheth KN,Woo D, International Stroke Conference, 1/1/2014
• Subjective Judgments of Physicians and Nurses are More Accurate than Formal Clinical Scales in Predicting Functional Outcome After Intracerebral Hemorrhage.
  Hwang DY, Dell CA, Sparks MJ, Watson TD, Langefeld CD, Comeau ME, Rosand J, Battey TW, Koch S, Perez ML, James ML, McFarlin J, Osborne JL, Woo DL, Kittner SJ, Sheth KN..., International Stroke Conference, 1/1/2014
• Brain MRI FLAIR Signal Intensity Ratio is Correlated with Matrix Metalloproteinase-9 Level in Acute Ischemic Stroke.
  Jha R, Battey TW, Pham L, Irvine H, Furie K, Sheth K, Kimberly WT, International Stroke Conference, 1/1/2014
• Association of Gender-Age Interaction with Outcome After Intracerebral Hemorrhage in Multiple Ethnicities.
  James M, Sekar P, Langfeld C, Moomaw C, Worrall B, Sheth K, Frankel M, Martin S, Osborne J, Woo D, International Stroke Conference, 1/1/2014
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Lectures

• "The Broad Relevance of Brain Swelling after Stroke and What We May Be Able to do About It" 
  Rochester, NY - 1/27/2015
• "The Management of Atrial Fibrillation in Stroke Patients" 
  1/24/2015
• "The Journey from Acute Brain Injury to Definitive Care" 
  Newport, RI - 1/23/2015
• "Recurrent Lobar Intracerebral Hemorrhage: New Problem with an Old Target" 
  American Academy of Neurology, Washington, DC - 1/22/2015
• "My Grandmother Doesn't Know the Difference Between Neurologists and Neurosurgeons-But Why Should She?" 
  NIH, Bethesda, MD - 1/20/2015
• "Update on Intracerebral Hemorrhage" 
  Scottsdale, AZ - 1/8/2015
• "Management of Large Ischemic Stroke in the ICU" 
  Orange, CT - 1/1/2015
• "Randomized Clinical Trials" 
  1/29/2014
• "GAMES (Glyburide Advantage in Malignant Edema and Stroke) RP: A Phase II Study Aimed at Preventing Brain Swelling After Ischemia" 
  Huntington Beach, CA - 1/28/2014
• "Principles of Emergency Neurology" 
  1/17/2014
• "Cerebral and Cerebellar Infarction with Swelling" 
  San Diego, CA - 1/14/2014
• "Translational Science: Advances in Intracerebral Hemorrhage" 
  Seattle, WA - 1/12/2014
• "SUR1, TRPM4, and Brain Swelling" 
  Worcester, MA - 1/11/2014
• "Research Mentorship & Career Development" 
  Seattle, WA - 1/10/2014
• "Ethical Issues in Managing Large Stroke" 
  Deerfield Beach, FL - 1/2/2014
• "Unique Emergency Interventions Available for Stroke Patients in Connecticut" 
  Orange, CT - 1/2/2014
• "Inflammation, Edema and the Neurovascular Unit" 
  1/25/2013
• Keynote Speaker, "Neurovascular Protection after Brain Ischemia" 
  Portland, OR - 1/19/2013
• "Intracranial Pressure in the Neuroscience Intensive Care Unit" 
  1/17/2013
• "SUR1, Glyburide, and A Novel Approach to the Primary Prevention of Cerebral Edema" 
  1/17/2013
• "What is the Value of Intracranial Pressure Control in Traumatic Brain Injury and Intracerebral Hemorrhage" 
  New Orleans, LA - 1/13/2013
• "Advanced Monitoring in the Neuroscience Intensive Care Unit" 
  1/11/2013
• Invited Speaker, "Neuroprotection in the Neuroscience Intensive Care Unit" 
  Tysons Corner, VA - 1/8/2013
• "Traumatic Brain Injury in the Neurointensive Care Unit" 
  1/7/2013
• "Withdrawal of Care in the Ethnic/Racial Variations of Intracerebral Hemorrhage Study" 
  Honolulu, HI - 1/6/2013
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Other

• "CT based measurements of peri-hematomal edema in intracerebral hemorrhage: Moving us one step closer." 
  Sheth KN
  http://strokeblog.strokeahajournal.org/
  1/13/2015
• "Drip and ship thrombolytic therapy for acute ischemic stroke common in US." 
  Sheth KN
  http://www.healio.com/cardiology/stroke/news/online/%7Bfe5d20b1-f04a-4fa7-a71f-bb7c8f5dd326%7D/drip-and-ship-thrombolytic-therapy-for-acute-ischemic-stroke-common-in-us
  1/11/2015
• "What's drip and ship got to do with it?" 
  Sheth KN
  http://strokeblog.strokeahajournal.org/
  1/11/2015
• "Drip and ship protocols protocol embraced by hospitals." 
  Sheth KN
  http://www.empr.com/drip-and-ship-stroke-protocol-embraced-by-hospitals/article/397700/
  1/11/2015
• "Drip and ship thrombolysis remains common for ischemic stroke." 
  Sheth KN
  http://www.anticoagulationhub.com/single-article/drip-and-ship-thrombolysis-remains-common-for-ischemic-stroke/c7b81b15a4ece1ab65e3a212eb7950b5.html?utm_source=Hubs_anti-enl150214_final&utm_medium=email&utm_content=%27Drip-and-ship%27+thrombolysis+remains
  1/11/2015
• "Stroke patients receiving better, more timely care." 
  Sheth KN
  http://medicalxpress.com/news/2015-02-patients.html
  1/11/2015
• "Stroke Patients Receiving Drip and Ship Method On The Rise." 
  Sheth KN
  http://www.neurologyadvisor.com/stroke-drip-and-ship-iv-tpa-treatment/article/397488/
  1/11/2015
• "Drug cuts mortality rate after stroke, trial finds." 
  Sheth KN
  http://news.yale.edu/2015/10/09/drug-cuts-mortality-rate-after-stroke-trial-finds
  1/9/2015
• "More Stroke Patients Getting Clot-Buster Quickly, Study Shows." 
  Sheth KN
  http://health.usnews.com/health-news/articles/2015/02/11/more-stroke-patients-getting-clot-buster-quickly-study-shows
  1/5/2015
• "Prehypertension found to increase the risk of recurrent intracerebral hemorrhage." 
  Sheth KN, Neurology Today
  1/4/2015
• "Fingolimod may benefit intracranial hemorrhage." 
  Sheth KN
  http://www.medscape.com/viewarticle/828598
  1/21/2014
• "Best Advances of 2014: Picks from the Neurology Today Editorial Advisory Board." 
  Sheth KN, Neurology Today
  1/18/2014
• "Decompressive Hemicraniectomy: To Halve or Not for Older Stroke Patients." 
  Sheth KN, Neurology Today
  1/17/2014
• "Stroke Rounds: An MS Drug for ICH?" 
  Sheth KN
  http://www.medpagetoday.com/Cardiology/Strokes/46673
  1/8/2014
• "Disparities Found in Use of Feeding Tubes in Stroke Care." 
  Sheth KN, Neurology Today
  1/4/2014
• "Fingolimod improves cerebral hemorrhage outcomes in pilot study." 
  Sheth KN
  http://www.hegalaxy.com/fingolimod-improves-cerebral-hemorrhage-outcomes-in-pilot-study/
  1/4/2014
• "Recommendations for the Management of Cerebral and Cerebellar Infarction with Swelling" 
  Sheth KN, AHA Professional Education Committee Presentation
  http://my.americanheart.org/idc/groups/ahamah-public/@wcm/@sop/@smd/documents/downloadable/ucm_460163.pdf
  1/1/2014
• "Why the ARUBA Trial on AVMs Was Stopped" 
  Sheth KN, Neurology Today
  1/20/2013
• "Skull Surgery Offers Perils and Potential" 
  Sheth KN, The New York Times
  http://www.nytimes.com/2013/07/16/science/skull-surgery-offers-perils-and-potential.html?pagewanted=all&_r=0
  1/16/2013
• "Common Diabetes Drug Could Play a Role in Stroke" 
  Sheth KN, Medscape Medical News
  1/15/2013
• "Best Advances of 2013: Picks from the Neurology Today Editorial Advisory Board." 
  Sheth KN, Neurology Today
  1/9/2013
• "Does Global Cerebral Edema Occur in Patients with Intracerebral Hemorrhage?" 
  Sheth KN, Neurology Today (Online Interview)
  http://journals.lww.com/neurotodayonline/Pages/videogallery.aspx?videoId=23&autoPlay=true
  1/8/2013
• "Is Performing Decompressive Hemicraniectomy for Malignant Ischemic Stroke Cost-Effective?" 
  Sheth KN, Neurology Today (Online Interview)
  http://journals.lww.com/neurotodayonline/Pages/videogallery.aspx?videoId=27&autoPlay=true
  1/8/2013
• "A Neurologic Emergency Department and the Growth of Emergency Neurology." 
  Sheth KN, Neurology Today
  1/4/2013
• "Best Advances of 2012: Picks from the Neurology Today Editorial Advisory Board." 
  Sheth KN, Neurology Today
  1/3/2013
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