KevinHoMD

Nephrology • Danville, PA

Acute Renal Failure, Chronic Renal Failure & Dialysis, Hereditary Kidney Disease Genetics

VP of Medical Support, Global Medical Office, In Center Hemodialysis, Quality & Regulatory

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Office
100 N Academy Ave
Danville, PA 17822
Phone+1 570-271-6393

Fax+1 570-271-5623

Summary

In nephrology, Dr. Ho identified defining member, ROMK1 (Kir1.1), of the overall inward rectifier potassium channel family (Kir). ROMK channels are the primary mechanism for renal potassium secretion, the basis for aldosterone-regulated potassium homeostasis. His ROMK1 model presented in '92 at Oxford demonstrated conservation of the potassium channel pore among structurally different potassium channel families. Research at Washington Univ focused on molecular basis for Kir channel assembly. Joining Univ of Pittsburgh in '02, his projects included study of cardiovascular ABCC9 genetic variants associated with early Type 1 diabetic CKD. He served as medical director for several dialysis units including UPMC Dialysis Services Network, Fabry disease nephrology consultant for the Lysosomal Storage Disease group, and organizer of Bone Works group focused on Kidney-Bone axis. As a Dept of Med Quality Council member, he led projects exploring transitions-of-care in chronic kidney disease and ESRD for inpatients developing AKI requiring dialysis, vascular access planning, and computer-assisted individualized dosing of erythropoiesis stimulating agents. He served on the PA Renal Disease Advisory Cmte, Board of Dirs for National Kidney Foundation serving the Alleghenies, and Renal Network Medical Review Board for PA and DE. Subsequently at Geisinger as a clinician-scientist, he developed electronic health record-based phenotypic algorithms (acute kidney injury, polycystic ovary syndrome contributing to type 2 diabetes, obesity, early CKD) for predictive analytics and integration with EHR in real-time and with genomic data (MyCode, eMERGE) for phenotype-genotype analyses. He served as Fabry Registry PI and CKDGen Consortium site PI and writing group member. He transitioned to industry as a Medical Director, U.S. Medical Affairs in Rare Diseases at Sanofi Genzyme. He is currently VP of Medical Support, Global Medical Office at Fresenius Medical Care North America.

Education & Training

Brigham and Women's Hospital/Massachusetts General HospitalFellowship, Nephrology, 1990 - 1994
New York Presbyterian Hospital (Columbia Campus)Residency, Internal Medicine, 1987 - 1990
Columbia University Vagelos College of Physicians and SurgeonsClass of 1987
Harvard UniversityA.B., Biological Sciences, 1978 - 1982

Certifications & Licensure

PA State Medical License 2002 - 2024

Awards, Honors, & Recognition

Top Patient Experience Clinician Award Geisinger Health System, 2017
Faculty Honoree, Honors Convocation University of Pittsburgh, 228th Anniversary, 2015
The Gift of Life Medical Award National Kidney Foundation, 2014
Recognition Plaque The Renal Network, Inc. Networks 4, 9 &10, 2013
Recognition Plaque The National Kidney Foundation Serving the Alleghenies, 2012
Recognition Plaque Pennsylvania Dept. of Health, 2011
Honors in 18 medical school courses/rotations Columbia University College of Physicians & Surgeons, 1987
John Harvard Scholarship for academic excellence 1982
Harvard Scholarship for academic excellence Harvard University, 1979, 1981
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Publications & Presentations

PubMed

221 citations
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels
Adrienne Tin, Jonathan Marten, Victoria L. Halperin Kuhns, Yong Li, Matthias Wuttke
Nature Genetics. 2019-10-01
117 citations
Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate
Morgan E. Grams, Yingying Sang, Shoshana H. Ballew, Juan Jesus Carrero, Ognjenka Djurdjev
Kidney International. 2018-06-01
173 citations
Change in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies
Josef Coresh, Hiddo J.L. Heerspink, Yingying Sang, Kunihiro Matsushita, Johan Ärnlöv
The Lancet. Diabetes & Endocrinology. 2019-02-01

Journal Articles

Variants in STAU2 associate with metformin response in a type 2 diabetes cohort: a pharmacogenomics study using real-world electronic health record data
Yanfei Zhang, Ying Hu, Kevin Ho, Dustin N Hartzel, Vida Abedi, Ramin Zand, Marc S Williams, Ming Ta M Lee., MedRxiv. doi: https://doi.org/10.1101/2020.03.18.20037218, 3/18/2020

Books/Book Chapters

Brenner and Rector's The Kidney
Chapter: Quality improvement initiatives in kidney disease
Page 2620 - 2636Sandeep S. Soman, Jerry Yee, Kevin HoEditors: Karl Skorecki, Glenn M. Chertow, Philip A. Marsden, Maarten W. Taal, Alan S.L. Yu.Elsevier, Philidelphia, PA2015

Abstracts/Posters

Cardiovascular gene ABCC9 is associated with Type 1 diabetic nephropathy
Ho K, Chang Y-F, Ferrell RE, Lawrence E, Fried L, Liu W, Kim SI, Choi M, Orchard TJ, J Amer Soc Nephrol 2005;16: 589A, American Society of Nephrology, https://app.box.com/s/ohb71285bc2vwxihn4ap, 11/2005
Regulatory elements in the sulphonylurea receptor 2 gene promoter
Ho K, Liu W, J. Am. Soc. Nephrol. 2007;18 Suppl.: 607A, P-097, American Society of Nephrology, https://app.box.com/s/hjrl0y4sp0wl4oaldw1i, 11/2007
Low renal recovery in inpatients starting hemodialysis and transitioning to outpatient dialysis: Prior chronic kidney disease and vascular access planning
Andersen SL, Chang YF, Seddon PA, Martin SC, Ho K, J. Am. Soc. Nephrol. 2011;22: 788A, P-2914, American Society of Nephrology, https://app.box.com/s/8ql3m4rmg7ncwobek7o5, 11/2011
Does the combination of two ABCC9 promoter SNPs predict microalbuminuria and renal function decline in Type 1 diabetes (T1D)? Pittsburgh Epidemiology of Diabetes Compl...
Ho K, Miller RG, Orchard TJ, J. Am. Soc. Nephrol. 2014; 25: 692A, P-246
ABCC9 variant is associated with a reduced risk of microalbuminuria (MA) in type 1 diabetes (T1D) with long-term followup: the Pittsburgh Epidemiology of Diabetes Comp...
Miller RG, Chang Y-F, Orchard TJ, Ferrell R, Costacou T, Ho K, Diabetes 2014; June Suppl.: 559-P
Modeling of individual hemoglobin responses to erythropoietin (EPO) in DCI hemodialysis patients using retrospective data
Mcmichael J, Meyer KB, Miskulin DC, Ho K, J Amer Soc Nephrol 2010;22: 483A, P-1107, American Society of Nephrology, https://app.box.com/s/gnpf754b3oz65of8i03v
Standardized vs. patient-specific computer-assisted erythropoietin dosing: a randomized controlled trial
Ho K, McMichael J, Argyropoulos C, Ladik V, Zickgraf L, Martin AA, Meyer KB, MD, Miskulin D, J. Am. Soc. Nephrol. 2011;22: 483A, P-1595, American Society of Nephrology, https://app.box.com/s/hthxb2d4wjoi83ocifk8, 11/2011
Early versus late arteriovenous fistula placement and use in the first year after an acute inpatient start of chronic hemodialysis
Andersen SL, Chang YF, Seddon PA, Martin SC, Ho K, J. Am. Soc. Nephrol. 2011;22: 787A, P-2910, American Society of Nephrology, https://app.box.com/s/78l0acm8b79doxhjvau2, 11/2011
Dialysis catheter to permanent vascular access in incident hemodialysis inpatients who transition to outpatient hemodialysis
Andersen S, Chang YF, Burr R, Seddon P, Marszalek J, Logue K, Ali A, Martin S, Ho K, Amer. J. Kidney Dis 2011;57(4): A21, P-19, National Kidney Foundation, https://app.box.com/s/hzhbgr28gw1j5h7i1pt2, 2011
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Lectures

Plenary Talk -- Update on Chronic Kidney Disease Symposium: CKD Global Trends – Past, Present & Future
Penn State College of Medicine, The Kidney Foundation of Central PA, Hershey, PA - 4/16/2019
Nephrology for Internists/Hospitalists Symposium: Hospital-associated acute kidney injury
Geisinger Medical Center, Danville, PA - 4/12/2019
Grand Rounds: Transforming acute kidney injury in the age of electronic health records
Division of Nephrology, University of Maryland, Baltimore, MD - 1/28/2019

Committees

Steering Committee and discussion group moderator, American Kidney Fund's 2020 "Unknown Causes of Kidney Disease Summit" 2020 - 2020
Member, Vascular Access Advisory Panel, Quality Insights Renal Network 4 (PA, DE) 2014 - 2014
Member, Medical Review Board, Quality Insights Renal Network 4 (PA, DE) 2013 - 2014
Member, Acute Kidney Injury Group, Critical Care Medicine-CRISMA (Clinical Research, Investigation, Systems Modeling of Acute Illness) Center 2012 - 2014
Member, Advisory Group Center for Assistance in Research using eRecord (CARe) 2012 - 2014
Member, Medical Review Board, ESRD Network 4 (PA, DE) of The Renal Network, Inc. 2012 - 2013
Member, The Renal Network Vascular Access Advisory Panel (ESRD Networks 4, 9, 10 for PA, DE, IL, IN, KY, OH) 2012 - 2013
Member, Department of Medicine Quality Council 2011 - 2014
Member, Board of Directors, National Kidney Foundation Serving the Alleghenies 2009 - 2012
Member, Renal Disease Advisory Committee, Commonwealth of Pennsylvania 2007 - 2011