KennethDWestoverMDPhD

PubMed

• SRC kinase drives multidrug resistance induced by KRAS-G12C inhibition.
  Xinxin Song, Zhuan Zhou, Ammar Elmezayen, Runliu Wu, Chunhua Yu
  Science Advances. 2024-12-13
• Experimental variables determine the outcome of RAS-RAS interactions.
  Zhiwei Zhou, Tra Ly Nguyen, Xingxiao Li, Christel Poujol, Ewa Berlinska
  The Journal of Biological Chemistry. 2024-11-01
• Another KRAS variant trapped.
  Kenneth Westover
  Nature Chemical Biology. 2024-09-01

Journal Articles

• A pilot study using kernelled support tensor machine for distant failure prediction in lung SBRT  
  Li S, Yang N, Li B, Zhou Z, Hao H, Folkert MR, Iyengar P, Westover K, Choy H, Timmerman R, Jiang S, Wang J., Med Image Anal., 1/1/2018
• Consolidative Radiotherapy for Limited Metastatic Non�Small-Cell Lung CancerA Phase 2 Randomized Clinical Trial  
  Iyengar P, Wardak Z, Gerber DE, Tumati V, Ahn C, Hughes RS, Dowell JE, Cheedella N, Nedzi L, Westover KD, Pulipparacharuvil S, Choy H, Timmerman RD., JAMA Oncol., 1/1/2018
• Shell feature: a new radiomics descriptor for predicting distant failure after radiotherapy in non-small cell lung cancer and cervix cancer  
  Hao H, Zhou Z, Li S, Maquilan G, Folkert MR, Iyengar P, Westover KD, Albuquerque K, Liu F, Choy H, Timmerman R, Yang L, Wang J, Medical Physics, 1/1/2017
• Inhibition of Cell Proliferation in an NRAS Mutant Melanoma Cell Line by Combining Sorafenib and alpha-Mangostin  
  Xia Y, Li Y, Westover KD, Sun J, Chen H, Zhang J, Fisher DE., PLOS one., 1/1/2016
• Progress on Covalent Inhibition of KRAS G12C  
  Westover KD, Janne P, Gray NS, Cancer Discovery, 1/1/2016
• Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair  
  Udayakumar D, Pandita RK, Horikoshi N, Liu Y, Liu Q, Wong KK, Hunt CR, Gray NS, Minna JD, , PanditaTK,*, Westover KD*., Radiation Research., 1/1/2016
• A PHGDH inhibitor reveals coordination between serine synthesis and 1-carbon unit fate  
  Pacold ME, Brimacombe K, Chan SH, Rohde J, Lewis CA, Swier L, Possemato R, Fiske B, Cho SW, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul Y, Liu CM, Chung H, Davidson S..., Nature Chemical Biology, 1/1/2016
• Data publication with the structural biology data grid supports live analysis  
  Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin A,..., Nature Communications., 1/1/2016
• Predicting distant failure in early stage NSCLC treated with SBRT using clinical parameters  
  Zhou Z, Folkert M, Cannon N, Iyengar P, Westover K, Zhang Y, Choy H, Timmerman R, Yan J, Xie XJ, Jiang S, Wang J, Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology, 1/1/2016
• SABR for aggressive local therapy of metastatic cancer: A new paradigm for metastatic non-small cell lung cancer  
  Westover KD, Iyengar P, Sharma AN, Timmerman R., Lung Cancer, 1/1/2015
• Discovery of Type II inhibitors of TGF-beta-activated kinase 1 (TAK1) and Mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)  
  Tan L, Nomanbhoy TK, Gurbani D, Patricelli M, Hunter J, Geng J, Herhaus L, Zhang J, Pauls E, Ham Y, Choi HG, Xie T, Deng X, Buhrlage SJ, Sim T, Cohen P, Sapkota G, Wes..., J Med Chem, 1/1/2015
• Neutrophil-lymphocyte and platelet-lymphocyte ratios as prognostic factors following stereotactic radiation therapy for early-stage non-small cell lung cancer  
  Cannon NA, Meyer J, Iyengar P, Ahn C, Westover KD, Choy H, Timmerman R, J Thorac Oncol, 1/1/2015
• Structural dataset for the fast-exchanging KRAS G13D  
  Lu J, Hunter J, Manandhar A, Gurbani D, Westover KD, Data in brief, 1/1/2015
• Radiation therapy as a backbone of treatment of locally advanced non-small cell lung cancer  
  Laine AM, Westover KD, Choy H, Semin Oncol, 1/1/2014
• Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor  
  Lim SM,* Westover KD*, Ficarro SB, Harrison RA, Choi HG, Choi HG, Pacold, ME, Carrasco M, Hunter J, Kim ND, Xie T, Sim T, Janne PA, Meyerson M, Marto JA, Engen JR, Gra..., Angew Chem Int Ed Engl., 1/1/2014
• Pharmacological Targeting of the Pseudokinase Her3  
  Xie T, Lim SM, Westover KD, Dodge ME, Ercan D, Ficarro SB, Udayakumar D, Gurbani D, Tae HS,. Riddle SM, Sim T, Marto JA, J�nne PA, Crews CM, Gray NS., Nat Chem Biol., 1/1/2014
• Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics  
  Liu Q, Kirubakaran S, Hur W, Niepel M, Westover KD, Thoreen CC, Wang J, Ni1 J, Patricelli MP, Vogel K, Riddle S, Waller DL, Traynor R, Sanda T, Zhao Z, Kang SA, Zhao J..., J Biol Chem, 1/1/2012
• Proton SBRT for Medically Inoperable Stage I NSCLC  
  Westover KD, Seco J, Adams JA, Lanuti M, Choi NC, Engelsman M, Willers H., J Thorac Oncol.: official publication of the International Association for the Study of Lung Cancer, 1/1/2012
• Quantitative analysis of Hsp90::client interactions reveals principles of substrate recognition  
  Taipale M, Krykbaeva I, Koeva M, Kayatekin C, Westover KD, Karras GI, and Lindquist S., Cell, 1/1/2012
• Radical Prostatectomy vs Radiation Therapy and Androgen Suppression Therapy in High Risk Prostate Cancer  
  Westover KD, Chen M, Moul J, Robertson C, Polascik T, Dosoretz D, Katin M, Salenius S, D�Amico AV., BJU Int., 1/1/2012
• Significance testing as perverse probabilistic reasoning  
  Westover MB, Westover KD, Bianchi MT., BMC Medicine., 1/1/2011
• Should a sentinel node biopsy be performed in patients with high risk breast cancer?  
  Westover KD, Westover MB, Winer EP, Richardson AL, Iglehart JD, Punglia RS., Int J Breast Cancer, 1/1/2011
• Comprehensive and efficient HBB mutation analysis for detection of beta-hemoglobinopathies in a pan-ethnic population  
  Chan OT, Westover KD, Dietz L, Zehnder JL, Schrijver I., Am J Clin Pathol., 1/1/2010
• Structural basis of transcription: backtracked RNA polymerase II at 34 angstrom resolution  
  Wang D, Bushnell DA, Huang X, Westover KD, Levitt M, Kornberg RD., Science, 1/1/2009
• Mycotic aneurysm of the left main coronary artery producing acute coronary occlusion and purulent pericarditis  
  Westover K, Benedick B., Int J Cardiol, 1/1/2007
• Join now to see all

Books/Book Chapters

• Conquering RAS: From Biology to Cancer Therapy 
  Chapter: GTP-competitive inhibitors of RAS family members 
  Hunter JC, Westover KDElsevier2016
• Human Radiation Injury 
  Chapter: Radiation Induced Liver Disease 
  Westover KD, Hong TS.Editors: Shrieve D and Loeffler JS.Lippincott Williams & Wilkins2011
• MGH Pocket Neurology 
  Chapter: Neurooncology 
  Rinne M, Westover KDEditors: David Greer.Lippincott Williams & Wilkins2010

Abstracts/Posters

• Safety Analysis From a Prospective Registry Study of Stereotactic Body Radiation Therapy for Aggressive Management of Late-Stage Disease.
  Maquilan G, Westover KD, Wardak Z, Timmerman RD, Hannan R, Iyengar P, Schwartz DL, Meyer JJ, Abdulrahman RE, Folkert MR, Laine AM, Desai NB, Albuquerque KV, Choy H, Ah..., Int J Radiat Oncol Biol Phys., 1/1/2016
• Distinctive structural dynamics in Ras and related proteins by hydrogen exchange mass spectrometry
  Harrison R, Carrasco M, Hunter J, Manandhar A, Westover KD, Engen J., 63rd Annual Meeting, American Society for Mass Spectrometry, 1/1/2015
• Assessing the impact of proton range uncertainties on nsclc lung patients treated with proton beam-based SBRT.
  Seco J*, Panahandeh H*, Westover KD, Adams J, Willers H, 53rd Annual Meeting of American Association of Physicists in Medicine, 1/1/2011
• Outcomes of proton beam based SBRT in medically inoperable stage I NSCLC
  Westover KD, Engelsman M, Adams J, Lanuti M, Choi N, Willers H., 53rd Annual Meeting American Society for Radiation Oncology, 1/1/2011
• Should a sentinel node biopsy be performed in patients with high risk breast cancer?
  Westover KD, Westover MB, Weiner E, Richardson A, Iglehart J, Punglia R, 52nd Annual Meeting American Society for Radiation Oncology, 1/1/2010
• Impact of Superposition/convolution Dose Algorithm Inaccuracies in SBRT of Patients with Early Stage NSCLC: A Monte Carlo Study
  Seco J, Westover K, Willers H., 52nd Annual Meeting American Society for Radiation Oncology, 1/1/2010
• Dosimetric benefit of a combination of respiratory-gating, image-guidance and intensity modulated radiation therapy for pancreatic cancer treatment.
  Park SJ, O�Farrell D, Westover KD, Mamon H, Berbecco R., 51st Annual Meeting of American Association of Physicists in Medicine, 1/1/2009
• Biochemical profiling of cancer-associated KRAS mutants: clues towards an understanding of differential clinical outcomes
  Hunter JC, Gurbani D, Carrasco M, Manandhar A, Gondi S, Westover KD, AACR 106th Annual Meeting, Philadelphia, PA, 1/18/2015
• Torin2 suppresses ionizing radiation induced DNA damage repair
  Udayakumar D, Pandita RK, Horikoshi N, Hunt CR, Liu Q, Wong KK, Gray NS, Pandita TK, Westover KD., Proceedings: AACR 106th Annual Meeting, Philadelphia, PA, 1/18/2015
• Structure guided development of irreversible inhibitors for TAK1.
  Gurbani D, Tan L, Ficarro S, Hunter JC, Singer W, Vazquez FB, Xie T, Lim SM, Marto J, Gray NS,. Westover KD., AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, Boston, MA, 1/5./2015
• Predicting Distant Failure in Lung Stereotactic Body Radiation Therapy Using Multiobjective Radiomics Model.
  Zhou Z, Folkert MR, Iyengar P, Zhang Y, Westover KD, Wang J, Int J Radiat Oncol Biol Phys., 1/1./2016
• A Phase III Randomized Study of Image Guided Conventional (60 Gy/30 fx) Versus Accelerated, Hypofractionated (60 Gy/15 fx) Radiation for Poor Performance Status Stage ...
  Iyengar P, Westover KD, Court LE, Patel MK, Shivnani AT, Saunders MW, Li Y, Chang JY, Gao A, Ahn C, Choy H, Timmerman RD., Int J Radiat Oncol Biol Phys, 1/1./2016
• Patterns of Failure after 5 Fraction Stereotactic Ablative Radiation Therapy in Early Stage Non-Small Cell Lung Cancer
  J.T. Mendel, K. Ward, K.D. Westover, R.D. Timmerman, H. Choy, P. Iyengar, L.A. Nedzi, D.J. Sher., Int J Radiat Oncol Biol Phys
• Join now to see all

Lectures

• Targeting RAS in an Allele-Specific Manner 
  First Affiliated Hospital of Chengdu Medical College, Chengdu, China - 1/1/2018
• Allele-Specific Approaches to targeting RAS 
  San Francisco, CA - 1/1/2018
• KRAS Q61H signals in a RAF dimer-dependent manner 
  San Diego, CA - 1/1/2018
• Structural Biology of RAS Mutants Found in RASopathies 
  Indianapolis, IN - 1/1/2017
• RAS Structure and biochemistry � opportunities for allele-tailored therapy 
  Lake Geneva, WI - 1/1/2017
• Progress on Tailored KRAS Therapy 
  Princess Margaret Hospital, Toronto, Canada - 1/1/2016
• Mutation-Specific RAS Therapies: How we are Getting There 
  Memorial Sloan Kettering Cancer Center, New York, NY - 1/1/2016
• Crystal structure of K-Ras G12C bound to an active site inhibitor 
  Orlando, FL - 1/1/2014
• Development of Covalent GTP-Competitive Inhibitors of K-Ras G12C 
  Frederick, MD - 1/1/2014
• Structural Basis of Initiation and Elongation by RNA Polymerase II. 
  Brigham Young University, Provo, UT. - 1/1/2005
• Join now to see all