Kenneth Ber Margulies MD

PubMed

• Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac pathology and early ...
  Konstanze Tan, Darwin Tay, Wilson Tan, Hong Kiat Ng, Eleanor Wong
  Clinical Epigenetics. 2025-03-08
• Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.
  Albert Henry, Xiaodong Mo, Chris Finan, Mark D Chaffin, Doug Speed
  Nature Genetics. 2025-03-04
• 2 citations
  Metabolic and Pharmacokinetic Profiling of a Ketone Ester by Background SGLT2 Inhibitor Therapy in HFrEF.
  Senthil Selvaraj, Lydia Coulter Kwee, Elizabeth J Thompson, Mengshu He, Christoph P Hornik
  JACC. Basic to Translational Science. 2025-03-01

Journal Articles

• Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients with Heart Failure with Preserved Ejection Fraction  
  Gregory D Lewis, David J Whellan, Martin M LeWinter, Margaret M Redfield, Andrew L Smith, Eugene Braunwald, Michael M Givertz, Adrian F Hernandez, Sanjiv J Shah, Horng..., JAMA
• Suppression of Detyrosinated Microtubules Improves Cardiomyocyte Function in Human Heart Failure  
  Kenneth Margulies, MD, Nature

Abstracts/Posters

• A Novel Needleless Liquid Jet Injection System for Heart Failure Gene Therapy: Feasibility Study Demonstrates Enhanced Myocardial Distribution and Safety Profile in th...
  Fargnoli AS, Mu A, Katz MG, Williams RD, Dvorak J, Walling T, Margulies KB, Bridges CR, J Cardiac Fail, 1/1/2013
• A Novel Anti-Inflammatory Formulation Approach To Enhance Myocardial Gene Transfer: An In-Vitro Assessment of Aspirin Loaded Poly-Lactic Glycolic Acid Nanoparticles
  Fargnoli AS, Mu A, Katz MG, Williams, Sumaroka, MV, Levy R,Weiner, DB, Diamond SL, Margulies KB, Yang S, Bridges, CR, Mol Therapy, 1/1/2013
• Patients with Obesity and Type-2 Diabetes Present Cardiac IAPP Accumulation: A Source of Cardiomyocyte Ca2+ Dysregulation
  Despa S, Margulies KB, Bers D, Despa F, Circulation, 1/1/2011
• Active Myocardial TGF-beta Level is Significantly Increased in End-Stage Human Heart Failure
  Khan S, Jennifer J, Margulies, K, Tsuda T, Circulation, 1/1/2011
• Intrinsically Disordered Islet Amyloid Polypeptide Is a Pathogenic Link Between Type-2 diabetes and Heart Disease
  Despa S, Koch B, Margulies KB, Bers D, Despa F, Biophys J, 1/1/2011
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Lectures

• Takutsobo's Cardiomyopathy: Diagnosis and Recovery 
  2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019
• Generation of 3D Myocardial Tissue from Stem Cells 
  11/17/2013
• Reverse Myocardial Remodeling Following LVAD: Where to We Stand? 
  1/13/2013
• Genomics and Transcriptional Profiling in Heart Failure 
  1/12/2013
• Changing Gene Expression w LVAD Support 
  9/1/2012
• Human Heart Tissue as a Platform for Translational Research 
  9/22/2011
• Cell Therapy and Cardiac Regeneration for Heart Failure: Where are we Now? 
  6/8/2011
• The Disconnect Between Cellular And Clinical Recovery: What Are We Missing? 
  4/15/2011
• MicroRNA During VAD Support 
  12/2/2010
• VADs as a Platform to Examine Myocardial Biology and Novel Therapeutics 
  2/16/2010
• Diastolic Heart Failure 
  12/12/2009
• VADs as a Platform to Understand Heart Failure Biology and Adjuvant Therapies 
  9/14/2009
• Transcriptional Profiling as a Mechanistic Discovery Platform 
  4/22/2009
• Sex-Based Differences in Contractile Reserve 
  11/9/2008
• Reverse Remodeling of the Heart: Phenomenology and Emerging Mechanistic Insights 
  1/7/2008
• Gene Expression Signatures in Human Heart Failure: Clinically Useful of Noise Discovery 
  11/4/2007
• State of the Art Lecture: Reverse Remodeling: Drugs, Genes, Proteins, Cells and the Heart. Does it Happen and is it Important? 
  10/19/2007
• Shear Stress Regulation of Endothelial Function in Heart Failure 
  4/16/2007
• Endogenous Cardiac Repair Potential in Human Hearts 
  3/17/2007
• Molecular Mechanisms of the Transition from Myocardial Hypertrophy to Failure 
  3/15/2007
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