KatrinaA(Gwinn-Hardy)GwinnMD

Neurology • Bethesda, MD

Movement Disorder

Program Director and Medical Officer

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Office
NINDS-NIH 6001 Executive Blvd
2143
Bethesda, MD 20892
Phone+1 301-496-5745

Fax+1 301-402-1501

Summary

I am a board-certified Neurologist, and Movement disorders specialist, with a track record of an academic career in human gene discovery (Neurodegenerative diseases). I am a Medical Officer managing grants and contracts for the National Institute of Neurological Disorders and Stroke (NINDS) at the NIH. I do not currently have a clinical practice. In the past I have worked clinically in both academics and private practice. Projects I have managed and am managing include the NINDS Human DNA and Cell Line Repository, The NINDS Parkinson's Disease Biomarkers Program, and the North American Mitochondrial Disease Consortium, among many others.

Education & Training

Mayo Clinic Hospital1995 - 1996
University of MichiganResidency, Neurology, 1992 - 1995
Vanderbilt University Medical CenterInternship, Internal Medicine, 1991 - 1992
Vanderbilt University School of MedicineClass of 1991
Wellesley CollegeB.A, Psychobiology, 1978 - 1982

Certifications & Licensure

MD State Medical License 2001 - 2026
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

NIH NINDS Group Merit Award BioFIND, 2012
NIH NINDS Group Merit Award Parkinson’s Disease Biomarkers Program, 2012
Hall of Fame for Distinguished Alumni Atherton Alumni Association, 2009
NIH Directors Award Genome Wide Association Studies Policy Committee, 2008
NIH NIMH Directors Award Normal Brain Development Contract, 2006
American Neurological Association 2005
NIH Director's Award Trans-NIH Muscular Dystrophy Working Group, 2004
NIH NINDS Merit Award NINDS Genetics Repository (Project Officer), 2004
NIH NINDS Group Merit Award Communications and Public Liaison, 2002
Best Doctors in America 1998, 2001, 2005, 2007
Travel Award National Spasmodic Torticollis Association, 1995
Amos Christie Award in Pediatrics Vanderbilt University School of Medicine, 1990
Wellesley Scholar 1982
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Publications & Presentations

PubMed

70 citations
Prioritized research recommendations from the National Institute of Neurological Disorders and Stroke Parkinson's Disease 2014 conference
Beth-Anne Sieber, Story C. Landis, Walter J. Koroshetz, Randall J. Bateman, Andrew Siderowf
Annals of Neurology. 2014-10-01
178 citations
Loci associated with ischaemic stroke and its subtypes (SiGN) : A genome-wide association study
Sara L. Pulit, Patrick F. McArdle, Quenna Wong, Rainer Malik, Katrina Gwinn
The Lancet. Neurology. 2016-02-01
54 citations
Stroke Genetics Network (SiGN) Study Design and Rationale for a Genome-Wide Association Study of Ischemic Stroke Subtypes
James F. Meschia, Donna K. Arnett, Hakan Ay, Robert D. Brown, Oscar R. Benavente
Stroke. 2013-09-10

Journal Articles

Neurodegenerative disease: a different view of diagnosis.
Hardy J, Gwinn-Hardy K, Mol Med Today
Deletion at ITPR1 underlies a young-onset autosomal recessive ataxia in mice and a late-onset autosomal domiant ataxia (SCA15) in humans.
van de Leemput J, Chandran J, Knight MA, Holtzclaw LA, Scholz S, Cookson MR, Gwinn-Hardy K, Fung H-C, Lin X, Hernandez D, Simon-Sanchez J, Rafferty I, Hardy J, Storey ..., PLoS Genet
Genomic investigation of Synuclein multiplication and parkinsonism.
Ross RA, Braithwaite AT, Skipper LM, Kachergus J, Hulihan MM, Middleton F, Nishioka K, Fuchs J, Gasser T, Maraganore DM, Adler CA, Larvor L, Chartier-Harlin M-C, Nilss..., Ann Neurol
GCH1 in early-onset Parkinson's disease.
Cobb SA, Wider C, Ross OA, Mata IF, Adler CH, Rajput A, Rajput AH, Wu RM, Hauser R, Josephs KA, Carr J, Gwinn K, Heckman MG, Aasly JO, Lynch T, Uitti RJ, Wszolek ZK, K..., Mov Disord
Mining the Genome for Susceptibility to Complex Neurological Disorders.
Gubitz AK, Gwinn KA, Current Molecular Medicine
Genetics in clinical trials.
Meschia JF, Gwinn K, Front Neurol Neurosci
Characterization of DCTN1 genetic variability in neurodegeneration.
Vilariño-Güell C, Wider C, Soto-Ortolaza AI, Cobb SA, Kachergus JM, Keeling BH, Dachsel JC, Hulihan MM, Dickson DW, Wszolek ZK, Uitti RJ, Graff-Radford NR, Boeve BF, J..., Neurology
The effect of template choice on morphometric analysis of pediatric brain data.
Yoon U, Fonov VS, Perusse D, Evans AC; Brain Development Cooperative Group, Neuroimage
Brain Development Cooperative Group. T(2) relaxometry of normal pediatric brain development.
Leppert IR, Almli CR, McKinstry RC, Mulkern RV, Pierpaoli C, Rivkin MJ, Pike GB, J Magn Reson Imaging
Genome-wide association study reveals genetic risk underlying Parkinson’s disease.
Simón-Sánchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Krüger R, Federoff M, Klein C, Goate A, Perlmutte..., Nature Genetics
Protected to Death.
Hardy J, Gwinn K, Journal of Alzheimer’s disease
A pilot study on the motor effects of rimantadine in Parkinson’s disease.
Evidente VGH, Adler CH, Caviness JN, Gwinn KA, Clin Pharm
Risperidone is effective in severe hemichorea/hemiballismus.
Evidente VGH, Gwinn-Hardy KA, Mov Dis
The genetics of disorders with synuclein pathology and parkinsonism.
Farrer M, Gwinn-Hardy K, Hutton M, Hardy J, Hum Mol Genet
A chromosome 4p haplotype segregating with Parkinson’s disease and postural tremor.
Farrer M, Gwinn-Hardy K, Muenter M, Wavrant DeVrieze F, Crook R, Tur J, Lincoln S, Maraganore D, Adler C, Newman S, MacElwee K, McCarthy P, Miller C, Waters C, Hardy J, Hum Mol Genet
Levodopa slows the progression of familial Lewy body parkinsonism.
Gwinn-Hardy KA, Evidente VGH, Waters C, Muenter MD, Hardy J, Lancet
BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups.
Xiromerisiou G, Hadjigeorgiou GM, Eerola J, Fernandez HH, Tsimourtou V, Mandel R, Hellström O, Gwinn-Hardy K, Okun MS, Tienari PJ, Singleton AB, Neurosci Lett
How Common Are the “Common” Neurological Disorders?
Hirtz D, Thurman DJ, Gwinn-Hardy K, Mohamed M, Chaudhuri AR, Zalutsky R, Neurology
Amyotrophic lateral sclerosis: an emerging era of collaborative gene discovery.
Gwinn K, Corriveau RA, Mitsumoto H, Bednarz K, Brown RH, Cudkowicz M, Gordon PH, Hardy J, Kasarskis EJ, Kaufmann P, Miller R, Sorenson E, Tandan R, Traynor BJ, Nash J,..., PLoS ONE
Comprehensive screening of a North American Parkinson's disease cohort for LRRK2 mutation.
Johnson J, Paisán-Ruíz C, Lopez G, Crews C, Britton A, Malkani R, Evans EW, McInerney-Leo A, Jain S, Nussbaum RL, Foote KD, Mandel RJ, Crawley A, Reimsnider S, Fernand..., Neurodegener Dis
DLB and PDD Boundary Issues: Diagnosis, Treatment, Molecular Pathology, and Biomarkers.
Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, Brooks DJ, Dickson DW, Dubois B, Emre M, Fahn S, Farmer JM, Galasko D, Galvin JE, Goetz CG, Growdon JH,..., Neurology
Pathogenicity of the Lrrk2 R1514Q substitution in Parkinson's disease.
Toft M, Mata IF, Ross OA, Kachergus J, Hulihan MM< Haugarvoli K, Stone JT, Blaxquez M, Gibson JM, Aasly JO, White LR, Lynch T, Adler CH, Gwinn-Hardy K, Farrer MJ, Mov Disord
Genotype-phenotype correlation of paroxysmal nonkinesigenic dyskinesia.
Bruno MK, Lee HY, Auburger GW, Friedman A, Nielsen JE, Lang AE, Bertini E, Van Bogaert P, Averyanov Y, Hallett M, Gwinn-Hardy K, Sorenson B, Pandolfo M, Kwiecinski H, ..., Neurology
Genetic Testing in Parkinson’s Disease.
McInerney-Leo A, Hadley DW, Gwinn-Hardy K, Hardy J, Mov Dis
Analysis of polyglutamine-coding repeates in the TATA-binding protein in different neurodegenerative diseases.
Wu YR, Fung HC, Lee-Chen GJ, Gwinn-Hardy K, Ro LS, Chen ST, Hsieh-Li M, Lin HY, Lin CY, Li SN, Chen CM, J Neural Transm
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Books/Book Chapters

The Woman Doctor's Guide to Health and Healing.
Page 51 - 52Alzheimer's and Parkinson'sOxmoor House
Surgical Treatment of Movement Disorders.
Gwinn KA, Adler CHEditors: Gilman S, Goldstein GW, Waxman SG.Neurobase, LaJolla, CA
Surgical Treatment of Movement Disorders.
Uitti, R, Gwinn-Hardy KA, Adler CHEditors: Neurobase, Gilman S, Goldstein GW, Waxman SG, eds.LaJolla, CA
Wilson’s Disease.
Chapter: Parkinson’s disease and movement disorders: diagnosis and treatment guidelines for the practicing physician
Gwinn-Hardy KAEditors: Adler CH, Ahlskog JE.Humana Press, Totowa, NJ
Familial variants of Parkinson's disease.
Chapter: Mapping the progress of Alzheimer's and Parkinson's disease
Gwinn-Hardy K, Hanson M, Wszolek Z, Adam A, Singleton A, Adler CH, Caviness JN, Bower J, Hickey S, Chen JY, Waseem S, Farrer MEditors: Mizuno Y, Fisher A, Hanin I.Kluver Academic/Plenum Publishers, New York, NY
Racial and ethnic influences on the expression of the genotype in neurodegenerative diseases.
Chapter: Genotype-proteotype-phenotype relationships in neurodegenerative diseases
Gwinn-Hardy KAEditors: Cummings J, Hardy J, Poncet M Christen Y.Spring Verlag, New York
Parkinson’s Disease: Insights from Genetic Causes.
Chapter: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine
Baptista M, Cookson M, Gwinn-Hardy KEditors: Ganten D, Ruckpaul K.Springer
The relationship between nosology, etiology and pathogenesis in neurodegenerative diseases.
Page 189 - 192Hardy J, Gwinn-Hardy KAHandb Clin Neurol
Pharmacogenetics of Stroke.
Chapter: Current Clinical Trials of Antithrombotic Therapy in Stroke Prevention; Seminars in Cerebrovascular Diseases and Stroke
Gwinn-Hardy, KEditors: Jose Biller.
The Genetics of Parkinson’s Disease.
Chapter: The Encyclopedia of Movement Disorders
Corriveau RA, Gubitz AK, Gwinn, KEditors: Chris Goetz.Elsevier, Oxford
The Genetics of Parkinsonism.
Chapter: The Encyclopedia of Movement Disorders
Gubitz, A.K., Corriveau, R.A., Gwinn, KEditors: Chris Goetz.Elsevier, Oxford
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Abstracts/Posters

X-linked dystonia (“lubag”) presenting predominantly with parkinsonism: a more benign phenotype?
Evidente, VGH, Gwinn-Hardy K, John Hardy J, Andrew Singleton A, Mov Disorder
Mutation at the SCA17 locus is not a common cause of parkinsonism.
Hernandez D, Melissa Hanson M, Singleton A, Gwinn-Hardy K, Freeman J, Doheny D, Gallardo M, Weiser R, Hardy J, Singleton A, Parkinsonism Relat Disord
Neuropathology of two members of a German-American kindred (Family C) with late onset parkinsonism.
Wszolek K, Gwinn-Hardy K, Muenter D, Pfeiffer F, Rodnitzky L, Uitti J, McComb D, Gasser T, Dickson W, Acta Neuropathol
A family with a tau P301L mutation presenting with parkinsonism.
Walker RH, Friedman J, Weiner J, Hobler R, Gwinn-Hardy K, Adam A, DeWolfe J, Gibbs R, Baker M, Farrer F, Hutton M, Hardy J, Parkinsonism Rel Dis
Racial differences in the expression of neurodegenerative disease: Machado-Joseph disease in Caucasians and Africans.
Subramony SH, Hernandez D, Adam A, Smith-Jefferson S, Hussey J, Gwinn-Hardy K, Lynch T, McDaniel O, Hardy J, Farrer M, Singleton A, Mov Disord
Accurate determination of SCA2 polyglutamine expansion in patients with intermediate range repeats.
Hussey J, Lockhart PJ, Seltzer W, Wszolek Z, Payami H, Hanson M, Gwinn-Hardy K, Farrer MJ, Genetic Testing
Clinical features and changing patterns of neurodegenerative disorders on Guam 1997-2000.
Hardy J, Gwinn-Hardy K, McGeer P, Morris H, Perez-Tur J, Steele J, Neurology
Parkinson's genetics: an embarrassment of riches.
Gwinn-Hardy, K. Farrer M, Ann Neurol
Genetics of parkinsonism.
Gwinn-Hardy, K, Mov Dis
The Tau H1 Haplotype is associated with Parkinson’s Disease in the Norwegian population.
Farrer MJ, Skipper L, Berg M, Bisceglio G, Hardy JA, Gwinn-Hardy K, Aasly JO, Neurosci Lett
alpha-Synuclein locus triplication causes Parkinson's disease.
Cookson MR, Muenter M, Baptista M, Miller D, Blancato J, Hardy J, Gwinn-Hardy K, Science
Phenomenology of "Lubag" or X-linked dystonia-parkinsonism.
Evidente VG, Advincula J, Esteban R, Pasco P, Alfon JA, Natividad FF, Cuanang J, Luis AS, Gwinn-Hardy K, Hardy J, Hernandez D, Singleton A, Mov Disord
ILAE Genetics Commission Conference Report: Molecular Analysis of Complex Genetic Epilepsies.
Anderson E, Berkovic S, Dulac O, Gardiner M, Jain S, Laue-Friis M, Lindhout D, Noebels J, Ottman R, Scaramelli A, Serratosa J, Steinlein O, Avanzini G, Bailey-Wilson J..., Epilepsia
DNA haplotype analysis of CAG repeat in Taiwanese Huntington’s disease patients.
Wang CK, Wu YR, Hwu WL, Chen CM, Ro LS, Chen ST, Gwinn-Hardy K, Yang CC, Wu RM, Chen TF, Wang HC, Chao MC, Chiu MJ, Lu CJ, Lee-Chen GJ, Eur Neurol
Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplication.
Singleton A, Gwinn-Hardy K, Sharabi Y, Li ST, Holmes C, Dendi R, Hardy J, Singleton A, Crawley A, Goldstein DS, Brain
Parkinson's disease and dementia with Lewy bodies: a difference in dose?
Singleton A, Gwinn-Hardy K, Lancet
Analysis of the PINK1 gene in a large cohort of cases with Parkinson’s Disease.
Rogaeva E, Johnson J, Lang AE, Gulick C, Gwinn-Hardy K, Kawarai T, Sato C, Morgan A, Werner J, Nussbaum R, Petit A, Okun MS, McInerney A, Mandel R, Groen JL, Fernandez..., Arch Neurol
Genome-wide analysis of the Parkinsonism-Dementia Complex of Guam.
Morris HR, Steele JC, Crook R, Wavrant-De Vrieze F, Onstead-Cardinale L, Gwinn-Hardy K, Wood NW, Farrer M, Lees AJ, McGeer PL, Siddique T, hardy J, Perez-Tur J, Arch Neurol
SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies.
Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, Lincoln S, Crawley A, Hanson M, Maraganore D, Adler..., Neurology
Synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication.
Miller DW, Hague SM, Clarimon J, Baptista M, Gwinn-Hardy K, Cookson MR, Singleton AB, Neurology
Spinocerebellar ataxia type 2 with parkinsonism in ethnic Chinese.
Gwinn-Hardy K, Chen Y, Liu H, Liu TY, Boss M, Seltzer W, Adam A, Singleton A, Hardy J, Waters C, Farrer M, Neurology
Lewy bodies and parkinsonism in families with parkin mutations.
Farrer M, Chan P, Chen R, Tan L, Lincoln S, Hernandez D, Forno L, Gwinn-Hardy K, Petrucelli L, Hussey J, Singleton A, Tanner C, Hardy J, Langston JW, Ann Neurol
Serum leptin is normal in Parkinson’s disease patients with weight loss.
Evidente VGH, Caviness JNC, Adler CH, Gwinn-Hardy KA, Pratley R, Mov Disord
Persistent chorea triggered by hyperglycemic crisis in new-onset diabetics.
Ahlskog JE, Evidente, VGH, Tulloch, JW, Forbes GS, Caviness JN, Gwinn-Hardy KA, Mov Disord
A clinical and pathological study of motor neuron disease on Guam.
Morris HR, Al-Sarraj S, Schwab C, Gwinn-Hardy K, Wood NW, Hardy J, Lees AJ, McGeer P, Daniel SE, Steele JC, Brain
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Lectures

Genetic Lessons and New Approaches in Learning about Parkinson’s Disease(s).
Parkinson Disease Foundation Symposium
re: confusion and intracranial hemorrhage.
Grey’s Anatomy (ABC)
re: Post-Encephalitic Parkinsonism.
National Geographic
A prospective, randomized, parallel-group, double-blind, placebo-controlled multicenter study to evaluate the short-term efficacy and safety of Entacapone administered...
Novartis, Inc
An open-label, safety study of Neurobloc™ (botulinum toxin type B) in patients with cervical dystonia.
Athena Neurosciences Inc
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