KatrinaA(Gwinn-Hardy)GwinnMD

PubMed

• 1 citations
  Use of Bayesian decision analysis to maximize value in patient-centered randomized clinical trials in Parkinson's disease.
  Shomesh E Chaudhuri, Zied Ben Chaouch, Brett Hauber, Brennan Mange, Mo Zhou
  Journal of Biopharmaceutical Statistics. 2023-03-02
• 7 citations
  Patient-Centered Identification of Meaningful Regulatory Endpoints for Medical Devices to Treat Parkinson’s Disease:
  Heather L. Benz, Brittany Caldwell, John P. Ruiz, Anindita Saha, Martin Ho
  MDM Policy & Practice. 2021-07-02
• 14 citations
  Parkinson's Patients' Tolerance for Risk and Willingness to Wait for Potential Benefits of Novel Neurostimulation Devices: A Patient-Centered Threshold Technique Study.
  Brett Hauber, Brennan Mange, Mo Zhou, Shomesh Chaudhuri, Heather L. Benz
  MDM Policy & Practice. 2021-01-18

Journal Articles

• Neurodegenerative disease: a different view of diagnosis.  
  Hardy J, Gwinn-Hardy K, Mol Med Today
• Deletion at ITPR1 underlies a young-onset autosomal recessive ataxia in mice and a late-onset autosomal domiant ataxia (SCA15) in humans.  
  van de Leemput J, Chandran J, Knight MA, Holtzclaw LA, Scholz S, Cookson MR, Gwinn-Hardy K, Fung H-C, Lin X, Hernandez D, Simon-Sanchez J, Rafferty I, Hardy J, Storey ..., PLoS Genet
• Genomic investigation of Synuclein multiplication and parkinsonism.  
  Ross RA, Braithwaite AT, Skipper LM, Kachergus J, Hulihan MM, Middleton F, Nishioka K, Fuchs J, Gasser T, Maraganore DM, Adler CA, Larvor L, Chartier-Harlin M-C, Nilss..., Ann Neurol
• GCH1 in early-onset Parkinson's disease.  
  Cobb SA, Wider C, Ross OA, Mata IF, Adler CH, Rajput A, Rajput AH, Wu RM, Hauser R, Josephs KA, Carr J, Gwinn K, Heckman MG, Aasly JO, Lynch T, Uitti RJ, Wszolek ZK, K..., Mov Disord
• Mining the Genome for Susceptibility to Complex Neurological Disorders.  
  Gubitz AK, Gwinn KA, Current Molecular Medicine
• Genetics in clinical trials.  
  Meschia JF, Gwinn K, Front Neurol Neurosci
• Characterization of DCTN1 genetic variability in neurodegeneration.  
  Vilariño-Güell C, Wider C, Soto-Ortolaza AI, Cobb SA, Kachergus JM, Keeling BH, Dachsel JC, Hulihan MM, Dickson DW, Wszolek ZK, Uitti RJ, Graff-Radford NR, Boeve BF, J..., Neurology
• The effect of template choice on morphometric analysis of pediatric brain data.  
  Yoon U, Fonov VS, Perusse D, Evans AC; Brain Development Cooperative Group, Neuroimage
• Brain Development Cooperative Group. T(2) relaxometry of normal pediatric brain development.  
  Leppert IR, Almli CR, McKinstry RC, Mulkern RV, Pierpaoli C, Rivkin MJ, Pike GB, J Magn Reson Imaging
• Genome-wide association study reveals genetic risk underlying Parkinson’s disease.  
  Simón-Sánchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Krüger R, Federoff M, Klein C, Goate A, Perlmutte..., Nature Genetics
• Protected to Death.  
  Hardy J, Gwinn K, Journal of Alzheimer’s disease
• A pilot study on the motor effects of rimantadine in Parkinson’s disease.  
  Evidente VGH, Adler CH, Caviness JN, Gwinn KA, Clin Pharm
• Risperidone is effective in severe hemichorea/hemiballismus.  
  Evidente VGH, Gwinn-Hardy KA, Mov Dis
• The genetics of disorders with synuclein pathology and parkinsonism.  
  Farrer M, Gwinn-Hardy K, Hutton M, Hardy J, Hum Mol Genet
• A chromosome 4p haplotype segregating with Parkinson’s disease and postural tremor.  
  Farrer M, Gwinn-Hardy K, Muenter M, Wavrant DeVrieze F, Crook R, Tur J, Lincoln S, Maraganore D, Adler C, Newman S, MacElwee K, McCarthy P, Miller C, Waters C, Hardy J, Hum Mol Genet
• Levodopa slows the progression of familial Lewy body parkinsonism.  
  Gwinn-Hardy KA, Evidente VGH, Waters C, Muenter MD, Hardy J, Lancet
• BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups.  
  Xiromerisiou G, Hadjigeorgiou GM, Eerola J, Fernandez HH, Tsimourtou V, Mandel R, Hellström O, Gwinn-Hardy K, Okun MS, Tienari PJ, Singleton AB, Neurosci Lett
• How Common Are the “Common” Neurological Disorders?  
  Hirtz D, Thurman DJ, Gwinn-Hardy K, Mohamed M, Chaudhuri AR, Zalutsky R, Neurology
• Amyotrophic lateral sclerosis: an emerging era of collaborative gene discovery.  
  Gwinn K, Corriveau RA, Mitsumoto H, Bednarz K, Brown RH, Cudkowicz M, Gordon PH, Hardy J, Kasarskis EJ, Kaufmann P, Miller R, Sorenson E, Tandan R, Traynor BJ, Nash J,..., PLoS ONE
• Comprehensive screening of a North American Parkinson's disease cohort for LRRK2 mutation.  
  Johnson J, Paisán-Ruíz C, Lopez G, Crews C, Britton A, Malkani R, Evans EW, McInerney-Leo A, Jain S, Nussbaum RL, Foote KD, Mandel RJ, Crawley A, Reimsnider S, Fernand..., Neurodegener Dis
• DLB and PDD Boundary Issues: Diagnosis, Treatment, Molecular Pathology, and Biomarkers.  
  Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, Brooks DJ, Dickson DW, Dubois B, Emre M, Fahn S, Farmer JM, Galasko D, Galvin JE, Goetz CG, Growdon JH,..., Neurology
• Pathogenicity of the Lrrk2 R1514Q substitution in Parkinson's disease.  
  Toft M, Mata IF, Ross OA, Kachergus J, Hulihan MM< Haugarvoli K, Stone JT, Blaxquez M, Gibson JM, Aasly JO, White LR, Lynch T, Adler CH, Gwinn-Hardy K, Farrer MJ, Mov Disord
• Genotype-phenotype correlation of paroxysmal nonkinesigenic dyskinesia.  
  Bruno MK, Lee HY, Auburger GW, Friedman A, Nielsen JE, Lang AE, Bertini E, Van Bogaert P, Averyanov Y, Hallett M, Gwinn-Hardy K, Sorenson B, Pandolfo M, Kwiecinski H, ..., Neurology
• Genetic Testing in Parkinson’s Disease.  
  McInerney-Leo A, Hadley DW, Gwinn-Hardy K, Hardy J, Mov Dis
• Analysis of polyglutamine-coding repeates in the TATA-binding protein in different neurodegenerative diseases.  
  Wu YR, Fung HC, Lee-Chen GJ, Gwinn-Hardy K, Ro LS, Chen ST, Hsieh-Li M, Lin HY, Lin CY, Li SN, Chen CM, J Neural Transm
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Books/Book Chapters

• The Woman Doctor's Guide to Health and Healing. 
  Page 51 - 52Alzheimer's and Parkinson'sOxmoor House
• Surgical Treatment of Movement Disorders. 
  Gwinn KA, Adler CHEditors: Gilman S, Goldstein GW, Waxman SG.Neurobase, LaJolla, CA
• Surgical Treatment of Movement Disorders. 
  Uitti, R, Gwinn-Hardy KA, Adler CHEditors: Neurobase, Gilman S, Goldstein GW, Waxman SG, eds.LaJolla, CA
• Wilson’s Disease. 
  Chapter: Parkinson’s disease and movement disorders: diagnosis and treatment guidelines for the practicing physician 
  Gwinn-Hardy KAEditors: Adler CH, Ahlskog JE.Humana Press, Totowa, NJ
• Familial variants of Parkinson's disease. 
  Chapter: Mapping the progress of Alzheimer's and Parkinson's disease 
  Gwinn-Hardy K, Hanson M, Wszolek Z, Adam A, Singleton A, Adler CH, Caviness JN, Bower J, Hickey S, Chen JY, Waseem S, Farrer MEditors: Mizuno Y, Fisher A, Hanin I.Kluver Academic/Plenum Publishers, New York, NY
• Racial and ethnic influences on the expression of the genotype in neurodegenerative diseases. 
  Chapter: Genotype-proteotype-phenotype relationships in neurodegenerative diseases 
  Gwinn-Hardy KAEditors: Cummings J, Hardy J, Poncet M Christen Y.Spring Verlag, New York
• Parkinson’s Disease: Insights from Genetic Causes. 
  Chapter: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine 
  Baptista M, Cookson M, Gwinn-Hardy KEditors: Ganten D, Ruckpaul K.Springer
• The relationship between nosology, etiology and pathogenesis in neurodegenerative diseases. 
  Page 189 - 192Hardy J, Gwinn-Hardy KAHandb Clin Neurol
• Pharmacogenetics of Stroke. 
  Chapter: Current Clinical Trials of Antithrombotic Therapy in Stroke Prevention; Seminars in Cerebrovascular Diseases and Stroke 
  Gwinn-Hardy, KEditors: Jose Biller.
• The Genetics of Parkinson’s Disease. 
  Chapter: The Encyclopedia of Movement Disorders 
  Corriveau RA, Gubitz AK, Gwinn, KEditors: Chris Goetz.Elsevier, Oxford
• The Genetics of Parkinsonism. 
  Chapter: The Encyclopedia of Movement Disorders 
  Gubitz, A.K., Corriveau, R.A., Gwinn, KEditors: Chris Goetz.Elsevier, Oxford
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Abstracts/Posters

• X-linked dystonia (“lubag”) presenting predominantly with parkinsonism: a more benign phenotype?
  Evidente, VGH, Gwinn-Hardy K, John Hardy J, Andrew Singleton A, Mov Disorder
• Mutation at the SCA17 locus is not a common cause of parkinsonism.
  Hernandez D, Melissa Hanson M, Singleton A, Gwinn-Hardy K, Freeman J, Doheny D, Gallardo M, Weiser R, Hardy J, Singleton A, Parkinsonism Relat Disord
• Neuropathology of two members of a German-American kindred (Family C) with late onset parkinsonism.
  Wszolek K, Gwinn-Hardy K, Muenter D, Pfeiffer F, Rodnitzky L, Uitti J, McComb D, Gasser T, Dickson W, Acta Neuropathol
• A family with a tau P301L mutation presenting with parkinsonism.
  Walker RH, Friedman J, Weiner J, Hobler R, Gwinn-Hardy K, Adam A, DeWolfe J, Gibbs R, Baker M, Farrer F, Hutton M, Hardy J, Parkinsonism Rel Dis
• Racial differences in the expression of neurodegenerative disease: Machado-Joseph disease in Caucasians and Africans.
  Subramony SH, Hernandez D, Adam A, Smith-Jefferson S, Hussey J, Gwinn-Hardy K, Lynch T, McDaniel O, Hardy J, Farrer M, Singleton A, Mov Disord
• Accurate determination of SCA2 polyglutamine expansion in patients with intermediate range repeats.
  Hussey J, Lockhart PJ, Seltzer W, Wszolek Z, Payami H, Hanson M, Gwinn-Hardy K, Farrer MJ, Genetic Testing
• Clinical features and changing patterns of neurodegenerative disorders on Guam 1997-2000.
  Hardy J, Gwinn-Hardy K, McGeer P, Morris H, Perez-Tur J, Steele J, Neurology
• Parkinson's genetics: an embarrassment of riches.
  Gwinn-Hardy, K. Farrer M, Ann Neurol
• Genetics of parkinsonism.
  Gwinn-Hardy, K, Mov Dis
• The Tau H1 Haplotype is associated with Parkinson’s Disease in the Norwegian population.
  Farrer MJ, Skipper L, Berg M, Bisceglio G, Hardy JA, Gwinn-Hardy K, Aasly JO, Neurosci Lett
• alpha-Synuclein locus triplication causes Parkinson's disease.
  Cookson MR, Muenter M, Baptista M, Miller D, Blancato J, Hardy J, Gwinn-Hardy K, Science
• Phenomenology of "Lubag" or X-linked dystonia-parkinsonism.
  Evidente VG, Advincula J, Esteban R, Pasco P, Alfon JA, Natividad FF, Cuanang J, Luis AS, Gwinn-Hardy K, Hardy J, Hernandez D, Singleton A, Mov Disord
• ILAE Genetics Commission Conference Report: Molecular Analysis of Complex Genetic Epilepsies.
  Anderson E, Berkovic S, Dulac O, Gardiner M, Jain S, Laue-Friis M, Lindhout D, Noebels J, Ottman R, Scaramelli A, Serratosa J, Steinlein O, Avanzini G, Bailey-Wilson J..., Epilepsia
• DNA haplotype analysis of CAG repeat in Taiwanese Huntington’s disease patients.
  Wang CK, Wu YR, Hwu WL, Chen CM, Ro LS, Chen ST, Gwinn-Hardy K, Yang CC, Wu RM, Chen TF, Wang HC, Chao MC, Chiu MJ, Lu CJ, Lee-Chen GJ, Eur Neurol
• Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplication.
  Singleton A, Gwinn-Hardy K, Sharabi Y, Li ST, Holmes C, Dendi R, Hardy J, Singleton A, Crawley A, Goldstein DS, Brain
• Parkinson's disease and dementia with Lewy bodies: a difference in dose?
  Singleton A, Gwinn-Hardy K, Lancet
• Analysis of the PINK1 gene in a large cohort of cases with Parkinson’s Disease.
  Rogaeva E, Johnson J, Lang AE, Gulick C, Gwinn-Hardy K, Kawarai T, Sato C, Morgan A, Werner J, Nussbaum R, Petit A, Okun MS, McInerney A, Mandel R, Groen JL, Fernandez..., Arch Neurol
• Genome-wide analysis of the Parkinsonism-Dementia Complex of Guam.
  Morris HR, Steele JC, Crook R, Wavrant-De Vrieze F, Onstead-Cardinale L, Gwinn-Hardy K, Wood NW, Farrer M, Lees AJ, McGeer PL, Siddique T, hardy J, Perez-Tur J, Arch Neurol
• SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies.
  Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, Lincoln S, Crawley A, Hanson M, Maraganore D, Adler..., Neurology
• Synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication.
  Miller DW, Hague SM, Clarimon J, Baptista M, Gwinn-Hardy K, Cookson MR, Singleton AB, Neurology
• Spinocerebellar ataxia type 2 with parkinsonism in ethnic Chinese.
  Gwinn-Hardy K, Chen Y, Liu H, Liu TY, Boss M, Seltzer W, Adam A, Singleton A, Hardy J, Waters C, Farrer M, Neurology
• Lewy bodies and parkinsonism in families with parkin mutations.
  Farrer M, Chan P, Chen R, Tan L, Lincoln S, Hernandez D, Forno L, Gwinn-Hardy K, Petrucelli L, Hussey J, Singleton A, Tanner C, Hardy J, Langston JW, Ann Neurol
• Serum leptin is normal in Parkinson’s disease patients with weight loss.
  Evidente VGH, Caviness JNC, Adler CH, Gwinn-Hardy KA, Pratley R, Mov Disord
• Persistent chorea triggered by hyperglycemic crisis in new-onset diabetics.
  Ahlskog JE, Evidente, VGH, Tulloch, JW, Forbes GS, Caviness JN, Gwinn-Hardy KA, Mov Disord
• A clinical and pathological study of motor neuron disease on Guam.
  Morris HR, Al-Sarraj S, Schwab C, Gwinn-Hardy K, Wood NW, Hardy J, Lees AJ, McGeer P, Daniel SE, Steele JC, Brain
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Lectures

• Genetic Lessons and New Approaches in Learning about Parkinson’s Disease(s). 
  Parkinson Disease Foundation Symposium
• re: confusion and intracranial hemorrhage. 
  Grey’s Anatomy (ABC)
• re: Post-Encephalitic Parkinsonism. 
  National Geographic
• A prospective, randomized, parallel-group, double-blind, placebo-controlled multicenter study to evaluate the short-term efficacy and safety of Entacapone administered... 
  Novartis, Inc
• An open-label, safety study of Neurobloc™ (botulinum toxin type B) in patients with cervical dystonia. 
  Athena Neurosciences Inc
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Other

• Parkinson’s Disease: An embarrassment of riches. 
  Gwinn-Hardy K, Farrer M, Ann Neurol
• When is ataxia not ataxia? 
  Gwinn-Hardy K, Arch Neurol