KathleenMLoomesMD

Pediatric Gastroenterology • Philadelphia, PA

Pediatric Hepatology and Liver Transplantation

Associate Professor, Pediatrics, Perelman School of Medicine

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Office
3401 Civic Center Blvd
Childrens Hospital of Phila Gastro Nutrition
Philadelphia, PA 19104
Phone+1 215-590-3247

Fax+1 215-590-3606

Education & Training

Children's Hospital of PhiladelphiaFellowship, Pediatric Gastroenterology, 1996 - 1999
Johns Hopkins UniversityResidency, Pediatrics, 1992 - 1995
University of Texas Southwestern Medical SchoolClass of 1992

Certifications & Licensure

FL State Medical License 2021 - Present
PA State Medical License 1996 - 2024
MD State Medical License 1995 - 1996
American Board of Pediatrics Pediatric Gastroenterology
American Board of Pediatrics Pediatric Transplant Hepatology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014

Clinical Trials

A Prospective Database of Infants With Cholestasis Start of enrollment: 2004 Apr 21
Recruiting
Open Label Study to Evaluate Efficacy and Long Term Safety of LUM001 (Maralixibat) in the Treatment of Cholestatic Liver Disease in Patients With Progressive Familial Intrahepatic Cholestasis Start of enrollment: 2014 Mar 01
Completed
Phase 2
Validation of the Itch Reported Outcome (ItchRO) Diaries in Pediatric Cholestatic Liver Disease Start of enrollment: 2014 Jul 01
Completed
A Study to Evaluate the Efficacy and Safety of Maralixibat in Subjects With Progressive Familial Intrahepatic Cholestasis (MARCH-PFIC) Start of enrollment: 2019 Jul 09
Completed
Phase 3
SHAPE of Portal Hypertension in Children Start of enrollment: 2021 Nov 03
Recruiting
Phase 2
TReatment for ImmUne Mediated PathopHysiology Start of enrollment: 2022 Feb 09
Recruiting
Phase 2
Roles: Principal Investigator, Contact
Evaluation of Maralixibat in Biliary Atresia Response Post-Kasai Start of enrollment: 2021 Jul 08
Completed
Phase 2
Roles: Principal Investigator, Contact
Long-Term Safety and Clinical Outcomes of Livmarli in Patients With Alagille Syndrome (LEAP) Start of enrollment: 2023 Sep 21
Recruiting
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Interleukin 8-CXCR2 mediated neutrophil extracellular trap (NET) formation in biliary atresia associated with NET-Induced stellate cell activation.
Yuhuan Luo, Lisa Fraser, Julia Jezykowski, Nitika A Gupta, Alexander G Miethke
Hepatology. 2024-12-18
Investigation of cryptic JAG1 splice variants as a cause of Alagille syndrome and performance evaluation of splice predictor tools.
Ernest Keefer-Jacques, Nicolette Valente, Anastasia M Jacko, Grace Matwijec, Apsara Reese
HGG Advances. 2024-10-10
Functional characterization of 2,832 JAG1 variants supports reclassification for Alagille syndrome and improves guidance for clinical variant interpretation.
Melissa A Gilbert, Ernest Keefer-Jacques, Tanaya Jadhav, Daniel Antfolk, Qianqian Ming
American Journal of Human Genetics. 2024-08-08

Other

Biliary atresia
Loomes KM, Erlichman J
http://www.uptodate.com/contents/biliary-atresia
UpToDate, Wolters Kluwer Health - 2013-02-28

Press Mentions

Albireo Presents Data on Greater Efficacy in PFIC with Earlier Bylvay® Treatment at NASPGHANOctober 14th, 2022

Grant Support

The Role Of The Notch Pathway In Bile Duct DevelopmentNational Institute Of Diabetes And Digestive And Kidney Diseases2005–2010
The Role Of Notch Signaling In Bile Duct DevelopmentNational Institute Of Diabetes And Digestive And Kidney Diseases2004
Signaling Molecules In Bile Duct DevelopmentNational Institute Of Diabetes And Digestive And Kidney Diseases2004
The Role Of Notch Signaling In Bile Duct DevelopmentNational Institute Of Diabetes And Digestive And Kidney Diseases2003
Signaling Molecules In Bile Duct DevelopmentNational Institute Of Diabetes And Digestive And Kidney Diseases2000–2003