KariCNadeauMD

Nadissy Foundation Professor of Medicine and Pediatrics; Director of the Sean Parker Center for Allergy and Asthma Research at Stanford University

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Office
110 Francis St Suite Gb
Boston, MA 02215
Phone+1 617-632-7706

Fax+1 650-723-5836

Summary

Dr. Kari Nadeau is the Naddisy Foundation Endowed Professor of Medicine & Pediatrics and, Director of the Sean N. Parker Center for Allergy and Asthma Research at Stanford University. She's Section Chief in Asthma and Allergy in the Pulmonary, Allergy and Critical Care Division at Stanford. She is the Sr. Director of Clinical Research for the Division of Hospital Medicine. Dr. Nadeau received her MD and PhD from Harvard Medical School through the NIH MSTP program. She completed a residency in pediatrics at Boston Children’s Hospital and a clinical fellowship at Stanford & UCSF.

For over 30 years, she's devoted herself to understanding how environmental and immune/genetic factors affect allergies, immune tolerance & asthma. She and her team are focused in areas of global climate change and health by studying air pollution and wildfire exposures, particularly in underserved areas. As one of the globe’s foremost experts in adult and pediatric allergy, immunology, and asthma, her research is laying the groundwork for a variety of potential future therapies to prevent and cure allergies and asthma. Dr. Nadeau leads a team of specialists spanning allergy, asthma, and immunology across Stanford. She has been a pioneer in the field of Translational Allergy and Immunology, both defining the mechanism of new therapies and then translating them clinically to make transformative changes for patients and their families. She has led research in oncology, transplant, infectious diseases, COVID, and autoimmune trials and is a member of the National Steering Committee for the intramural clinical research programs at the NIH Immune Tolerance Network. She and her team have been awarded many patents and have started 4 biotech companies in the Bay Area under Stanford patents and has worked in industry to shepherd two drugs through the FDA to approval. She also is an author of the Lancet Countdown in Global Climate Change 2020 and the book: The End of Food Allergy (published 2020).

About the Sean N. Parker Center for Allergy & Asthma Research at Stanford Univer

Our mission is to transform the lives of our patients and families through innovative science and compassionate care.

Education & Training

Stanford Health Care-Sponsored Stanford UniversityResidency, Allergy and Immunology, 1995 - 1997
Boston Children’s Hospital/Boston Medical CenterResidency, Pediatrics, 1995 - 1997
Harvard Medical SchoolClass of 1995
Haverford CollegeBS, Biology, 1984 - 1988

Certifications & Licensure

CA State Medical License 2000 - 2026
MA State Medical License 1997 - 2025
American Board of Allergy and Immunology Allergy & Immunology

Awards, Honors, & Recognition

Medical Unit Consultant White House, 2016
Annual Innovations Lecture United Nations, 2015
Grand Rounds and Pierson Lectureship University of Washington, 2015
Visiting Professorship Lecture Texas Children's Hospital, 2015
Consultant and Panel Participant Institute of Medicine, National Academy of Sciences (U.S.), 2015
Faculty Fellow Stanford Center for Innovation in Global Health, 2015
National Scientific Advisory Board Environmental Protection Agency (U.S.), 2015
Distinguished Lecture Award NIEHS Annual Distinguished Lecture, 2014
Member The American Society of Clinical Investigation, 2014
Research Award American Academy of Asthma, Allergy, and Immunology, 2014
Helen F. Cserr Memorial Lecture Award 2014
Plenary Speaker Award Canadian Allergy and Clinical Immunology Society, 2013
Faculty Fellows Program Stanford University School of Medicine, 2012
Junior Faculty Award Clinical Immunological Society (CIS), 2010
Elected to Collegium Internationale Allergologicum 2010
National Junior Faculty Award American Lung Association, 2009
ART Trust Award American Academy of Allergy, Asthma and Immunology, 2008
Fellow American Academy of Asthma, Allergy and Immunology, 2008
Speaker Award La Entrada Inspirational Speaker Series, 2007
Teaching Award Stanford Cardinal Free Clinic, 2007
Guest Speaker-Biological Therapies Massachusetts State Legislature, 2000
Member, Board of Directors Lupus Foundation of Massachusetts, 1998
Speaker Awardee American Society of Transplantation, 1997-1999
Von Mayer Scholarship Awardee Children's Hospital, 1995
Soma Weiss Speaker Harvard Medical School, 1993
Medical Student Teaching Award Harvard Medical School, 1991-1993
Fellow (FAAAAI) American Academy of Allergy Asthma and Immunology
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Clinical Trials

Safety Study of Nebulized RNS60 to Treat Asthma. Start of enrollment: 2010 May 01
Completed
Phase 1
Use of Symbicort or Pulmicort to Treat Viral-mediated Asthma Exacerbations Start of enrollment: 2009 Sep 01
Completed
Not Applicable
Sublingual Immunotherapy Studies for Grass and Dust Mite Allergies Start of enrollment: 2005 Jan 01
Completed
Phase 1
Understanding and Diagnosing Allergic Disease in Twins Start of enrollment: 2010 Aug 01
Completed
Single Center Study Using Omalizumab in Subjects With Atopic Dermatitis Start of enrollment: 2004 May 01
Completed
Phase 1
Peanut Reactivity Reduced by Oral Tolerance in an Anti-IgE Clinical Trial Start of enrollment: 2013 Jan 01
Completed
Phase 1, Phase 2
Peanut Oral Immunotherapy in Children Start of enrollment: 2013 Aug 13
Completed
Phase 2
Oral Immunotherapy for Wheat Allergy Start of enrollment: 2013 Oct 01
Completed
Phase 1, Phase 2
A Phase 2 Randomized, Controlled, Blinded Study Omalizumab With Oral Food Immunotherapy in Children and Adults With Multiple Food Allergies Start of enrollment: 2014 Feb 01
The Peanut Oral Immunotherapy Study: Safety, Efficacy and Discovery Start of enrollment: 2014 Apr 01
Completed
Phase 2
Food Allergen OIT for Shrimp and Cashew Start of enrollment: 2019 Jul 09
Terminated
Phase 2
Effect of Different Skin Creams on TEWL Start of enrollment: 2018 Sep 01
Completed
Phase 1
Clinical Study Using Biologics to Improve Multi OIT Outcomes (COMBINE) Start of enrollment: 2020 Feb 05
Recruiting
Phase 2
Seal, Stopping Eczema and Allergy Study Start of enrollment: 2021 Jun 30
Recruiting
Phase 2
Understanding Immunity to SARS-CoV-2, the Coronavirus Causing COVID-19 Start of enrollment: 2020 Apr 08
Completed
Immune Tolerance Dysfunction in Pregnancy Due to Ambient Air Pollution Exposure Start of enrollment: 2020 Aug 01
Completed
Understanding Immunity to the Flu Vaccine in COVID-19 Patients Start of enrollment: 2020 Oct 29
Recruiting
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Publications & Presentations

PubMed

Role of allergen immunotherapy and biologics in allergic diseases.
Xiaoying Zhou, Elisabeth M Simonin, Youn S Jung, Stephen J Galli, Kari C Nadeau
Current Opinion in Immunology. 2024-12-01
Inborn errors of immunity reveal the molecular requirements for the generation and maintenance of human IL-9 expressing cells.
Geetha Rao, Corinne D Mack, Tina Nguyen, Natalie Wong, Kathryn Payne
The Journal of Allergy and Clinical Immunology. 2024-11-30
Baseline epitope-specific IgE profiles are predictive of sustained unresponsiveness or high threshold 1-year post oral immunotherapy in the POISED trial.
Maria Suprun, Ashley Sang Eun Lee, Robert Getts, Simon Peck, Sayantani B Sindher
The Journal of Allergy and Clinical Immunology. 2024-11-05

Journal Articles

The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States
Ruchi S Gupta, Kari C Nadeau, AAP News
IgE blockade during food allergen ingestion enhances the induction of inhibitory IgG antibodies
Stranks AJ, Minnicozzi SC, Miller SJ, Burton OT, Logsdon SL, Spergel JM, Nadeau KC, Pongracic JA, Umetsu DT, Rachid R, MacGinnitie AJ, Schneider L, Oettgen HC, Ann Allergy Asthma Immunol, 1/4/2018
Multicenter, randomized, double-blind, placebo-controlled clinical trial of vital wheat gluten oral immunotherapy
J Allergy Clin Immunol, 1/4/2018
Realizing the Paris Climate Agreement to Improve Cardiopulmonary Health: Where Science Meets Policy
Rice MB, Malea NM, Pinkerton KE, Schwartz J, Nadeau KC, Browner CM, Whitehouse S, Thurston GD, Ann Am Thorac Soc, 1/1/2018
Development of a Tool Predicting Severity of Allergic Reaction During Peanut Challenge
Chinthrajah RS, Purington N, Andorf S, Rosa JS, Mukai K, Hamilton R, Smith BM, Gupta R, Galli SJ, Desai M, Nadeau KC, Ann Allergy Asthma Immunol, 1/1/2018
High dimensional immune biomarkers demonstrate differences in phenotypes and endotypes in food allergy and asthma
Chinthrajah RS, Purington N, Sampath V, Andorf S, Manohar M, Prunicki M, Zhou X, Tupa D, Nadeau KC, Ann Allergy Asthma Immunol, 1/1/2018
Heterogeneity of Ara h Component-Specific CD4 T Cell Responses in Peanut-Allergic Subjects
Renand A, Farrington M, Whalen E, Wambre E, Bajzik V, Chinthrajah S, Nadeau KC, Kwok WW, Front Immunol, 1/1/2018
Impact of allergen immunotherapy in allergic asthma
Zhang W, Lin C, Sampath V, Nadeau K, Immunotherapy, 1/1/2018
Isotype-Specific Agglutination- PCR (ISAP): a sensitive and multiplex method for measuring allergen-specific IgE
Tsai CT, Mukai K, Robinson PV, Gray MA, Waschmann MB, Lyu SC, Tsai M, Chinthrajah RS, Nadeau KC, Bertozzi CR, Galli SJ, Allergy Clin Immunol, 1/1/2018
Comparison of Sublingual Immunotherapy and Oral Immunotherapy in Peanut Allergy
Zhang W, Sindher S, Sampath V, Nadeau KC, Allergo J Int, 1/1/2018
New treatment directions in food allergy
Sampath V, Sindher SB, Zhang W, Nadeau KC, Ann Allergy Asthma Immunol, 1/1/2018
Anti-IgE Treatment with Oral Immunotherapy in Multifood Allergic Patients
Andorf A, Purington N, Block W, Long A, Tupa D, Brittain E, Spergel A, Desai M, Galli S, Nadeau K, Chinthrajah S, Lancet Gastroenterol Hepatol, 1/1/2018
Food allergy and omics
Dhondalay GK, Rael E, Acharya, S, Zhang W, Sampath V, Galli SJ, Tibshirani, R, Boyd SD, Maecker, H, Nadeau KC, Andorf S, J Allergy Clin Immunol, 1/1/2018
Peanut-specific Tr1 cells induced in vitro from allergic individuals are functionally impaired
Pellerin L, Jenks JA, Chinthrajah S, Dominguez T, Block W, Zhou X, Noshirvan A, Gregori S, Roncarolo MG, Bacchetta R, Nadeau KC, J Allergy Clin Immunol, 1/1/2018
Cord blood T cell subpopulations and associations with maternal cadmium and arsenic exposures
Nygaard UC, Li Z, Palys T, Jackson B, Subbiah M, Malipatlolla M, Sampath V, Maecker H, Karagas MR, Nadeau KC, PLoS One, 1/29/2017
Purification and Characterization of a Black Walnut (Juglans nigra) Allergen, Jug n 4
Zhang YZ, Du WX, Fan Y, Yi J, Lyu SC, Nadeau KC, Thomas AL, McHugh T, J Agric Food Chem, 1/18/2017
Effect of Varying Doses of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Exposure Among Patients With Peanut Sensitivity: A Randomized Clinical T...
Sampson HA, Shreffler WG, Yang WH, Sussman GL, Brown-Whitehorn TF, Nadeau KC, Cheema AS, Leonard SA, Pongracic JA, Sauvage-Delebarre C, Assa'ad AH, de Blay F, Bird JA,..., JAMA (Journal of the American Medical Association), 1/14/2017
IL-4Ralpha Inhibitor for Atopic Disease
Chang, H, Nadeau KC, Cell, 1/13/2017
Immune Monitoring for Precision Medicine in Allergy and Asthma
Boyd S, Hoh R, Nadeau K, Galli S, Curr Opin Immunol, 1/6/2017
Combining anti-IgE with oral immunotherapy
Lin C, Lee IT, Sampath V, Dinakar C, DeKruyff RH, Schneider LC, Nadeau KC, Pediatr Allergy Immunol, 1/1/2017
Mechanistic correlates of clinical responses to omalizumab in the setting of oral immunotherapy for milk allergy
Frischmeyer-Guerrerio PA, Masilamani M, Gu W, Brittain E, Wood R, Kim J, Nadeau K, Jarvinen KM, Grishin A, Lindblad R, Sampson HA, J Allergy Clin Immunol, 1/1/2017
Association of clinical reactivity with sensitization to allergen components in multifood-allergic children
Andorf S, Borres MP, Block W, Tupa D, Bollyky JB, Sampath V, Elizur A, Lidholm J, Jones JE, Galli SJ, Chinthrajah S, Nadeau KC, J Allergy Clin Immunol Pract, 1/1/2017
Effectiveness of air purifier on health outcomes and indoor particles in homes of children with allergic diseases in Fresno, California: A pilot study
Park HK, Cheng KC, Tetteh AO, Hildemann LM, Nadeau KC, J Asthma, 1/1/2017
Precision Medicine in Allergic Disease - Food Allergy, Drug Allergy, and Anaphylaxis- PRACTALL document of the European Academy of Allergy and Clinical Immunology and ...
Muraro A, Lemanske RF Jr, Castells M, Torres MJ, Khan D, Simon HU, Bindslev- Jensen C, Burks W, Poulsen LK, Sampson HA, Worm M, Nadeau KC, Allergy, 1/1/2017
Traffic- Related Air Pollution and Telomere Length in Children and Adolescents Living in Fresno, CA: A Pilot Study
Lee EY, Lin J, Noth EM, Hammond SK, Nadeau KC, Eisen EA, Balmes JR, J Occup Environ Med, 1/1/2017
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Books/Book Chapters

Extreme Weather, Health, and Communities: Interdisciplinary Engagement Strategies
Chapter: "The Air We Breathe: How Extreme Weather Conditions Harm Us"
Page 293 - 310Prunicki MM, Nadeau KCEditors: Steinberg SL, Sprigg WA.Springer International Publishing, Cham2016
Present Pediatric Reviews
Chapter: "Apoptosis and Pediatric Idiopathic Neutropenia"
Page 321 - 328Nadeau KC and Jeng, MBentham Science Publishers2011
Neonatology: Clinical Practice and Procedural Atlas
Chapter: "T cell immunodeficiencies of the Neonate"
Nadeau KEditors: Ronald Cohen, Krisa Van Meurs, David Stevenson.2011
Best Practice and Research: Clinical Endocrinology and Metabolism
Chapter: "STAT5b Deficiency: Lessons from STAT5b Gene Mutations"
Hwa V, Nadeau K, Lit J, Rosenfeld R2011
Hematology: Basic Principles and Practice
Chapter: "Primary Immunodeficiencies in Hematology"
Lewis DB, Cleary A, Nadeau KElsevier ScienceEdition 5th,2006
Pharmacotherapy Handbook
Chapter: "Anti-IgE therapy in Asthma in Allergy and Immunology"
Nadeau KMcGraw HillEdition 7th,2006
"The Pathology and Diagnosis of Asthma in Allergy: Guide for Medical Students and Residents"
Nadeau K and Umetsu DElsevier ScienceEdition 3rd,2005
Transplantation Reviews
Chapter: "The Role of Sequential Cytokine Analysis in Acute and Chronic Allograft Rejection"
Page 99 - 107Nadeau K and Tilney NL1996
Organ Transplantation
Chapter: "Chronic Rejection"
Page 124 - 150Nadeau K and Tilney NLEditors: Morris, P.London1996
Present Topics in Cellular Regulation
Chapter: "Molecular Studies on Trypanothione Reductase: An Anti-Parasitic Target Enzyme"
Page 571 - 574Walsh C, Bradley M, Nadeau K1992
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Lectures

Immunophenotyping of children with AD.
Rockville, MD - 1/5/2018
Studying Immunological Mechanisms to Try to End Food Allergy.
New Haven, CT - 1/1/2018
Mechanisms of action of IT.
Copenhagen, Denmark - 1/1/2018
Prevention Approaches.
Copenhagen, Denmark - 1/1/2018
Knowledge of Pathways Causing Allergies Lead to Roads to Prevention.
Chapel Hill, NC - 1/1/2018
Immune Mechanisms in Food Allergy.
Boston, MA - 1/1/2018
Immunotherapy and Biologics, Multi-Allergen.
Aspen, CO - 1/1/2018
Novel Immune Subsets in Mechanisms of Immunotherapy.
Seattle, WA - 1/1/2018
Prevention and Treatment mechanisms of Food Allergy.
Bethesda, MD - 1/1/2018
"Ambient Air Pollution and Immune Changes in Children"
1/1/2017
Mechanisms of Allergy and Asthma.
Boston, MA - 1/1/2017
Extreme Weather Conditions, Global Climate Change, and Air Pollution effects on Asthma.
Fresno, CA - 1/1/2017
OIT to foods - what can our patients look forward to?
London, England - 1/1/2017
Allergen Products for Diagnosis and Therapy: Regulation and Science.
Homburg, Germany - 1/1/2017
Epigenetic Mechanisms of Air Pollution-Induced Immune Dysfunction in Children.
Andover, NH - 1/1/2017
Early Intervention in Allergy Prevention.
Helsinki, Finland - 1/1/2017
Effect of Pollution on the Epigenetic Profile of T Cells in Asthma.
Washington, DC - 1/1/2017
Effects of Climate Change on Children and Adults with Asthma.
Washington, DC - 1/1/2017
Impact of Environmental Pollutants on T Cell Populations.
Washington, DC - 1/1/2017
Environmental Influences on Children's Pulmonary Health: Mulitfaceted Effects of Tobacco Smoke on Immunity.
Washington, DC - 1/1/2017
Immunomics to Study Mechanisms of Tolerance in Food Allergy Immunotherapy.
Davos, Switzerland - 1/1/2017
Precision Medicine in Food Allergy.
Davos, Switzerland - 1/1/2017
"Epigenetic Changes after Ambient Air Pollution"
1/1/2016
Food OIT, EPIT and More.
San Francisco, CA - 1/1/2016
Oral Immunotherapy.
San Francisco, CA - 1/1/2016
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Other

How Ambient Air Pollution could cause Immune Dysregulation.
Nadeau K, EPA/NIEHS Children's Centers Webinar
1/13/2012

Authored Content

The Public Health Impact of Parent-Reported Childhood Food Allergies in the United StatesNovember 2018

Press Mentions

Allergy Season Is Dragging on Thanks to Dry and Warm WeatherOctober 30th, 2024
Weeks After Ohio Train Derailment, Health Concerns MountMarch 9th, 2023
East Palestine Residents Worry Rashes, Headaches and Other Symptoms May Be Tied to Chemicals from Train CrashFebruary 17th, 2023
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