KarenH.LuMD

Obstetrics & Gynecology • Houston, TX

Gynecologic Oncology

Professor and Chair

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Office
1515 Holcombe Blvd
Houston, TX 77030
Phone+1 713-792-6161

Fax+1 713-792-7586

Education & Training

Brigham and Women’s HospitalFellowship, Gynecologic Oncology, 1996 - 1999
Brigham and Women's Hospital/Massachusetts General Hospital/Harvard Medical SchoolResidency, Obstetrics and Gynecology, 1991 - 1995
Yale School of MedicineClass of 1991

Certifications & Licensure

FL State Medical License 2024 - 2026
TX State Medical License 1999 - 2026
OK State Medical License 2023 - 2025
WA State Medical License 2022 - 2025
AL State Medical License 2023 - 2024
AZ State Medical License 2023 - 2024
GA State Medical License 2023 - 2024
LA State Medical License 2023 - 2024
MS State Medical License 2023 - 2024
TN State Medical License 2023 - 2024
MA State Medical License 1995 - 2000
American Board of Obstetrics and Gynecology Obstetrics & Gynecology
American Board of Obstetrics and Gynecology Gynecologic Oncology
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Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2010-2014
Top Doctors:SE Texas Castle Connolly, 2013
America's Top Doctors for Cancer Castle Connolly, 2009-2013
Fellow (FACOG) American Congress of Obstetricians and Gynecologists
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Clinical Trials

Hormone Therapy in Preventing Endometrial Cancer in Patients With a Genetic Risk For Hereditary Nonpolyposis Colon Cancer Start of enrollment: 2002 Feb 01
Completed
Phase 2
RAD001 in Recurrent Endometrial Cancer Patients Start of enrollment: 2004 Jun 01
Completed
Phase 2
Ovarian Cancer Patient Questionnaire on Genetic Testing Start of enrollment: 2007 Jun 01
Completed
Study of Insulin Resistance and Endometrial Cancer in Harris County, Texas Start of enrollment: 2005 Oct 01
Completed
Prevalence of Endometrial Abnormalities In Obese Women Start of enrollment: 2004 Jun 01
Active, not recruiting
Registry for Women Who Are At Risk Or May Have Lynch Syndrome
COMPLETED
Combined Colon and Endometrial Cancer Screening in Women With HNPCC Start of enrollment: 2002 Mar 01
Completed
Use of the CA 125 Algorithm for the Early Detection of Ovarian Cancer in Low Risk Women Start of enrollment: 2001 Jul 02
RECRUITING
NA
Lynne Cohen Consortium Project: Multi-Center Database/Registry Start of enrollment: 2008 Jul 01
Completed
An Endometrial Cancer Chemoprevention Study of Metformin Start of enrollment: 2013 May 02
COMPLETED
PHASE3
TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention Start of enrollment: 2020 Mar 01
Recruiting
Not Applicable
Roles: Contact, Principal Investigator
Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women to Assess the Safety of Prevention - US Cohort Study Start of enrollment: 2022 May 10
RECRUITING
NA
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Mitochondrial defects and metabolic vulnerabilities in Lynch syndrome-associated MSH2-deficient endometrial cancer.
Mikayla Borthwick Bowen, Brenda Melendez, Qian Zhang, Diana Moreno, Leah Peralta
JCI Insight. 2025-02-18
Use Patterns of Levonorgestrel-Releasing Intrauterine System among American Women.
Paul G Yeh, Allen Haas, Charlotte C Sun, Karen H Lu, Larissa A Meyer
Cancer Prevention Research. 2025-02-11
A phase I study of temsirolimus in combination with metformin in patients with advanced or recurrent endometrial cancer.
Jibran Ahmed, Bettzy Stephen, Muhammad R Khawaja, Yali Yang, Israa Salih
Gynecologic Oncology. 2025-02-01

Journal Articles

Variants in Genes Encoding Small GTPases and Association with Epithelial Ovarian Cancer Susceptibility
Julie M Cunningham, Robert P Edwards, Elizabeth M Poole, Tanja Pejovic, Karen Lu, Kunle Odunsi, Beth Y Karlan, Christine S Walsh, Douglas A Levine, Andrew Berchuck, Da..., PLoS One
KMT2D/MLL2 Inactivation Is Associated with Recurrence in Adult-Type Granulosa Cell Tumors of the Ovary
R Tyler Hillman, Karen H Lu, David M Gershenson, Nature
Systematic Identification of Druggable Epithelial–Stromal Crosstalk Signaling Networks in Ovarian Cancer
Samuel C Mok, Karen H Lu, Journal of the National Cancer Institute

Lectures

Women's Health 2013: The 21st Annual Congress
Academy of Women's Health, Washington, Dist Of Col - 3/22/2013

Other

Endometrial and ovarian cancer screening and prevention in women with Lynch syndrome (hereditary nonpolyposis colorectal cancer)
Lu KH, Schmeler KM
http://www.uptodate.com/contents/endometrial-and-ovarian-cancer-screening-and-prevention-in-women-wi
UpToDate, Wolters Kluwer Health - 2012-11-12

Press Mentions

Get to Know SGO’s Incoming PresidentMarch 17th, 2025
Dark Chocolate Could Help You Ward off Type 2 DiabetesDecember 5th, 2024
AACR Announces Recipients of Its 2022 Scientific Achievement Awards and LectureshipsApril 4th, 2022
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Grant Support

Training Of Academic Gynecologic OncologistsNational Cancer Institute2011
Metformin For The Chemoprevention Of Endometrial Cancer In Obese, Insulin-ResistaNational Cancer Institute2010–2011
M.D. Anderson Gynecologic Spore For Uterine CancersNational Cancer Institute2010–2011
Administrative CoreNational Cancer Institute2010–2011
Annual Uterine Cancer Biology SymposiumNational Cancer Institute2010
MD Anderson Cancer Ctr. Gynecology SPORE: Uterine CancerNational Cancer Institute2007–2009
Annual Uterine Cancer SymposiumNational Cancer Institute2004–2008
Phase II Clinical Trail - An Exploratory Study To IdentiDivision Of Cancer Prevention And Control2000

Professional Memberships

American College of Obstetricians and Gynecologists
Fellow