JudithKarpMD

Oncology • Baltimore, MD

Professor of Oncology and Medicine, Director Leukemia Program, Johns Hopkins

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Office
600 N Wolfe St
Baltimore, MD 21287
Phone+1 410-955-8964

Education & Training

Johns Hopkins UniversityResidency, Internal Medicine, 1972 - 1974
Stanford Health Care-Sponsored Stanford UniversityInternship, Internal Medicine, 1971 - 1972
Stanford University School of MedicineClass of 1971

Certifications & Licensure

MD State Medical License 1975 - 2016

Clinical Trials

R115777 in Treating Patients With Refractory or Recurrent Acute Leukemia or Chronic Myelogenous Leukemia Start of enrollment: 1999 Jun 01
Completed
Phase 1
LMB-9 Immunotoxin in Treating Patients With Advanced Colon, Breast, Non-small Cell Lung, Bladder, Pancreatic, or Ovarian Cancer Start of enrollment: 2000 Apr 01
Completed
Phase 1
MS-275 in Treating Patients With Hematologic Cancer Start of enrollment: 2001 Feb 01
Completed
Phase 1
Bevacizumab, Cytarabine, and Mitoxantrone on Treating Patients With Hematologic Cancers Start of enrollment: 2001 Apr 01
Completed
Phase 2
Flavopiridol, Cytarabine, and Mitoxantrone in Treating Patients With Acute Leukemia Start of enrollment: 2001 Feb 01
Completed
Phase 1, Phase 2
Tipifarnib in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Start of enrollment: 2001 Oct 01
Completed
Phase 2
A Phase II Study Of The Farnesyltransferase Inhibitor ZANESTRA (R115777, NSC #702818, IND #58,359) In Complete Remission Following Induction And/Or Consolidation Chemotherapy In Adults With Poor-Risk Acute Myelogenous Leukemia (AML) And High-Risk Myelodysplasia (MDS) Start of enrollment: 2002 Jun 01
Completed
Phase 2
3-AP Followed By Fludarabine In Treating Patients With Relapsed or Refractory Acute or Chronic Leukemia or High-Risk Myelodysplastic Syndrome Start of enrollment: 2004 Jan 01
Completed
Phase 1
Tipifarnib and Etoposide in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2005 Mar 01
Completed
Phase 1
Clofarabine and Cyclophosphamide in Treating Patients With Relapsed or Refractory Acute Leukemia, Chronic Myelogenous Leukemia, or Myeloproliferative Disorders Start of enrollment: 2005 Nov 01
Completed
Phase 1
Flavopiridol, Cytarabine, and Mitoxantrone in Treating Patients With Relapsed or Refractory Acute Leukemia Start of enrollment: 2007 Apr 01
Completed
Phase 1
Timed Sequential Therapy (TST) With Alvocidib (Flavopiridol), Ara-C and Mitoxantrone (FLAM) Versus "7+3" for Newly Diagnosed Acute Myelogenous Leukemia (AML) Start of enrollment: 2011 May 01
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Publications & Presentations

PubMed

16 citations
Histone Deacetylase Inhibitors Target the Leukemic Microenvironment by Enhancing a Nherf1-Protein Phosphatase 1α-TAZ Signaling Pathway in Osteoblasts.
Kimberly N. Kremer, Amel Dudakovic, Allan D. Hess, B. Douglas Smith, Judith E. Karp
The Journal of Biological Chemistry. 2015-12-04
73 citations
MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors
Katherine L. B. Knorr, Paula A. Schneider, Xue Wei Meng, Haiming Dai, B D Smith
Cell Death and Differentiation. 2015-06-05
68 citations
Phase 1 and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias
Judith E. Karp, B. Douglas Smith, Linda S. Resar, Jacqueline Greer, Amanda L. Blackford
Blood. 2011-03-24

Journal Articles

Final Results of a Randomized Multicenter Phase II Study of Alvocidib, Cytarabine, and Mitoxantrone Versus Cytarabine and Daunorubicin (7+3) in Newly Diagnosed High-Ri...
Joshua F Zeidner, Mark R Litzow, Jeffrey E Lancet, Prithviraj Bose, Raoul Tibes, Ivana Gojo, Richard F Little, Judith E Karp, Leukemia Research

Authored Content

Final Results of a Randomized Multicenter Phase II Study of Alvocidib, Cytarabine, and Mitoxantrone Versus Cytarabine and Daunorubicin (7+3) in Newly Diagnosed High-Risk Acute Myeloid Leukemia (AML)August 2018

Press Mentions

Improving Transparency in Phase 1 Clinical TrialsFebruary 9th, 2023
Rana R. McKay, MD: Developing Clinical Trials to Answer Questions Raised in PracticeApril 20th, 2022
Judith Esther Karp, MD, Presented with the Albert Nelson Marquis Lifetime Achievement Award by Marquis Who's WhoDecember 13th, 2017