JosephASparanoMD

Breast Cancer

Ezra M Greenspan MD Professor of Clinical Cancer Therapeutics; Chief, Division of Hematology and Medical Oncology; Deputy Director, Tisch Cancer Institute; Icahn School of Medicine at Mount Sinai, NY, NY

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Office
1425 Madison Avenue
New York, NY 10029
Phone+1 212-659-6754

Education & Training

Montefiore Medical Center/Albert Einstein College of Medicine (Moses and Weiler Campuses)Fellowship, Hematology and Medical Oncology, 1986 - 1987
New York Medical College at St Vincent's Hospital and Medical Center of New YorkResidency, Internal Medicine, 1982 - 1985
New York Medical CollegeClass of 1982

Certifications & Licensure

NY State Medical License 1985 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

New York Magazine: Top Doctors Castle Connolly, 2002, 2006, 2018
Top Doctors: New York Metro Area Castle Connolly, 2003-2008, 2010-2014
Super Doctor SuperDoctors.com

Clinical Trials

Marimastat or No Further Therapy in Treating Women With Metastatic Breast Cancer That Is Responding or Stable Following Chemotherapy Start of enrollment: 1997 Dec 02
Completed
Phase 3
Combination Chemotherapy in Treating Women With Stage II or Stage IIIA Breast Cancer That Has Spread to the Lymph Nodes Start of enrollment: 1999 Nov 16
Completed
Phase 3
Combination Chemotherapy and Rituximab in Treating Patients With HIV-Associated Stage I, Stage II, Stage III, or Stage IV Non-Hodgkin's Lymphoma Start of enrollment: 2003 Mar 01
Completed
Phase 2
Tipifarnib, Doxorubicin, and Cyclophosphamide in Treating Women With Locally Advanced Breast Cancer Start of enrollment: 2003 Feb 01
Completed
Phase 2
Capecitabine and Tipifarnib in Treating Women With Taxane-Resistant Metastatic Breast Cancer Start of enrollment: 2004 May 01
Completed
Phase 2
Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial) Start of enrollment: 2006 Apr 07
Active, not recruiting
Phase 3
Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer Start of enrollment: 2007 Feb 28
Completed
Phase 2
Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer Start of enrollment: 2006 Sep 01
Completed
Phase 2
Phase I-II Study of Vorinostat, Paclitaxel, and Bevacizumab in Metastatic Breast Cancer Start of enrollment: 2006 Jul 01
Completed
Phase 1, Phase 2
Tipifarnib and Combination Chemotherapy in Treating Patients With Stage II or Stage III Breast Cancer Start of enrollment: 2007 Apr 01
Completed
Phase 1, Phase 2
Trial for Locally Advanced Breast Cancer Using Vorinostat Plus Chemotherapy Start of enrollment: 2007 Dec 01
Completed
Phase 1, Phase 2
Identifying Genes That Predict Recurrence in Women With Breast Cancer Treated With Chemotherapy Start of enrollment: 2005 Oct 07
Completed
Fulvestrant With or Without Bortezomib in Patients With Inoperable Locally Advanced or Metastatic Estrogen Receptor Positive Breast Cancer Start of enrollment: 2010 May 26
Completed
Phase 2
Veliparib and Pegylated Liposomal Doxorubicin Hydrochloride in Treating Patients With Recurrent Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer or Metastatic Breast Cancer Start of enrollment: 2010 Jun 01
Completed
Phase 1
Veliparib With or Without Carboplatin in Treating Patients With Stage III or IV Breast Cancer Start of enrollment: 2010 Jun 30
Active, not recruiting
Phase 2
Vorinostat and Combination Chemotherapy With Rituximab in Treating Patients With HIV-Related Diffuse Large B-Cell Non-Hodgkin Lymphoma or Other Aggressive B-Cell Lymphomas Start of enrollment: 2010 Oct 06
Completed
Phase 1, Phase 2
Veliparib and Carboplatin in Treating Patients With HER2-Negative Metastatic Breast Cancer Start of enrollment: 2010 Nov 16
Completed
Phase 1
MK2206 in Treating Patients With Stage I, Stage II, or Stage III Breast Cancer Start of enrollment: 2011 Apr 01
Terminated
Phase 2
Azacitidine and Entinostat in Treating Patients With Advanced Breast Cancer Start of enrollment: 2011 Apr 21
Active, not recruiting
Phase 2
Cyclophosphamide and Veliparib in Treating Patients With Locally Advanced or Metastatic Breast Cancer Start of enrollment: 2011 May 02
Active, not recruiting
Phase 1
A Phase II Study Of Imtox-25 In Adults With Refractory/Relapsed Cd25 Positive Adult T Cell Leukemia/Lymphoma Start of enrollment: 2010 Sep 01
Terminated
Phase 2
Alisertib, Bortezomib, and Rituximab in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma or B-cell Low Grade Non-Hodgkin Lymphoma Start of enrollment: 2012 Aug 31
Active, not recruiting
Phase 1
PTX-200, Paclitaxel, Doxorubicin Hydrochloride, and Cyclophosphamide in Treating Patients With Stage IIB-IV Breast Cancer Start of enrollment: 2012 Jan 01
Terminated
Phase 1, Phase 2
Pilot Study to Evaluate Safety & Biological Effects of Orally Administered Reparixin in Early Breast Cancer Start of enrollment: 2013 Feb 01
Terminated
Phase 2
Chemotherapy Before Surgery and Tissue Sample Collection in Patients With Stage IIA-IIIC Breast Cancer Start of enrollment: 2013 Jun 01
Active, not recruiting
Not Applicable
Study of Efficacy and Safety of LEE011 in Postmenopausal Women With Advanced Breast Cancer.(MONALEESA-2) Start of enrollment: 2013 Dec 17
Completed
Phase 3
Endocrine Response in Women With Invasive Lobular Breast Cancer Start of enrollment: 2015 Sep 30
Active, not recruiting
Phase 2
Roles: Contact
Study of Efficacy of Ribociclib After Progression on CDK4/6 Inhibition in Patients With HR+ HER2- Advanced Breast Cancer Start of enrollment: 2016 Mar 01
Active, not recruiting
Phase 2
TMEM-MRI: A Pilot Feasibility Study of MRI for Imaging of TMEM in Patients With Operable Breast Cancer Start of enrollment: 2018 Dec 12
Recruiting
Not Applicable
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Publications & Presentations

PubMed

1965 citations
The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014
Roberto Salgado, Carsten Denkert, Sandra Demaria, Nicolas Sirtaine, Frederick Klauschen
Annals of Oncology. 2015-02-01
951 citations
Prospective Validation of a 21-Gene Expression Assay in Breast Cancer
Joseph A. Sparano, Robert Gray, D. F. Makower, Kathleen I. Pritchard, Kathy S. Albain
The New England Journal of Medicine. 2015-11-18
7 citations
Development and Validation of a Simulation Model-Based Clinical Decision Tool: Identifying Patients Where 21-Gene Recurrence Score Testing May Change Decisions
Jinani Jayasekera, Joseph A. Sparano, Suzanne C. O'Neill, Young Chandler, Claudine Isaacs
Journal of Clinical Oncology. 2021-07-12

Journal Articles

Deconstructing Racial and Ethnic Disparities in Breast Cancer
Joseph A Sparano, Otis W Brawley, JAMA Oncology
Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer
Matthew P Goetz, Thomas J Saphner, Joseph A Sparano, Lynne I Wagner, Peter M Ravdin, Daniel F Hayes, Adam M Brufsky, Della F Makower, Sunil S Badve, Robert J Gray, Wil..., The New England Journal of Medicine

Abstracts/Posters

Response-Adapted Therapy with Infusional EPOCH Chemotherapy Plus Rituximab in HIV-Associated, B-Cell Non-Hodgkin's Lymphoma
Joseph Sparano, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
A Randomized Trial of EPOCH-Based Chemotherapy with Vorinostat for Highly Aggressive HIV-Associated Lymphomas: Updated Results Evaluating Impact of Diagnosis-to-Treatm...
Joseph Sparano, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019

Lectures

Impact of clinical risk category on prognosis and prediction of chemotherapy benefit in early breast cancer (EBC) by age and the 21-gene recurrence score (RS) in TAILORx.
2019 ASCO Annual Meeting - 6/1/2019
Selected Updates in Breast Cancer
2007 Annual Meeting, Chicago, Illinois, USA

Press Mentions

TAILORx Update: 12-Year Recurrence and Survival Outcomes for Patients with Early-Stage Breast CancerDecember 13th, 2022
SABCS: Updated Analysis Confirms Endocrine Therapy Effective With/Without ChemoDecember 12th, 2022
Global Cardio-Oncology Viewpoints ‘Contextualize’ ESC GuidelinesDecember 12th, 2022
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Grant Support

Albert Einstein Core SiteNational Cancer Institute2010–2011
Centralized Protocol And Data Management UnitNational Cancer Institute2007–2011
Eastern Cooperative Oncology GroupNational Cancer Institute2004–2011
Montefiore Medical Center / Albert Einstein School Of MedicineNational Cancer Institute2006
AIDS Malignancy ConsortiumNational Cancer Institute1999–2005
Eastern Cooperative Oncology GroupNational Cancer Institute2002–2003