JosephJCullenMD

General Surgery • Iowa City, IA

Professor, Surgery, University of Iowa College of Medicine

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Office
200 Hawkins Dr
Iowa City, IA 52242
Phone+1 319-353-8297

Fax+1 319-353-6399

Education & Training

University of Iowa Hospitals and ClinicsResidency, Surgery, 1986 - 1991
University of Iowa Roy J. and Lucille A. Carver College of MedicineClass of 1986

Certifications & Licensure

IA State Medical License 1986 - 2027
American Board of Surgery Surgery

Awards, Honors, & Recognition

Fellow (FACS) American College of Surgeons

Clinical Trials

A Research Trial of High Dose Vitamin C and Chemotherapy for Metastatic Pancreatic Cancer Start of enrollment: 2009 Dec 01
Completed
Phase 1
Ketogenic Diet With Concurrent Chemoradiation for Pancreatic Cancer Start of enrollment: 2011 Jul 01
Terminated
Not Applicable
Clinical Trial of High-dose Vitamin C for Advanced Pancreatic Cancer Start of enrollment: 2012 Sep 01
Terminated
Phase 2
A Phase I Trial of High-Dose Ascorbate in Glioblastoma Multiforme Start of enrollment: 2013 Apr 01
Active, not recruiting
Phase 1
Gemcitabine, Ascorbate, Radiation Therapy for Pancreatic Cancer, Phase I Start of enrollment: 2014 Jan 01
Active, not recruiting
Phase 1
A Phase 2 Trial of High-dose Ascorbate for Pancreatic Cancer (PACMAN 2.1) Start of enrollment: 2018 Nov 28
Active, not recruiting
Phase 2
A Clinical Trial Evaluating the Effect of Pharmacological Ascorbate on Radiation Therapy for Pancreatic Cancer Patients Start of enrollment: 2025 Dec 31
Not yet recruiting
Phase 2
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Publications & Presentations

PubMed

A randomized trial of pharmacological ascorbate, gemcitabine, and nab-paclitaxel for metastatic pancreatic cancer.
Kellie L Bodeker, Brian J Smith, Daniel J Berg, Chandrikha Chandrasekharan, Saima Sharif
Redox Biology. 2024-11-01
1 citations
Pharmacologic Ascorbate Radiosensitizes Pancreatic Cancer but Radioprotects Normal Tissue: The Role of Oxidative Stress-Induced Lipid Peroxidation.
Gloria Y Chen, Brianne R O'Leary, Juan Du, Rory S Carroll, Garett J Steers
Antioxidants. 2024-03-18
9 citations
Magnetic Resonance Imaging of Iron Metabolism with T2* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM.
Michael S Petronek, Varun Monga, Kellie L Bodeker, Michael Kwofie, Chu-Yu Lee
Clinical Cancer Research. 2024-01-17

Journal Articles

Pharmacological Ascorbate Reduces Radiation-Induced Normal Tissue Toxicity and Enhances Tumor Radiosensitization in Pancreatic Cancer
Samuel R Schroeder, Matthew S Alexander, Joseph J Cullen, Daniel J Berg, Bryan G Allen, John M Buatti, Clinical Cancer Research

Press Mentions

Common Vitamin Could Double Life Expectancy for Pancreatic Cancer Patients Says TrialDecember 5th, 2024
Pancreatic Cancer Patient Survival Doubled with High Dose of Common Vitamin, Study FindsDecember 4th, 2024
High-Dose Vitamin C: Promising Treatment May Extend Survival of Pancreatic Cancer PatientsDecember 1st, 2024
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Grant Support

Mechanisms Of Ascorbate-Induced Cytotoxicity In Pancreatic CancerNational Cancer Institute2009–2010
Mechanisms Of Dicumarol-Induced CytotoxicityNational Cancer Institute2006–2007
Mechanistic Role Of Peroxynitrite In Gallbladder DiseaseNational Institute Of Diabetes And Digestive And Kidney Diseases2002–2004

Professional Memberships

American College of Surgeons - ACS
Member