Joseph Michael Ahearn MD

PubMed

• Multi-centered clinical validation demonstrating superior precision in lupus diagnosis: T cell autoantibodies and TC4d outperform conventional lupus erythematosus biom...
  Vasileios Kyttaris, Daniel J Wallace, Arezou Khosroshahi, Andrew Concoff, Nicole Wilson
  Frontiers in Immunology. 2025-01-01
• 7 citations
  Cell-bound complement activation products associate with lupus severity in SLE.
  Cristina Arriens, Roberta Vezza Alexander, Sonali Narain, Amit Saxena, Christopher E Collins
  Lupus Science & Medicine. 2020-04-01
• 18 citations
  Study rationale, design, and pretransplantation alloantibody status: A first report of Clinical Trials in Organ Transplantation in Children-04 (CTOTC-04) in pediatric ...
  Warren A. Zuckerman, Adriana Zeevi, Kristen L Mason, Brian Feingold, Carol Bentlejewski
  American Journal of Transplantation. 2018-09-01

Journal Articles

• Study rationale, design, and pretransplantation alloantibody status: A first report of Clinical Trials in Organ Transplantation in Children-04 (CTOTC-04) in pediatric ...  
  Zuckerman WA, Zeevi A, Mason KL, Feingold B, Bentlejewski C, Addonizio LJ, Blume ED, Canter CE, Dipchand AI, Hsu DT, Shaddy RE, Mahle WT, Demetris AJ, Briscoe DM, Moha..., Am J Transplant, 1/1/2018
• Potential Roles of Antiphospholipid Antibodies in Generating Platelet-C4d in Systemic Lupus Erythematosus  
  Liu CC, Schofield T, Tang A , Manzi S and Ahearn JM, Antibodies, 1/1/2017
• CB-CAPS as Lupus Biomarkers: Diagnosis, Monitoring and Stratification  
  Ahearn JM, Liu CC, and Manzi S, Expert Rev Clin Imm, 1/1/2017
• Lupus Biomarker Discovery, Validation, Approval, and Impact on Clinical Trials  
  Ahearn J, Liu CC, Manzi S, Current Treatment Options in Rheumatology, 1/1/2015
• Cardiovascular Disease Biomarkers Across Autoimmune Diseases  
  Ahearn JM, Shields, KJ, Liu CC, and Manzi S, Clinical Immunol: Biomarkers-Special Edition, 1/1/2015
• The lupus biomarker odyssey: one experience  
  Ahearn JM, Manzi S, and Liu CC, Methods Mol Biol, 1/1/2014
• Anti-Lymphocyte Autoantibodies Generate T Cell-C4d Signatures in Systemic Lupus Erythematosus  
  Liu C, Manzi C, and Ahearn JM, Translational Research, 1/1/2014
• Cell bound complement activation products in systemic lupus erythematosus: Comparison to double stranded DNA and standard complement measurements  
  Putterman C, Furie R, Ramsey-Goldman R, Askanase A, Buyon J, Kalunian K, Chatham WW, Massarotti E, Kirou K, Jordan N, Blanco I, Weinstein A, Chitkara P, Manzi S, Ahear..., Lupus Sci Med, 1/1/2014
• Cadiovascular Disease in Autoimmune Rheumatic Diseases  
  Hollan I, Meroni PL, Ahearn JM, Tervaert JWC, Curran S, Goodyear CSBSc, Hestad KA, Kahaleh, Riggio M, Shields K, Wasko MC, Autoimmunity Reviews, 1/27/2013
• Biomarkers in Systemic Lupus Erythematosus: Challenges and Prospects for the Future  
  Liu CC, Kao AH, Manzi S and Ahearn JM, Ther Adv in Musculoskel Dis, 1/1/2013
• Diagnosis of Lupus in the New Age of Biomarkers Part II: New and Emerging Biomarker Technology in the Diagnosis of Lupus  
  Ahearn JM, Rheumatology News, 1/1/2013
• Complement fragment C3d is colocalized within lipid rafts of T cells and promotes cytokine production  
  Borschukova, O, Paz Z, Ghiran IC, Liu C-C, Kao AH, Manzi S, Ahearn JM, and Tsokos GC, Lupus, 1/1/2012
• Biomarkers for Systemic Lupus Erythematosus  
  Ahearn J, Liu CC, Kao A and Manzi S, Translational Research (Special Biomarkers Issue), 1/1/2012
• Complement Proteins C3 and C4 Bind to Collagen and Elastin in the Vascular Wall: A Potential Role in Vascular Stiffness and Atherosclerosis  
  Shields KJ, Stolz D, Watkins SC and Ahearn JM, Clin Trans Sci, 1/1/2011
• Increased Erythrocyte C4d is Associated with Known Alloantibodies and Autoantibody Markers of Antibody Mediated Rejection in Human Lung Transplant Recipients  
  Golecheikine A, Nath D, Basha H, Saini D, Phelan D, Aloush A, Trulock E, Hachem R, Patterson A, Ahearn J, Mohanakumar T, J Heart Lung Transplant, 1/1/2010
• The Search for Lupus Biomarkers  
  Liu CC, Ahearn JM, Best Prac Res Clin Rheumatol, 1/1/2009
• Lymphocyte-Bound Complement Activation Products as Biomarkers for Diagnosis of Systemic Lupus Erythematosus  
  Liu CC, Kao AH, Sattar A, Hawkins DM, Wilson N, Manzi S, and Ahearn JM, Clin Trans Sci, 1/1/2009
• The Lupus Center of Excellence: A Model for Integrated Patient Care and Clinical-Translational Research  
  Manzi S and Ahearn JM, Clin Trans Sci, 1/1/2008
• Relative Contributions of Age and Atherosclerosis to Vascular Stiffness  
  Santelices LC, Calano SJ, Prantil RL, Vorp DA, Ahearn JM, Clin Trans Sci, 1/1/2008
• Platelet C4d is Associated with Severity of Acute Ischemic Stroke  
  Mehta N, Uchino K, Fakhran S, Sattar A, Branstetter BF, Au K, Navratil JS, Paul B, Lee M, Gallagher K, Manzi M, Ahearn JM, Kao AH, Stroke, 1/1/2008
• Mannose-Binding Lectin is a Disease-Modifying Factor in North American Patients with Systemic Lupus Erythematosus  
  Piao W, Liu CC, Kao A, Manzi S, Vogt M, Ruffing M, Ahearn JM, J Rheum, 1/1/2007
• Experimental system for ex vivo measurement of murine aortic stiffness  
  Santelices LC, Calano SJ, Erhart JC, Prantil RL, Haney JL, Vorp DA, Ahearn JM, Physiol Meas, 1/1/2007
• Apoptosis and Autoimmunity  
  Navratil JS, Liu CC, Ahearn JM, Immunological Research, 1/1/2006
• Reticulocytes bearing C4d as biomarkers of disease activity for systemic lupus erhtematosus  
  Liu CC, Manzi S, Kao AH, Ruffing MJ, Ahearn JM, Arthritis Rheum, 1/1/2005
• Mining the complement system for lupus biomarkers  
  Liu CC, Danchenko N, Navratil JS, Nilson SE, Manzi S, Ahearn JM, Clinic Appl Immunol Rev, 1/1/2005
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Books/Book Chapters

• Systemic Lupus Erythematosus 
  Chapter: Complement and tissue injury in SLE. 
  Liu CC and Ahearn JMEditors: Lahita RG, Buyon J, Koike T, and Tsokos G.Elsevier, Inc.Edition 5th,2010
• Dubois� Lupus Erythematosus. 
  Chapter: Complement and Systemic Lupus Erythematosus. 
  Liu CC and Ahearn JMEditors: Wallace DJ, Hahn BH, Dubois EL.Lippincott Williams & Wilkins, Philadelphia, PAEdition 7th,2007
• Systemic Lupus Erythematosus: A companion to Rheumatology. 
  Chapter: Role of Complement in SLE Pathogenesis. 
  Liu CC, Navratil JS, Kao AH, Manzi S, and Ahearn JMEditors: Tsokos, Goreon, Smolen.Elsevier ScienceEdition 1st,2006
• Measuring Immunity: Basic Biology and Clinical Assessment. 
  Chapter: Acute-phase proteins and inflammation: immunological and clinical implications. 
  Page 131 - 134Liu CC, Ahearn JMEditors: Lotze MT, Thomson AW.Elsevier Academic Press, London, United Kingdom2005
• Measuring Immunity: Basic Biology and Clinical Assessment. 
  Chapter: Complement in Health and Disease. 
  Page 144 - 147Liu CC, Ahearn JMEditors: Lotze MT, Thomson AW.Elsevier Academic Press, London, United Kingdom2005
• Rheumatic Diseases: Immunological Mechanisms and Prospects for New Therapies. 
  Chapter: Complement Receptors. 
  Page 245 - 276Ahearn JM, Rosengard AMEditors: Gaston J.S.Hill.Cambridge University Press, New York, NY1999
• Report of the NIAID Task Force on Immunology. Novel Strategies for Vaccine Development. 
  Chapter: Targeting Antigens to Follicular Dendritic Cells for Antibody Responses. 
  Ahearn JMEditors: Liu MA, Siliciano R.U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Bethesda, MD1998
• The Human Complement System in Health and Disease. 
  Chapter: Complement Receptors. 
  Page 167 - 202Ahearn JM, Rosengard AMEditors: Frank M, and Volanakis J.M. Dekker, New York, NY1998
• Cellular and Molecular Mechanisms of Inflammation 1. 
  Chapter: CR1 and CR2: Receptors mediating cellular recognition in the complement system. 
  Page 55 - 82Fearon DT, Carter RH, Ahearn JMAcademic Press, San Diego, CA1990
• Biochemistry of the Acute Allergic Reaction. 
  Chapter: Immunoregulatory functions of complement: Structural and functional studies of complement receptor type 1 (CR1; CD35) and type 2 (CR2; CD21). 
  Page 211 - 220Fearon DT, Klickstein LB, Wong WW, Wilson JG, Moore, Jr. FD, Weis JJ, Weis JH, Jack RM, Carter RH, Ahearn JMEditors: Tauber A, Wintraub B, Stolper Simon A.Liss, New York, NY1989
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Lectures

• Current and Future Paradigms for Lupus Diagnosis 
  Coral Gables, FL - 1/1/2015
• Complement as a Source of Biomarkers for Lupus Nephritis 
  New York, NY - 1/22/2013
• The Avise Test for SLE Diagnosis 
  UCLA and Cedars Sinai Medical Center, Los Angeles, CA - 1/11/2013
• The Complement Gold Mine of Lupus Biomarkers 
  La Jolla Institute of Allergy and Immunology, La Jolla, CA - 1/11/2013
• CB-CAP Assays for Stratification and Monitoring in SLE 
  Rockville, MA - 1/27/2012
• Cell-Bound Complement Activation Products in SLE: Tree Rings or Barnacles? 
  Madrid, Spain - 1/27/2012
• Platelets, Thrombosis and Biomarkers in SLE: Tree Rings or Barnacles? 
  Temple University School of Medicine, Philadelphia, PA - 1/23/2012
• The Child is Father of the Man: Lessons from Lupus 
  1/22/2012
• Cell-Bound Complement Activation Products Update 
  San Diego, CA - 1/20/2012
• Complement Biomarkers for Lupus Diagnosis 
  Washington, DC - 1/14/2012
• Mining Complement for the Development of SLE Biomarkers 
  Istanbul, Turkey - 1/18/2011
• Biomarkers, Barnacles and the Boy on a String: Lessons from Lupus 
  Allegheny Singer Research Institute, Pittsburgh, PA - 1/1/2011
• CB-CAPs: Tree Rings or Barnacles? 
  University of Texas Health Science Center, Houston, TX - 1/23/2009
• The Lupus Center of Excellence: A Model for Integrated Patient Care and Translational Research 
  Cleveland Clinic Foundation, Cleveland, OH - 1/14/2009
• CB-CAPs as Lupus Biomarker of Diagnosis, Prognosis and Monitoring 
  Bethesda, MD - 1/31/2008
• CB-CAPs: Lupus Biomarkers and Clues to Pathogenesis 
  Harvard Medical School, Boston, MA - 1/19/2008
• Apoptosis and Immune Tolerance: Novel Insights into the Pathogenesis of SLE 
  Multiple Locations, 2001, 2008 - 1/3/2008
• New Developments in Complement Biology 
  San Diego, CA - 1/23/2007
• Biomarkers in SLE: The RBC Complement Footprint 
  New York, NY - 1/21/2007
• Practical use of biomarkers, biomarker battery, treatment algorithms 
  Lillehammer, Norway - 1/12/2007
• Discovery and Validation of Lupus Biomarkers: Lessons Learned 
  Lillehammer, Norway - 1/12/2007
• Complement Deposition during Progression of Vascular Stiffness and Atherosclerosis 
  Porto Heli, Greece - 1/11/2007
• Advances in Lupus Biomarkers 
  Giant Stadium, Meadowlands, NJ, 2006; University of Pittsburgh, 2006, 2007 - 1/7/2007
• CB-CAPs as Universal Biomarkers of Immune Response 
  Washington, DC - 1/6/2007
• Walk With Us to Cure Lupus 
  Detroit, MI - 1/6/2007
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Other

• Genetics and Treatment of SLE (Live Chat Session) 
  Ahearn JM, Guest Expert with Dr. Susan Manzi, DNA.com (DNA Sciences)
  1/1/2000