JosefTPrchalMD

PubMed

• 1167 citations
  Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals
  Mervin C. Yoder, Laura E. Mead, Daniel N. Prater, Theresa R. Krier, Karim N. Mroueh
  Blood. 2007-03-01
• 170 citations
  Hypoxia-inducible Factor-1 Deficiency Results in Dysregulated Erythropoiesis Signaling and Iron Homeostasis in Mouse Development
  Donghoon Yoon, Yves D. Pastore, Vladimir Divoky, Enli Liu, Agnieszka E. Mlodnicka
  The Journal of Biological Chemistry. 2006-09-01
• 25 citations
  Unusual patterns of exon skipping in Bruton tyrosine kinase are associated with mutations involving the intron 17 3' splice site
  Robert N. Haire, Yuko Ohta, Scott J. Strong, Ronda T. Litman, Yunying Liu
  American Journal of Human Genetics. 1997-04-01

Journal Articles

• Hypoxia and Thrombosis  
  Josef Prchal, MD, Blood
• Non-anemic Homozygous o Thalassemia in an African-American Family: Association of High Fetal Hemoglobin Levels with Thalassemia Alleles.  
  Vladimir Divoky, Michal Mrug, Denyse Thornley-Brown, Martina Divoka, and Josef T. Prchal, Am J Hemat
• Four Different Mutations in Codon 28 of  Spectrin Are Associated with Structurally and Functionally Abnormal Spectrin I/74 in Hereditary Elliptocytosis.  
  Coetzer TL, Sahr K, Prchal J, Blacklock H, Peterson L, Koler R, Doyle J, Manaster J, Palek J, J. Clin. Invest
• A Polymorphism of the X-Linked Gene IDS Increases the Number of Females Informative for Transcriptional Clonality Assays.  
  Xylina T. Gregg, Robert Kralovics, and Josef T. Prchal, Am J Hemat
• Losartan, Angiotensin II Type I receptor antagonist, lowers hematocrit in possttransplant erythrocytosis.  
  Julian BA, Brantley RR, Barker CV, Stopka T, Gaston RS, Curtis JJ, Lee JY, Prchal JT, J Am Soc Nephrol
• Absence of Polycythemia Phenotype in a Child in with a unique EPO Receptor Mutation.  
  Kralovics R, Sokol L, Prchal JT, J Clin Invest
• Angiotensin II Facilitates Erythropoietin Mediated Proliferation of Normal Early Erythroid Progenitors.  
  Mrug M, Stopka T, Julian BA, Prchal JF, Prchal JT, J. Clin. Invest
• Rapid Determination of Clonality by Detection of Two Closely-Linked X-Chromosome Exonic Polymorphisms Using Allele-Specific PCR.  
  Liu Y, Phelan JT, Go RCP, Prchal JF, Prchal JT, Journal of Clinical Investigation
• Unusual Patterns of Exon Skipping in Bruton Tyrosine Kinase Are Associated with Mutations Involving the Intron 17 3’ Splice Site.  
  Haire RN, Ohta Y, Strong SJ, Litman RT, Liu Y, Prchal JT, Cooper MD, Litman GW, Am J Hum Genet
• Benign erythrocytosis’ and other familial and congenital polycythemias (invited Editorial).  
  Prchal JT, Sokol L, Eur. J. Haematol
• Sickle Cell Acute Chest Syndrome Associated with Parvovirus B19 Infection: Case Series and Review.  
  Elizabeth A. Lowenthal, D.O., Alan Wells, M.D., DMS, Peter D. Emanuel, M.D., Rick Player, M.D.and Prchal, JT, Amer J Hemat
• Clonal Stability analysis of all blood lineages indicated by X-Chromosomal transcriptional polymorphism.  
  Prchal JT, Prchal JF, Belickova M, Chen S, Guan YL, Gartland L, Cooper MD, J Exp Med
• Triosephosphate Isomerase Deficiency: Repetitive Occurrence of Point Mutation in Amino Acid 104 in Multiple Apparently Unrelated Families.  
  Schneider A, Westwood B, Yim C, Prchal JT, Berkow R, Labotka R, Warrier R, Beutler, E, Amer J Hematology
• Effects of hydroxyurea on frequency of painful crises in SCD.  
  Charache, S et al, N Engl J Med
• Alpha G-Philadelphia, Beta O-Arab, and Beta C Globins Present in a Single Patient.  
  Prchal JT, Kutlar A, Hall K, Robinson CA, Scott, CW, Amer J of Med Sci
• The Origin of Glucose-6-Phosphate-Dehydrogenase (G6PD) Polymorphism in African-Americans.  
  Kay AG, Kuhl W, Prchal JT, Beutler E, Am. J. Hum
• Molecular Defect of Truncated -Spectrin Associated with Hereditary Elliptocytosis -Spectrin Gottingen.  
  Yoon SH, Yu H, Eber S and Prchal JT, J of Biol Chem
• Genetic heterogeneity of primary familial and congenital polycythemia.  
  Kralovics R, Prchal JT, Am J Hemat
• Mutations of von Hippel-Lindau tumor suppressor gene and congenital polycythemia.  
  Pastore Y, Jedlickova K, Guan YL, Liu E, James Fahner J, Hasle H, Prchal JF , and Prchal JT, Am J Hum Genet
• Erythropoietin and erythropoiesis: polycythemias due to disruption of oxygen homeostasis.  
  Prchal JT and Pastore YD, Hematology J
• HIF-1alpha -deficiency results in dysregulated EPO signaling and iron homeostasis in mouse development.  
  Yoon D, Pastore YD, Divoky V, Liu E, Mlodnicka AE, Rainey K, Ponka P, Semenza GL, Schumacher A, Prchal JT, J Biol Chem
• An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions.  
  Xiong Z, Liu E, Yan Y, Silver RT, Yang F, Chen IH, Chen Y, Verstovsek S, Wang H, Prchal J, Yang XF, J. Immunol
• Are erythropoietin receptors expressed in tumors?  
  Agarwal N, Gordeuk VR, Prchal JT, J Clin Oncol
• Endogenous Erythropoietin
 Signaling Is Required For Normal Neural Progenitor Cell Proliferation.  
  Chen ZY, Asavaritikrai P, Prchal JT, Noguchi CM, J?Biol Chem
• . A novel unconventional antigen MPD5 elicits anti-tumor humoral immune responses in a subset of patients with polycythemia vera.  
  Xiong Z, Liu E, Yan Y, Silver RT, Yang F, Chen IH, Hodge I, Verstovsek S, Segura FJ, Wang H, Prchal J, Yang XF, Int J Immunopathol Pharmacol
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Books/Book Chapters

• Alterations in the NK-Cell population: Phenotypic Heterogeneity of Granular Lymphocytes in Lymphoproliferative Disorders. 
  Chapter: Contributions of Modern Biology to Medicine 
  Page 139 - 149Grossi CE, Velardi A, Prchal JT, Cooper MDEditors: U. Bertazzoni, F.J. Bollum, M. Ghione.Raven Press, Serono Symposia

Abstracts/Posters

• Final Results of Prospective Treatment with Pegylated Interferon Alfa-2a for Patients with Polycythemia Vera and Essential Thrombocythemia in First and Second-Line Set...
  Josef T. Prchal, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Normal Hemoglobin Concentrations in Obstructive Sleep Apnea and Associated Neocytolysis-Mediated Hemolysis and Inflammation Mediated Suppression of Expected Elevated H...
  Josef T. Prchal, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Pegylated Interferon-Alfa Suppresses Clonal Hematopoiesis in Polycythemia Vera and Essential Thrombocythemia and Is Associated with Immune Responses to Tumor Antigens
  Josef T. Prchal, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Hypoxia Inducible FactorsÍ Transcriptional Activity in Polycythemia Vera
  Josef T. Prchal, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Results from a Phase 2 Study of Navitoclax in Combination with Ruxolitinib in Patients with Primary or Secondary Myelofibrosis
  Josef T. Prchal, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Hypoxia Dependent and Independent Dysregulation of the Transcriptome in Sickle Cell Anemia
  Josef T. Prchal, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Hematological Changes in Chronic Sustained Hypoxia and Chronic Intermittent Hypoxia in a Mouse Model
  Josef T. Prchal, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
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Lectures

• Pathophysiology of Obstructive Sleep Apnea (OSA) - Blood Cells` Reactive Oxygen Species and Inflammation Prevent Polycythemia 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Tibetan Enriched PKLR Variant Is Beneficial to High Altitude Adaption By Improving Oxygen Delivery 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Myelodysplasia and Myeloproliferative Disorders. 
  Denver, Colorado
• Erythrocyte and Hemoglobin Subcommittee: The EPO Receptor. 
  Seattle, WA
• Gene Therapy By Manipulation of Hematopoietic stem Cells. 
  Charles University Medical School, Prague, Czech Republic
• Assessment of hematopoiesis by transcriptional polymorphism of active X-chromosome in health and disease. 
  Sloan Kettering Memorial Cancer Institute and Rockefeller University, NY
• J T. Prchal: Erythropoietin receptor and human disease. 
  Seattle, Washington
• Cellular and Molecular Biology of Polycythemias. 
  Baylor University, Houston
• Molecular Control of Erythropoiesis in Health and Disease. 
  Montreal Jewish General hospital and Lady Davis Institute, Montreal, Canada
• Erythropoietin Signaling in Polycythemic and other Disorders. 
  Royal Victoria hospital, Mc Gill University, Montreal, Canada
• Clonality studies of MPD. 
  San Diego
• Clinical Features and Molecular Basis of Familial Polycythemias and Polycythemia Vera. 
  Bergamo, Italy
• Clinical Features and Molecular Basis of Primary and Congenital Polycythemias. 
  Biozentrum, Basel, Switzerland
• J T. Prchal: Myeloproliferative Disorders: Familial and Congenital Polycythemia. 
  Miami Beach, FL
• Clinical Features and Molecular Basis of Primary and Congenital Polycythemias. 
  Albert Einstein University, NY
• Clinical Features and Molecular Basis of Primary and Congenital Polycythemias. 
  Medical Grand round
• Chuvash Polycythemia and other congenital Polycythemic states. 
  Mc Gill University, Montreal, Canada
• Molecular Biology of Congenital Polycythemias. 
  NIH HLBI, Bethesda, Maryland
• Genetics and Molecular Biology of Primary polycythemic states. 
  Medical College of Georgia, Dpt. Of Medicine and Institute of Molecular Medicine and Genetics
• Speaker–Gordon Research Conference on Comparative Hematopoiesis, Erythropoietin-erythropoietin receptor interaction; lessons from phylogenesis. 
  Tilton, NH
• Animal Model of congenital Polycythemia. 
  Baylor College of Medicine, Houston, TX
• In search of Polycythemia Vera gene and animal model of PFCP. 
  Albert Einstein College of Medicine
• Molecular Basis and Pathogenesis of Polycythemia Vera. 
  New Orleans
• Meet the Professor. 
  Polycythemic Disorders. 41st the Annual Meeting of American Society of Hematology, New Orleans
• Molecular Defect of Polycythemia vera. 
  Houston Texas
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Other

• Deficiency of G6PD in erythrocytes of foreign students (in Czech). 
  Prchal J, Konopasek B, Manova I
• Glucose-6-phosphate dehydrogenase deficiency in the erythrocytes of foreign students. 
  Manova I, Prchal J, Konopasek B, Wagner J
• The fate of D-lactate in red cells. 
  Prchal J, Beutler E, IRCS (Medical Sciences)
• Active transport of GSSG from reconstituted erythrocyte ghosts. 
  Prchal J, Srivastava S, Beutler E
• Association of presenile cataracts with heterozygosity for galactosemic states and with riboflavin deficiency. 
  Prchal JT, Conrad ME, Skalka HW, Lancet
• Cataract formation in patients heterozygous for galactosemic states. 
  Skalka HW, Prchal JT, Conrad ME, Metabolic Ophthal
• A common progenitor for human myeloid and lymphoid cells. 
  Prchal JT, Throckmorton DW, Carroll III AJ, Fuson EA, Gams RA, Prchal JF
• Multiple myeloma masquerading as chromophobe adenoma. 
  Poon MC, Prchal JT, Murad T, Galbraith JG
• Gamma 3-heavy-chain disease (gamma 3-HCD) in a young patient with Down syndrome. Study of peripheral blood lymphocytes and of susceptibility to infection. 
  Pruzanski W, Parr DM, Prchal J, Chan EY, Clin Immunol Immunopathol
• Splenectomy for hematologic disease. 
  Laws HL, Burlingame MW, Carpenter JT, Prchal JT, Conrad ME, Surgery, Gynecology and Obstretrics
• A study of a patient with chronic lymphocytic leukemia which demonstrates that proliferation of the lymphocytic clones in CLL does not include T-lymphocytes. 
  Prchal JT, Lucivero G, Carroll AJ, Lawton AR, Scott CW, Clin Immuno& Immunopathy
• A new variant associated with chronic hemolytic anemia. 
  Prchal J, Moreno H, Conrad M, Vitek A: G-6-PD Dothan, IRCS (Medical Sciences)
• Presence of J Chain in human lymphoid cells. 
  Mestecky J, Preud'Homme JL, Crago SS, Mihaesco E, Prchal J, Okos AJ, Clin Exp Immunol
• Presenile cataract formation and decreased activity of galactosemic enzymes. 
  Skalka H, Prchal JT, Archives of Ophthal
• Red cell enzymes: An overview. 
  Prchal JT, Continuing Education
• The effect of corticosteroids on cataract formation. 
  Skalka H, Prchal JT, Archives of Ophthal
• Diabetes and risks of cataract development. 
  21. Prchal J, Skalka H, Clements RS, Bradley EL, Conrad ME, Pittman C, Metab Pediat Ophthal
• Wiscott-Aldrich syndrome: Cellular impairments and their implication for carrier detection. 
  Prchal JT, Carroll AJ, Prchal JF, Crist WM, Skalka HW, Gealy WJ, Harley J, Malluh A
• Angioimmunoblastic lymphoma: An immunological study. 
  Prchal JT, Crago SS, Mestecky J, Okos AJ, Flint A
• Riboflavin deficiency and cataract formation. 
  Skalka H, Prchal J, Metab Pediat Ophthal
• The effect of diabetes mellitus diabetic therapy on cataract formation. 
  Skalka H, Prchal J
• Defective membrane skeleton assembly in hereditary elliptocytosis. 
  Liu SC, Palek J, Prchal J, Prog Clin Biol Res
• Altered assembly of spectrin in red cell membranes in hereditary pyropoikilocytosis. 
  Palek J, Liu SC, Liu PY, Prchal J, Castleberry RP
• Colonic villous adenoma: Monoclonal origin. 
  Adolphson CC, Prchal JT, Carroll AJ
• Defective spectrin dimer-dimer association in hereditary elliptocytosis. 
  Liu SC, Palek J, Prchal J
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