JoseAlejandroLuchsingerMD

Associate Professor of Medicine at NewYork-Presbyterian/Columbia University Medical Center Associate Professor of Epidemiology at CUMC

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Office
622 W 168th St
New York, NY 10032
Phone+1 212-305-4730

Education & Training

Columbia University Joseph P. Mailman School of Public HealthMPH, Epidemiology, 1997 - 1999
Icahn School of Medicine at Mount Sinai/Morningside/WestResidency, Internal Medicine, 1993 - 1997
Central University of VenezuelaClass of 1991

Certifications & Licensure

NY State Medical License 1996 - 2026

Awards, Honors, & Recognition

Community Health Award Riverstone Life Services, Riverstone Annual Gala, 2014
Nominated for Standing Membership National Advisory Council on Minority Health and Health Disparities, National Institute on Minority Health and Health Disparities, 2014
Physician Practice Connections Recognition Program National Committee for Quality Assurance, 2011-2013
Patient-Centered Medical Home Recognition Program National Committee for Quality Assurance, 2011-2013
Herbert Pardes Advanced Scholar Award 2010
Awardee, "Fund a Scientist" Program Alzheimer's Drug Discovery Foundation Third Annual Connoisseur's Dinner, 2009
Florence and Herbert Irving Clinical Research Career Awards (Irving Scholar). Irving Center for Clinical Research. Columbia University Medical Center, 2007
Won Third Place for Best Abstract 7th Annual Scientific Session of the Society of Geriatric Cardiology, 2001
Best Scientific Abstract by a Fellow Mid-Atlantic Regional Meeting of the Society of General Internal Medicine, 1999
The Anne C. Gelman Award for Excellence in Epidemiology Columbia University Joseph Mailman School of Public Health, 1999
The Michael Rauchman Award for Dedication, Service and Academic Excellence Department of Medicine, St. Luke's-Roosevelt Hospital Center, 1996
The Chief Residents' Award for Excellence in Academic and Clinical Medicine Exhibited by a Junior Assistant Resident Department of Medicine, St. Luke's-Roosevelt Hospital Center, 1995
The Chief Residents' Award to an Intern for Excellence in Clinical Medicine Department of Medicine, St. Luke's-Roosevelt Hospital Center, 1994
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Clinical Trials

Metformin in Amnestic Mild Cognitive Impairment Start of enrollment: 2008 Jun 01
Completed
Phase 2
Northern Manhattan Caregiver Intervention Project Start of enrollment: 2011 Mar 01
Completed
Not Applicable
Northern-Manhattan Hispanic Caregiver Intervention Effectiveness Study Start of enrollment: 2014 Mar 01
Completed
Not Applicable
TAU PET Imaging in Northern Manhattan Study of Metabolism and Mind Start of enrollment: 2017 Dec 01
Withdrawn
Phase 2
Tau PET Imaging in the Northern Manhattan Study of Metabolism and Mind. Start of enrollment: 2018 Jul 24
Enrolling by invitation
Phase 2
Brain Imaging in the Diabetes Prevention Program Outcomes Study Start of enrollment: 2019 Oct 01
Terminated
Early Phase 1
Metformin in Alzheimer's Dementia Prevention Start of enrollment: 2021 Mar 22
Recruiting
Phase 2, Phase 3
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Publications & Presentations

PubMed

584 citations
Aggregation of vascular risk factors and risk of incident Alzheimer disease.
José A. Luchsinger, Christiane Reitz, Lawrence S. Honig, Ming-Xin Tang, Steven Shea
Neurology. 2005-08-23
402 citations
Relation of diabetes to mild cognitive impairment.
José A. Luchsinger, Christiane Reitz, Bindu Patel, Ming-Xin Tang, Jennifer J. Manly
Archives of Neurology. 2007-04-01
235 citations
Alcohol Intake and Risk of Dementia
José A. Luchsinger, Ming-Xin Tang, Maliha Siddiqui, Steven Shea, Richard Mayeux
Journal of the American Geriatrics Society. 2004-04-01

Journal Articles

Peer-led Healthy Lifestyle Program in Supportive Housing: Study Protocol for a Randomized Controlled Trial
Cabassa LJ, Stefancic A, O'Hara K, El-Bassel N, Lewis-Fernandez R, Luchsinger JA, Gates L, Younge R, Wall M, Weinstein L, Palinkas LA, Trials, 1/1/2015
Reconsidering Harbingers of Dementia: Progression of Parietal Lobe White Matter Hyperintensities Predicts Alzheimer's Disease Incidence
Brickman AM, Zahodne LB, Guzman VA, Narkhede A, Meier IB, Griffith EY, Provenzano FA, Schupf N, Manly JJ, Stern Y, Luchsinger JA, Mayeux R, Neurobiol Aging, 1/1/2015
Mild Cognitive Dysfunction Does Not Affect Diabetes Mellitus Control in Elderly Adults
Palta P, Golden SH, Teresi J, Palmas W, Weinstock RS, Shea S, Manly JJ, Luchsinger JA, J Am Geriatric Soc, 1/1/2014
Depression Is Not Associated with Diabetes Control in Minority Elderly
Palta P, Golden SH, Teresi JA, Palmas W, Trief P, Weinstock RS, Shea S, Manly JJ, Luchsinger JA, J Diabetes Complications, 1/1/2014
Cerebral Microbleeds in a Multiethnic Elderly Community: Demographic and Clinical Correlates
Wiegman AF, Meier IB, Schupf N, Manly JJ, Guzman VA, Narkhede A, Stern Y, Martinez-Ramirez S, Viswanathan A, Luchsinger JA, Greenberg SM, Mayeux R, Brickman AM, J Neurol Sci, 1/1/2014
High Rates of Depressive Symptoms in Low-income Urban Hispanics of Caribbean Origin with Poorly Controlled Diabetes: Correlates and Risk Factors
March D, Luchsinger JA, Teresi JA, Eimicke JP, Findley SE, Carrasquillo O, Palmas W, Journal of Health Care for the Poor and Underserved, 1/1/2014
Plasma Nutrient Status of Patients with Alzheimer's Disease: Systematic Review and Meta-analysis
Lopes da Silva S, Vellas B, Elemans S, Luchsinger J, Kamphuis P, Yaffe K, Sijben J, Groenendijk M, Stijnen T, Alzheimers Dement, 1/1/2014
Regional White Matter Hyperintensity Volume and Cognition Predict Death in a Multi-ethnic, Community Cohort of Older Adults
Wiegman AF, Meier IB, Provenzano FA, Schupf N, Manly JJ, Stern Y, Luchsinger JA, Brickman AM, Journal of the American Geriatrics Society, 1/1/2013
Adiposity and Cognitive Decline in the Cardiovascular Health Study
Luchsinger JA, Biggs ML, Kizer JR, Barzilai J, Fitzpatrick A, Newman A, Longstreth WT, Lopez O, Siscovick D, Kuller L, Neuroepidemiology, 1/1/2013
Long Term Effects of the Diabetes Prevention Program Interventions on Cardiovascular Risk Factors: A Report from the DPP Outcomes Study
Diabetes Prevention Program Outcomes Study Group, Diabet Med, 1/1/2013
Risk Factors for Type 2 Diabetes Mellitus Preceded by Beta-cell Dysfunction, Insulin Resistance, or Both in Older Adults: The Cardiovascular Health Study
Imamura F, Mukamal KJ, Meigs JB, Luchsinger JA, Ix JH, Siskovick DS, Mozaffarian D., Am J Epidemiol, 1/1/2013
Late-life Depression, Mild Cognitive Impairment, and Dementia
Richard E, Reitz C, Honig LS, Schupf N, Manly JJ, Mayeux R, Devanand D, Luchsinger JA, JAMA Neurology, 1/1/2013
High Adiposity: Risk Factor for Dementia and Alzheimer's Disease?
Gustafson DR, Luchsinger JA, Alzheimers Res Ther, 1/1/2013
Central Obesity in the Elderly Is Related to Late-onset Alzheimer Disease
Luchsinger JA, Cheng D, Tang MX, Schupf N, Mayeux R, Alzheimer Dis Assoc Disor, 1/1/2012
White Matter Hyperintensity Volume and Impaired Mobility among Older Adults
Willey JZ, Scarmeas N, Provenzano FA, Luchsinger JA, Mayeux R, Brickman AM, J Neurol, 1/1/2012
The Northern Manhattan Caregiver Intervention Project: A Randomised Trial Testing the Effectiveness of a Dementia Caregiver Intervention in Hispanics in New York City
Luchsinger J, Mittelman M, Mejia M, Silver S, Lucero RJ, Ramirez M, Kong J, Teresi JA, BMJ Open, 1/1/2012
Regional White Matter Hyperintensity Volume, Not Hippocampal Atrophy, Predicts Incident Alzheimer Disease in the Community
Brickman AM, Provenzano FA, Muraskin J, Manly JJ, Blum S, Apa Z, Stern Y, Brown TR, Luchsinger JA, Mayeux R, Arch Neurol, 1/1/2012
Type 2 Diabetes and Ethnic Disparities in Cognitive Impairment
Noble JM, Manly JJ, Schupf N, Tang MX, Luchsinger JA, Ethn Dis, 1/1/2012
Adiponectin and All-cause Mortality in Elderly People with Type 2 Diabetes
Singer JR, Palmas W, Teresi J, Weinstock R, Shea S, Luchsinger JA, Diabetes Care, 1/1/2012
Nutrient Intake and Plasma Beta-amyloid
Gu Y, Schupf N, Cosentino SA, Luchsinger JA, Scarmeas N, Neurology, 1/1/2012
Depressive Symptoms, Antidepressant Use, and Brain Volumes on MRI in a Population-based Cohort of Old Persons without Dementia
Geerlings MI, Brickman AM, Schupf N, Devanand DP, Luchsinger JA, Mayeux R, Small SA., J Alzheimer Dis, 1/1/2012
Regional White Matter Hyperinstensity Volume, Not Hippocampal Atrophy, Predicts Incident Alzheimer's Disease in the Community
Brickman AM, Provenzano FA, Muraskin J, Manly JJ, Blum S, Apa Z, Stern Y, Brown TR, Luchsinger JA, Mayeux R, Arch Neurol, 1/1/2012
Genetic Variants in the Fat and Obesity Associated (FTO) Gene and Risk of Alzheimer's Disease
Reitz C, Tosto G, Mayeux R, Luchsinger JA, PLoS One, 1/1/2012
Type 2 Diabetes and Cognitive Impairment: Linking Mechanisms
Luchsinger JA, J Alzheimer's Dis, 1/1/2012
Food Combination and Alzheimer's Disease Risk: A Protective Diet
Gu Y, Nieves JW, Stern Y, Luchsinger JA, Scarmeas N, Arch Neurol, 1/1/2010
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Books/Book Chapters

Chronic Medical Disease and Cognitive Aging
Chapter: Metabolic Syndrome, Other Composite Vascular Risk Scores, and Cognitive Impairment
Page 111.0 - 132.0Luchsinger JAEditors: Yaffe K.Oxford University Press, New York, NY2013
Diabetes, Insulin, and Alzheimer's Disease
Chapter: The Relationship between the Continuum of Elevated Adiposity, Hyperinsulinemia, and Type 2 Diabetes and Late Onset Alzheimer's Disease: An Epidemiologic Perspective
Page 89.0 - 107.0Luchsinger JAEditors: Craft S., Christen Y.Springer-Verlag, Berlin Heidelberg2010
Type 2 Diabetes, Related Conditions, and Dementia
Luchsinger JAEditors: Luchsinger JA, Biessels GJ.Humana Press, Totowa, NJ2009
Diabetes and the Brain
Editors: Luchsinger JA, Biessels GJ.Humana Press, Totowa, NJ2009
Psychiatric Disorders in Diabetes Mellitus
Chapter: Diabetes and Cognitive Impairment
Luchsinger JA, Flores HEditors: Malphurs JE, Llorente MD.Informa Healthcare, London, UK2007
Cognitive Decline and Aging
Chapter: Antioxidant Vitamin Intake and Risk of Alzheimer's Disease
Page 32.0 - 38.0Luchsinger JA, Tang MX, Shea S, Mayeux REditors: Vellas B.Serdi Publishers, Paris2005
Health Issues in the Latino Community
Chapter: Diabetes among Latinos in the U.S.
Luchsinger JAEditors: Aguirre-Molina M, Molina C, Enid Zambrana R.Jossey-Bass, Publishers, San Francisco, CA2001
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Abstracts/Posters

Possible Disparate Contribution of Diabetes to Cognitive Impairment in Elderly Minorities
Noble JM, Manly JJ, Schupf N, Mayeux R, Luchsinger JA, Neuroepidemiology, 1/1/2007
Diabetes and the Risk of Alzheimer's Disease and Dementia
Luchsinger JA, Tang MX, Moroney JT, Stern Y, Shea S, Mayeux R, J Am Geriatr Soc, 1/1/2000
A Case of a False Positive HIV Viral Load in a Man Suspected of Primary HIV Infection
Luchsinger JA, Hembree W, J Gen Intern Med, 1/1/1999
Use of Antichlamydial Antibiotics and Risk of Myocardial Infarction
Luchsinger JA, Pablos-Mendez A, Knirsch C, et al, J Gen Intern Med, 1/1/1999
Reversal of Cardiomyopathy after Successful Radiofrequency Ablation of Atrial Flutter
Luchsinger JA, Steinberg JA, Pacing Clin Electrophysiol, 1/1/1996
Low Sensitivity of the Current Questions to Detect Alcoholism in the General Medical Check-up of the CMDLT
Luchsinger JA, Piras R, Aguirre T, 3rd Scientific sessions of the Centro Medico Docente La Trinidad, Caracas, Venezuela, 1/1/1993
Cross-Sectional Relation of Diabetes Control And Cognition
Luchsinger JA, Rivero A, Shea S, Manly JJ, Palmas W, International Conference of Alzheimer's Disease, Chicago, IL, 1/30/2008
A Case of a False Positive HIV Viral Load Test in a Man Suspected of Primary HIV Infection
Luchsinger JA, Mid-Atlantic Regional Meeting of the Society of General Internal Medicine, Washington, DC, 1/26/1999
Brain Structure and Memory in the Elderly with Diabetes
Luchsinger JA, Rivero A, Palmas W, Shea S, Mayeux R, DeCarli C, Brown T, Manly JJ, International Conference of Alzheimer's Disease, Chicago, IL, 1/27/2008
White Matter Hyperintensities as a Microvascular Mechanism Mediating Memory Impairment in Elderly Persons with Type 2 Diabetes
Luchsinger JA, Rivero A, Palmas W, Field L, Shea S, Mayeux R, Fifth International Congress on Vascular Dementia, Budapest, Hungary, 1/9./2007
Metabolic Syndrome and Dementia Risk in a Multiethnic Elderly Cohort
Muller M, Tang MX, Schupf N, Manly JJ, Mayeux R, Luchsinger JA, 3rd Meeting of the International Society of Vascular Behavioral and Cognitive Disorders (VASCOG 2007), San Antonio, TX, 1/13/2007
Neuropsychological Profile of Persons with Diabetes without Cognitive Impairment
Cho SJ, Tang MX, Schupf N, Manly JJ, Mayeux R, Luchsinger JA, 3rd Meeting of the International Society of Vascular Behavioral and Cognitive Disorders (VASCOG 2007), San Antonio, TX, 1/13/2007
Relation of Plasma Homocysteine to Plasma Amyloid Beta Levels
Luchsinger JA, Tang MX, Miller J, Green R, Mehta, PD, Mayeux R, AD Biomarkers Meeting, Washington, D.C., 1/7./2007
Relation of Diabetes to Mild Cognitive Impairment
Luchsinger JA, Reitz C, Patel B, Tang MX, Manley JJ, Mayeux R, 11th International Conference of Alzheimer's Disease and Related Disorders, Madrid, Spain, 1/18/2006
Depression, Vascular Risk Factors, and Alzheimer's Disease
Luchsinger JA, Tang MX, Honig L, Devanand D, 11th International Conference of Alzheimer's Disease and Related Disorders, Madrid, Spain, 1/16/2006
Mediterranean Diet and Risk of Alzheimer's Disease
Scarmeas N, Stern Y, Tang MX, Mayeux R, Luchsinger JA, "Nutrition and Alzheimer's Disease" Symposium of the International Academy of Nutrition and Aging, Chicago, IL, 1/1./2006
Relation of Measures of Adiposity with Dementia in the Elderly
Luchsinger JA, Patel B, Tang MX, Schupf N, Mayeux R, University of California-San Diego Conference on Epidemiology of Alzheimer's Disease, San Diego, CA, 1/28/2006
Relation of Measures of Adiposity with Dementia in the Elderly
Luchsinger JA, Patel B, Tang MX, Schupf N, Mayeux R, Second Congress of the International Society of Vascular Behavioral and Cognitive Disorders, Florence Italy, 1/11/2005
Aggregation of Vascular Risk Factors and Risk of Alzheimer's Disease
Luchsinger JA, Reitz C, Honig L, Tang MX, Mayeux R, 9th International Conference on Alzheimer's Disease and Related Disorders, Neurobiol Aging, Philadelphia, Pennsylvania, 1/19/2004
Antioxidant Vitamin Intake and Risk of Alzheimer's Disease among Elderly African-Americans, Caribbean Hispanics, and Whites in New York City
Luchsinger JA, Tang MX, Shea S, Mayeux R, 24th Annual Meeting of the Society of General Internal Medicine, San Diego, CA, 1/2./2001
Body Mass Index and Complications from Cardiac Surgery in a Geriatric Population
Maurer M, Luchsinger JA, 7th Annual Scientific Session of the Society of Geriatric Cardiology, Orlando, FL, 1/17/2001
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Lectures

Effects of Chronic Metformin Use on Cognition
ENDO 2018: 100th Endocrine Society Annual Meeting - Chicago, Illinios - 03/18/2018
Reversal of Cardiomyopathy after Successful Radiofrequency Ablation of Atrial Flutter
Seattle, Washington - 1/18/1996
Statistical Inference for Clinicians
Columbia-Presbyterian Medical Center and Beth Israel Deaconess Medical Center. Sheraton New York Hot - 1/4./1998
Preventive Health Care Screening
Division of General Medicine, Columbia-Presbyterian Medical Center. Columbia-Presbyterian Medical Ce - 1/5./1998
Use of Antibiotics and Risk of Myocardial Infarction
Washington, DC - 1/26/1999
Applying the Evidence to Individual Patients
Cabrini Hospital. New York, NY - 1/3./1999
Clinical Study Designs
Cabrini Hospital, New York, NY - 1/31/1999
Statistical Inference
Cabrini Hospital, New York, NY - 1/13/1999
Screening
Cabrini Hospital, New York, NY - 1/18/1999
Testing a Test
Cabrini Hospital, New York, NY - 1/27/1999
An Internist's Approach to Cognitive Impairment in the Elderly
Columbia University. New York, NY - 1/8./2000
Alzheimer's Disease Care and Research in Northern Manhattan
New York University Medical Center - 1/25/2001
Infection, Antibiotics, and Coronary Artery Disease
Department of Medicine. St. Vincent's Hospital, Bridgeport, CN - 1/24/2001
Chronic Diseases in Latinos
Joseph P. Mailman School of Public Health. New York, NY - 1/13/2002
What Is Dementia?
Lincoln Hospital, New York, NY - 1/25/2003
Vascular Risk Factor and Cognition
Mt. Sinai Hospital, NY - 1/1./2003
Vascular Risk Factors and Alzheimer's Disease
St.Vincent's Hospital. Bridgeport, CN - 1/7./2003
Enfermedades metabolicas y memoria: una perspective epidemiologica
Universidad del Zulia. Maracaibo, Venezuela - 1/19/2003
Nutritional Factors and Alzheimer's Disease
Veterans Affairs Hospital, Madison, WN - 1/15/2003
Vascular Risk Factors and Cognition
St.Vincent's Hospital. Bridgeport, CN - 1/7./2006
Types of Research Studies
Downtown Hospital, New York, NY - 1/6./2006
Research during Residency
Downtown Hospital, New York, NY - 1/13/2006
Adiposity and Alzheimer's Disease
Latin American School of Neurosciences, Maracaibo, Venezuela - 1/21/2006
Trastornos cognitivos desde la perspectiva del internista
Simposio de Enfermedad de Alzheimer, Maracaibo, Venezuela - 1/22/2006
Alzheimer's Disease in Latinos
Neurological Institute Auditorium, New York, NY - 1/4./2006
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Other

Dementia in Parkinson's Disease
Merino JG, Luchsinger J, eMedicine: Medicine, OB/GYN, Psychiatry, and Surgery
http://www.emedicine.com/med/topic3110.htm
1/1/2001
Hispanic/Latino Perspectives
Webinar on Diverse Populations, Health Disparities, and Dementia, organized by Administration on Agi
1/24/2013

Press Mentions

A Pill for Alzheimer's Disease? Clinical Trials on a New Approach to Treating Alzheimer's Starts at 50 Medical Centers Across the CountrySeptember 23rd, 2024
$45M Grant Funds Trial of Vitamin B1 Precursor for Cognitive DeclineJuly 14th, 2022
Burke Neurological Institute Receives a $45 Million NIH Grant to Study a Vitamin B1 Precursor for Treatment of Alzheimer’s Disease in Multi-Center Clinical TrialJuly 7th, 2022
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Grant Support

Columbia Center For Health Of Urban Minorities (CHUM)National Center On Minority Health And Health Disparities2009–2012
Northern Manhattan Initiative For Minority Involvement In Clinical TrialsNational Center On Minority Health And Health Disparities2011
Environmental Health Disparities Research In NocemhdNational Center On Minority Health And Health Disparities2011
Columbia Center For The Health Of Urban Minorities - Noma CeredNational Center On Minority Health And Health Disparities2010
Pilot Trial Of Metformin In Amnestic MCINational Institute On Aging2008–2010
Vascular Factors And Mild Cognitive Impairment And Alzheimer'S DiseaseNational Institute On Aging2004–2008
Vascular Factors, Amyloid Beta, And Alzheimer'S DiseaseNational Institute On Aging2002–2004