JorgeABezerraMD(He/Him)

PubMed

• 21 citations
  Advances in biliary atresia : from patient care to research
  Jorge Luiz dos Santos, Elisa de Carvalho, Jorge A. Bezerra
  Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas e Biologicas. 2010-04-30
• 69 citations
  Growth failure and outcomes in infants with biliary atresia: A report from the biliary atresia research consortium
  Patricia A. DeRusso, Wen Ye, Ross W. Shepherd, Barbara Haber, Benjamin L. Shneider
  Hepatology. 2007-11-01
• 58 citations
  Identification of intramural epithelial networks linked to peribiliary glands that express progenitor cell markers and proliferate after injury in mice
  Frank DiPaola, Pranavkumar Shivakumar, Janet Pfister, Stephanie Walters, Gregg Sabla
  Hepatology. 2013-10-01

Journal Articles

• MDR3 mutation analysis: A step closer to precision medicine  
  Bezerra JA, Hepatology, 1/17/2017
• Paracrine signals regulate human liver organoid maturation from iPSC  
  Asai A, Aihara E, Watson C, Mourya R, Mizuochi T, Shivakumar P, Kieran P, Mayhew C, Helmrath M, Takebe T, Wells J, Bezerra JA, Development, 1/1/2017
• Preferential TN alpha signaling via TNFR2 regulates epithelial injury and duct obstruction in experimental biliary atresia  
  Shivakumar P, Mizuochi T, Mourya R, Gutta S, Yang A, Huo Z, Bezerra JA, JCI Insight, 1/1/2017
• Biliary atresia and other cholestatic childhood diseases: Advances and future challenges  
  Verkade HJ, Bezerra JA, Davenport M, Schreiber RA, Mieli-Vergani G, Hulscher JB, Sokol RJ, Kelly DA, Ure B, Whitington PF, Samyn M, Petersen C, J Hepatol, 1/1/2016
• Effect of diet on intestinal sucrose (su) lactase (la), and maltase (ma) activity in pigs  
  Flores C, Bezerra J, Goda T, Bustamante S, Pongratz G, Koldovsky O, Am J Clin Nutr, 1/1/2016
• Pathogenesis of biliary atresia: defining biology to understand clinical phenotypes  
  Asai A, Miethke A, Bezerra JA, Nat Rev Gastroenterol Hepatol, 1/12/2015
• IL-33 facilitates oncogene-induced cholangiocarcinoma in mice by an interleukin-6-sensitive mechanism  
  Yamada D, Rizvi S, Razumilava N, Bronk SF, Davila JI, Champion MD, Borad MJ, Bezerra JA, Chen X, Gores GJ, Hepatology, 1/1/2015
• High frequency of double and triple heterozygous gene variants in patients with idiopathic cholestasis  
  Goldschmidt ML, Mourya R, Connor J, Dexheimer P, Karns R, Miethke A, Sheridan R, Aronow B, Zhang K, Bezerra JA, Hepatol Res, 1/1/2015
• The effect of natural killer cells on the development of progressive hepatobiliary inflammation in a novel model of liver injury in experimental biliary atresia  
  Squires JE, Shivakumar P, Mourya R, Bessho K, Walters S, Bezerra JA, PLoS ONE, 1/1/2015
• Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in biliary atresia  
  Venkat VL, Shneider BL, Magee JC, Turmelle Y, Arnon R, Bezerra JA, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston J, Murray KF, Ng VL, Raghunathan T, Rosenthal P..., J Pediatr Gastroenterol Nutr, 1/1/2014
• Perforin and granzymes work in synergy to mediate cholangiocyte injury in experimental biliary atresia  
  Shivakumar P, Mourya R, Bezerra JA, J Hepatol, 1/1/2014
• Replication of a GWAS signal in a Caucasian population implicates ADD3 in susceptibility to biliary atresia  
  Tsai EA, Grochowski CM, Bessho K, Hakonarson H, Bezerra JA, Russo PA, Haber BA, Spinner NB, Devoto M, Hum Genet, 1/1/2014
• Molecular signature with high accuracy for biliary atresia identifies a role for interleukin-8 in pathogenesis of disease  
  Bessho K, Mourya R, Shivakumar P, Walters S, Magee JC, Rao M, Jegga AG, Bezerra JA, Hepatology, 1/1/2014
• A randomized trial of corticosteroids in infants with biliary atresia: Results of the START trial  
  Bezerra JA, Spino C, Magee J, Shneider B, et al, JAMA, 1/1/2014
• Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation  
  Li Jun, Razumilava N, Gores GJ, Walters S, Mizuochi T, Mourya R, Bessho K, Wang YH, Glaser SS, Shivakumar P, Bezerra JA, Nature Rev Gastroenterol Hepatol, 1/1/2014
• Medical status of 219 children with biliary atresia surviving long-term with their native livers: results from a North American multicenter consortium  
  Ng VL, Haber BH, Magee JC, Miethke A, Murray KF, Michail S, Karpen SJ, Kerkar N, Molleston JP, Romero R, Rosenthal P, Schwarz KB, Shneider BL, Turmelle YP, Alonso EM, ..., J Pediatr, 1/1/2014
• Integrative genomics identifies candidate microRNAs for pathogenesis of experimental biliary atresia  
  Bessho K, Shanmukhappa K, Sheridan R, Shivakumar P, Mourya R, Walters S, Kaimal V, Dilbone E, Jegga AG, Bezerra JA, BME System Biol, 1/1/2013
• Extra-hepatic anomalies in infants with biliary atresia: results of a large prospective North American multi-center study  
  Schwarz KB, Haber BH, Philip R, Mack CL, Jeffrey M, Kevin B, Bezerra JA, Karpen SJ et al; for the Childhood Liver Disease Research and Education Network, Hepatology, 1/1/2013
• Identification of an intramural epithelial network linked to peribiliary glands that expresses progenitor cell markers and proliferates after injury  
  DiPaola F, Shivakumar P, Pfister J, Walters S, Sabla G, Bezerra JA, Hepatology, 1/1/2013
• 50 Years Ago in The Journal of Pediatrics: Persistent jaundice in infancy Brent, RL J Pediatr  
  DiPaola F, Bezerra JA, J Pediatr, 1/1/2012
• F1000 Recommendation of Yeh CY et al  
  Bezerra J, Proc Natl Acad Sci U S A, 1/1/2012
• A prospective multi-centered analysis of fat-soluble vitamin supplementation in infants with biliary atresia  
  Shneider BL, Magee JC, Bezerra JA, Suchy FJ, Haber B, Karpen SK, Whitington PF, Turmelle Y, Schwarz K, Rosenthal P, Raghunathan T, Robuck P, Sokol RJ, Pediatrics, 1/1/2012
• Conditional removal of SV40T from transformed primary human hepatocytes recovers selective CYP gene expression  
  Liu C, Bezerra JA, J Surg Cl Res, 1/1/2012
• Th2 signals induce epithelial injury and are compatible with the biliary atresia phenotype  
  Li J, Beesho K, Shivakumar P, Mourya R, Mohanty S, Santos JL, Miura IK, Porta G, Bezerra JA, Clin Investigation, 1/1/2011
• Dentritic cells regulate NK cell activation and epithelial injury in experimental biliary atresia  
  Saxena V, Shivakumar P, Sabla G, Mourya R, Chougnet C, Bezerra JA, Science Trans Med Sci Transl Med, 1/1/2011
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Books/Book Chapters

• Transplantation of the liver 
  Chapter: Transplantation for cholestatic liver disease in children 
  Page 288 - 304Ibrahim SH, Bezerra JA, Balistreri WFEditors: Busuttil RW, Klintmalm GBG.ElsevierEdition 3rd,2015
• Gastroenterologia e Hepatologia em Pediatria: Diagnostico e Tratamento 
  Chapter: Disorders of protein metabolism 
  Page 390 - 405Bezerra JAEditors: Ferreira, Carvalho, and Silva.Manole, Sao Paulo, BrazilEdition 1st,2012
• Gastroenterologia e Hepatologia em Pediatria: Diagnostico e Tratament 
  Chapter: Congenital disorders of glycosylation 
  Page 416 - 420Bezerra JAEditors: Ferreira, Carvalho, and Silva.Manole, Sao Paulo, BrazilEdition 1st,2012
• Molecular Pathology of Liver Diseases 
  Chapter: Biliary atresia 
  Page 753 - 765Bezerra JAEditors: Monga SS.Springer2011
• Nutricion y enfermedades del aparato digestivo en ninos 
  Chapter: Advances in genetics and treatment of syndromes of intrahepatic cholestasis 
  Page 287 - 304Bezerra JAEditors: Larrosa-Haro A and Vasquez-Garibay EM.Nestle Nutrition Institute, Mexico2011
• Textbook of clinical pediatrics 
  Vitolla B, Bezerra JAEditors: Elzouki AY.SpringerEdition 2nd,2011
• Textbook of Pediatric Gastrointestinal Disease 
  Chapter: Biliary atresia 
  Page 817 - 829Bezerra JAEditors: Kleinman RE, et al.BC Decker Inc., Hamilton, ON, CanadaEdition 5th,2008
• Endoscopia Pediatrica (Pediatric Endoscopy) 
  Chapter: Gastrointestinal evaluation in immunodeficient children 
  Page 151 - 163Guthery S, Bezerra JAEditors: Silva MGD and Milward G.Guanabara Koogan, Rio de Janeiro, RJ, Brazil2004
• Textbook of Pediatric Gatrointestinal Disease 
  Chapter: Biliary atresia 
  Page 1122 - 1135Campbell K, Bezerra JAEditors: Walker A, et al.BC Decker, Lewiston, NYEdition 4th,2004
• Gastroenterologia e Hepatologia em Pediatria: Diagnostico e Tratamento 
  Chapter: Metabolic liver disease 
  Page 659 - 676Bezerra JAEditors: Ferreira, Carvalho, and Silva.Medsi, Rio de Janeiro, Brazil2003
• Gastroenterologia e Hepatologia em Pediatria: Diagnostico e Tratamento 
  Chapter: Neonatal cholestasis 
  Page 581 - 597Bezerra JAEditors: Ferreira, Carvalho, and Silva.Medsi, Rio de Janeiro, Brazil2003
• National Organization of Rare Disorders: A guide to rare disorders 
  Chapter: Biliary atresia 
  Bezerra JA2002
• Transplantation of the liver 
  Chapter: Transplantation for cholestatic liver disease 
  Page 176 - 185Bezerra JA, Balistreri WEditors: Busuttil RW, Klintmalm GB.W.B. Saunders Co., Philadelphia, PA1996
• Current Pediatric Therapy Vol. 14 
  Chapter: Cirrhosis 
  Bezerra JA, Balistreri WEditors: Burg FD, Ingelfinger JR, Wald ER.W.B. Saunders Co., Philadelphia, PA1993
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Abstracts/Posters

• Single Cell RNA sequencing reveals novel innate lymphoid cell populations in extrahepatic bile ducts.
  Anna Peters, Jun Li, Zhenhua Luo, Bruce Aronow, Pranavkumar Shivakumar, Jorge A Bezerra, Annual meeting of the American Association for the Study of liver diseases (AASLD), Hynes Convention Center, Boston, MA, 1/11/2016
• High-throughput Proteomics Identifies MMP7 as a Biomarker of Biliary Atresia.
  Chatmanee Lertudomphonwanit, Reena Mourya, Lin Fei, Yue Zhang, Kevin E. Bove, Pranavkumar Shivakumar, Jorge A. Bezerra, Annual meeting of the American Association for the Study of liver diseases (AASLD), Hynes Convention Center, Boston, MA, 1/11/2016
• Inflammasome-microbiome-IL8 axis links disease progression and duct injury in experimental biliary atresia.
  Li Yang, Junbae Jee, Reena Mourya, Tatsuki Mizuochi, Sridevi Gutta, Pranavkumar Shivakumar, Jorge A. Bezerra, Annual meeting of the American Association for the Study of liver diseases (AASLD), Hynes Convention Center, Boston, MA, 1/11/2016
• Activation of mDCs and CD8+ T cells is associated with PSC-like cholangiopathy induced by small bowel bacterial overgrowth in a mouse model of autoimmune biliary disease.
  Wang Q, Saxena V, Wang B, Miles L, Ryan MA, Bezerra JA, Ridgway WM, Nathan JD, Hepatology, 1/1/2014
• IL-33 Facilitates Oncogene Driven Cholangiocarcinoma in Mice
  Yamada D, Rizvi S, Razumilava S, Bronk SF, Li J, Bezerra JA, Chen X, Gores GJ, Hepatology, AASLD Meeting, 1/1/2014
• Interleukin-33 induces cholangiocyte proliferation via IL13/IL-4R/STAT6 pathway
  Li L, Mourya R, Walters S, Kosar K, Shivakumar P, Huppert SS, Bezerra JA, Hepatology, AASLD Meeting, 1/1/2014
• IL-1 signaling regulates bile duct injury and obstruction in biliary atresia
  Mizuochi T, Shivakumar P, Mourya R, Walters S, Donnelly B, Shanmukhappa S, Bezerra JA, Hepatology, AASLD Meeting, 1/1/2014
• Novel genetic model of cholangiocarcinoma in mice.
  Razumilava N, Yamada D, Bronk S, Li J, Bezerra JA, Gores GJ, AASLD, 1/1/2013
• High-dose corticosteroid therapy following portoenterostomy in infants with biliary atresia does not improve outcome: The multi-center, randomized, double-blind, place...
  Bezerra JA, Spino C, Magee JC, Shneider BL, et al, Hepatology, AASLD Meeting, 1/1/2013
• Elevator effector and target cell transmembrane TNFAlpha regulates mucosal injury in experimental biliary atresia.
  Shivakumar P, Squires JE, Walters S, Bezerra JA, AASLD, 1/1/2013
• Heterozygosity for deleterious mutations in Abcb4 is associated with a pro-inflammatory hepatic transcriptome predisposing neonatal mice to cholestatic liver injury.
  Menchise AN, Lages CS, Simmons J, Bezerra JA, Miethke AG, AASLD, 1/1/2013
• Diagnostic and predictive value of serum biomarkers in biliary atresia.
  Squires JE, Bessho K, Mourya R, Shivakumar P, Bezerra JA, AASLD, 1/1/2013
• Interleukin-33 induces a potent cholangiocyte proliferation via a novel paracrine circuit.
  Jun L, Shivakumar P, Walters S, Mizuochi T, Mourya R, Bessho K, Bezerra JA, AASLD, 1/1/2013
• A biomarker study: Plasma osteopontin levels reflect hepatic fibrogenesis-related gene expression in biliary atresia
  Asai A, Malladi S, Misch J, Malladi P, Bezerra JA, Whitington PF, AASLD, 1/1/2013
• High-throughput mutation screen identifies high frequency of double and triple heterozygous gene variants in patients with idiopathic cholestasis.
  Dexheimer P, Connor J, Karns R, Miethke A, Aronow G, Zhang K, Bezerra JA, AASLD, 1/1/2012
• TNFAlpha regulates pathogenesis of bile duct injury in experimental biliary atresia via Tnf-R2.
  Shivakumar P, Walters S, Mourya R, Pfister J, Bezerra JA, AASLD, 1/1/2012
• Loss of orthologous IL8 signaling decreases susceptibility to experimental biliary atresia.
  Bessho K, Sheridan S, Walters S, Shivakumar P, Bezerra JA, AASLD, 1/1/2012
• A molecular signature of biliary atresia highly distinct from other cholestatic diseases at diagnosis.
  Bessho K, Mourya R, Dilbone E, Kaimal V, Xu H, Shivakumar P, Rao M, Jegga AG, Bezerra JA, Hepatology, 1/1/2011
• Complement receptor C5ar regulates hepatic inflammatory response, epithelial injury and duct obstruction in biliary atresia.
  Pfister J, Sheridan R, Bessho K, Bezerra JA, Shivakumar P, Hepatology, 1/1/2011
• Peribiliary glands connect to form three-dimensional epithelial networks within the wall of extrahepatic bile ducts and proliferate in response to injury.
  DiPaola F, Shivakumar P, Walters S, Sabla G, Pfister J, Bezerra JA, Hepatology, 1/1/2011
• Prospective multicenter analysis of post-operative total bilirubin as a biomarker for short-term outcome after hepatoportoenterostomy for biliary atresia.
  Shneider BL, Magee JC, Karpen SJ, Rand E, Narkewicz MR, Schwarz KB, Whitington PF, Bezerra JA, et al, Hepatology, 1/1/2011
• Screening and identification of potential microRNAs involved in bile duct injury in experimental biliary atresia.
  Beesho K, Mourya R, Sheridan R, Kaimal V, Xu H, Mohanty SK, Shivakumar P, Jegga AG, Bezerra JA, Hepatology, 1/1/2011
• Perforin-independent mechanisms of biliary atresia in experimental biliary atresia
  Shivakumar P, Bezerra JA, Hepatology, AASLD Meeting, 1/1/2010
• Th2 response induces biliary injury in experimental biliary atresia.
  Li J, Bezerra JA, Hepatology, AASLD Meeting, 1/1/2010
• A multicenter cross sectional assessment of quality of life in biliary atresia patients aged 2-25 years.
  Sundaram SS, Fredericks EM, Kamath BM, Haber B, Roghumathan T, Magee JC, Bezerra JA, et al, Hepatology, AASLD Meeting, 1/1/2009
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Lectures

• Intrahepatic cholestasis in the XXI Century: Role of Genetic Panels 
  Porto, Portugal - 1/1/2017
• Immunologic effectors of biliary atresia: Injury and survival signals 
  Bethesda, MD - 1/1/2017
• The immune system as a modulator of biliary injury and repair 
  Mayo Clinic, Rochester, MN - 1/1/2016
• "The microbiome and liver diseases" 
  Vitoria, Brazil - 1/1/2016
• "Building livers and bile ducts: Time for organoids" 
  Vitoria, Brazil - 1/1/2016
• "Neonatal cholestasis: Diagnostics and Etiologies 
  Vitoria, Brazil - 1/1/2016
• Pathogenesis of biliary atresia 
  Montreal, Canada - 1/1/2016
• Translational opportunities in biliary atresia: Improving outcomes 
  Wuhan, China - 1/1/2016
• Biliary Atresia: How has the outcome changed since the Kasai operation? 
  Boston, MA - 1/1/2016
• iPSC: A game changer in Hepatology Research 
  Boston, MA - 1/1/2016
• "Mining the immune system to understand biliary injury and repair 
  Cincinnati Children's Hospital Medical Center, Cincinnati, OH - 1/1/2016
• Liver development and clinical manifestations of disease 
  Cincinnati Children's Hospital Medical Center, Cincinnati, OH - 1/1/2016
• Paracrine promotion of cholangiocyte proliferation and cholangiocarcinoma 
  Cincinnati, OH - 1/1/2015
• Lymphocyte-cholangiocyte circuit to control epithelial proliferation 
  Yale Liver Center, Yale University - 1/1/2015
• Biliary atresia: Understanding biology to define clinical phenotypes 
  Lurie Children's Hospital-Northwestern Hospital, Chicago, IL - 1/1/2015
• "Biliary atresia: What's new that impacts treatment and outcome" 
  Porto Alegre, Brazil - 1/1/2015
• "Inborn errors of bile acid metabolism" 
  Porto Alegre, Brazil - 1/1/2015
• "Steroid treatment in biliary atresia: Gone or not yet?" 
  Porto Alegre, Brazil - 1/1/2015
• "Intrahepatic cholestasis: What to do when genotype does not match phenotype?" 
  Porto Alegre, Brazil - 1/1/2015
• "Emerging therapies for intrahepatic cholestasis" 
  Porto Alegre, Brazil - 1/1/2015
• Translational research on biliary atresia 
  Cincinnati Children's Hospital Medical Center, Cincinnati, OH - 1/1/2015
• What's new in biliary atresia 
  Natal, Brazil - 1/1/2014
• Round-table conference: "Genetic diagnosis of cholestasis: The challenge continues" 
  Natal, Brazil - 1/1/2014
• Neonatal immunity and biliary atresia: A story of guilt and redemption 
  Bethesda, MD - 1/1/2014
• Cytokines as unexpected survival signals to cholangiocytes 
  Hamilton, OH - 1/1/2014
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Other

• Biliary atresia 
  Bezerra JA, National Organization of Rare Disorders: A guide to rare disorders
  www.raredisease.org
  1/1/2015