JonathanWilsonYewdellMDPhD

Allergy & Immunology • Bethesda, MD

Clinical & Laboratory Immunology

Senior Investigator, Cellular Biology and Viral Immunology Section at NIAID/DIR

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Office
33 North Drive
Building 33, Room 2E13C1
Bethesda, MD 20892
Phone+1 301-402-4602

Summary

Dr. Yewdell received an A.B. in biochemistry magna cum laude from Princeton University in 1975, working with Dr. Arnold Levine for his undergraduate thesis on immune recognition of virus-transformed cells. He received an M.D. and a Ph.D. in immunology from the University of Pennsylvania in 1981, working with Dr. Walter Gerhard on using monoclonal antibodies to understand influenza A virus hemagglutinin antigenicity and function. As a postdoctoral fellow, he worked with Dr. David Lane at the Imperial College in London, studying the newly discovered p53 protein. From 1983 to 1987, he was an assistant professor at the Wistar Institute in Philadelphia. In 1987, Dr. Yewdell joined the Laboratory of Viral Diseases and in 1993 was appointed to lead its Cellular Biology Section.

Education & Training

Imperial CollegePost-doc, 1982 - 1983
Perelman School of Medicine at the University of PennsylvaniaClass of 1981, MD
University of PennsylvaniaPh.D., Immunology, 1981
University of PennsylvaniaPh.D., Immunology, 1981
Princeton UniversityAB, Biochemistry, Magna cum laude, 1975
Princeton UniversityA.B., Biochemistry, Magna Cum Laude, 1975

Awards, Honors, & Recognition

Life Fellow Clare Hall College, Cambridge University, 2015
King Fellow Clare Hall College, Cambridge University, 2014
Fellow American Academy of Microbiology, 2009

Publications & Presentations

PubMed

1172 citations
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
Ulrich S. Schubert, Luis C. Antón, James P. Gibbs, Christopher C. Norbury, Jonathan W. Yewdell
Nature. 2000-04-13
44 citations
Casting a wider net: Immunosurveillance by nonclassical MHC molecules
M. Patricia D'Souza, Erin J. Adams, John D. Altman, Michael E. Birnbaum, Cesar Boggiano
Plos Pathogens. 2019-02-21
252 citations
Immune recognition of a human renal cancer antigen through post-translational protein splicing.
Ken-ichi Hanada, Jonathan W. Yewdell, James Chih-Hsin Yang
Nature. 2004-01-15

Journal Articles

Casting a Wider Net: Immunosurveillance by Nonclassical MHC Molecules
Jonathan Yewdell, MD, PLoS One
Influenza A Virus Negative Strand RNA Is Translated for CD8+ T Cell Immunosurveillance
Jonathan W Yewdell, Jacqueline W Mays, The Journal of Immunology
Serious Adverse Events of Older Adults in Nursing Home and Community Intervention Trials
Datta R, Trentalange M, Van Ness PH, McGloin JM, Guralnik JM, Miller ME, Walkup MP, Nadkarni N, Pahor M, Gill TM, Quagliarello V, Juthani-Mehta M for the Life Study Group, Contemp Clin Trials Commun, 1/1/2018
Distressing Symptoms, Disability and Hospice Services at the End of Life: Prospective Cohort Study (with editorial)
Gill TM, Han L, Leo-Summers LS, Gahbauer EA, Allore HG, J Am Geriatr Soc, 1/1/2018
The Effect of Testosterone on Cardiovascular Biomarkers in the Testosterone Trials
Mohler ER 3rd, Ellenberg SS, Lewis CE, Wenger NK, Budoff MJ, Lewis MR, Barrett-Connor E, Swerdloff RS, Stephens-Shields AJ, Bhasin S, Cauley JA, Crandall JP, Cunningha..., J Clin Endocrinol Metab, 1/1/2018
Risk association of congenital anomalies in patients with ambiguous genitalia: A 22-year single-center experience
Heeley JM, Hollander AS, Austin PF, Merritt DF, Wesevich VG; Washington University School of Medicine in St Louis DSD Team, Amarillo IE, J Pediatr Urol, 1/17/2017
Evaluation and management of tethered cord syndrome in occult spinal dysraphism: Recommendations from the international children's continence society
Tuite GF, Thompson DNP, Austin PF, Bauer SB, Neurourol Urodyn, 1/9/2017
Diagnosis and management of bladder bowel dysfunction in children with urinary tract infections: a position statement from the International Children's Continence Society
Yang S, Chua ME, Bauer S, Wright A, Brandström P, Hoebeke P, Rittig S, De Gennaro M, Jackson E, Fonseca E, Nieuwhof-Leppink A, Austin P, Pediatr Nephrol, 1/3/2017
The Current Status of Clinical Drug Trials in Pediatric Urology
Austin PF, J Urol, 1/1/2017
Review of Incidence of Pseudophakic Cystoid Macular Edema and OCT-Detectable Changes in central macular thickness in patients receiving prostaglandin analogues in the ...
SH, J Allen, K Petro, J Wilgucki, Z Balest, N Anand, J Lockwood, J Katz, J Micheletti, H Park, S Reddy, and S Walia, EyeWorld, 1/1/2017
Prospective assessment of cosmesis before and after genital surgery
Nokoff NJ, Palmer B, Mullins AJ, Aston CE, Austin P, Baskin L, Bernabe K, Chan YM, Cheng EY, Diamond DA, Fried A, Frimberger D, Galan D, Gonzalez L, Greenfield S, Kolo..., J Pediatr Urol, 1/1/2017
CEVL interactive - Best surgical practices to repair high common urogenital sinus by anterior sagittal transrectal approach (ASTRA) and genitoplasty
Salle JL, Maizels M, Yerkes EB, Austin P, J Pediatr Urol, 1/1/2017
Changes in levels of parental distress after their child with atypical genitalia undergoes genitoplasty
Wolfe-Christensen C, Wisniewski AB, Mullins AJ, Reyes KJ, Austin P, Baskin L, Bernabe K, Cheng E, Fried A, Frimberger D, Galan D, Gonzalez L, Greenfield S, Kolon T, Kr..., J Pediatr Urol, 1/1/2017
Stepwise treatment for overactive bladder is prudent
Austin PF, Can Urol Assoc J, 1/1/2017
Enuresis: practical guidelines for primary care
Vande Walle J, Rittig S, Tekgül S, Austin P, Yang SS, Lopez PJ, Van Herzeele C, Br J Gen Pract, 1/1/2017
Pediatric Meningiomas: Sixty-five year experience at a single institution
Grossbach AJ, Mahaney KB, Menezes A, Journal of Neurosurgery: Pediatrics, 1/1/2017
Catastrophic trunnion failure with adverse local tissue reaction in total hip arthroplasty Orthopaedic Proceedings The International Society for Technology in Arthropl...
Urish K., Hamlin B., Plakseychuk A., Levison T., Digioia A., British Editorial Society of Bone&Joint Surgery, 1/1/2017
Ring-Shaped Leiomyoma of the Ciliary Body
Tucker SH, E Szalai, M Rivellese, and H Grossniklaus, Ocular Oncology and Pathology, 1/1/2017
Psychological Adjustment of Parents of Children Born with Atypical Genitalia 1 Year after Genitoplasty
Ellens REH, Bakula DM, Mullins AJ, Scott Reyes KJ, Austin P, Baskin L, Bernabe K, Cheng EY, Fried A, Frimberger D, Galan D, Gonzalez L, Greenfield S, Kolon T, Kropp B,..., J Urol, 1/1/2017
Cataract Video Coaching: Surgical Curriculum Enhancement in a US Residency Program
Tucker SH, JK Jones, MM Aaron, and YM Khalifa, Journal of Academic Ophthalmology, 1/1/2017
Trunnion Failure of the Recalled LFIT Cobalt Chromium Alloy Femoral Head
Urish K., Hamlin B., Plakseychuk A., DiGioia A, Journal of Arthroplasty, 1/1/2017
Head-On Allograft Transplantation: A Unique Case Report Where a Large Piece of Femoral Bone was Extruded from One Patient’s Body and Impaled Another Patient’s Tibia
Rossman SR, Shaath K, Graf KW, Journal of Orthopedic Case Reports, 1/1/2017
Frailty and Subsequent Disability and Mortality Among Patients With Critical Illness (with editorial)
Brummel NE, Bell SP, Girard TD, Pandharipande PP, Jackson JC, Morandi A, Thompson JL, Chandrasekhar R, Bernard GR, Dittus RS Gill TM, Ely EW, Am J Respir Crit Care Med, 1/1/2017
Emergency Department Visits Without Hospitalization are Associated With Functional Decline in Older Persons
Nagurney JM, Fleischman W, Han L, Leo-Summers L, Allore HG, Gill TM, Ann Emerg Med, 1/1/2017
Do the Tenets of Late-life Disability Apply to Middle Age?
Gill TM, Ann Intern Med, 1/1/2017
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Books/Book Chapters

Immunology of Infectious Diseases
Chapter: Overview of the viral antigens.
Yewdell, J.W. , Bennink, J.R.Editors: S. H. E. Kaufmann, S.H.E., Sacks, D., Rouse, B..ASM Press, Washington, DCEdition 2nd,2009
Immunobiology of Influenza Infection: Approaches for an Emerging Zoonotic Disease
Chapter: Frontiers in viral immunology: Sympathetic nervous system control of anti-influenza immunity.
Page 73 - 84Grebe, K.M., Irvine, K.R., Hickman, H.D., Yewdell, J.W., Bennink, J.R.Editors: R.A. Tripp.Research Signpost, Kerala, India2008
Immunodominance: the choice of the immune system
Chapter: Endogenous antigen processing.
Page 75 - 90Yewdell, J.W.Editors: J. Frelinger.Wiley, Hoboken, NJ2006
Topley and Wilson’s Microbiology and Microbial Infections, Immunology Volume
Chapter: MHC class I antigen processing system.
Page 403 - 418Yewdell, J.W.Editors: S.H.E. Kauffman, M.W. Steward.Hodder Arnold, London, United KingdomEdition 10th,2005
Immunology of Infectious Diseases
Chapter: Overview of the viral antigens
Yewdell, J.W. , Bennink, J.R.Editors: S. H. E. Kaufmann, S.H.E., Sher, A., Ahmed. R..ASM Press, Washington, DC2002
Clinical Virology
Chapter: Immune response to viruses.
Page 273 - 310Yewdell, J.W., Bennink, J.R.Editors: D.D. Richman, R.J. Whitely, F.G. Hayden.ASM press, Washington, DCEdition 2nd,2002
DNA Vaccines
Chapter: Minigene-based vaccines for eliciting CD8+ T cell responses.
Yewdell, J.W.Editors: H.C.J. Ertl.Landes Bioscience, Austin, TX2002
Textbook of Influenza
Chapter: Cell-mediated immunity to influenza.
Epstein, S.L., Yewdell, J.W., Bennink, J.R.Editors: K. Nicholson, R. Webster, A. Hay, N. Cox.Blackwell, Oxford, United KingdomEdition 2nd,2002
Options for the control of influenza III
Chapter: Why are so few viral peptides recognized by MHC class I restricted T lymphocytes?
Page 195 - 202Deng, Y, Bennink, J.R., Yewdell, J.W.Editors: L.E. Brown, A.W. Hampson, R.G. Webster.Elsevier, New York, NY1996
Options for the control of influenza III
Chapter: Using N-linked glycosylation to study the generation of MHC class I associated peptides from exported proteins.
Page 203 - 208Bacik, I., Snyder, H.-L., Anton, Russ, G., Otvos, L., Yewdell, J.W., Bennink, J.R.Editors: L.E. Brown, A.W. Hampson, R.G. Webster.Elsevier, New York, NY1996
Antigen Processing and Presentation
Chapter: Where do MHC class I-associated peptides come from?
Page 17 - 31Yewdell, J.W., Cox, J.H., Link, H., Bacik, I., and Bennink, J.R.Editors: R.E. Humphries, S. Pierce.Academic Press, New York, NY1994
Encyclopedia of Virology
Chapter: Structure of influenza virus antigens.
Page 722 - 727Yewdell, J.W., Bennink, J.R., and Laver, W.G.Editors: A. Granoff, R. Webster.1994
Viruses and the cellular immune response
Chapter: Processing and presentation of viral proteins to MHC Class I-restricted T lymphocytes.
Page 31 - 48Yewdell, J.W., Eisenlohr, L., Cox, J., Esquivel, F., Anderson, R., Lapham, C., Ffrench, R., Bennink, J.R.Editors: D. B. Thomas.Plenum, New York, NY1993
Immunogenicity: UCLA Symposium on Molecular and Cellular Biology Vol. 113
Chapter: Where do class I molecules associate with foreign antigens?
Page 1 - 6Yewdell, J.W., Eisenlohr, L.C., and Bennink, J.R.Editors: C.A. Janeway, Jr., J. Sprent and E. Sercarz.Wiley-Liss, New York, NY1990
Progress in Immunology: 7th International Congress of Immunology
Chapter: Blockade of MHC class I molecule transport from the endoplasmic reticulum inhibits presentation of protein antigens to cytotoxic T lymphocytes.
Page 922 - 930Cox, J.H., Bennink, J.R., Eisenlohr, L.C., and Yewdell, J.W.Editors: F. Melchers et al.Springer-Verlag, New York, NY1989
Influenza Viruses
Chapter: The specificity and function of T lymphocytes induced by influenza A viruses.
Page 361 - 429Yewdell, J.W., and Hackett, C.J.Editors: R. Krug.Plenum Press, New York, NY1989
Cell Biology of Virus Entry, Replication, and Pathogenesis
Chapter: B-cell lysis of mouse hepatitis virus-infected cells: fusion of target and effector cells.
Page 417 - 423Wysocka, M., Korngold, R., Yewdell, J.W., and Bennink, J.R.Editors: R. Compans, A. Helenius, M.B.A. Oldstone.A.R. Liss, New York, NY1988
Vaccines: New Concepts and Developments
Chapter: Recognition of individual viral antigens by cytotoxic T lymphocytes.
Page 202 - 210Yewdell J.W., Bennink, J.R.; Smith, G., and Moss, B.Editors: H. Kohler and P.T. LoVerde.Longman Scientific and Technical, Essex, United Kingdom1986
Virus Attachment and Entry into Cells
Chapter: Monoclonal antibodies as probes for influenza virus hemagglutinin structure and function during the infectious cycle.
Page 60 - 65Yewdell, J.W., Taylor, A., Caton, A., Gerhard, W., and Bachi, T.Editors: R. Crowell and K. Lonborg-Holmes.ASM, Washington, DC1986
Options for the Control of Influenza
Chapter: Vaccinia virus recombinants expressing influenza virus genes.
Page 375 - 391Smith, G.L., Bennink, J.R., Yewdell, J.W., Small, P.A., Murphy, B.R., and Moss, B.Editors: A.P. Kendal and P.A. Patriaca.Alan R. Liss, New York, NY1986
Current communications in molecular biology. Immune recognition of protein antigens
Chapter: B cell recognition sites of the hemagglutinin molecule of A/PR/8/34 influenza virus analyzed by means of a series of sequentially selected virus mutants.
Page 24 - 29Yewdell J.W., Taylor, A., McCreedy, D., Caton, A., Gerhard, W.Editors: W.G. Laver and GM Air.Cold Spring Harbor Laboratory, Cold Spring Harbor, NY1985
T Cell Clones
Chapter: The role of virus-specific CTL in vivo.
Page 237 - 242Bennink, J.R., Yewdell, J.W., Feldman, A., Gerhard W., and Doherty,, P.C.Editors: H Von Boehmer and W Haas.Elsevier Press, New York, NY1985
Vaccinia viruses as vectors for vaccine antigens
Chapter: Influenza virus specific cell-mediated immunity to vaccinia virus recombinants.
Page 169 - 174Bennink, J.R., Yewdell, J.W., Smith, G.L., Moss, B.Editors: G. Quinnan.Elsevier Press, New York, NY1985
Current communications in molecular biology. Immune recognition of protein antigens
Chapter: Recognition of cloned influenza A virus gene products by cytotoxic T lymphocytes.
Page 124 - 128Yewdell J.W., Bennink, J.R., Smith G.L. and Moss, B.Editors: W.G. Laver and GM Air.Cold Spring Harbor Laboratory, Cold Spring Harbor, NY1985
Segmented Negative Stranded Viruses: Arenaviruses, Bunyaviruses, and Orthomyxoviruses
Chapter: Antigenic characterization of influenza A matrix protein with monoclonal antibodies.
Page 307 - 314van Wyke, K.L, Yewdell, J.W., Michalek, S.Z., McGhee, J.R., and Murphy, B.R.Editors: D.H.L. Bishop et al.Academic, New York, NY1984
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Press Mentions

Covid Will Become Endemic. The World Must Decide What That MeansDecember 31st, 2021
Here's Your Decision: Get Vaccinated First or Be Infected FirstAugust 24th, 2021
How the Covid Pandemic Ends: Scientists Look to the Past to See the FutureMay 19th, 2021
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Grant Support

H1N1 Influenza Virus Evolution In VivoNational Institute Of Allergy And Infectious Diseases2011
Processing Of Viral Proteins For T Cell RecognitionNational Institute Of Allergy And Infectious Diseases2009–2011
Delivery Of Antigens To The MHC Class I Processing PathwayNational Institute Of Allergy And Infectious Diseases2009–2011
Biology And Pathogenesis Of Influenza A VirusNational Institute Of Allergy And Infectious Diseases2009–2011
Antigenic Drift In Influenza A VirusNational Institute Of Allergy And Infectious Diseases2009–2011
Arra: H1N1 Influenza Virus Evolution In VivoNational Institute Of Allergy And Infectious Diseases2010
Antigenic Drift In Influenza A VirusNational Institute Of Allergy And Infectious Diseases2008
Biology And Pathogenesis Of Influenza A VirusNational Institute Of Allergy And Infectious Diseases2007–2008
Delivery Of Antigens To The MHC Class I Processing PathwayNational Institute Of Allergy And Infectious Diseases1997–2008
Processing Of Viral Proteins For T Cell RecognitionNational Institute Of Allergy And Infectious Diseases1990–2008
Proteolytic Generation Of Antigenic PeptidesNational Institute Of Allergy And Infectious Diseases1992–2007
Delivery Of Antigens To The MHC Class I Processing PathwNational Institute Of Allergy And Infectious Diseases2002–2006
Virus Induction Of Primary CD8+ T Cell ResponsesNational Institute Of Allergy And Infectious Diseases1997–2006
Delivery Of Antigens To MHC Class I Processing PathwayNational Institute Of Allergy And Infectious Diseases2003–2005
Study Of Viral Antigens Recognized By Anti-Influenza CTLNational Institute Of Allergy And Infectious Diseases1985–1986
Neutralization Of Influenza By Monoclonal AntibodiesNational Institute Of Allergy And Infectious Diseases1985

External Links

Truth Winshttps://drive.google.com/drive/folders/0B-L2EorQfzbIUFk4d1BjMW1qMDQ