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Jonathan Megerian, MD, Child Neurology, Orange, CA

JonathanThomasMegerianMD

Child Neurology Orange, CA

Division Chief, Neurodevelopmental Medicine Clinical Director, Thompson Autism and Neurodevelopmental Center

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  • Office

    170 S Main St
    Orange, CA 92868
    Phone+1 714-288-7651
    Fax+1 714-288-7379

Summary

  • J. Thomas Megerian, M.D., PhD, FAAP is a board certified pediatrician and child neurologist specializing in Autistic spectrum and other neurodevelopmental disorders. Dr. Megerian has extensive interest and experience in designing and executing clinical trials for neurological disorders. He is currently attending neurologist and Associate Professor (volunteer faculty) at CHOC and University of California, Irvine, respectively. Currently, Dr. Megerian serves as the Clinical Director of the Thompson Autism and Neurodevelopmental Center at CHOC, as well as the Division Chief for Neurodevelopmental Medicine.

    Dr. Megerian also serves as Senior Vice President for Clinical Development and Chief Medical Officer at Yamo Pharmaceuticals, where he is leading drug development for the treatment of the core deficits in autistic spectrum disorders. He also consults for Kuzani Pharmaceuticals for their autism development program where he is working on several studies for their candidate molecule for the treatment of cores symptoms.

    Dr Megerian has had extensive experience in developing candidate treatments for various neurodegenerative and neurodevelopmental disorders in both the academic and biotechnology arena during his tenure in the Neurology Department at Boston Children’s Hospital, as well as his roles at Massachusetts General Hospital for Childrens at North Shore, Hospital, University of Massachusetts Medical Center, and Boston Medical Center. In addition, Dr Megerian has served as part of the executive management team responsible for clinical and scientific development activities for neurological disorders within several biomedical research companies, including Johnson and Johnson, Avanir, Epix Pharmaceuticals, and Neurometrix. as well He has led clinical development programs for the treatment of autistic spectrum disorders, hydrocephalus, brain injury, spasticity, stroke, attention deficit hyperactivity disorder, and intracranial atherosclerosis.

Education & Training

  • Boston Children’s Hospital/Beth Israel Deaconess Medical Center/Harvard Medical School
    Boston Children’s Hospital/Beth Israel Deaconess Medical Center/Harvard Medical SchoolFellowship, Child Neurology, 1995 - 1998
  • Boston Children’s Hospital/Boston Medical Center
    Boston Children’s Hospital/Boston Medical CenterResidency, Pediatrics, 1993 - 1995
  • Northwestern University Medical School
    Northwestern University Medical SchoolPhD, 1985 - 1993
  • Northwestern University The Feinberg School of Medicine
    Northwestern University The Feinberg School of MedicineClass of 1993
  • Union College
    Union CollegeB.S., Biology/Chemistry, Magna Cum Laude, 1981 - 1985

Certifications & Licensure

  • MA State Medical License
    MA State Medical License 1995 - 2026
  • CA State Medical License
    CA State Medical License 2015 - 2025
  • FL State Medical License
    FL State Medical License 2012 - 2018
  • American Board of Pediatrics Pediatrics
  • American Board of Psychiatry and Neurology Neurology with Special Qualification in Child Neurology

Awards, Honors, & Recognition

  • Neurological Science Academic Development Award National Institutes of Health, 1995
  • Fellow (FAAP) American Academy of Pediatrics

Clinical Trials

Publications & Presentations

PubMed

Journal Articles

  • Melatonin Deficiency and Disrupted Circadian Rhythms in Pediatric Survivors of Craniopharyngioma.  
    Lipton J, Megerian JT, Kothare, SV, et al, Neurology, 7/28/2009
  • Utility of Nerve Conduction Studies for Medicine Physicians  
    Megerian, J.T, Kong, X. and Gozani, S. N., J Am Board Fam Med, 1/1/2007
  • "Diabetic Nerve Conduction Abnormalities in the Primary Care Setting"  
    Vinik, A.I., Kong, X, Megerian, J.T., Gozani, S.N., Diabetes Technology & Therapeutics, 12/1/2006
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Abstracts/Posters

  • Recurrent encephalopathy with coma: An unusual late delayed effect of whole-brain radiotherapy.
    Megerian JT, Paleologos NA, Vick, Am Acad. Neurol, 1/1/1995
  • Delayed Phosphorylation of GAP-43 During Neurite Outgrowth in a Mouse Neuroblastoma Line.
    Megerian, J.T., Meiri, K.F., & Klein, W.L., Soc.Neurosci., 1/1/1991
  • Expression of Tau and ALZ-50 in Human Cortical Cell Line HCN-1A and Non-Human Neuroblastoma Cell Lines.
    Enam, S.A., Megerian, J.T., & Klein, W.L., Soc. Neurosci., 1/1/1991
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Lectures

  • Autism: What Have We Learned and How to Manage 
    Children's Hospital Boston Pediatric Health Care Summit, Beverly, MA - 4/29/2009
  • Alzheimer's Disease Treatment Update: Present and Future 
    Medical Grand Rounds, North Shore Medical Center; Medical Grand Rounds, Union Hospital, Jun 2009 - 3/13/2009
  • Pipeline Projects Session. Results from a Phase 2A clinical study of a novel 5HT4 agonist for the treatment of Alzheimer's Disease. 
    American Society for Experimental Neurotherapeutics Annual Meeting, Arlington, VA - 3/6/2009
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Other

  • Results of a Phase 2A Study of PRX-03140 For the Treatment of Alzheimer's disease. 
    Megerian, J.T., Shacham, S, Kalafer, M, and Uprichard, A., ICAD, Blog
    Chicago, IL - 7/1/2008
  • CELLULAR AND MOLECULAR CORRELATES OF NEURITOGENESIS: MOLECULES REGULATING GROWTH CONE BEHAVIOR AND NEURITE OUTGROWTH. 
    Megerian, J. T., Dissertation
    Northwestern University Medical School - 1/1/1993

Authored Content

  • Treating Sleep Disturbances in Children with Developmental DisordersOctober 2022

Grant Support

  • Behavioral Effects Of Dietary Glycemic Index In ADHDNational Center For Research Resources2000–2002

Professional Memberships

Industry Relationships

  • Senior Vice President, Chief Medical Officer, Yamo Pharmaceuticals2017 - Present