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Office
170 S Main St
Orange, CA 92868Phone+1 714-288-7651Fax+1 714-288-7379
Summary
- J. Thomas Megerian, M.D., PhD, FAAP is a board certified pediatrician and child neurologist specializing in Autistic spectrum and other neurodevelopmental disorders. Dr. Megerian has extensive interest and experience in designing and executing clinical trials for neurological disorders. He is currently attending neurologist and Associate Professor (volunteer faculty) at CHOC and University of California, Irvine, respectively. Currently, Dr. Megerian serves as the Clinical Director of the Thompson Autism and Neurodevelopmental Center at CHOC, as well as the Division Chief for Neurodevelopmental Medicine.
Dr. Megerian also serves as Senior Vice President for Clinical Development and Chief Medical Officer at Yamo Pharmaceuticals, where he is leading drug development for the treatment of the core deficits in autistic spectrum disorders. He also consults for Kuzani Pharmaceuticals for their autism development program where he is working on several studies for their candidate molecule for the treatment of cores symptoms.
Dr Megerian has had extensive experience in developing candidate treatments for various neurodegenerative and neurodevelopmental disorders in both the academic and biotechnology arena during his tenure in the Neurology Department at Boston Children’s Hospital, as well as his roles at Massachusetts General Hospital for Childrens at North Shore, Hospital, University of Massachusetts Medical Center, and Boston Medical Center. In addition, Dr Megerian has served as part of the executive management team responsible for clinical and scientific development activities for neurological disorders within several biomedical research companies, including Johnson and Johnson, Avanir, Epix Pharmaceuticals, and Neurometrix. as well He has led clinical development programs for the treatment of autistic spectrum disorders, hydrocephalus, brain injury, spasticity, stroke, attention deficit hyperactivity disorder, and intracranial atherosclerosis.
Education & Training
- Boston Children’s Hospital/Beth Israel Deaconess Medical Center/Harvard Medical SchoolFellowship, Child Neurology, 1995 - 1998
- Boston Children’s Hospital/Boston Medical CenterResidency, Pediatrics, 1993 - 1995
- Northwestern University Medical SchoolPhD, 1985 - 1993
- Northwestern University The Feinberg School of MedicineClass of 1993
- Union CollegeB.S., Biology/Chemistry, Magna Cum Laude, 1981 - 1985
Certifications & Licensure
- MA State Medical License 1995 - 2026
- CA State Medical License 2015 - 2025
- FL State Medical License 2012 - 2018
- American Board of Pediatrics Pediatrics
- American Board of Psychiatry and Neurology Neurology with Special Qualification in Child Neurology
Awards, Honors, & Recognition
- Neurological Science Academic Development Award National Institutes of Health, 1995
- Fellow (FAAP) American Academy of Pediatrics
Clinical Trials
- Enterprise Stent Aneurysm Treatment (ESAT) Study - France Start of enrollment: 2009 Feb 01
Publications & Presentations
PubMed
- 361 citationsEffect of a Balloon-Expandable Intracranial Stent vs Medical Therapy on Risk of Stroke in Patients With Symptomatic Intracranial Stenosis The VISSIT Randomized Clinica...Osama O. Zaidat, Brian-Fred Fitzsimmons, Britton Keith Woodward, Zhigang Wang, Monika Killer-Oberpfalzer
JAMA. 2015-03-24 - 6 citationsReview of Machine Learning and Artificial Intelligence (ML/AI) for the Pediatric Neurologist.Grace Y Gombolay, Nakul Gopalan, Andrea Bernasconi, Rima Nabbout, Jonathan T Megerian
Pediatric Neurology. 2023-04-01 - 35 citationsCerebrospinal shunt infection in patients receiving antibiotic-impregnated versus standard shunts.Scott L. Parker, William N. Anderson, Sean Lilienfeld, J. Thomas Megerian, Matthew J. McGirt
Journal of Neurosurgery. Pediatrics. 2011-09-01
Journal Articles
- Melatonin Deficiency and Disrupted Circadian Rhythms in Pediatric Survivors of Craniopharyngioma.Lipton J, Megerian JT, Kothare, SV, et al, Neurology, 7/28/2009
- Utility of Nerve Conduction Studies for Medicine PhysiciansMegerian, J.T, Kong, X. and Gozani, S. N., J Am Board Fam Med, 1/1/2007
- "Diabetic Nerve Conduction Abnormalities in the Primary Care Setting"Vinik, A.I., Kong, X, Megerian, J.T., Gozani, S.N., Diabetes Technology & Therapeutics, 12/1/2006
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Abstracts/Posters
- Recurrent encephalopathy with coma: An unusual late delayed effect of whole-brain radiotherapy.Megerian JT, Paleologos NA, Vick, Am Acad. Neurol, 1/1/1995
- Delayed Phosphorylation of GAP-43 During Neurite Outgrowth in a Mouse Neuroblastoma Line.Megerian, J.T., Meiri, K.F., & Klein, W.L., Soc.Neurosci., 1/1/1991
- Expression of Tau and ALZ-50 in Human Cortical Cell Line HCN-1A and Non-Human Neuroblastoma Cell Lines.Enam, S.A., Megerian, J.T., & Klein, W.L., Soc. Neurosci., 1/1/1991
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Lectures
- Autism: What Have We Learned and How to ManageChildren's Hospital Boston Pediatric Health Care Summit, Beverly, MA - 4/29/2009
- Alzheimer's Disease Treatment Update: Present and FutureMedical Grand Rounds, North Shore Medical Center; Medical Grand Rounds, Union Hospital, Jun 2009 - 3/13/2009
- Pipeline Projects Session. Results from a Phase 2A clinical study of a novel 5HT4 agonist for the treatment of Alzheimer's Disease.American Society for Experimental Neurotherapeutics Annual Meeting, Arlington, VA - 3/6/2009
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Other
- Results of a Phase 2A Study of PRX-03140 For the Treatment of Alzheimer's disease.Megerian, J.T., Shacham, S, Kalafer, M, and Uprichard, A., ICAD, Blog
Chicago, IL - 7/1/2008 - CELLULAR AND MOLECULAR CORRELATES OF NEURITOGENESIS: MOLECULES REGULATING GROWTH CONE BEHAVIOR AND NEURITE OUTGROWTH.Megerian, J. T., Dissertation
Northwestern University Medical School - 1/1/1993
Authored Content
- Treating Sleep Disturbances in Children with Developmental DisordersOctober 2022
Grant Support
- Behavioral Effects Of Dietary Glycemic Index In ADHDNational Center For Research Resources2000–2002
Professional Memberships
- Fellow
- Member
- Child Neurology SocietyMember
- Member
- American Academy of Cerebral Palsy and Developmental MedicineMember
Industry Relationships
- Senior Vice President, Chief Medical Officer, Yamo Pharmaceuticals2017 - Present
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