JonathanTienMaMDFAAP

Chronic Lung Disease of Prematurity and Infancy, Cystic Fibrosis Pulmonology, Pediatric Bronchoscopy

Assistant Professor

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I am a pediatric pulmonologist and physician-scientist interested in macrophages, innate immunity, airway inflammation, and mucociliary clearance disorders. Clinically, I have an interest in cystic fibrosis, chronic mechanical home ventilation, and the care of technology-dependent children.

Virginia Commonwealth University Health SystemFellowship, Pediatric Pulmonology, 2016 - 2020
Virginia Commonwealth University Health SystemResidency, Pediatrics, 2013 - 2016
Rutgers Robert Wood Johnson Medical SchoolClass of 2013, MD
University of PennsylvaniaBA, Biochemistry, Cum Laude, 2005 - 2009

Cystic Fibrosis Foundation Fourth Year Clinical Fellowship Award Cystic Fibrosis Foundation, 2019-2020
Cystic Fibrosis Foundation Third Year Clinical Fellowship Award Cystic Fibrosis Foundation, 2018-2019
Cystic Fibrosis Foundation First and Second Year Clinical Fellowship Award Cystic Fibrosis Foundation, 2016-2018

PubMed

Neutrophil elastase activates macrophage calpain as a mechanism for phagocytic failure.
Jonathan Ma, Apparao B Kummarapurugu, Shuo Zheng, Andrew J Ghio, Laxmikant S Deshpande
American Journal of Physiology. Lung Cellular and Molecular Physiology. 2025-01-01
3 citations
Neutrophil Elastase Degrades Histone Deacetylases and Sirtuin 1 in Primary Human Monocyte Derived Macrophages.
Shuo Zheng, Gamze B Bulut, Apparao B Kummarapurugu, Jonathan Ma, Judith A Voynow
International Journal of Molecular Sciences. 2024-04-12
3 citations
Neutrophil elastase decreases SARS-CoV-2 spike protein binding to human bronchial epithelia by clipping ACE-2 ectodomain from the epithelial surface.
Apparao B Kummarapurugu, Adam M Hawkridge, Jonathan Ma, Stephanie Osei, Rebecca K Martin
The Journal of Biological Chemistry. 2023-06-01

Books/Book Chapters

Pediatric Pulmonology, Asthma, and Sleep Medicine: A Quick Reference Guide
Chapter: Cystic Fibrosis
Page 471 - 481Ma J, Schechter MSEditors: Stokes, DC., Dozor, AJ., Brooks, LJ., Cataletto, ME., Hutchison. LH., Katkin, JP., Schechter, MS., Stout, JW., Van Hook, K.American Academy of Pediatrics, Itasca, IL2018

Abstracts/Posters

Proteomic-based approach to study neutrophil elastase mediatied macrophage dysfunction in cystic fibrosis
Ma, J., Kummarapurugu, A.B., Hawkridge, A., Voynow, J., North American Cystic Fibrosis Conference, Denver, CO, 10/18/2018
Changes in cystic fibrosis sputum neutrophil elastase activity and rheology during pulmonary exacerbations
Kummarapurugu, A.B., Levit, S.L., Tang, C., Ma, J., Rubin, B.K., Voynow, J., North American Cystic Fibrosis Conference, Orlando, FL, 10/28/2016
Developing a prognostic tool for cystic fibrosis using a longitudinal analysis of sputa. Am J Respir Crit Care Med 191;2015:A3329.
Ma T., Jonathan, Bradley L., Jennifer, Rubin K., Bruce., American Thoracic Society Conference, Denver, CO, 5/18/2015

Harry Shwachman Clinical Investigator AwardCystic Fibrosis Foundation2020–2023
Cystic Fibrosis Foundation Fourth Year Clinical Fellowship AwardCystic Fibrosis Foundation2019–2020
Third Year Clinical Fellowship AwardCystic Fibrosis Foundation2018–2019
First & Second Year Clinical Fellowship AwardCystic Fibrosis Foundation2016–2018

Postdoctoral FellowCystic Fibrosis, Airway Mucus, Airway Inflammation, Rheology, Biomarkers2014 - Present
Undergraduate ResearcherCytochromes, iron transporters2006 - 2009