JonathanLichtMD

PubMed

• The C-terminal PHDVC5HCH tandem domain of NSD2 is a combinatorial reader of unmodified H3K4 and tri-methylated H3K27 that regulates transcription of cell adhesion gene...
  Andrea Berardi, Charlotte Leonie Kaestner, Michela Ghitti, Giacomo Quilici, Paolo Cocomazzi
  Nucleic Acids Research. 2025-01-07
• 8 citations
  Recruitment of FBXO22 for targeted degradation of NSD2.
  David Y Nie, John R Tabor, Jianping Li, Maria Kutera, Jonathan St-Germain
  Nature Chemical Biology. 2024-12-01
• 1 citations
  KDM6A regulates immune response genes in multiple myeloma.
  Daphné Dupéré-Richer, Alberto Riva, Benjamin G Barwick, Sayantan Maji, Heidi Casellas Román
  Blood. 2024-10-03

Abstracts/Posters

• Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias _ Implications for the Biology ...
  Jonathan D. Licht, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins
  Jonathan D. Licht, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• DNMT3A with Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks
  Jonathan D. Licht, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Identification of Genetic Vulnerabilities and Synthetic-Lethal Targets in NSD2-High Multiple Myeloma
  Jonathan D. Licht, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance Via Blocking Receptor Auto-Induction and BIM/Bmf Expression in ALLCl...
  Jonathan D. Licht, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
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Lectures

• Targeting Epigenetic Regulation in Myeloma 
  60th American Society of Hematology Annual Meeting - 12/2/2018
• CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoprotein... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Functional Genomic Landscape of Genes with Recurrent Mutations in Multiple Myeloma 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018