JonathanSethJaffeMD

Allergy & Immunology • Annandale, NJ

Clinical & Laboratory Immunology

Vice President for Clinical Development, Antares Pharma Inc.

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Office
38 Southgate Dr
Annandale, NJ 08801
Phone+1 908-730-0831

Summary

Jonathan Jaffe, MD is officially retired. Previously an Allergy & Immunology specialist based in Annandale, NJ, with a subspecialty in Clinical & Laboratory Immunology. His extensive education includes a Fellowship in Allergy and Immunology from the National Institutes of Health Clinical Center and residencies in both Ophthalmology and Internal Medicine. Dr. Jaffe's employment history features senior roles in several pharmaceutical companies and academic institutions, including Antares Pharma, Novartis Pharmaceutical Corporation, Schering Plough (now Merck), Wyeth Ayerst (now Pfizer) and Hahnemann University Hospital. He has published a number of papers in credible journals, primarily summaries of clinical development studies. Over his career, Dr. Jaffe has received several awards for his contributions to the medical field.

Education & Training

National Institutes of Health Clinical CenterFellowship, Allergy and Immunology, 1988 - 1992
Zucker School of Medicine at Hofstra/Northwell at Lenox Hill HospitalResidency, Internal Medicine, 1986 - 1988
NYU Grossman School of MedicineResidency, Ophthalmology, 1985 - 1986
Abington Memorial HospitalInternship, Internal Medicine, 1984 - 1985
Sidney Kimmel Medical College at Thomas Jefferson UniversityClass of 1984
Lehigh UniversityBA, Biology, Summa Cum Laude

Certifications & Licensure

NY State Medical License 1985 - 2026
PA State Medical License 1984 - 2016
MD State Medical License 1988 - 1992
American Board of Allergy and Immunology Allergy & Immunology
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Clinical & Laboratory Immunology

Awards, Honors, & Recognition

Pharma Development Business Excellence Award Novartis, 2007
Transplant and Immunology Business Excellence Award Novartis, 2006
Excellence Award Schering-Plough, 2002
Allergy Fellowship Award for Basic Research Allen & Hanburys Respiratory Institute, 1993
Hobart Amory Hare Honor Medical Society 1989
Physicians Recognition Award American Medical Association, 1989, 1992
Pope Foundation Award for Research in Immunology 1988
Alpha Omega Alpha 1984
William W. Bodine Jr. Award for Research in Physiology Jefferson Medical College of Thomas Jefferson University, 1982
Pharmacology Honors Jefferson Medical College of Thomas Jefferson University, 1982
Phi Betta Kappa 1980
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Publications & Presentations

PubMed

Allometric Scaling of Testosterone Enanthate Pharmacokinetics to Adolescent Hypogonadal Males (IM and SC Administration).
Maria G Vogiatzi, Jonathan S Jaffe, Takugo Amy, Alan D Rogol
Journal of the Endocrine Society. 2023-05-05
7 citations
Pharmacokinetics of testosterone therapies in relation to diurnal variation of serum testosterone levels as men age
Alexander W. Pastuszak, Marc Gittelman, James P Tursi, Jonathan S. Jaffe, David Schofield
Andrology. 2021-09-12
9 citations
Testosterone Use in Adolescent Males: Current Practice and Unmet Needs.
Maria G. Vogiatzi, James P Tursi, Jonathan S Jaffe, Sue Hobson, Alan D. Rogol
Journal of the Endocrine Society. 2021-01-01

Journal Articles

Head-to-head, randomised, crossover study of oral versus subcutaneous methotrexate in patients with rheumatoid arthritis: drug-exposure limitations of oral methotrexat...
Schiff MH, Jaffe JS, Freundlich B, Ann Rheum Dis, 4/12/2014
In response to dosing omalizumab in allergic asthma
Jonathan S. Jaffe, Marc Massanari, The Journal of Allergy and Clinical Immunology, 1/1/2007
Everolimus and reduced-exposure cyclosporine in de novo renal-transplant recipients: a three-year phase II, randomized, multicenter, open-label study
Nashan B, Curtis J, Ponticelli C, Mourad G, Jaffe J, Haas T, 156 Study Group, Transplantation, 11/15/2004
Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism in renal transplant patients
Morrisett JD, Abdel-Fattah G, Hoogeveen R, Mitchell E, Ballantyne CM, Henry J. Pownall HJ, Opekun AR, Jaffe JS, Oppermann S, Kahan BD, J. Lipid Res., 1/1/2002
Effect of sirolimus on the metabolism of apoB100- containing lipoproteins in renal transplant patients
Hoogeveen RC. Ballantyne CM. Pownall HJ. Opekun AR. Hachey DL. Jaffe JS. Oppermann S. Kahan BD. Morrisett JD, Transplantation, 10/15/2001
Hydrogen peroxide release from human eosinophils on fibronectin: scopoletin enhances eosinophil activation
Raible DG, Mohanty JG, Jaffe JS, Stella HJ, Sprenkle BE, Glaum MC, Schulman ES, Free Radic Biol Med, 6/1/2000
Stimulated response of peripheral lymphocytes may distinguish cyclosporine effect in renal transplant recipients receiving a cyclosporine and rapamycin regimen
Sindhi R, LaVia MF, Paulling E, McMichael JM, Burckhart G, Shaw S, Sindhi LA, Livingston R, Sehgal S, Jaffe J, Transplantation, 2/1/2000
Sirolimus in pediatric gastrointestinal transplantation: The use of sirolimus for pediatric patients with tacrolimus-related cardiomyopathy
Pappas PA, Weppler D, Pinna AD, Rusconi P, Thompson JF, Jaffe JS, Tzakis AG, Pediatr Transplantation, 2/1/2000
Cytokine mRNA expression in human platelets and a megakaryocytic cell line and cytokine modulation of platelet function
Soslau G. Morgan DA. Jaffe JS. Brodsky I. Wang Y, Cytokine, 6/1/1997
A highly sensitive fluorescent micro-assay of H2O2 release from activated human leukocytes using a dihydroxyphenoxazine derivative
Mohanty JG. Jaffe JS. Schulman ES. Raible DG, Journal of Immunological Methods, 3/28/1997
Human Lung Mast Cell Activation Leads to IL-13 mRNA Expression and Protein Release
Jaffe JS, Raible DG, Post TJ, Wang Y, Glaum MC, Butterfield JH, Schulman ES, Am J Resp Cell and Mol Biol, 10/1/1996
Differential usage of T-cell receptor V beta gene families by CD4+ and CD8+ T Cells in patients with CD8hi common variable immunodeficiency: evidence of a post-thymic ...
Duchmann R, Jaffe J, Ehrhardt R, Alling DW, Strober W, Immunology, 1/1/1996
IgE-mediated Interleukin-5 Generation by Human Lung Fragments and Mast Cells
Jaffe JS, Glaum MC, Raible DG, Post TJ, Dimitry E, Govindarao D, Wang Y, Schulman ES, Am J Resp Cell and Mol Biol, 12/1/1995
IgE-Dependent expression of IL-5 mRNA and protein in human lung: modulation by dexamethasone
Glaum MG, Jaffe JS, Gillespie DH, Raible DG, Post TJ, Wang Y, Dimitry E, Schulman ES, Clin Immunol Immunopathol, 5/1/1995
Evidence for an abnormal profile of IL-4, IL-5, and gamma-IFN in peripheral blood T cells from patients with allergic eosinophilic gastroenteritis
Jaffe JS, James SP, Mullins GE, Lubensky I and Metcalfe DD, J Clin Immunol, 9/1/1994
Abnormal cytokine expression in Sezary and adult T-cell leukemia cells correlates with the biologic diversity between these T-cell malignancies
Tendler CL, Burton JB, Jaffe J, Danielpour D, Charley M, McCoy JP, Pittelkow MR, Waldmann TA, Cancer Research, 8/15/1994
Acute bronchospasm Caused by Sulfites
Szema AM, Lang DM, Jaffe JS, Contemporary Internal Medicine, 1/1/1994
Cytokines and their role in the pathogenesis of severe food hypersensitivity reactions
Jaffe JS and Metcalfe DD, Ann Allergy, 10/1/1993
Functional abnormalities of CD8+ T cells define a unique subset of patients with common variable immunodeficiency
Jaffe JS, Strober WS, and Sneller MC, Blood, 7/1/1993
Impaired CD4+ T lymphocytes in of patients with common variable immune deficiency
Eisenstein EM, Jaffe JS, and Strober WS, J Clin Immunol, 7/1/1993
RT-PCR with affinity captured mRNA
Cuddy K, Foley B, Jaffe JS, Gillespie D, Nucleic Acids Res., 5/11/1993
Abnormalities of CD8+ T-cell function in a subgroup of patients with common variable immunodeficiency, pp 726-727 In: Sneller MC, moderator New insights into common...
Jaffe JS, Ann Intern Med, 5/1/1993
T-cell abnormalities in common variable immunodeficiency
Jaffe JS, Eisenstein EM, Sneller MC and Strober W, Pediatric Research, 1/1/1993
A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld disease
Sneller MC, Straus SE, Jaffe ES, Jaffe JS, Fleisher TA, Stetler-Stevenson M and Strober W, J Clin Invest, 8/1/1992
Beneficial Actions of Nalorphine During Hemorrhagic Shock in Cats
Hock CE, Curtis MT, Jaffe JS, Lefer AM, Proceedings of the Society for Experimental Biology and Medicine, 5/1/1983
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Abstracts/Posters

A liquid formulation of omalizumab is bioequivalent to the current lyophilized formulation.
G-J Riviere, P Kuebler, J. Jaffe, C. M Yeh, C. Reynolds L. Brookman, AJRCCM, 1/1/2008
The Effect of Discontinuing Omalizumab Therapy on Free IgE Concentration.
P. Lowe, J. Jaffe, C. Martin, L. Brookman, H. Fox, The Journal of Allergy and Clinical Immunology, 1/1/2007
Everolimus In De Novo Pediatric Renal Transplantation: Results At 24 Months.
R Ettenger , V M Moeller, P F Hoyer, J Lemire , J Mahan , N Webb , P Niaudet and J Jaffe, American Transplantation Congress, 1/1/2004
36 Month Results With Everolimus (E) In Liver Transplantation.
G. Levy, V. M. Moeller, J. Jaffe, J. Punch, P. Neuhaus, D. Mayer, American Transplantation Congress, 1/1/2004
24 Month Safety Results Of A Randomized, Multicenter, Double-Blind Study Of Everolimus Vs Azathioprine In De Novo Heart Transplant Recipients.
H. Eisen, J. Kobashigawa, R. C. Starling, N. Cretin, J. Jaffe, J. Murphy, American Transplantation Congress, 1/1/2004
A Multi-Center, Randomized, Placebo-Controlled, Double-Blind, Parallel Group, Dose-Finding Study To Evaluate The Safety, Tolerability And Pharmacokinetics Of Everolimu...
Gary Levy, Virginia Moeller, Jonathan Jaffe, Jeffrey Punch, David Mayer, Peter Neuhaus, American Transplantation Congress, 1/1/2004
Favorable Effect Of Everolimus On Cardiac Allograft Vasculopathy Is Maintained Through 24 Months.
E. M. Tuzcu, J. A. Kobashigawa, H. J. Eisen, R. C. Starling, T. Crowe, K. Abeywickrama, J. Jaffe., American Transplantation Congress, 1/1/2004
Risk Factors For Acute Rejection And Vasculopathy Among 634 Patients Treated With Everolimus Or Azathioprine.
R. C. Starling, J. Kobashigawa, H. Eisen, J. Jaffe, Y. Li, American Transplantation Congress, 1/1/2004
Sirolimus Does Not Prevent Seroconversion In CMV Seronegative Recipients Of CMV Positive Kidneys.
Pescovitz MD, Jaffe JS, Ekeland R, Brown J, ASTS 25th Annual Meeting; Transplantation, 5/19/1999
Triglyceride Elevations in Renal Transplant Recipients Treated with Sirolimus (Rapamycin, RAPA) Added to a Cyclosporine/Prednisone Regimen.
Kahan BD, Jaffe JS, ASTS 25th Annual Meeting; Transplantation, 5/19/1999
Pharmacokinetic/Pharmacodynamic Profiles of African Americans in a Phase III Randomized Placebo-Controlled Trial of Sirolimus (RAPA) in Renal Transplantation.
Sindhi R, Jaffe J, Caulfield M, ASTS 25th Annual Meeting; Transplantation, 5/19/1999
Effect of Sirolimus on Plasma Lipid and Lipoprotein Levels and Metabolism In Renal Transplant Patients.
Morrisett JD, Ballentyne CM, Pownall HJ, Poekun AR Jaffe JS, Opperman S, Kahan BD, American Society of Transplantation 18th Annual Meeting, 5/1/1999
Rapamycin (RAPA) Lowers Dose Requirements of Cyclosporine (CsA) In Renal Transplant Patients (RTX).
Ahuja M, Jaffe JS, Bresnahan B, Adams MB, Johnson CP, Roza AM, Hariharan, American Society of Transplantation 18th Annual Meeting, 5/1/1999
Effect Of Race On Efficacy And Safety Of Sirolimus Vs AZA And Standard Immunotherapy In Renal Transplantation.
Neylan JF, Wickersham P, Jaffe J, American Society of Transplantation 18th Annual Meeting, 5/1/1999
Outcomes Of African American In A Phase III Randomized Placebo-Controlled Trial Of Sirolimus In Renal Transplantation.
Sindhi R, Wickersham PS, Jaffe JS, American Society of Transplantation 18th Annual Meeting, 5/1/1999
Intracellular IL-2 Production In CD4 Lymphocytes Decreases Predictably In Renal Transplant Recipients Receiving Neoral At Peak (Cmax) Blood Concentrations.
Sindhi R, Mariano FL, Shah J, Pauling E, Shaw S, Baliga PK, Rajagopalan PR, Livingston R, Jaffe J, ASN 17th Annual Meeting, Philadelphia, PA, 10/29/1998
A Sensitive Fluorescent Micro-Assay Of H2O2 Release From Activated Human Leukocytes Using A Dihydroxyphenoxazine Derivative.
Mohanty JG, Jaffe JS, Schulman ES, Raible DG, Inflammation Research Association International Conference, 1/1/1997
Activated Human Lung Fragments And Human Mast Cells Synthesize IL-13.
Jaffe JS, Wang Y, Post TJ, Glaum MC, Raible DG, Mohanty JG, Butterfield JH, Lang DM, Schulman ES, J. Allergy and Clin. Immunol., 1/1/1996
Psychological comorbidity in asthma.
Lang, DM, Sherman MS, Jaffe JS, Verdecchia S, Rutigliano PJ, Derogatis LR, J. Allergy and Clin. Immunol., 1/1/1996
Propranolol enhances histamine and interleukin-5 generation from anti-IgE challenged human lung fragments: evidence for inverse agonist effect.
Remy FJ, Jaffe JS, Raible DG, Post TJ, Wang Y,Glaum MC, Schulman ES, J. Allergy and Clin. Immunol., 1/1/1996
Isoproterenol and Salmeterol-induced attenuation of interleukin-5 mRNA and protein from anti-IgE challenged human lung fragments.
Remy FJ, Dimitry EA, Jaffe JS, Raible DG, Post TJ, Glaum M, Wang Y, Schulman ES, Am J Resp and Crit Care Med, 1/1/1995
B-adrenergic agonist-induced attenuation of interleukin-5 mRNA and protein from anti-IgE challenged human lung fragments.
Dimitry EA, Jaffe JS, Post TJ, Glaum M, Wang Y, Gillespie D, Schulman ES, Am J Resp and Crit Care Med, 1/1/1994
IgE-dependent secretion of IL-5 by lung fragments and human lung mast cells.
Jaffe JS, Schulman ES, Wang Y, J. Allergy and Clin. Immunol., 1/1/1994
Cultured B cells and T cells from patients with common variable immunodeficiency lack evidence of viral infection.
Eisenstein EM, Selvaggi TA, Jaffe JS, Goff J, Frenkel N, Wyatt L, Strober W, J. Allergy and Clin. Immunol., 1/1/1994
Activation of human lung mast cells induces early expression of IL-5 mRNA, but not IL-3, IL-4 and GM-CSF.
Jaffe JS, Schulman ES, Abstract-AAI/CIS meeting); J Immunol., 1/1/1993
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