JonathanJHalfordMD

Neurology • Charleston, SC

Epilepsy, Neurophysiology, Sleep Medicine

Professor of Neurology at the Medical University of South Carolina and Staff Neurologist at the Ralph H. Johnson VAMC

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Office
96 Jonathan Lucas St
Charleston, SC 29425
Phone+1 843-792-3221

Fax+1 843-792-8626

Summary

Dr. Halford is a native of South Carolina and grew up in Charleston. He graduated Cum Laude from Duke University with a major in Religious Studies in 1990. After time off to work in medical missions in the Amazon area of Brazil, he attended medical school at the Medical University of South Carolina where he graduated in 1996. He was a neuro-anatomy instructor part-time as a medical student and he won the AMSA Special Appreciation Award from for teaching medical students in 1993.

After medical school, he spent one year training in Internal Medicine at Virginia Commonwealth University and spent six years training at Duke University Medical Center, where he completed a dual neurology-psychiatry residency training program and a neurophysiology fellowship. He accepted a faculty position in the Department of Neurology at MUSC in 2003. He worked at MUSC from 2003 through 2024, attaining the rank of Professor of Neurology. He joined the staff of the Ralph H. Johnson VA Medical Center in 2004 and continues to take care of patients and do research at this hospital.
At the Ralph H. Johnson VA Medical Center, he is the Director of an Epilepsy Centers of Excellence Consortium Site and does research to test new methods for recording EEG and automatically detecting patterns in EEG. He is an Adjunct Associate Professor in the Departments of Electrical and Computer Engineering and the School of Computing at Clemson University.
At the Charleston VAMC, he sees adults with epilepsy and sleep medicine disorders.

Education & Training

Duke University HospitalFellowship, Clinical Neurophysiology, 2002 - 2003
Duke University HospitalResidency, Psychiatry, 2000 - 2002
Duke University HospitalResidency, Neurology, 1997 - 1999
Virginia Commonwealth University Health SystemInternship, Internal Medicine, 1996 - 1997
Medical University of South CarolinaClass of 1996
Duke UniversityB.A., Religious Studies, Cum Laude, 1986 - 1990

Certifications & Licensure

SC State Medical License 2003 - 2025
NC State Medical License 1997 - 2016
American Board of Psychiatry and Neurology Neurology
American Board of Psychiatry and Neurology Psychiatry
American Board of Psychiatry and Neurology Epilepsy
American Board of Psychiatry and Neurology Sleep Medicine
American Board of Clinical NeurophysiologyAdvanced Electroencephalography and Epilepsy Monitoring
American Board of Sleep MedicineSleep Medicine
DEA and SC DHECClass 1 Prescription License

Awards, Honors, & Recognition

Fellow American Epilepsy Society, 2016
Fellow American Clinical Neurophysiology Society, 2014
Golden Apple Special Appreciation Award Medical University of South Carolina, 1996

Clinical Trials

Seizure Detection and Warning System for Epilepsy Patients Start of enrollment: 2013 Jul 01
Active, not recruiting
An Open Label Extension Study of Cannabidiol (GWP42003-P) in Children and Adults With Dravet or Lennox-Gastaut Syndromes Start of enrollment: 2015 Jun 11
Completed
Phase 3
Safety and Pharmacokinetic Study of YKP3089 as Adjunctive Therapy in Subjects With Partial Onset Seizures Start of enrollment: 2016 Aug 03
Completed
Phase 3
Automated Identification of Psychogenic Nonepileptic Seizures Start of enrollment: 2017 Jan 01
Active, not recruiting
Study of TAK-935 as an Adjunctive Therapy in Participants With Developmental and/or Epileptic Encephalopathies Start of enrollment: 2017 Aug 17
Completed
Phase 1, Phase 2
Phase 2 Efficacy, Safety, and Tolerability Study of Natalizumab in Focal Epilepsy Start of enrollment: 2018 Mar 20
Completed
Phase 2
Testing a Novel Dry Electrode Headset for Electroencephalography Telehealth Start of enrollment: 2022 Oct 01
Enrolling by invitation
Not Applicable
Roles: Contact, Principal Investigator
A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut Syndrome Start of enrollment: 2022 Mar 04
Recruiting
Phase 3
Roles: Principal Investigator
A Trial of the Efficacy and Safety of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures Start of enrollment: 2020 Jan 27
Active, not recruiting
Phase 2
Roles: Contact
A Study of Soticlestat as an Add-on Therapy in Children and Young Adults With Dravet Syndrome Start of enrollment: 2021 Oct 28
Completed
Phase 3
Roles: Principal Investigator
A Study of Soticlestat as an Add-on Therapy in Children, Teenagers, and Adults With Lennox-Gastaut Syndrome Start of enrollment: 2021 Nov 08
Completed
Phase 3
Roles: Principal Investigator
Impact of Capturing Ictal Events With Ultra-long-term Ambulatory EEG Monitoring With Remote EEG Monitoring System. Start of enrollment: 2023 Oct 13
Recruiting
Not Applicable
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

10 citations
Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG Interpretation.
Jin Jing, Wendong Ge, Shenda Hong, Marta Bento Fernandes, Zhen Lin
Neurology. 2023-04-25
5 citations
Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs.
Jin Jing, Wendong Ge, Aaron F Struck, Marta Bento Fernandes, Shenda Hong
Neurology. 2023-04-25
2 citations
Epilepsy diagnosis using a clinical decision tool and artificially intelligent electroencephalography.
Robert P McInnis, Muhammad Abubakar Ayub, Jin Jing, Jonathan J Halford, Farrah J Mateen
Epilepsy & Behavior. 2023-04-01

Journal Articles

Standardized Database Development for EEG Epileptiform Transient Detection: EEGnet Scoring System and Machine Learning Analysis
Halford JJ, Schalkoff RJ, Zhou J, Benbadis SR, Tatum WO, Turner RP, Sinha S, Fountain NB, Arain A, Pritchard PB, Kutluay E, Martz G, Edwards JC, Waters C, Dean BC, Journal of Neurosciences Methods, 1/1/2013
Hippocampal atrophy in temporal lobe epilepsy: the generator and receiver
Bonilha L, Halford JJ, Morgan PS, Edwards JC, Acta Neurologica Scandanavia, 2/1/2012
Quantitative EEG Analysis for Automated Detection of Nonconvulsive Seizures in Intensive Care Units
Sackellares JC, Shiau DS, Halford JJ, LaRoche SM, Kelly KM, Epilepsy & Behavior, 1/1/2011
Signal Regularity-Based Automated Seizure Prediction Algorithm on Scalp EEG
Chien JH, Shiau D-S, Halford JJ, Kelly KM, Kern RT, Yang MC, Zhang J, Sackellares JC, Pardalos PM, Cybernetics and Systems Analysis, 1/1/2011
Web-based Collection of Expert Opinion on Routine Scalp EEG: Software Development and Inter-rater Reliability
Halford JJ, Pressly WB, Benbadis SR, Tatum WO, Turner RP, Arain A, Prichard PB, Edwards JC, Dean BC, ournal of Clinical Neurophysiology, 1/1/2011
A randomized, double-blind, placebo-controlled study of the efficacy, safety and tolerability of adjunctive carisbamate treatment in patients with partial-onset seizures
Halford JJ, Ben-Menachem E, Kwan P, Ness S, Schmitt J, Eerdekens M, Novak G, Epilepsia, 1/1/2011
Responsive cortical stimulation for the treatment of medically intractable partial epilepsy
Morrell MJ; On behalf of the RNS System in Epilepsy Study Group (Halford JJ), Neurology, 1/1/2011
Response to "Spike Detection Algorithm Performance and Methods of Acquiring Expert Opinion"
Halford JJ, Clinical Neurophysiology, 1/1/2010
Seizure Detection Software Used to Complement the Visual Screening Process for Long-Term EEG Monitoring
Halford JJ, Shiau D-S, Kern RT, Stroman C, Kelly KM, Sackellares JC, American Journal of Electroneurodiagnotic Technologists, 1/1/2010
Assessment of a scalp EEG-based automated seizure detection system
Kelly KM, Shiau D-S, Kern, RT, Chien J-H, Yang MC, Yandora, K, Valeriano, JP, Halford JJ, Sackellares JC, Clinical Neurophysiology, 1/1/2010
Signal Regularity-Based Automated Seizure Detection System for Scalp EEG Monitoring
Shiau D-S, Halford JJ, Kelly KM, Kern RT, Inman M, Chien J-H, Pardalos PM, Sackellares JC, Cybernetics and Systems Analysis, 1/1/2010
Hippocampal gray matter loss and hippocampal deafferentation in patients with temporal lobe epilepsy
Bonilha L, Edwards JC, Kinsman SL, Morgan PS, Fridriksson J, Rorden C, Rumboldt Z, Roberts DR, Eckert MA, Halford JJ, Epilepsia, 1/1/2010
Lacosamide as adjunctive therapy for partial-onset seizures: a randomized controlled trial
Chung S, Sperling MR, Biton V, Krauss G, Hebert D, Rudd GD, Doty P, SP754 Study Group (Halford JJ), Epilepsia, 1/1/2010
Interrater reliability of EEG-video monitoring (NES Treatment Workshop 2003)
Benbadis SR, Halford JJ et al, Neurology, 1/1/2009
Clinical Perspectives on Lacosamide
Halford JJ, LaPointe M, Epilepsy Currents, 1/1/2009
The influence of hippocampal atrophy on extra-hippocampal gray matter loss in temporal lobe epilepsy
Bonilha L, Halford JJ, Neurology, 1/1/2009
Computerized Epileptiform Transient Detection in Scalp EEG: Obstacles to Progress and the Example of Computerized ECG Interpretation
Halford JJ, Clinical Neurophysiology, 1/1/2009
Detection of Paroxysmal EEG Discharges using Multi-taper Blind Signal Source Separation
Halford JJ, Lecture Notes in Computer Science, 1/1/2007
Asymmetrical extra-hippocampal grey matter loss related to hippocampal atrophy in patients with medial temporal lobe epilepsy
Bonilha L, Rorden C, Halford JJ, Eckert M, Appenzeller S, Cendes F, Li LM, J Neurol Neurosurg Psychiatry, 1/1/2007
APOE2 allele increased in tardive dyskinesia
Halford J, Mazeika G, Slifer S, Speer M, Saunders AM, Strittmatter WJ, Morgenlander JC, APOE2 allele increased in tardive dyskinesia, 1/1/2006
Neurophysiologic correlates of psychiatric disorders and potential applications in epilepsy
Halford JJ, Epilepsy and Behavior, 1/1/2003
Dementia presenting as postpartum depression
Dell DL, Halford JJ, Obstetrics & Gynecology, 1/1/2002
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Press Mentions

Palmetto Pot War: A Look at the Science Behind Medical Marijuana and Obstacles Researchers FaceFebruary 26th, 2021
Brain Cholesterol: The New Landscape of Neurological Disease ManagementNovember 2nd, 2023

Professional Memberships

American Academy of Neurology - AAN
Member