JonathanGrinsteinMD, FACC

Heart Failure & Transplantation

Associate Professor of Medicine, University of Chicago - Director of Mechanical Circulatory Support - Director of Research - Advanced Heart Failure, Mechanical Circulatory Support and Cardiac Transplantation

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Office
5841 S. MARYLAND AVE.
M/C 6080
Chicago, IL 60637
Phone+1 773-702-9324

Summary

Jonathan Grinstein, MD, is an advanced heart failure physician and Director of Mechanical Circulatory Support for the Advanced Heart Failure Group at The University of Chicago. He is an Assistant Professor of Medicine at The University of Chicago and a member of the Alpha Omega Alpha Medical Society and the Gold Humanism Honor Society.

As a specialist in the field of cardiovascular disease and advanced heart failure, Dr. Grinstein treats patients through the use of left ventricular assist devices (LVADs), long-term IV medications or continuous infusion pump medications, and heart transplantation.

Dr. Grinstein received his medical degree from the University of Chicago. He then joined Brigham and Women’s Hospital, associated with Harvard Medical School, for internship and residency training in internal medicine. Finally, he returned to the University of Chicago for a three-year fellowship in cardiology followed by specialty training in advanced heart failure.

Dr. Grinstein participates in novel research involving LVADs. In lieu of a physical examination or an invasive right heart catheterization procedure, Dr. Grinstein has researched, perfected, and currently utilizes an echocardiographic and computed tomography techniques to noninvasively monitor the pressure and volume inside the heart of individuals with an implanted LVAD. This technique allows cardiologists to analyze how well a patient is responding to the device and make necessary adjustments in real time. He is conducting research to develop a “smart” LVAD that can intuitively adjust its speed based on the physiological needs of the patient. He is also using computational fluid dynamics to study and predict blood flow patterns through the LVAD to maximize device performance.

He is board certified in Advanced Heart Failure and Transplant Cardiology, Cardiovascular Disease and Internal Medicine.

Education & Training

University of ChicagoFellowship, Advanced Heart Failure and Transplant Cardiology, 2016 - 2017
University of ChicagoFellowship, Cardiovascular Disease, 2013 - 2016
Brigham and Women's HospitalResidency, Internal Medicine, 2011 - 2013
Brigham and Women's HospitalInternship, Internal Medicine, 2010 - 2011
University of Chicago Division of the Biological Sciences The Pritzker School of MedicineClass of 2010
McGill UniversityB.S., Physiology, 2002 - 2006

Certifications & Licensure

IL State Medical License 2019 - 2026
DC State Medical License 2017 - 2020
MA State Medical License 2010 - 2013
American Board of Internal Medicine Advanced Heart Failure and Transplant Cardiology
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

Member of FLIGHT (Future Leaders in Growing Heart Failure Therapies) Program Abbott
Fellow of The American College of Cardiology American College of Cardiology
Jay N Cohn New Investigator Finalist Heart Failure Society of America, 2019
Alpha Omega Alpha
Gold Humanism Honors Society
Dean's Scholarship for Outstanding Promise in Medicine Pritzker School of Medicine, University of Chicago, 2006
Morton Arnsdorf Award for Best Research University of Chicago, 2015
Award for Academic Excellence and Achievement American Society for Clincal Pathology, University of Chicago, 2009
Dr. Kathleen Terroux Prize in Physiology McGill University, 2006
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Publications & Presentations

PubMed

Dynamic assessment of left ventricular coupling and myocardial reserve in patients with cardiogenic shock.
Anthony J Kanelidis, Michael J Randazzo, Sara Kalantari, Bryan Smith, Ann Nguyen
European Heart Journal Open. 2024-09-01
Galectin-3 as a Prognostic Biomarker of Left Ventricular Assist Device Implantation Outcomes.
Ryan Hoang, Mary E Acosta, Mark N Belkin, Nabeel F Rasheed, Umar Siddiqi
ASAIO Journal. 2024-08-02
New-Onset Neurosarcoidosis Following Heart Transplant for Cardiac Sarcoidosis.
Nikita Deshpande, Anthony J Kanelidis, Ann Nguyen, Nitasha Sarswat, JoDel Powers
JACC. Case Reports. 2024-06-05

Journal Articles

Ventricular Assist Devices in Advanced Heart Failure: Exploring the Technology�s Current Utilization, Limitations and Future Directions
Grinstein J, Hofmann Bowman MA, Fedson S, J Cardiobiol, 1/1/2014

Abstracts/Posters

Increased Rate of Pump Thrombosis and Cardioembolic Events Following Ventricular Tachycardia Ablation in Patients Supported with Left Ventricular Assist Devices
Grinstein J, Garan AR, Flatley E, Kim GH, Mai X, Sarswat N, Kalantari S, Adatya S, Raikhelkar J, Sayer G, Oesterle A, Jeevanandam V, Moss J, Uriel N, J Heart Lung Transplant, 1/1/2017
Right Ventricular Pacing Improves Functional Status and Quality of Life Compared to Biventricular Pacing in Left Ventricular Assist Device Patients
Grinstein J, Medvedofsky D, Flatley E, Moss, J, Beiser D, Adatya S, Sayer G, Sarswat N, Raikhelkar J, Kim GH, Kagan V, Lee W, Ota T, Jeevanandam V, Lang R, Uriel N, J Heart Lung Transplant, 1/1/2017
Echocardiographic Predictors of Hemodynamics in Patients Supported with Left Ventricular Assist Devices
Grinstein J, Kruse E, Kalantari Tannenbaum S, Rodgers D, Adatya S, Sayer G, Kim GH, Sarswat N, Raikhelkar J, Kagan V, Costantini H, Burkhoff D, Jeevanandam V, Lang R, ..., J Heart Lung Transplant, 1/1/2017
The Impact of Race on Hemodynamics and Heart Transplant Outcomes
Smith BA, Bassi N, Wright C, Kalantari-Tannenbaum S, Grinstein J, Kim G, Sayer G, Adatya S, Sarswat N, Fedson S, Ota T, Jeevanandam V, Uriel N, J Heart Lung Transplant, 1/1/2017
Reduced PF4 and C6orf25 Gene Copies Prior to LVAD in Patients with Thromboembolic Events
Kim GH, Sayer G, Rodgers D, Woodward R, Arnold P, Sarswat N, Grinstein J, Kalantari S, Adatya S, Yee J, Ota T, Jeevanandam V, Uriel N, J Heart Lung Transplant, 1/1/2017
Management of Cardiac Implantable Electronic Devices (CIEDs) in Patients with Left Ventricular Assist Devices
Grinstein J, Uriel N, Upadhyay GA, 1/22/2016
The Hemodynamic Effects of Intravenous Inotrope/Vasodilator Therapy in the Beta-Blocker Era
Kalantari S, Grinstein J, Smith B, Sayer G, Adatya S, Sarswat N, Kim G, Burkhoff D, Uriel N, JACC, 1/1/2016
Impact of Aortic Insufficiency on Unloading Properties of Continous-Flow Left Ventricular Assist Devices
Sayer G, Kruse E, Addetia K, Grinstein J, Adatya S, Sarswat N, Kim GH, Ota T, Jeevanandam V, Lang R, Uriel N, J Heart Lung Transplant, 1/1/2016
Discordance Between C4d Staining by Immunohistochemistry and Immunofluorescence and Clinical Outcomes
Tannenbaum SK, Uraizee I, Grinstein J, Smith B, Marinescu K, Sayer G, Sarswat N, Kim GH, Adatya S, Jeevanandam V, Ota T, Husain A, Uriel N, J Heart Lung Transplant, 1/1/2016
The Hemodynamic Effects of Milrinone in the Beta-Blocker Era
Tannenbaum SK, Grinstein J, Smith B, Marinescu K, Sarswat N, Adatya S, Sayer G, Kim GH, Ota T, Jeevanandam V, Uriel N, J Heart Lung Transplant, 1/1/2016
LVAD Outflow Cannula Systolic Slope in Patients with Left Ventricular Assist Devices: A Marker of Myocardial Contractility
Grinstein J, Kruse E, Sayer G, Kim GH, Sarswat N, Adatya S, Ota T, Jeevanandam V, Mor-Avi V, Lang RM, Uriel N, J Heart Lung Transplant, 1/1/2016
HVAD Waveform as a Surrogate Marker of Cardiac Index and Pulmonary Capillary Wedge Pressure
Grinstein J, Rodgers DE, Tannenbaum SK, Adatya S, Sarswat N, Kim GH, Sayer G, Ota T, Jeevanandam V, Mor-Avi V, Burkhoff D, Uriel N, J Heart Lung Transplant, 1/1/2016
Discordance between Thermodilution and Indirect Fick Cardiac Outpit Measurements in LVAD Patients
Tehrani DM, Grinstein J, Anyanwu EC, Kim G, Sarswat N, Adatya S, Sayer G, Uriel N, J Car Fail, 1/1/2016
Improved prognostic performance of novel parameters for grading aortic insufficiency severity in patients with left ventricular assist devices
Grinstein J, Kruse E, Collins KA, Sayer G, Fedson S, Kim GH, Jeevanandam V, Lang RM, Uriel N, Circulation, 1/1/2015
Screening for Outflow Cannula Malfunction of Left Ventricular Assist Devices Using Doppler Echocardiography: Establishing New Reference Values
Grinstein J, Kruse E, Sayer G, Fedson S, Kim GH, Shah A, Paul J, Lang RM, Uriel N, Circulation, 1/1/2015
Novel parameters for grading aortic insufficiency severity in patients with left ventricular assist devices
Grinstein J, Kruse E, Collins KA, Sayer G, Fedson S, Kim GH, Jeevanandam V, Lang RM, Uriel N, JASE, 1/1/2015
Doppler echocardiographic assessment of the left ventricular assist device outflow cannula in the screening of cannula malfunction
Kruse E, Grinstein J, Sayer G, Fedson S, Kim GH, Shah A, Paul J, Uriel N, Lang RM, JASE, 1/1/2015
Quantification of Aortic Insufficiency in Patients With Left Ventricular Assist Devices: A Novel Approach Combining Invasive Hemodynamics and Echocardiography
Grinstein J, Kruse E, Sayer G, Fedson S, Kim GH, Jorde UP, Juricek C, Ota T, Jeevanandam V, Lang RM, Uriel N, J Heart Lung Transplant, 1/1/2015
Prognostic implications of low-level cardiac troponin elevation using the high-sensitivity assay for cardiac troponin T: Results from EARLY ACS & SEPIA-TIMI 42
Grinstein J, Bonaca M, Sabatine M, Jarolim P, Conrad M, Braunwald E, Giugliano R, Newby LK, Morrow D, J Am Coll Cardiol, 1/1/2013
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