JonathanBrestoffMDPhD, MPH
Pathology • Saint Louis, MOAnatomic Pathology, Clinical Pathology
Assistant Professor
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Office
660 S Euclid Ave
# 8118
Saint Louis, MO 63110Phone+1 314-362-5943
Summary
- I am a physician-scientist trained in clinical pathology with a research focus on how the immune system regulates metabolic homeostasis and the development of obesity and type 2 diabetes.
Education & Training
Perelman School of Medicine at the University of PennsylvaniaClass of 2016, MD
U Penn Med SchoolPhD, Cell & Molecular Biology, 2011 - 2014- University College Cork - National University of IrelandMPH, Epidemiology & Biostatistics, 1st Class Honours, 2009 - 2010
- Skidmore CollegeBS, Chemistry (Biochemistry) and Exercise Science, Summa Cum Laude, 2004 - 2008
Certifications & Licensure
MO State Medical License 2016 - 2025- American Board of Pathology Pathology - Clinical
Awards, Honors, & Recognition
- NIH Director's Early Independence Award NIH Office of the Director, 2019
- Career Award for Medical Scientists Burroughs Wellcome Fund, 2019
- Paul E. Strandjord Young Investigator Award Academy of Clinical Laboratory Physicians and Scientists, 2018-2019
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Publications & Presentations
PubMed
- 249 citationsβ2-adrenergic receptor–mediated negative regulation of group 2 innate lymphoid cell responsesSaya Moriyama, Jonathan R. Brestoff, Anne-Laure Flamar, Jesper B. Moeller, Christoph S.N. Klose
Science. 2018-03-02 - 631 citationsSensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic ItchLandon K. Oetjen, Madison R. Mack, Jing Feng, Timothy M. Whelan, Haixia Niu
Cell. 2017-09-21 - 733 citationsGroup 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesityJonathan R. Brestoff, Brian S. Kim, Steven A. Saenz, Rachel R. Stine, Laurel A. Monticelli
Nature. 2015-03-12
Books/Book Chapters
Press Mentions
LUCA Science Publishes Groundbreaking Research in Nature Metabolism: Mitochondria Transfer-Based Therapies Reduce the Morbidity and Mortality of Leigh SyndromeSeptember 5th, 2024
Brestoff, Theunissen Recognized by NIH for Innovative ResearchOctober 1st, 2019- Brestoff Receives Prestigious Medical Scientists AwardSeptember 27th, 2019
Grant Support
- NIH Director's Early Independence AwardOffice of the Director, National Institutes of Health2019–2024
- Career Award for Medical ScientistsBurroughs Wellcome Fund2019–2024
- Ruth L. Kirschstein F30 FellowshipNational Institute of Allergy & Infectious Disease (NIAID)2014–2016
- Ruth L. Kirschstein T32 Fellowship (Microbial Pathogenesis and Genomics)National Institutes of Allergy & Infectious Disease2012–2014
Research History
- PhD studentPerelman School of Medicine at the University of Pennsylvania; Advisor, David Artis, PhD; Dissertation, "Innate immune cell regulation of metabolic homeostasis"2011 - 2014
- ResearcherSkidmore College; Advisor, TH Reynolds, PhD; Thesis, "Identification of a novel anti-obesity compound"2006 - 2008
Professional Memberships
- Member
- American Association of Immunologists - AAIMember
- Member
- Academy of Clinical Laboratory Physicians and Scientists - ACLPSMember
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