JonathanBrestoffMDPhD, MPH

Anatomic Pathology, Clinical Pathology

Assistant Professor

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I am a physician-scientist trained in clinical pathology with a research focus on how the immune system regulates metabolic homeostasis and the development of obesity and type 2 diabetes.

Perelman School of Medicine at the University of PennsylvaniaClass of 2016, MD
U Penn Med SchoolPhD, Cell & Molecular Biology, 2011 - 2014
University College Cork - National University of IrelandMPH, Epidemiology & Biostatistics, 1st Class Honours, 2009 - 2010
Skidmore CollegeBS, Chemistry (Biochemistry) and Exercise Science, Summa Cum Laude, 2004 - 2008

NIH Director's Early Independence Award NIH Office of the Director, 2019
Career Award for Medical Scientists Burroughs Wellcome Fund, 2019
Paul E. Strandjord Young Investigator Award Academy of Clinical Laboratory Physicians and Scientists, 2018-2019
William L. Roberts Award with Distinction Academy of Clinical Laboratory Physicians and Scientists, 2018-2019
Endocrine Society Award for Medical Student Achievement The Endocrine Society, 2016
Dr. Roy G. Williams Award (Best Research Paper Competition) University of Pennsylvania, 2015
Joseph  C.  Palamountain  Award  for  Young  Alumni  Achievement     Skidmore College, 2013
George  J.  Mitchell  Scholarship  U.S.-Ireland Alliance, 2009
Margaret  Paulding  Award  in  Exercise  Science  Skidmore College, Department of Health & Exercise Sciences, 2008
Jo  C.  Hebard  ’69  Memorial  Prize      Skidmore College, 2008
The  Katherine  Scranton  Rozendaal  Outstanding  Citizenship  Award  Skidmore College, 2008
Barry  M.  Goldwater  Scholarship  The Barry Goldwater Scholarship and Excellence in Education Program, 2006-2008
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PubMed

Cardiac Troponin to Adjudicate Subclinical Heart Failure in Diabetic Patients and a Murine Model of Metabolic Syndrome.
Hannah M Brown, Nicholas C Spies, Wentong Jia, John Moley, Sydney Lawless
The Journal of Applied Laboratory Medicine. 2024-11-04
Brown fat fuels the fire in fever.
Samantha J Krysa, Jonathan R Brestoff
Journal of Lipid Research. 2024-11-01
Adipocyte lipin 1 expression associates with human metabolic health and regulates systemic metabolism in mice.
Andrew LaPoint, Jason M Singer, Daniel Ferguson, Trevor M Shew, M Katie Renkemeyer
The Journal of Clinical Investigation. 2024-10-15

Books/Book Chapters

Epidemiology: Principles and Practical Guidelines
Chapter: Definition and scope of epidemiology
Page 3 - 18Van den Broeck J, Brestoff JR and Baum MEditors: Van den Broeck J and Brestoff JR.Springer Science+Business Media, DordrechtEdition 1st,2013
Encyclopedia of Global Studies: Volume 2
Chapter: Global Health and Nutrition
Brestoff JR and Van den Broeck JEditors: Jeurgensmeyer  M  and  Anheier  HK.SAGE Reference, USAEdition 1st,2012

LUCA Science Publishes Groundbreaking Research in Nature Metabolism: Mitochondria Transfer-Based Therapies Reduce the Morbidity and Mortality of Leigh SyndromeSeptember 5th, 2024
Brestoff, Theunissen Recognized by NIH for Innovative ResearchOctober 1st, 2019
Brestoff Receives Prestigious Medical Scientists AwardSeptember 27th, 2019

NIH Director's Early Independence AwardOffice of the Director, National Institutes of Health2019–2024
Career Award for Medical ScientistsBurroughs Wellcome Fund2019–2024
Ruth L. Kirschstein F30 FellowshipNational Institute of Allergy & Infectious Disease (NIAID)2014–2016
Ruth L. Kirschstein T32 Fellowship (Microbial  Pathogenesis  and  Genomics)National Institutes of Allergy & Infectious Disease2012–2014

PhD studentPerelman School of Medicine at the University of Pennsylvania; Advisor, David Artis, PhD; Dissertation, "Innate immune cell regulation of metabolic homeostasis"2011 - 2014
ResearcherSkidmore College; Advisor, TH Reynolds, PhD; Thesis, "Identification of a novel anti-obesity compound"2006 - 2008