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Office
75 Francis St
Department of Pathology
Boston, MA 02115Phone+1 617-732-5500
Education & Training
- Brigham and Women's HospitalResidency, Pathology-Anatomic and Clinical, 1987 - 1992
- University of Michigan Medical SchoolClass of 1987
Certifications & Licensure
- MA State Medical License 1991 - 2025
- American Board of Pathology Anatomic Pathology
Publications & Presentations
PubMed
- 1813 citationsAn immunogenic personal neoantigen vaccine for patients with melanomaPatrick A. Ott, Zhuting Hu, Derin B. Keskin, Sachet A. Shukla, Jing Sun
Nature. 2017-07-05 - 683 citationsc-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphomaAndrew P. Weng, John M. Millholland, Yumi Yashiro-Ohtani, Marie Laure Arcangeli, Arthur Lau
Genes & Development. 2006-08-01 - 78 citationsNotch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALLJessica Tatarek, Kathleen Cullion, Todd Ashworth, Rachel M. Gerstein, Jon C. Aster
Blood. 2011-08-11
Abstracts/Posters
- Single Cell RNA-Seq Reveals Deranged Developmental Hierarchy with Coexisting Oncogenic States and Immune Evasion Programs in ETP T-ALLJon C. Aster, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
- Enhancer Rewiring Dependent Switch from BCL2 to MCL1 Dependency Predicts NOTCH1 Inhibition Response in T-ALLJon C. Aster, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Other
- Intravascular large cell lymphomaAster JC, Bí_er-Auer A, Freedman AS
http://www.uptodate.com/contents/intravascular-large-cell-lymphoma
UpToDate, Wolters Kluwer Health - 2012-04-05 - Clinical manifestations, pathologic features, and diagnosis of mantle cell lymphomaAster JC, Freedman AS
http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-mantle
UpToDate, Wolters Kluwer Health - 2013-03-05 - Clinical manifestations, pathologic features, and diagnosis of precursor B cell acute lymphoblastic leukemia/lymphomaAster JC, Freedman AS
http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-precur
UpToDate, Wolters Kluwer Health - 2013-01-10 - Join now to see all
Press Mentions
- Targeting Notch and EGFR Signaling in Human Mucoepidermoid CarcinomaJanuary 21st, 2021
- Spatial Tumor Analysis Tool Combines Structural Details with Molecular InsightsJune 24th, 2023
Grant Support
- Oncogenic Notch Signaling: Mechanisms Of ActionNational Cancer Institute2006–2010
- Oncogenic Notch SignalingNational Cancer Institute2006–2010
- HematopathologyNational Cancer Institute2006–2010
- Pathogenesis Of Notch LeukemiaNational Cancer Institute2003–2007
- Core--PathologyNational Institute Of Dental &Craniofacial Research2001–2005
- Core--Murine HematopathologyNational Institute Of Diabetes And Digestive And Kidney Diseases2002
- Core--HematopathologyNational Cancer Institute2001–2002
- Pathogenesis Of Notch 1 LeukemiaNational Cancer Institute1999–2002
- Core--Human HematopathologyNational Cancer Institute2000
- Induction Of Lymphoid Leukemia By Tan-1National Cancer Institute1995–1999
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