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Office
75 Francis St
Department of Pathology
Boston, MA 02115Phone+1 617-732-5500
Education & Training
- Brigham and Women's HospitalResidency, Pathology-Anatomic and Clinical, 1987 - 1992
- University of Michigan Medical SchoolClass of 1987
Certifications & Licensure
- MA State Medical License 1991 - 2025
- American Board of Pathology Anatomic Pathology
Publications & Presentations
PubMed
- 508 citationsSCF FBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destructionHiroyuki Inuzuka, Shavali Shaik, Ichiro Onoyama, Darning Gao, Alan Tseng
Nature. 2011-03-03 - 52 citationsNotch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice.Lin Shan, Jon C. Aster, Jeffrey Sklar, Mary E. Sunday
American Journal of Physiology. Lung Cellular and Molecular Physiology. 2007-02-01 - 10 citationsDetection of the KIT D816V mutation in myelodysplastic and/or myeloproliferative neoplasms and acute myeloid leukemia with myelodysplasia-related changes predicts conc...Jeffrey W Craig, Robert P. Hasserjian, Annette S. Kim, Jon C. Aster, Geraldine S. Pinkus
Modern Pathology. 2020-01-02
Abstracts/Posters
- Single Cell RNA-Seq Reveals Deranged Developmental Hierarchy with Coexisting Oncogenic States and Immune Evasion Programs in ETP T-ALLJon C. Aster, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
- Enhancer Rewiring Dependent Switch from BCL2 to MCL1 Dependency Predicts NOTCH1 Inhibition Response in T-ALLJon C. Aster, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Other
- Intravascular large cell lymphomaAster JC, Bí_er-Auer A, Freedman AS
http://www.uptodate.com/contents/intravascular-large-cell-lymphoma
UpToDate, Wolters Kluwer Health - 2012-04-05 - Clinical manifestations, pathologic features, and diagnosis of mantle cell lymphomaAster JC, Freedman AS
http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-mantle
UpToDate, Wolters Kluwer Health - 2013-03-05 - Clinical manifestations, pathologic features, and diagnosis of precursor B cell acute lymphoblastic leukemia/lymphomaAster JC, Freedman AS
http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-precur
UpToDate, Wolters Kluwer Health - 2013-01-10 - Join now to see all
Press Mentions
- Targeting Notch and EGFR Signaling in Human Mucoepidermoid CarcinomaJanuary 21st, 2021
- Spatial Tumor Analysis Tool Combines Structural Details with Molecular InsightsJune 24th, 2023
Grant Support
- Oncogenic Notch Signaling: Mechanisms Of ActionNational Cancer Institute2006–2010
- Oncogenic Notch SignalingNational Cancer Institute2006–2010
- HematopathologyNational Cancer Institute2006–2010
- Pathogenesis Of Notch LeukemiaNational Cancer Institute2003–2007
- Core--PathologyNational Institute Of Dental &Craniofacial Research2001–2005
- Core--Murine HematopathologyNational Institute Of Diabetes And Digestive And Kidney Diseases2002
- Core--HematopathologyNational Cancer Institute2001–2002
- Pathogenesis Of Notch 1 LeukemiaNational Cancer Institute1999–2002
- Core--Human HematopathologyNational Cancer Institute2000
- Induction Of Lymphoid Leukemia By Tan-1National Cancer Institute1995–1999
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