JohnathanAEnghMD

PubMed

• 502 citations
  Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha.
  A Soeda, M Park, Dae Hee Lee, Arlan Mintz, Andreas Androutsellis-Theotokis
  Oncogene. 2009-11-12
• 12 citations
  Outcomes of the ACT III Study: Rindopepimut (CDX-110) Therapy for Glioblastoma.
  Benjamin M Zussman, Johnathan A. Engh
  Neurosurgery. 2015-06-01
• 88 citations
  ICES (Intraoperative Stereotactic Computed Tomography-Guided Endoscopic Surgery) for Brain Hemorrhage: A Multicenter Randomized Controlled Trial.
  Paul M. Vespa, Daniel F. Hanley, Joshua Betz, Alan Hoffer, Johnathan A. Engh
  Stroke. 2016-11-01

Journal Articles

• Stereotactic-guided dilatable endoscopic port surgery for deep-seated brain tumors: technical report with comparative case analysis  
  Newman WC, Engh JA, World Neurosurg, 1/8/2019
• Clinical and molecular recursive partitioning analysis of high-grade glioma treated with IMRT  
  Sutera P, Kalash R, Flickinger J, Engh J, Heron DE, Am J Clin Oncol, 1/1/2019
• Stereotactic body radiation therapy for benign spine tumors: is dose de-escalation appropriate?  
  Kalash R, Glaser SM, Flickinger JC, Burton S, Heron DE, Gerszten PC, Engh JA, Amankulor NM, Vargo JA, J Neurosurg Spine, 1/1/2018
• Long-term outcomes after stereotactic radiosurgery for spine metastases: radiation dose-response for late toxicity  
  Ling DC, Flickinger JC, Burton SA, Heron DE, Quinn AE, Bejjani GK, Engh JA, Gerszten PC, Amankulor NM, Vargo JA, Int J Radiat Oncol Biol Phys, 1/1/2018
• Cardioversion-responsive ventriculo-atrial shunt malfunction precipitated by atrial fibrillation  
  Kim WJ, Zenonos G, McDowell MM, Gardner PA, Engh JA, World Neurosurg, 1/1/2018
• The utility of early postoperative head computed tomography in brain tumor surgery: a retrospective analysis of 755 cases  
  Alkhalili K, Zenonos G, Tataryn Z, Amankulor N, Engh J, World Neurosurg, 1/1/2018
• Assessing the structural footprint of minimally invasive brain cannulation on cerebral white matter: a cadaveric model  
  Sivakanthan S, Ochalski PG, Schirda C, Engh JA, J Neurol Surg A Cent Eur Neurosurg, 1/1/2018
• Salvage stereotactic radiosurgery for recurrent gliomas with prior radiation therapy  
  Sutera PA, Bernard ME, Gill BS, Quan K, Engh JA, Burton SA, Heron DE, Future Oncol, 1/1/2017
• Tip design for safety of steerable needles for robot-controlled brain insertion  
  Lehocky CA, Fellows-Mayle W, Engh JA, Riviere CN, Robot Surg, 1/1/2017
• A first-in-class TWIST1 inhibitor with activity in oncogene-driven lung cancer  
  Yochum ZA, Cades J, Mazzacurati L, Neumann NM, Kheterpal SK, Chatterjee S, Wang H, Attar MA, Huang EH, Chatley SN, Nugent K, Somasundaram A, Engh JA, Ewald AJ, Cho YJ,..., Mol Can Res, 1/1/2017
• Endoscopic third ventriculostomy as adjunctive therapy in the treatment of low-pressure hydrocephalus in adults  
  Foster KA, Deibert CP, Choi PA, Gardner PA, Tyler-Kabara EC, Engh JA, Surg Neurol Int, 1/10/2016
• (ICES) Intraoperative Computer Guided Endoscopic Surgery for Brain Hemorrhage: A Multicenter Randomized Controlled Trial  
  Vespa P, Harley D, Betz J, Hoffer A, Engh J, Carter R, Nakaji P, Ogilvy C, Jallo J, Selman W, Bistran-Hall A, Lane K, McBee N, Saver J, Thompson RE, Martin N, Stroke, 1/1/2016
• IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression  
  Zhang X, Rao A, Sette P, Deibert C, Pomerantz A, Kim WJ, Kohanbash G, Chang Y, Park Y, Engh J, Choi J, Chan T, Okada H, Lotze M, Grandi P, Amankulor N, Neuro Oncol, 1/1/2016
• Salvage stereotactic radiosurgery for recurrent glioblastoma multiforme with prior radiation therapy  
  Holt DE, Bernard ME, Quan K, Clump DA, Engh JA, Burton SA, Heron DE, J Cancer Res Ther, 1/1/2016
• Tumor bed radiosurgery following resection and prior stereotactic radiosurgery for locally persistent brain metastasis  
  Holt DE, Gill BS, Clump DA, Leeman JE, Burton SA, Amankulor NM, Engh JA, Heron DE, Front Oncol, 1/1/2015
• Post-operative stereotactic radiosurgery to the resection cavity for large brain metastases: clinical outcomes, predictors of intracranial failure, and implications fo...  
  Ling D, Vargo JA, Wegner RE, Flickinger JC, Burton S, Engh J, Amankulor N, Quinn AE, Ozhasoglu C, Heron DE, Neurosurgery, 1/1/2015
• Ommaya reservoir with ventricular catheter placement for chemotherapy with frameless and pinless electromagnetic surgical neuronavigation  
  Weiner GM, Chivukula S, Chen CJ, Ding D, Engh JA, Amankulor N, Clin. Neurol Neurosurg, 1/1/2015
• Induction of robust type-1 CD8+ T-cell responses in WHO grade II low-grade glioma patients receiving peptide-based vaccines in combination with poly-ICLC  
  Okada H, Butterfield LH, Hamilton RL, Hoji A, Sakaki M, Ahn BJ, Kohanbash G, Drappatz J, Engh J, Amankulor N, Lively MO, Chan MD, Salazar AM, Shaw EG, Potter DM, Liebe..., Clin. Cancer Res., 1/1/2015
• A Singular Case of Intracranial Sinus Histiocytosis "without" Massive Lymphadenopathy: Isolated Rosai-Dorfman Disease of the Hypothalamus  
  Chivukula S, Engh J, Journal of Neurological Surgery A Cent Eur Neurosurg, 1/27/2014
• Endoneurosurgical resection of intraventricular and intraparenchymal lesions using the port technique  
  McLaughlin N, Prevedello DM, Engh J, Kelly DF, Kassam AB, World Neurosurg, 1/1/2013
• Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics  
  Parry PV, Engh JA, Neurosurgery, 1/1/2013
• Multiple discrete aneurysmal subarachnoid hemorrhages during multimodality management of a hypothalamic glioma-case report  
  Faraji AH, Engh JA, Horowitz M, Lunsford LD, Park DM, Clinical Neurology and Neurosurgery, 1/1/2013
• Differential scanning calorimetry of gliomas: a new tool in brain cancer diagnostics?  
  Chagovetz AA, Quinn C, Damarse N, Hansen LD, Chagovetz AM, Jensen RL, Neurosurgery, 1/1/2013
• Predictive Value of Somatosensory Evoked Potential Monitoring during Resection of Intraparenchymal and Intraventricular Tumors Using an Endoscopic Port  
  Thirumala P, Lai D, Engh J, Habeych M, Crammond D, Balzer J, J Clin Neurol, 1/1/2013
• Combined Awake Craniotomy with Endoscopic Port Surgery for Resection of a Deep-Seated Temporal Lobe Glioma: A Case Report  
  Bodily L, Mintz A, Engh J, Case Reports in Medicine, 1/1/2013
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Books/Book Chapters

• Tumors of the Central Nervous System, Volume 3 Brain Tumors (Part 1) 
  Chapter: Endoscopic Port Surgery for Intraparenchymal Brain Tumors 
  Page 261 - 267Ochalski P, Engh JAEditors: M.A. Hayat.Springer, Dordrecht; Heidelberg; New York2011
• Principles and Practices of Neuro-Oncology: A Multidisciplinary Approach 
  Chapter: Endoscopic operations for cranial tumors. 
  Engh JA, Kassam AB, Prevedello DM, Gardner PAEditors: Mehta MP, Chang SM, Vogelbaum MA, Guha A.Demos Medical Publishing, New York2010
• Operative Otolaryngology-Head and Neck Surgery 
  Chapter: Microvascular decompression of the seventh cranial nerve. 
  Page 1385 - 1392Engh JA, Kassam AB, Horowitz M, Balzer J, Lee JYKEditors: Myers EN.Elsevier, PhiladelphiaEdition 2nd,2008
• Surgical Recall 
  Blackbourne LH, Engh JA (contributor)Lippincott Williams & Wilkins, Philadelphia, PAEdition 3rd,2002
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Abstracts/Posters

• Long-term Outcomes after Stereotactic Radiosurgery for Spine Metastases: Radiation Dose-Response for Late Toxicity.
  Ling DC, Flickinger JC, Burton SA, Heron DE, Quinn AE, Amankulor NM, Engh JA, Bejjani GK, Gerszten PC, Vargo JA, ASTRO (American Society for Radiation Oncology) Annual Meeting, San Diego, CA, 1/24/2017
• Stereotactic Radiosurgery for Spine Metastases: A Multidisciplinary Approach.
  Vargo JA, Quinn A, Engh J, Amankulor N, Cancer Insight: News from UPMC Cancer Center, 1/1/2016
• Stereotactic Dilatable Port Surgery for Brain Tumors Implementing the Next Generation of Minimally Invasive Brain Surgery.
  Engh J, University of Pittsburgh Neurosurgery News, 1/1/2016
• Multidisciplinary Approach to Brain Tumor Treatment Produces Meaningful Results.
  Engh J, Amankulor N, University of Pittsburgh Neurosurgery News, 1/1/2016
• Pharmacokinetic and pharmacodynamic analysis of pre-operative therapy with dabrafenib alone and in combination with trametinib in patients with BRAF mutation-positive ...
  Davies M, Tawbi H, Ouellet D, Lazar A, Weinberg J, Butterfield L, Hamilton R, Amankulor N, Engh J, Shivalingham B, Kefford R, Scolyer R, Mahmood S, Richards-Peterson L..., ASTRO (American Society for Radiation Oncology) Annual Meeting, 1/30/2014
• Post-operative Stereotactic Radiosurgery To The Resection Cavity for Large Brain Metastases.
  Ling DC, Vargo JA, Wegner RE, Flickinger JC, Burton SA, Engh J, Amankulor N, Quinn AE, Ozhasoglu C, Heron DE, ASTRO (American Society for Radiation Oncology) Annual Meeting, San Francisco, CA, 1/14/2014
• Fluorescent-Guided Brain Tumor Surgery Facilitates Better Resection.
  Engh J, Amankulor N, University of Pittsburgh Neurosurgery News, 1/1/2014
• Alteration of the Ki-67 Proliferative Index of Intracranial Tumors Following Surgical Resection With or Without Adjuvant Radiation or Chemotherapy.
  Faraji AH, Tonetti DA, Shin SS, Tormenti MJ, Flickinger JC, Engh JA, CNS Annual Meeting, San Francisco, CA, 1/19/2013
• Intra-operative use of HDFT with image-guidance valuable in awake craniotomy for tumor resection.
  Mintz A, Engh J, Pathak S, Fernandez-Miranda JC, University of Pittsburgh Neurosurgery News, 1/1/2012
• Endoscopic port surgery for colloid cyst resection: the best of both worlds?
  Engh JA, University of Pittsburgh Neurosurgery News, 1/1/2012
• HDFT, endoscopic port surgery synergistic in management of deep brain tumors.
  Engh J, Pathak S, Fernandez-Miranda JC, University of Pittsburgh Neurosurgery News, 1/1/2012
• Phase I/II vaccine study targeting novel HLA-A2-restricted CTL epitopes in combination with poly-ICLC in patients with recurrent malignant glioma.
  Okada H, Kalinski P, Mintz AH, Engh JA, Butterfield LH, Hamilton RH, Potter DM, Salazar AM, Lieberman FS, ASCO (American Society of Clinical Oncology) Annual Meeting, Chicago, IL, 1/3/2011
• The SRC activating protein AFAP1, is positioned to promote invasion in glioblastoma multiforme.
  Clump DA, Engh JA, Mintz AH, Cunnick J, Flynn D, 15th Annual Society Neuro-Oncology Meeting, Montreal, Quebec, Canada, 1/18/2010
• Successful induction of Type-1 CD8+ T cell responses and clinical activity by glioma vaccine with Alpha-Type-1-Polarized DCS and Poly-ICLC.
  Okada H, Kalinski P, Ueda R, Hoji A, Kohanbash G, Donegan TE, Mintz AH, Engh, JA, Bartlett, DL, Brown, C Zeh H, Holtzman M, Reinhart R, Whiteside TL, Butterfield L, Ha..., 15th Annual Society Neuro-Oncology Meeting, Montreal, Quebec, Canada, 1/18/2010
• Dilatable Endoscopic Port for Neurosurgery.
  Engh JA, 2010 First Look Technology Showcase, Guide to Technologies, University of Pittsburgh, Pittsburgh, PA, 1/6/2010
• Endoscopic Port Surgery for Resection of Lesions of the Cerebellar Peduncles.
  Engh JA, Ochalski P, 2010 AANS (American Association of Neurological Surgeons) Annual Meeting, Philadelphia, PA, 1/1/2010
• Ki-67 Proliferative Index Changes Following Resection and/or Radiation Therapy in Intracranial Tumors.
  Tormenti MJ; Faraji AH, Engh JA; Flickinger JC, 2009 Joint Meeting of the Society for Neuro-Oncology and the AANS (American Association of Neurological Surgeons)/CNS Section on Tumors, New Orleans, LA, 1/22/2009
• Testing of neurosurgical needle steering via duty-cycled spinning in brain tissue in vitro.
  Minhas D, Engh JA, Riviere CN, Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, IEEE Engineering in Medicine and Biology Society, 1/1/2009
• Completely endoscopic resection of glioblastomas using a transparent conduit: proof of concept.
  Engh JA, Mintz AH, Lieberman FS, Kassam AB, J Clin Oncol, 1/1/2008
• Flexible needle steering system for percutaneous access to deep zones of the brain.
  Engh JA, Podnar G, Khoo SY, Riviere CN, IEEE 32nd Annual Northeast Bioeng Conf, 1/1/2006
• Rates of hemorrhage associated with external ventricular drainage.
  Gardner PA, Engh JA, Atteberry DS, Moossy JJ, Annual Meeting of the American Association of Neurological Surgeons, 1/1/2005
• Occult intracranial metastasis detection on fine-cut MRI for radiosurgery.
  Engh JA, Flickinger JC, Amin DV, Lunsford LD, Annual Meeting of the Congress of Neurological Surgeons, 1/1/2005
• Early and late reoperation for hemifacial spasm: an analysis of 41 microvascular decompressions.
  Engh J, Kassam AB, Burkhart L, Chang YF, Horowitz M, Skull Base: An Interdisciplinary Approach, 1/1/2004
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Lectures

• Innovations in endoscopic minimally invasive brain surgery. 
  Orlando, FL - 1/16/2019
• Comprehensive overview of endoscopic port surgery. 
  Orlando, FL - 1/16/2019
• "Modern neurosurgical management of brain tumors." 
  Lexington Medical Center, West Columbia, SC - 1/5/2018
• "UPMC Presbyterian Shadyside Quality TQC Presentation Quality Data, Shadyside Neurosurgery-February 2017" 
  1/28/2017
• Multidisciplinary Application of Radiosurgery into a Neurosurgical Practice and Mock Tumor Board. 
  Pittsburgh, PA - 1/17/2017
• Radiosurgery: Cyberknife vs. GammaKnife vs. LINAC. 
  1/15/2017
• Radiosurgery for Brain Metastasis. 
  Pittsburgh, PA - 1/9/2017
• "Innovations in minimally invasive deep-seated brain tumor resection." 
  Hotel Monaco, Pittsburgh, PA - 1/8/2017
• "The Foramen of Monro-surgical considerations." 
  UPMC (University of Pittsburgh Medical Center) Presbyterian - 1/1/2017
• "Neuroendoport update." 
  UPMC (University of Pittsburgh Medical Center) Shadyside - 1/29/2016
• "UPMC Presbyterian Shadyside Quality TQC Presentation Quality Data, Shadyside Neurosurgery- August 2016" 
  1/23/2016
• "UPMC Presbyterian Shadyside Quality TQC Presentation Quality Data, Shadyside Neurosurgery-February 2016" 
  1/23/2016
• "CNS for radiation oncology residents." 
  1/20/2016
• "Neurosurgical Emergencies in Oncology" 
  1/9/2016
• "The future of port surgery for brain tumors." 
  UPMC (University of Pittsburgh Medical Center) Presbyterian - 1/6/2016
• "Case presentation, General Tumor Board" 
  1/4/2016
• Intracranial Endoscopy. 
  Chicago, IL - 1/2/2016
• State of the Art Cranial Endoscopy. 
  Chicago, IL - 1/1/2016
• "UPMC Presbyterian Shadyside Quality TQC Presentation Quality Data, Shadyside Neurosurgery-August 2015" 
  1/25/2015
• "54 Year Old With Personality Changes and Cognitive Deficit" 
  Shadyside Hospital, Pittsburgh, PA - 1/25/2015
• "UPMC Presbyterian Shadyside Quality TQC Presentation Quality Data, Shadyside Neurosurgery-February 2015" 
  1/24/2015
• "Improving intraoperative visualization of brain tumors." 
  1/11/2015
• "Comprehensive Management of Brain and Spinal Tumors" 
  1/3/2015
• "Management of Occult Neurosurgical Emergencies" 
  1/3/2015
• "Mortality and Morbidity Case Presentation-Review and Understanding of Intraparenchymal Hematoma" 
  1/29/2014
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Other

• "Timeout for Health" 
  Engh JA, WNKT-FM 107.5 Radio Interview
  Columbia, SC - 1/27/2018
• "Modern management of brain tumors" 
  Engh JA, Media Appearance - WLTX Spotlight Segment
  Columbia, SC - 1/26/2018
• UPMC trial of neoadjuvant radiosurgery offers a novel treatment option for metastatic brain tumors. 
  Engh JA, University of Pittsburgh Neurosurgery News
  1/1/2017
• Microscope Visualization of Intraoperative Yellow Fluorescein for Guided Tumor Identification and Resection. 
  Engh JA, CNS Webinar
  1/12/2016
• Stereotactic dilatable port surgery for brain tumors: implementing the next generation of minimally invasive brain surgery. 
  Engh JA, University of Pittsburgh Neurosurgery News
  1/1/2016
• Multidisciplinary approach to brain tumor treatment produces meaningful results. 
  Engh JA, Amankulor NM, University of Pittsburgh Neurosurgery News
  1/1/2016
• Stereotactic Radiosurgery-Truebeam vs. Cyberknife. 
  Engh JA, Teleconference - Cancer Treatment Services International Meeting of Neurosurgeons
  Hyderabad, Telangana, India - 1/23/2015
• "Glioma Treatment Using Neuroendoport." 
  Engh JA, Physician Education Video for UPMC Department of Neurosurgery Website
  1/1/2015
• Fluorescent-guided brain tumor surgery facilitates better resection. 
  Engh JA, Amankulor NM, University of Pittsburgh Neurosurgery News
  1/1/2014
• Quote "Carlton, James. "Ask Discover" 
  Engh JA, Discover, pg. 12
  1/1/2013
• "Pitt RB hospitalized: Derrick Burns in stable condition." 
  Engh JA, WTAE.com
  1/24/2012
• "Doctors find cyst on local teen's brain during concussion examination." 
  Engh JA, WPXI-TV Evening News
  1/17/2012
• "Strokes in Young Patients." 
  Engh JA, WTAE-TV Evening News
  1/11/2012
• HDFT, endoscopic port surgery synergistic in management of deep brain tumors. 
  Engh J, Pathak S, Fernandez-Miranda JC, University of Pittsburgh Neurosurgery News
  1/1/2012
• Intra-operative use of HDFT with image-guidance valuable in awake craniotomy for tumor resection. 
  Mintz A, Engh J, Pathak S, Fernandez-Miranda JC, University of Pittsburgh Neurosurgery News
  1/1/2012
• Endoscopic port surgery for colloid cyst resection: the best of both worlds? 
  Engh JA, University of Pittsburgh Neurosurgery News
  1/1/2012
• Predictive Value of Somatosensory Evoked Potential Monitoring During Resection of Intraparenchymal and Intraventricular Tumors Using an Endoscopic Port. 
  Engh J, Crammond D, Balzer J, Habeych M, Thirumala P, Kassam A, 4th Annual World Congress for Endoscopic Surgery of the Brain, Skull Base, and Spine
  Pittsburgh, PA - 1/28/2010
• UPMC team uses 'straw' to reach, remove tumor. 
  Engh JA, Tribune-Review
  Pittsburgh, PA - 1/19/2009
• UPMC surgeons ease Chicago teen's brutal suffering. 
  Engh JA, Tribune-Review
  Pittsburgh, PA - 1/11/2009
• NeuroendoportSM surgery facilitates removal of hard-to-reach brain tumors. 
  Engh JA, Kavel D, University of Pittsburgh Neurosurgery News
  1/1/2009
• NeuroendoportSM surgery implemented with success at Children's Hospital. 
  Engh JA, Pollack I, Neurosurgery News (Fall)
  University of Pittsburgh, Pittsburgh, PA - 1/1/2009
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