John Zajecka MD

PubMed

• Suicide characteristics in patients with marked treatment-resistant major depressive disorder: A RECOVER trial report.
  Victoria C de Leon, Rebecca M Allen, João Quevedo, Patricio Riva-Posse, Scott T Aaronson
  Journal of Affective Disorders. 2025-04-01
• 3 citations
  Effects of vagus nerve stimulation on daily function and quality of life in markedly treatment-resistant major depression: Findings from a one-year, randomized, sham-c...
  A John Rush, Charles R Conway, Scott T Aaronson, Mark S George, Patricio Riva-Posse
  Brain Stimulation. 2024-12-18
• 3 citations
  Vagus nerve stimulation in treatment-resistant depression: A one-year, randomized, sham-controlled trial.
  Charles R Conway, Scott T Aaronson, Harold A Sackeim, Mark S George, John Zajecka
  Brain Stimulation. 2024-12-18

Journal Articles

• Association of obesity and inflammatory marker levels on treatment outcome: Results from a double-blind, randomized study of adjunctive L-methylfolate calcium in pati...  
  Shelton RC, Pencina MJ, Barrentine LW, Ruiz JA, Fava M, Zajecka JM, Papakostas GI, J Clin Psychiatry, 1/1/2015
• The pro-inflammatory profile of depressed patients is (partly) related to obesity  
  Shelton R, Falola M, Papakostas G, Zajecka J, Barrentine L, Ruiz J, Fava M, J Psych Research, 1/1/2015
• A Randomized, placebo-controlled, active-reference, double-blind, flexible-dose tudy of the efficacy of vortioxetine on cognitive function in major depressive disorder  
  Mahableshwarkar AR, Zajecka J, Jacobson W, Chen Y, Keefe RSE, Neuropsychopharm, 1/1/2015
• Prevention of relapse & recurrence of bipolar type I depression: A study protocol for a multi-site randomized, double-blind, placebo-substitution trial  
  Amsterdam JD, Zajecka J, Soeller I, Topel M, Goldstein C, DeRubeis RJ, J Clinical Trials, 1/1/2014
• A clinical overview of monoamine oxidase inhibitors (MAOIs): Pharmacological profile, efficacy, safety/tolerability, and strategies for successful outcomes in the man...  
  Zajecka JM, Zajecka AM, Psych Annals, 1/1/2014
• Effect of Cognitive Therapy with Antidepressant Medications vs Antidepressants Alone on the Rate of Recovery in Major Depressive Disorder: A Randomized Trial  
  Hollon SD, DeRubeis RJ, Fawcett J, Amsterdam JD, Shelton RC, Zajecka J, Young PR, Gallop R, JAMA, 1/1/2014
• Effect of adjunctive l-methylfolate 15 mg among inadequate responders to SSRIs in depressed patients who were stratified by biomarker levels and genotype: results fro...  
  Papakostas GI, Shelton RC, Zajecka JM, Bottiglieri T, Roffman J, Cassiello C, Stahl SM, Fava M, J Clin Psychiatry, 1/1/2014
• Residual Symptoms and relapse: Mood, cognitive symptoms, and sleep disturbances  
  Zajecka J, J Clin Psychiatry, 1/1/2013
• Residual symptoms in major depressive disorder: prevalence, effects, and management  
  Zajecka J, Kornstein SG, Blier P, J Clin Psychiatry, 1/1/2013
• L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials  
  Papakostas GI, Shelton RC, Zajecka JM, Etemad B, Rickels K, Clain A, Baer L, Dalton ED, Sacco G, Schoenfeld D, Pencina M, Meisner A, Bottiglieri T, Nelson E, Mischoulo..., Am J Psychiatry, 1/1/2012
• Using what we have: combining medications to achieve remission  
  Topel ME, Zajecka JM, Goldstein CN, Siddiqui UA, Schwartz TL, Clinical Neuropsychiatry, 1/1/2011
• Efficacy and Safety of Agomelatine in the Treatment of Major Depressive Disorder  
  Zajecka J, Schatzberg A, Stahl S, Shah A, Caputo A, Post A, J Clin Psychopharmacol, 1/1/2010
• The use of referenced-EEG (rEEG) in assisting medication selection for the treatment of depression  
  DeBattista C, Kinrys G, Hoffman D, Goldstein C, Zajecka J, Kocsis J, Teicher M, Potkin S, Preda A, Multani G, Brandt L, Schiller M, Iosifescu D, Fava M, J Psych Research, 1/1/2010
• Assessing rates and predictors of tachyphylaxis during the prevention of recurrent episodes of depression with venlafaxine ER for two years (PREVENT) study  
  Rothschild AJ, Dunlop BW, Dunner DL, Friedman ES, Gelenberg A, Holland P, Kocsis JH, Kornstein SG, Shelton R, Trivedi MH, Zajecka JM, Goldstein CG, Thase ME, Ahmed S, ..., Psychopharmacol Bulletin, 1/1/2009
• Oral Divalproex Sodium Loading for Adolescent Outpatients With Acute Mania/Hypomania  
  Zajecka J, Gutierrez S, J Clin Psychiatry, 1/1/2008
• Preventing recurrent depression: long-term treatment for major depressive disorder  
  Dunner DL, Blier P, Keller MB, Pollack MH, Thase ME, Zajecka JM, J Clin Psychiatry, 1/1/2007
• The prevention of recurrent episodes of depression with venlafaxine for two years (PREVENT) study: outcomes from the 2-year and combined maintenance phases  
  Keller MB, Trivedi MH, Thase ME, Shelton RC, Kornstein SG, Nemeroff CB, Friedman ES, Gelenberg AJ, Kocsis JH, Dunner DL, Hirschfeld RMA, Rothschild AJ, Ferguson JM, Sc..., J Clin Psychiatry, 1/1/2007
• High-dose sertraline strategy for nonresponders to acute treatment for obsessive-compulsive disorder: a multicenter double-blind trial  
  Ninan PT, Koran LM, Kiev A, Davidson JRT, Rasmussen SA, Zajecka JM, Robinson DG, Crits-Cristoph P, Mandel FS, Austin C, J Clin Psychiatry, 1/1/2006
• Book Review/forward: Out of the Black Hole  
  Zajecka J, Doody's Health Sciences Book Review Journal, 1/1/2006
• Calming the bipolar storm: treating acute mania and mixed episodes in patients with bipolar disorder  
  Zajecka, JM, CNS Spectr, 1/1/2006
• The modified rush sexual inventory: preliminary psychometric findings  
  Rao D, Zajecka J, Skubiak T, Psychiatry Research, 1/1/2005
• Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial  
  Rush JA, Marangell LB, Sackeim HA, George MS, Brannan SK, Davis SM, Howland R, Kling MA, Rittberg BR, Burke WJ, Rapaport MH, Zajecka J, Nierenberg AA, Husain MM, Ginsb..., Biol Psychiatry, 1/1/2005
• Combining and augmenting: choosing the right therapies for treatment-resistant depression  
  Zajecka J, Goldstein C, Psychiatric Annals, 1/1/2005
• A double-blind, randomized trial of st john’s wort, fluoxetine and placebo in major depressive disorder  
  Fava M, Alpert J, Nierenberg AA, Mischoulon D, Otto MW, Zajecka J, Murck H, Rosenbaum JF, J Clin Psychopharmacology, 1/1/2005
• Treatment-resistant depression: benefits of tricyclic antidepressants  
  Zajecka J, Primary Care Special Edition, 1/1/2004
• Join now to see all

Books/Book Chapters

• Second Generation Antipsychotic Medications in the Treatment of Affective Disorders 
  Chapter: Antipsychotic Drugs:P Pharmacology, Side Effects and Abuse Prevention 
  Goldstein CN, Topel ME, Zajecka JMEditors: Schwartz TL, Megna J, Topel ME.Nova Biomedical2013
• Depression: Treatment Strategies and Management 
  Chapter: Combining Medications to Achieve Remission 
  Zajecka J, Goldstein CEditors: Schwartz TL, Petersen T.Informa Healthcare, LondonEdition 2nd,2009
• Handbook of Treating Depression/Depression: Treatment Strategies and Management 
  Chapter: Combining Drug Treatments to Achieve Remission 
  Zajecka J, Goldstein C, Barowski JEditors: Schwartz TL, Petersen T.Taylor and Francis Group, New York, NY2006
• The Side Effect Profiles of Antipsychotic Medications 
  Zajecka J, Goldstein CMBL Communications, Inc, New York, NY2003
• Handbook of Chronic Depression 
  Chapter: Improving long-term adherence to treatment in major depression 
  Zajecka J, Beeler MEditors: Fava M, Alpert JE.Marcel Dekker, Inc, New York, NY2003
• Obsessive-Compulsive Disorder Casebook 
  Chapter: Contribution of 5 cases of OCD comorbid with other psychiatric disorders 
  Zajecka JMAmerican Psychiatric Press1994
• Effective Strategies for the Management of Depression in Primary Care Practice 
  Zajecka JM, Wood WNCM Publishers, Inc1992
• Join now to see all

Abstracts/Posters

• Association of ob esity and levels of inflammatory markers on outcome with adjunctive L-methylfolate in MDD patients who are inadequate responders to SSRIs
  Shelton R, Pancina M, Barrentine L, Ruiz J, Papakostas G, Zajecka J, Fava M, Biological Psychiatry, Toronto, Canada, 1/1/2015
• Symptomatic response to lamotrigine maintenance in bipolar I disorder
  Gyulai L, Zajecka JM, Forrester BR, et al, APA, San Francisco, CA, 1/1/2003
• A double-blind, randomized trial of st. john's wort, fluoxetine and placebo in major depressive disorder
  Fava M, Alpert J, Nierenberg AA, Mischoulon D, Otto M, Zajecka J, et al, APA/NIMH NCDEU, Philadelphia, PA, 2002; Boca Raton, Florida, 2002, 1/1/2002
• Lithium as a mood stabilizer: 50+ years later
  Fieve R, Adler L, Allen M, Zajecka J, Kusumakar V, Ascher J Earl N, 2001 meeting of the ACNP/Annual meeting of the APA/NCDEU, Waikoloa, Hawaii, 2001; Philadelphia, PA, 2002; Boca Raton, Florida, 2002, 1/1/2002
• Reboxetine and sexual side effects
  Clayton A, Zajecka J, Ferguson J, NIMH NCDEU, Boca Raton, Florida, 1/1/2002
• Sexual function and satisfaction in the treatment of chronic depression with nefazodone, psychotherapy and their combination
  Zajecka J, Dunner DL, Hirschfeld R, Kornstein SG, Ninan PT, Rush AJ, Thase ME, Borian FE, Proceedings from the 40th annual NCDEU meeting, 1/1/2000
• Divalproex sodium vs. olanzapine for the treatment of mania in bipolar disorder: effects on body weight change and related outcomes
  Zajecka JM, Meredith C, Swann AC, Sachs G, et al, ACNP, Puerto Rico, 1/1/2000
• Functional imaging (FDG-PET) of two formulations of lithium carbonate
  Zajecka JM, Metz JT, Brown TF, Kinnunen LH, ACNP, Puerto Rico, 1/1/2000
• Sexual function and satisfaction in the treatment of chronic major depression with nefazodone, CBAS-psychotherapy (CBASP) and their combination
  Zajecka J, Dunner DL, Hirschfeld R, Kornstein SG, Ninan PT, Rush AJ, Trivedi MH, Gelenberg AJ, Thase ME, Borian FE, ACNP, Puerto Rico, 1/1/2000
• Symptomatic anxiety in the treatment of chronic major depression with nefazodone, CBAS-psychotherapy (CBASP), and their combination
  Ninan PT, Rush AJ, Kornstein SG, Rothbaum BO, Manber R, Thase ME, Trivedi M, Zajecka J, Nemeroff CB, Borian FE, ACNP, Puerto Rico, 1/1/2000
• Mood stabilisation with lamotrigine in rapid cycling bipolar disorder
  Earl N, Greene P, Ascher J, Fouche N, Chang C, Evoniuk G, Swann A, Pope S, Ketter T, McElroy S, Post R, Zajecka J, Altshuler L, Apter J, West S, Risch C, Khan A, Glaxo..., ACNP, Puerto Rico, 1/1/2000
• Divalproex sodium vs olanzapine for the treatment of mania in bipolar disorder
  Zajecka JM, Weisler R, Swann AC, Sachs G, Tracy K, Sommerville KW, Wozniak P, Martin J, ACNP, Puerto Rico, 1/1/2000
• Quantitative functional imaging (FDG-PET) and intra-class drug effects
  Metz J, Cooper M, Brown T, Kinnunen L, Zajecka J, Cooper D, ACNP, Puerto Rico, 1/1/2000
• Effects of acute bupropion and venlafaxine on cerebral glucose metabolism
  Metz J, Cooper M, Kinnunen L, Brown T, Zajecka J, ACNP, Puerto Rico, 1/1/2000
• Psychometric analyses of the Modified Rush Sexual Inventory (RSI)
  Rao D, Zajecka J, Skubiak T, Rosenblate R, NIMH NCDEU, Boca Raton, FL, 1/1/2000
• Sexual function and satisfaction in the treatment of chronic major depression with nefazodone, CBAS-psychotherapy (CBASP) and their combination
  Zajecka J, Dunner DL, Hirschfeld R, Kornstein SG, Ninan PT, Rush AJ, Trivedi MH, Gelenberg AJ, Thase ME, Borian FE, APA, Chicago, IL, 1/1/1999
• Nefazodone treatment of patients with poor responses to SSRIs
  Thase ME, Zajecka J, Kornstein SG, Borian FE, Jody DN, APA, Chicago, IL, 1998; Puerto Rico, 1998, 1/1/1998
• Undertreatment of chronic depression
  Thase M, Trapp G, Holzer C, Zajecka J, Rush J, Hawland R, APA, 1/1/1994
• The efficacy of divalproex sodium vs. placebo in the treatment of panic disorder
  Zajecka J, Fanelli J, Ross J, Kravitz H, Fawcett J, NCDEU, 1/1/1994
• Depression in multiple sclerosis: Where is the mood disturbance?
  Nyenhuis DL, Rao SM, Zajecka JM, Garron DC, International Neuropsychological Society, 1/1/1993
• The development and initial validation of the multiscale depression inventory for use with multiple sclerosis patients
  Nyenhuis DL, Rao SM, Zajecka JM, Garron DC, International Neuropsychological Society, 1/1/1993
• Prevalence of Pain and Impact on Treatment Outcomes in Patients with Recurrent Major Depressive Disorder
  Schatzberg AF, Friedman ES, Rothschild AJ, Trivedi MH, Dunner DL, Gelenberg A, Ninan P, Shelton R, Zajecka JM, Ahmed S, Musgnung J, Li T, Pedersen R, Keller MB, 2007 U.S. Psychiatric and Mental Health Congress/European College of Neuropsychopharmacology, Orlando, Florida, 2007; Vienna, Austria, 2007, 1/13/2007
• Efficacy of vortioxetine on cognitive function in patients with major depressive disorder: Cognitive test performance results from a randomized, double-blind, duloxeti...
  Mahableshwarkar AR, Zajecka J, Jacobson W, Chen Y, Keefe RSE, Annual Meeting of the American College of Neuropsychopharmacology, Phoenix, AZ, 1/7./2014
• Efficacy of vortioxetine on cognitive function in adult patients with major depressive disorder: Results of a randomized, double-blind, active-referenced, placebo-cont...
  Mahableshwarkar AR, Zajecka J, Jacobson W, Chen Y, Keefe RSE, 29th CINP World Congress, Vancouver, Canada, 1/22/2014
• Adjunctive lanicemine (AZD6765) in patients with major depressive disorder and a history of inadequate response to antidepressants: Preliminary results from a randomi...
  Sanacora G, Johnson M, Khan A, Atkinson S, Riesenberg R, Schronen J, Burke M, Zajecka J, Su, HL, Mathew S, Pathak S, 2014 Annual Meeting of the American Society of Clinical Psychopharmacology, Hollywood, Florida, 1/16/2014
• Join now to see all

Lectures

• Strategies for the Treatment of Anxious Depression 
  162nd Annual Meeting, San Francisco, California, USA
• Strategies for the Treatment of Anxious Depression 
  American Psychiatric Association, 162nd Annual Meeting, San Francisco, California, USA

Other

• Introduction to Bipolar Disorder with Dr. John Zajecka 
  Zajecka J, National Depressive and Bipolar Support Alliance
  1/1/2013
• Assessing and Managing Residual Depressive Symptoms in the Continuation/Maintenance Phase of Treatment 
  Zajecka J, Teleconference series, “Residual Symptoms in Major Depressive Disorder: Prevalence, Effects, and Ma
  1/1/2012
• Treatment-resistant depression: benefits of tricyclic antidepressants 
  Goldstein C, Zajecka J, Monograph, CNS News
  New York, New York - 1/1/2005
• Novel strategies in depression treatment: a balanced solution for broader symptom relief 
  Zajecka JM, Live interactive audio and web conference CME series
  OPTIMA Education Solutions, Inc., and University of California, Irvine, CA - 1/1/2003
• The Assessment of Patients with Treatment Resistant Depression 
  Zajecka JM, A webcast for PGY-1 and PGY-2 residents
  OPTIMA Education Solutions, Inc., and University of California, Irvine, CA - 1/1/2002
• Serzone: First Use Video 
  Zajecka J, Osprey Communications
  1/1/1995
• Venlafaxine (Effexor) in clinical practice 
  Zajecka JM, Currents (interview)
  1/1/1994
• ProPartners Working Together to Treat Depression 
  Zajecka J, Eli Lilly and Company
  1/1/1994
• Venlafaxine: A new antidepressant medication 
  Zajecka J, Innovations and Research
  1/1/1994
• Consultations in clinical psychopharmacology: A rational approach to antidepressant drug selection 
  Fawcett J, Rosenbaum J, Schatzberg AF, Zajecka JM, Monograph, NCM Publishers
  New York, New York - 1/1/1993
• An algorithmic approach to treatment-resistant depression 
  Zajecka J, Currents (interview)
  1/1/1993
• Consultation in Clinical Psychopharmacology: A Rational Approach to Antidepressant Drug Selection 
  Zajecka J, NCM
  1/1/1993
• Depression in the Medically Ill 
  Zajecka J, Eli Lilly and Company
  1/1/1993
• Recent advances in the treatment of major depression 
  Zajecka J, Depression Briefing
  1/1/1992
• Pharmacology, pharmacokinetics and safety issues of mood-stabilizing agents 
  Zajecka J, Bugamor Pharma Inc
  1/1/1992
• Antidepressant Side Effects 
  Zajecka J, Eli Lilly and Company
  1/1/1992
• Recent advances in the treatment of depression 
  Zajecka JM, Fawcett J, Current Opinion in Psychiatry
  1/1/1991
• Major depression in women 
  Zajecka JM, The Female Patient
  1/1/1990
• Dumping the blues 
  Zajecka JM, Chicago Medicine
  1/1/1990
• Treatment of psychotic affective disorders 
  Zajecka JM, Fawcett J, Easton MS, Current Opinion in Psychiatry
  1/1/1990
• Diagnosis and treatment of major depression 
  Zajecka JM, Physician Assistant
• New treatments to fight depression 
  Zajecka J, Chicago Medicine
  1/21/1992
• Diagnosis and Treatment of Depression: Sublime Insights into the Pharmacotherapy of Depression 
  Zajecka J, Audio-Digest Psychiatry
  1/21/2007
• Join now to see all