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Office
Duke Medical Ctr
# Dumc
Durham, NC 27710Phone+1 919-684-8111
Summary
- John Strickler, MD is a Professor of Medicine at Duke University, where he is Co-Leader for the Precision Cancer Medicine and Investigational Therapeutics Program at the Duke Cancer Institute, Leader of the Molecular Tumor Board, and Associate Director of Clinical Research – GI Oncology. Dr. Strickler’s clinic specializes on the treatment of gastrointestinal malignancies, with a particular emphasis on gastroesophageal, pancreatic, and colorectal cancers. His research focuses on precision cancer medicine: identification of biomarkers that predict sensitivity or resistance to targeted therapies and immunotherapy. He has designed and executed clinical trials that test novel therapies and innovative therapeutic strategies. He was Principal Investigator on an investigator sponsored trial that led to the first FDA-approved therapy for HER2+ metastatic colorectal cancer. He has first-author publications in several high impact factor medical journals, including the New England Journal of Medicine, Clinical Cancer Research, Cancer Discovery, Journal of Clinical Oncology, and Lancet Oncology. Nationally, he has served as a member of the American Society of Clinical Oncology (ASCO) Treatment Guidelines Committee for Advanced Colon Cancer.
Education & Training
- Duke University HospitalFellowship, Hematology and Medical Oncology, 2008 - 2011
- University of WashingtonResidency, Internal Medicine, 2006 - 2008
- University of WashingtonInternship, Internal Medicine, 2005 - 2006
- University of Chicago Division of the Biological Sciences The Pritzker School of MedicineClass of 2005
Certifications & Licensure
- NC State Medical License 2008 - 2025
- VA State Medical License 2009 - 2011
- WA State Medical License 2005 - 2008
- American Board of Internal Medicine Internal Medicine
- American Board of Internal Medicine Medical Oncology
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
Clinical Trials
- QUILT-3.019: Phase 2 Study of NPC-1C Chimeric Monoclonal Antibody to Treat Pancreatic and Colorectal Cancer Start of enrollment: 2012 Jan 01
- A Phase 1b/2 Study of OMP-59R5 (Tarextumab) in Combination With Nab-Paclitaxel and Gemcitabine in Subjects With Previously Untreated Stage IV Pancreatic Cancer Start of enrollment: 2012 Oct 01
- Phase I/II Study of Capecitabine Plus Aflibercept to Treat Metastatic Colorectal Cancer Start of enrollment: 2012 Aug 01
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Publications & Presentations
PubMed
- 29 citationsPhase I Study of 2- or 3-Week Dosing of Telisotuzumab Vedotin, an Antibody–Drug Conjugate Targeting c-Met, Monotherapy in Patients with Advanced Non–Small Cell Lung Ca...D. Ross Camidge, Daniel Morgensztern, Rebecca S. Heist, Minal A. Barve, Everett E. Vokes
Clinical Cancer Research. 2021-08-23 - 661 citationsKRASG12C Inhibition with Sotorasib in Advanced Solid Tumors.David S. Hong, Marwan Fakih, John H. Strickler, Jayesh Desai, G. Durm
The New England Journal of Medicine. 2020-09-20 - 7 citationsImpact of Anti-EGFR Therapies on HER2-Positive Metastatic Colorectal Cancer: A Systematic Literature Review and Meta-Analysis of Clinical Outcomes.Tanios S Bekaii-Saab, Krzysztof Lach, Ling-I Hsu, Muriel Siadak, Mike Stecher
The Oncologist. 2023-10-03
Journal Articles
- Anti-EGFR Resistant Clones Decay Exponentially After Progression: Implications for Anti-EGFR Re-ChallengeB Kee, N Garg, M J Overman, V K Morris, B Johnson, J Wu, J H Strickler, S Kopetz, X Liu, D S Hong, Annals of Oncology
Press Mentions
- Georgia Man Is Proof of Increasing Cases of Advanced Colorectal CancerMarch 31st, 2023
- Tucatinib and Trastuzumab Combination Approved for Advanced Colorectal CancerFebruary 10th, 2023
- Colorectal Cancer: Why Some People May Be Able to Delay Regular ColonoscopiesJanuary 22nd, 2023
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Professional Memberships
- Member
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