John Z Metcalfe MD
Critical Care Medicine
Assistant Professor, Division of Pulmonary and Critical Care Medicine UC San Francisco
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1001 Potrero Ave RM 5k1San Francisco, CA 94110
Phone+1 415-206-4679
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Education & Training
University of California, BerkeleyPhD, Epidemiology, 2008- University of California, BerkeleyBoard Certifications, Internal Medicine, Pulmonary Medicine, Critical Care Medicine, 2007 - 2009
University of California (San Francisco)Fellowship, Pulmonary Disease and Critical Care Medicine, 2006 - 2009- University of California (San Francisco)Residency, Pulmonary Disease and Critical Care Medicine, 2006 - 2009
- University of California (San Francisco)Residency, Internal Medicine, 2003 - 2006
- Tufts University School of MedicineMPH, Medicine, International Health, 1998 - 2003
Tufts University School of MedicineClass of 2003- Humboldt State UniversityBS, Molecular Biology, 1995 - 1998
Certifications & Licensure
CA State Medical License 2005 - 2026
American Board of Internal Medicine Pulmonary Disease
Awards, Honors, & Recognition
- Chancellor’s Fellowship for Graduate Education University of California, Berkeley, CA, 2008, 2009, 2010
- Robert Wood Johnson Medical Faculty Development Award, Semifinalist 2008, 2009
- Tufts University School of Medicine Half-Tuition Scholarship 1998-2002, 2003
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Clinical Trials
- Clofazimine- and Rifapentine-Containing Treatment Shortening Regimens in Drug-Susceptible Tuberculosis: The CLO-FAST Study Start of enrollment: 2021 Jun 16
Publications & Presentations
PubMed
- Xpert MTB/RIF Ultra-resistant and MTBDRsusceptible rifampicin results in people with tuberculosis: utility of FluoroType MTBDR and deep sequencing.Yonas Ghebrekristos, Aysha Ahmed, Natalie Beylis, Sarishna Singh, Christoffel Opperman
Antimicrobial Agents and Chemotherapy. 2025-03-05 - URAdime - a tool for analyzing primer sequences in sequencing data to identify dimers and super-amplicons.Jason D Limberis, John Z Metcalfe
Biorxiv. 2025-01-28 - spotPCR: A Rapid and Efficient Approach for Indexing Individual Template Molecules using Unique Molecular Identifiers.Jason D Limberis, Roland J Nagel, Soumitesh Chakravorty, Dena Block, Scot Dewell
Biorxiv. 2024-12-12
Journal Articles
- Endemic malaria in the Peruvian Amazon region of Iquitos.Roshanravan B, Kari E, Gilman RH, Cabrera L, Lee E, Metcalfe J, Calderon M, Lescano AG, Montenegro SH, Calampa C, Vinetz JM, Am J Trop Med Hyg
- Leptospirosis–associated Severe Pulmonary Hemorrhage Syndrome, Salvador, Brazil.Gouveia EL, Metcalfe J, de Carvalho AL, Aires TS, Villasboas-Bisneto JC, Queirroz A, Santos AC, Salgado K, Reis MG, Ko AI, Emerg Infect Dis
- Systematic review of clofazimine for the treatment of drug-resistant tuberculosis.Gopal M, Padayatchi N, Metcalfe J, O’donnell M, Int J Tub Lung Dis
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Press Mentions
TGen Sequencing Test Enables Precise Identification of Drug-Resistant TBOctober 9th, 2017
Grant Support
- A novel cartridge-based sequencing solution for decentralized M. tuberculosis resistance detectionUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2023–2028
- Handheld and population-based sequencing for rapid detection of new and repurposed drug resistance in M. tuberculosisUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2021–2027
- Comprehensive characterization of Rv0678 bedaquiline resistance-conferring polymorphismsUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2024–2026
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