JohnAndrewMengsholMD,PhD, FACG

Gastroenterology • Lone Tree, CO

Gastroenterology Practice Director, Highlands Ranch Hospital

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Office
9548 Park Meadows Dr
Lone Tree, CO 80124
Phone+1 720-848-5146

Fax+1 720-516-2131

Summary

Gastroenterology Practice Director Highlands Ranch Hospital

Education & Training

University of ColoradoFellowship, Gastroenterology, 2005 - 2009
University of ColoradoResidency, Internal Medicine, 2003 - 2005
Geisel School of Medicine at DartmouthClass of 2003
Dartmouth Medical SchoolPh.D., Biochemistry, 2001
Dartmouth MedPhD, Biochemistry, 2001
Dartmouth Medical SchoolPhD, Biochemistry, 2001
University of California, DavisBS, Biochemistry, With Honors, 1992

Certifications & Licensure

CO State Medical License 2005 - 2025
American Board of Internal Medicine Gastroenterology

Awards, Honors, & Recognition

Liver Scholar award American Liver Foundation/American Association for the Study of Liver Diseases, 2012
Freedman award for leadership and academic potential Division of Gastroenterology and Hepatology, 2009
NIH T32 postdoctoral fellow, Gastroenterology Training Grant 2006
Medical Student Achievement Award American College of Rheumatology, 2001
NIH postdoctoral fellowship, Autoimmunity and Connective Tissue Biology Training Grant 2001
Glenn Scholarship American Federation for Aging Research, 2000
NIH T32 Pre-Doctoral Fellowship, Immunology Training Grant 2000
Summer Research Fellowship Norris Cotton Cancer Center, 1996
Phi Sigma (A biological sciences honor society) 1993
U.C President’s Undergraduate Fellowship 1992
Howard Hughes Undergraduate Summer Research Fellowship 1992
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Clinical Trials

Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Start of enrollment: 2012 Apr 30
Active, not recruiting
Not Applicable

Publications & Presentations

PubMed

14 citations
Octreotide: A Drug Often Used in the Critical Care Setting but Not Well Understood
Mallory M. Chan, Michael M. Chan, John A. Mengshol, Douglas N. Fish, Edward D. Chan
Chest. 2013-12-01
533 citations
Interleukin‐1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c‐jun N‐terminal kinase, and nuclear factor κB: Di...
John A. Mengshol, Matthew P. Vincenti, Charles I. Coon, Aaron Barchowsky, Constance E. Brinckerhoff
Arthritis and Rheumatism. 2000-04-01
297 citations
Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8+ T Cells Associated with Reversible Immune Dysfunction
Lucy Golden-Mason, Brent E. Palmer, Jared Klarquist, John A. Mengshol, Nicole Castelblanco
Journal of Virology. 2007-09-01

Journal Articles

Somatosatin and octreotide: drugs not uncommonly used but not commonly understood
Chan, M. M., Chan M. M., Mengshol, J.A., Fish D. N., Chan E. D, Chest, 1/1/2013
A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in chronic hepatitis C infection
Mengshol, J.A.*, Golden-Mason, L.*, Arikawa, T., Smith, M., Niki, T., McWilliams, R., Randall, J., McMahan, R., Rangachari, M., Dobrinskikh, E., Busson, P., Polyak, S...., PLoS ONE, 1/1/2010
Impaired Plasmacytoid Dendritic Cell Maturation and Differential Chemotaxis in Chronic HCV: Associations with Antiviral Treatment Outcomes
Mengshol, J. A., Golden-Mason, L., Castelblanco, N., Im, K., Dillon, S., Wilson, C. C., Rosen, H. R. for the Virahep-C Study Group, Gut, 1/1/2009
Mechanisms of Disease: HCV-induced liver injury
Mengshol, J. A., Golden-Mason, L., Rosen, H. R, Nat Clin Pract Gastroeneterol and Hepatol, 1/1/2007
How Hepatitis C Injures the Liver
Mengshol, J. A., Golden-Mason, L., Rosen, H. R, AASLD Postgraduate Course, 1/1/2006
Matrix Metalloproteinases as Therapeutic Targets in Arthritic Diseases: Bulls-Eye or Missing the Mark?
Mengshol, J. A., Mix, K.S., Brinckerhoff, C.E, Arthritis and Rheumatism, 1/1/2002
A Synthetic Triterpenoid Selectively Inhibits the Induction of Matrix Metalloproteinases 1 and 13 by Inflammatory Cytokines
Mix, K. S., Mengshol, J. A., Benbow, U., Vincenti, M.P., Sporn, M.B., Brinckerhoff, C. E., Arthritis and Rheumatism, 1/1/2001
Mengshol, J. A., Vincenti, M.P., Coon, C.I., Barchowsky, A., Brinckerhoff, C. E., Arthritis and Rheumatism, 1/1/2000
Cloning of the gene for interstitial collagenase-3 (matrix metalloproteinase-13) from rabbit synovial fibroblasts: differential expression with collagenase-1 (matrix m...
Vincenti, M.P., Coon, C. I., Mengshol, J. A., Yocum, S., Mitchell, P. Brinckerhoff, C. E., Biochem J, 1/1/1998
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Abstracts/Posters

Macrophage Immunoregulatory Galectin-9 Production is increased by Contact with Hepatitis C Virus-infected Hepatocytes and Differentiation
Harwood, N., Golden-Mason, L., Rosen, H. R., Mengshol, J.A., Hepatology, 10/1/2013
Digestive Disease Week
Mengshol, J.A, 1/1/2008
Combination Antiviral Therapy Differentially Affects Dendritic Cell Chemokine Receptor and Maturation Marker Expression in Chronic Hepatitis C Infection
Mengshol, J. A., Golden-Mason, L., Castelblanco, N., Im, K., Rosen, H.R., Gastroenterology, 1/1/2008
Upregulation of Programmed Death-1 (PD-1) on HCV-specific and CMV-specific CD8+ T cells in Chronic HCV Infection Associated with Reversible Immune Exhaustion
Golden-Mason, L., Palmer, B., Klarquist, J., Mengshol J.A., Castelblanco N., Rosen, H.R., Hepatology, 1/1/2007
American College of Physicians, Colorado Chapter Annual Meeting
Mengshol, J.A, 1/1/2005
American Federation for Aging Research, American Aging Association grantee conference
Mengshol, J.A, Madison, WI, 1/1/2001
Gordon Research Conference on Matrix Metalloproteinases
Mengshol, J.A, Ciocco, Italy, 1/1/2001
Transcriptional Regulation of Collagenase-3 (MMP-13) by IL-1 in Chondrocytic Cells Requires Stable Chromatin Integration and the transcription factors RUNX-2 and AP-1
Mengshol, J. A., Vincenti, M. P., Brinckerhoff, C. E., Arthritis and Rheumatism, 1/1/2001
Effects of a Novel Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO), on Collagenase-3 (Matrix Metalloproteinase-13) Gene Expression
K.S. Mix, J.A. Mengshol, M.P. Vincenti, T. Honda, G.W. Gribble, and M.B. Sporn, 91st American Association for Cancer Research Annual Meeting, San Francisco, CA, 4/1/2000
American College of Rheumatology, Annual Meeting
Mengshol, J.A, Philadelphia, PA, 1/1/2000
Regulation of Collagenase-3 by Core Binding Factor Alpha-1 (Cbfa1) in Chondrocytic Cells
Mengshol, J. A., Vincenti, M.P., Brinckerhoff, C.E., Arthritis and Rheumatism, 1/1/2000
A Potential Chondroprotective Agent, 2-Cyano-3,12,-Dioxoolean-1,9-dien-28-Oic Acid (CDDO), Inhibits Collagenase (Matrix Metalloproteinase-1 and 13) Gene Expression and...
Mix, K.S, Mengshol, J.A., Vincenti, M. P., Honda, T., Gribble, G.W., Sporn, M.B., Brinckerhoff, C. E, Arthritis and Rheumatism, 1/1/2000
Interleukin-1 (IL-1) Induction of Collagenase-3 (MMP-13) Requires p38 MAPK Activity in Articular Chondrocytes
Mengshol, J. A., Vincenti, M.P., Coon, C. I., Brinckerhoff, C. E., Arthritis and Rheumatism, 1/1/1999
American College of Rheumatology, Annual Meeting
Mengshol, J.A, San Francisco, CA, 1/1/1998
Interleukin-1 (IL-1) Regulation of Collagenase-3 (MMP-13) Gene Expression
Mengshol, J. A., Vincenti, M.P., Coon, C. I., Brinckerhoff, C. E., Arthritis and Rheumatism, 1/1/1998
Lectins as microbicides and spermicides
Hedrick, J.L., Mengshol J. A., and M.J. Wieduwilt, Molecular Biology of the Cell, 1/1/1994
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Lectures

AASLD Liver meeting HCV pathogenesis parallel session
1/1/2013
Clinical Cytometry Society Meeting
1/1/2009
Hepatology Young Investigators Forum
Breckenridge, CO - 1/1/2009
Denver Translational Immunology Symposium
1/1/2007
American College of Rheumatology, International Annual Meeting
San Francisco, CA - 1/1/2001
American College of Rheumatology, Annual Meeting
Boston, MA - 1/1/1999
National M.D./Ph.D. Student Conference
Aspen, CO - 1/1/1998
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