John David Heiss MD

Neurosurgery•Bethesda, MD

Head, Clinical Unit, Surgical Neurology Branch, NINDS, National Institutes of Health

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10 Center DrRm 5D37Bethesda, MD 20892
Phone+1 301-496-2921
Fax+1 301-402-0380

Education & Training

NIH Clinical Center1991 - 1994
University of Cincinnati Medical Center/College of MedicineResidency, Neurological Surgery, 1980 - 1987
University of Michigan Medical SchoolClass of 1980
University of MichiganB.S., Biomedical Sciences, 1974 - 1977

Certifications & Licensure

MD State Medical License 1999 - 2026
OH State Medical License 1981 - 2026
American Board of Neurological Surgery Neurological Surgery

Awards, Honors, & Recognition

NIH Director’s Award Niemann-Pick Disease, type C, Therapeutic Development Team, 2013
Excellence in Technology Transfer Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), 2012
Special Recognition Award, for “exemplary performance while demonstrating significant leadership, skill, and ability in serving as a mentor.” NINDS, 2010
Special Act or Service Award, “In recognition of his contributions for outstanding leadership as Vice Chair NINDS/NIDCD Institutional Review Board, 2007
Special Recognition Award for “Fellow Recognition of Exceptional Mentoring NINDS, 2005
Special Act or Service Award Institutional Review Board (IRB), 2003
Special Act or Service Award IRB committee, 2001
Merit Award for Mentoring NINDS, 2001
Fellow (FAANS) American Association of Neurological Surgeons
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Clinical Trials

Genetic Analysis of the Chiari I Malformation Start of enrollment: 2001 Jun 04
COMPLETED
Study of Brain and Spinal Cord Tumor Growth and Cyst Development in Patients With Von Hippel Lindau Disease Start of enrollment: 2001 Feb 15
ACTIVE_NOT_RECRUITING
Brain Infusion of Muscimol to Treat Epilepsy Start of enrollment: 2000 Jun 23
Terminated
Phase 1
Neurotropin to Treat Chronic Neuropathic Pain Start of enrollment: 2000 Sep 01
Terminated
Phase 2
Study of Specimens Obtained During Epilepsy Surgery Start of enrollment: 2001 Oct 10
COMPLETED
Evaluation and Treatment of Neurosurgical Disorders Start of enrollment: 2003 Jun 04
RECRUITING
Natural History Study of Patients With Neurofibromatosis Type 2 Start of enrollment: 2008 Mar 21
RECRUITING
Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer Start of enrollment: 2009 Aug 14
RECRUITING
PHASE1
An Open Label Dose Escalation Safety Study of Convection-Enhanced Delivery of IL13-PE38QQR in Patients With Progressive Pediatric Diffuse Infiltrating Brainstem Glioma and Supratentorial High-grade Glioma Start of enrollment: 2009 Apr 07
Terminated
Phase 1
A Prospective Natural History Study of Patients With Syringomyelia Start of enrollment: 2010 Aug 03
ACTIVE_NOT_RECRUITING
Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients Start of enrollment: 2010 Sep 22
Completed
Surgery as a Treatment for Medically Intractable Epilepsy Start of enrollment: 2011 Mar 21
RECRUITING
AAV2-GDNF for Advanced Parkinson s Disease Start of enrollment: 2013 Mar 13
COMPLETED
PHASE1
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Publications & Presentations

PubMed

Optimizing Colocalized Cell Counting Using Automated and Semiautomated Methods.
Hasita V Nalluri, Shantelle A Graff, Dragan Maric, John D Heiss
Neuroinformatics. 2025-03-21
Gene Therapy for Glioblastoma Multiforme.
Smit Shah, Joshua Green, Shantelle A Graff, Qi Li, John D Heiss
Viruses. 2025-01-16
Head and neck paraganglioma in Pacak-Zhuang syndrome.
Jared S Rosenblum, Yasemin Cole, Danielle Dang, Pashayar P Lookian, Hussam Alkaissi
JNCI Cancer Spectrum. 2025-01-03

Journal Articles

“Hidden” bone metatstasis from thyroid carcinoma: a clinical note.
Sioka C, Skarulis MC, Tulloch-Reid MK, Heiss JD, Reynolds JC, Rev Esp Med Nucl Imagen Mol, Published Online July 8, 2013, 1/1/2013
Rapidly progressive monoparesis caused by Chiari malformation type 1 without syringomyelia.
Oishi M, Hayashi Y, Kita D, Fukui I, Shinohara M, Heiss JD, Hamada, J. Surgical Neurology Int, Published Online June 12, 2013, 1/1/2013
Normalization of hindbrain morphology after decompression of Chiari malformation Type 1.
Heiss JD, Suffredini G, Bakhtian KD, Sarntinoranont M, Oldfield EH, J Neurosurg, 1/1/2012
Pathophysiology of primary spinal syringomyelia.
Heiss JD, Snyder K, Peterson M, Patronas NJ, Butman JA, Smith RK, DeVroom HL, Sansur CA, Eskioglu E, Kammerer WA, Oldfield EH, J Neurosurg Spine, 1/1/2012
PET of serotonin 1A receptors and cerebral glucose metabolism for temporal lobectomy.
Theodore WH, Martinez AR, Khan Ol, Liew CJ, Auh S, Dustin IM, Heiss J, Sato S, J Nucl Med, 1/1/2012
Convection-enhanced delivery of M13 bacteriophage to the brain.
Ksendzovsky A, Walbridge S, Saunders RC, Asthagiri AR, Heiss JD, Lonser RR, J Neurosurg, 1/1/2012
Effect of concentration on accuracy of convective imaging distribution of a gadolinium-based surrogate tracer.
Asthagiri AR, Walbridge S, Heiss JD, Lonser RR, J Neurosurg, 1/1/2011
Tracking accuracy of T2- and diffusion-weighted magnetic resonance imaging for infusate distribution by convection-enhanced delivery.
Iyer RR, Butman JA, Walbridge S, Gai ND, Heiss JD, Lonser RR, J Neurosurg, 1/1/2011
Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: What should be the policy?
Kateb B, Chiu K, Yamamoto V, Khalsa B, Black KL, Ljubimova JY, Ding H, Patil R, Portilla-Arias JA, Modo M, Moore D, Farahani K, Okun M, Prakash N, Neman J, Ahdoot D, ..., NeuroImage 54 Suppl, 1/1/2011
Surgical management of melanoma brain metastases in patients treated with immunotherapy.
Lonser RR, Song DK, Klapper J, Hagan M, Auh S, Kerr PB, Citrin DE, Heiss JD, Camphausen K, Rosenberg SA, J Neurosurg, 1/1/2011
Intrathecal gene therapy for treatment of leptomeningeal carcinomatosis.
Heiss JD, Taha S, Oldfield EH, Ram Z, J Neurooncol, 1/1/2011
Image-guide convection-enhanced delivery of muscimol to the primate brain.
Heiss JD, Walbridge S, Asthagiri AR, Lonser RR, J Neurosurg, 1/1/2010
Pathophysiology of Persistent Syringomyelia after Decompressive Craniocervical Surgery.
Heiss JD, Suffredini G, Smith R, DeVroom HL, Patronas N, Butman J, Thomas F, Oldfield EH, J Neurosurg Spine, 1/1/2010
Chiari malformation Type I (Response to Editorial).
Heiss JD, Oldfield EH, J Neurosurg Spine, 1/1/2010
Neurological surgery at the National Institutes of Health.
Mehta GU, Heiss JD, Park JK, Asthagiri AR, Zaghloul KA, Lonser RR, World Neurosurg, 1/1/2010
Cortical mapping and frameless stereotactic navigation in the high-field intraoperative magnetic resonance imaging suite—Technical Note.
Weingarten DM, Asthagiri AR, Butman JA, Susumu S, Wiggs EA, Damaska B, Heiss JD, J Neurosurg, 1/1/2009
Long-term result of the Echols Procedure for treating syringomyelia: Case Report and Historical Review.
Peterson MM, Craciun L, Heiss JD, J Neurosurg (Spine), 1/1/2009
Temporal lobectomy: resection volume, neuropsychological effects and seizure outcome.
Shamim S, Wiggs E, Heiss J, Sato S, Liew C, Solomon J, Theodore W, Epilepsy Behav, 1/1/2009
Time course of syringomyelia resolution following decompression of Chiari I malformation.
Wetjen NJ, Heiss JD, Oldfield EH, J Neurosurg (Pediatrics), 1/1/2008
Association of human herpesvirus-6B with mesial temporal lobe epilepsy.
Fotheringham J, Donati D, Akhyani N, Fogdell-Hahn A, Vortmeyer A, Heiss JD, Williams E, Weinstein S, Bruce DA, Gaillard WD, Sato S, Theodore WH, Jacobson S, PLoS Medicine, 1/1/2007
High-resolution global genomic survey of 178 gliomas reveals novel regions of copy number alteration and allelic imbalances.
Kotliarov Y, Steed ME, Christopher N, Walling J, Su Q, Center A, Heiss J, Rosenblum M, Mikkelsen T, Zenklusen JC, Fine HA, Cancer Res, 1/1/2006
Technique for enhanced accuracy and reliability in non-human primate stereotaxy.
Walbridge S, Murad GJA, Heiss JD, Oldfield EH, Lonser RR, J Neurosci Meth, 1/1/2006
Peripheral and central hypomyelination with hypogonadotropic hypogonadism and hypodontia.
Timmons M, Tsokos M, Asab MA, Seminara SB, Zirzow GC, Kaneski CR, Heiss JD, van der Knaap MS, Vanier MT, Schiffmann R, Wong K, Neurology, 1/1/2006
The post-syrinx syndrome: stable central myelopathy and collapsed or absent syrinx.
Bogdanov EI, Heiss JD, Mendelevich EG, J Neurology, 1/1/2006
Local distribution and toxicity of prolonged hippocampal infusion of muscimol.
Heiss JD, Walbridge S, Morrison P, Hampton RR, Sato SS, Vortmeyer A, Butman JA, O’Malley J, Vidwan P, Dedrick RL, Oldfield EH, J Neurosurg, 1/1/2005
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Books/Book Chapters

The Chiari Malformations.
Chapter: Epidemiology of Chiari I Malformation.
Heiss JDEditors: Oakes WJ, Tubbs RS.Springer, New York2013
The Chiari Malformations.
Chapter: Treatment of Chiari I Malformation.
Heiss JD, Oldfield EHEditors: Oakes WJ, Tubbs RS.Springer, New York2013
Nanoneurosurgery.
Chapter: From Nanotechnology to Nanoneuroscience/Nanoneurosurgery and Nanobioelectronics: A Historical Review of Milestones.
Yamamoto V, Suffredini G, Nikzad S, Hoenk ME, Boer MS, Teo C, Heiss JD, Kateb BEditors: Kateb B, Heiss JD.Taylor & Francis, New York2013
Nanoneurosurgery.
Chapter: Peptide and Protein-Based Nanoparticles.
Khawaja AM, Heiss JDEditors: Kateb B, Heiss JD.Taylor & Francis, New York2013
Nanoneurosurgery.
Chapter: Dendrimers.
Khawaja AM, Heiss JD, Brady ROEditors: Kateb B, Heiss JD.Taylor & Francis, New York2013
Nanoneurosurgery.
Chapter: Therapy for Neuronopathic Lysosomal Storage Diseases.
Khawaja AM, Heiss JD, Brady ROEditors: Kateb B, Heiss JD.Taylor & Francis, New York2013
Nanoneurosurgery.
Chapter: Using Nanoparticles in the Diagnosis and Treatment of CNS Infection.
Zibly Z, Schlaff CD, Heiss JDEditors: Kateb B, Heiss JD.Taylor & Francis, New York2013
Nanoneurosurgery.
Chapter: Applications of Nanotechnology in Degenerative Disorders of the Brain.
Khawaja AM, Heiss JDEditors: Kateb B, Heiss JD.Taylor & Francis, New York2013
Nanoneurosurgery.
Chapter: Food and Drug Administration Regulatory Framework for Nanodrugs and Nanodevices and the Combination.
Yamamoto Y, Suffredini G, Heiss JD, Mishelevich D, Palmer G, Grundfest W, Kateb BEditors: Kateb B, Heiss JD.Taylor & Francis, New York2013
Schmidek & Sweet Operative Neurosurgical Techniques: Indications, Methods, and Results.
Chapter: Chiari Malformations and Syringomyelia.
Heiss JD, Oldfield EHEditors: Quinones-Hinojosa A.Elsevier, New YorkEdition 6th ,2012
Encyclopedia of Life Sciences (Nature, Scientific American)
Chapter: Syringomyelia and Related Diseases
Heiss JD, Oldfield EHEditors: Weatherall D, Nathan D.Macmillan Reference Limited, LondonEdition 2nd ,2009
Syringomyelia. Current concepts in pathogenesis and management.
Chapter: Hydrodynamics of Syringomyelia.
Oldfield EH, DeVroom H, Heiss JDEditors: Tamaki N, Batzdorf U, Nagashima T.Springer, Tokyo2001
Encyclopedia of Life Sciences (Nature, Scientific American)
Chapter: Syringomyelia and related diseases.
Heiss JD, Oldfield EHEditors: Weatherall D, Nathan D.Macmillan Reference Limited, London2001
Cancer: principles and practice of oncology.
Chapter: Spinal Cord Compression.
Fuller BG, Heiss JD, Oldfield EHEditors: DeVita VT Jr, Hellman S, Rosenberg SA.J.B. Lippincott, Philadelphia1996
Anterior cervical spine surgery.
Chapter: Anterior cervical diskectomy.
Page 15 - 29Heiss JD, Tew JM JrEditors: Whitecloud TS, Dunsker SB.Raven Press, New York1993
Neurosurgery: state of the art reviews
Chapter: Transsphenoidal Laser Microsurgery.
Page 441 - 445Heiss JD, Tew JM Jr.Editors: Sawaya R, Tew JM Jr.Hanley and Belfus, Philadelphia1987
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Abstracts/Posters

A Method to Record, Store, and Analyze Multiple Physiologic Pressure Recordings.
Sansur C, Eidsath A, DeVroom H, Heiss JD, The 14th IEEE Symposium on Computer-Based Medical Systems, Bethesda, MD, 7/1/2001

Lectures

Which Patients with Chiari Malformation
7/1/2013
Pathophysiology of Syringomyelia, International Guest Speaker,
Kazan, Tartar Republic, Russia - 6/1/2013
AAV2-GDNF Clinical Trial for Parkinson’s Disease.
NINDS, NIH - 6/1/2013
RTX Pain Study
Bethesda, MD - 5/1/2013
Pain And Function in Syringomyelia and Chiari I Malformation
New Orleans, LA - 4/1/2013
Basis and Plans for the Upcoming AAV2-GDNF Clinical Trial for PD
Clearwater Beach, FL - 4/1/2013
CSF Matters in Syrinx Formation
Sydney, Australia - 2/1/2013
Epidemiology of Chiari I Malformation
Chicago, IL - 11/1/2012
Quality of Life in Patients with Syringomyelia and Chiari I malformation.
Chicago, IL - 11/1/2012
Pathophysiology of Syringomyelia.
Bethesda, MD - 11/1/2012
Convection-Enhanced Delivery of Muscimol to the Epileptic Focus: Preclinical and Clinical Research
Chicago, IL - 10/1/2012
Primary Spinal Syringomyelia
Chicago, IL - 10/1/2012
Convection-Enhanced Delivery for Epilepsy
Chicago, IL - 10/1/2012
Intractable Pain—Ongoing and Future Research Studies
Bethesda, MD - 10/1/2012
Clinical Management of Syringomyelia and Chiari I Malformation.
Washington, DC - 9/1/2012
Pathophysiology of Syringomyelia
Cincinnati, OH - 9/1/2012
Chairman of Oral Poster Session
Toronto, Ontario, Canada - 6/1/2012
Brain Mapping in the Intraoperative MRI Suite
Washington, DC - 5/1/2012
Initial and Long-term Management of Patients with Chiari Malformations and Syringomyelia
Washington, DC - 10/1/2011
History of Convection Enhanced Delivery.
San Francisco, CA - 6/1/2011
Review of Syringomyelia
Washington, DC - 2/1/2011
Changes in Hindbrain Morphology after Craniocervical Decompression in Patients with Chiari I Malformation.
White Sulfur Springs, WV - 1/1/2011
Changes in Morphology of Hindbrain Structures after Craniocervical Decompression.
Chicago, IL - 11/1/2010
Surgical Management of Chiari and Syringomyelia.
San Francisco, CA - 10/1/2010
Syringomyelia.
Washington, DC - 10/1/2010
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