JohnAlexanderFreemanMDPh.D

Journal Articles

• Over 300 publications in peer-reviewed journals  
  John A. Freeman, et al, Science, Nature, PNAS
• Rapid arrest of axon elongation by brefeldin A: a role for the small GTP-binding protein ARF in neuronal growth cones  
  Hess D.T., Smith, D.S., Patterson, S.I., Kahn, R.A., Skene, J.H., Freeman, J. A., and Norden, J.J., J Neurobiol, 1/1/1999
• Up-regulation of fast-axonally transported proteins in retinal ganglion cells of adult rats with optic-peroneal nerve grafts  
  Wouters, B C, Bock-Samson, S, Little, K,, Freeman, J. A., and Norden, J. J., Brain Res Mol Brain Res, 1/1/1998
• Hess, D T, Lin, L H, Freeman, J A, Norden, J J Modification of cysteine residues within G(o) and other neuronal proteins by exposure to nitric oxide  
  Hess, D T, Lin, L H, Freeman, J A, Norden, J J, Neuropharmacology, 1/1/1994
• Dynamics of retinotectal synaptogenesis in normal and 3-eyed frogs: evidence for the postsynaptic regulation of synapse number  
  Norden, J J, Freeman, J. A., and Constantine-Paton, M., J Comp Neurol, 1/1/1994
• The role of GAP-43 in axon growth and synaptic plasticity in the visual system: Evolutionary implications  
  Norden, J. J., Wouters, B., Knapp, J., Bock, S. and Freeman, J. A., Vision and Visual Dysfunction, 1/1/1991
• Possible role of GAP-43 in calcium regulation/neurotransmitter release  
  Norden, J J, Lettes, A, Costello, B, Lin, L H, Wouters, B, Bock, S, Freeman, J A, Ann N Y Acad Sci, 1/1/1991
• Expression of the growth- and plasticity-associated neuronal protein, GAP-43, in PC12 pheochromocytoma cells  
  Costello, B, Lin, L H, Meymandi, A, Bock, S, Norden, J J, Freeman, J A, Prog Brain Res, 1/1/1991
• Light-microscopic immunolocalization of the growth- and plasticity-associated protein GAP-43 in the developing rat brain  
  McGuire, C B, Snipes, G J, Freeman, J. A., and Norden, J J, Brain Res, 1/1/1988
• Cloning of complementary DNA for GAP-43, a neuronal growth-related protein  
  Karns, K. R., Ng, S. C., Freeman, J. A. and MC Fishman, M. C., Science, 1/1/1987
• Evidence for the co-identification of GAP-43, a growth-associated protein, and F1, a plasticity-associated protein  
  Snipes, G. J., Chan, S. Y., McGuire, C. B., Costello, B. R., Norden, J. J., Freeman, J. A. and Routtenberg, A, J. Neurosci., 1/1/1987
• Regulation of specific neuronal and non-neuronal proteins during development and following injury in the rat CNS  
  Snipes, G. J., Costello, B., McGuire, C. B., Mayes, B. N., Bock, S. S., Norden, J. J. and Freeman, J. A., Prog. Brain Res, 1/1/1987
• Evidence for the coidentification of GAP-43, a growth-associated protein, and F1, a plasticity-associated protein  
  Snipes, G J, Chan, S Y, McGuire, C B, Costello, B R, Norden, J J, Freeman, J A, Routtenberg, A, J Neurosci, 1/1/1987
• A protein induced during nerve regeneration (GAP-43) is a major component of growth cone membranes  
  Skene, J.H.P., R.D. Jacobson, G.J. Snipes, C.B. McGuire, J.J. Norden, and J.A. Freeman, Science, 1/1/1986
• Nerve injury stimulates the secretion of Apolipoprotein E by non-neuronal cells  
  Snipes, G.J., C.B. McGuire, J.J. Norden, and J.A. Freeman, Proc. Nat. Acad. Sci., USA, 1/1/1986
• Steady growth cone currents revealed by a novel circularly vibrating probe: a possible mechanism underlying neurite growth  
  Freeman, J.A., P.B. Manis, G.J. Snipes, B.N. Mayes, P.C. Samson, J.P. Wikswo, and D.B. Freeman, J. Neurosci. Res., 1/1/1985
• Stereological methods for quantitating synapses  
  Norden, J.J., and J.A. Freeman, Acta Stereologica, 1/1/1984
• Real-time optical imaging of naturally evoked electrical activity in intact frog brain  
  Grinvald, A., L. Anglister, J.A. Freeman, R. Hildesheim, and A. Hanker, Nature, 1/1/1984
• Optimization of a circularly vibrating microprobe to measure minute biological currents  
  Freeman, J.A., Proc. Int. Physiol. Gong., 1/1/1983
• Magnetic measurements of action currents in an isolated lobster axon  
  Wikswo, J.P., J.P. Barach, S.C. Gunderson, J.O. Palmer, and J.A. Freeman, II Nuovo Cimeto, 1/1/1983
• First magnetic measurements of action currents in isolated cardiac Purkinje fibers  
  Wikswo, J.P., J.P. Barach, S.C. Gunderson, J.O. Palmer, and J.A. Freeman, II Nuovo Cimento, 1/1/1983
• Development of a circularly vibrating microprobe for measuring steady currents from living tissue  
  Freeman, J.A., and J.P. Wikswo, Biophysical J., 1/1/1982
• Analysis of alpha-bungarotoxin binding in the goldfish central nervous system  
  Oswald, R.E., and J.A. Freeman, J. Neurochem., 1/1/1982
• Measurement and interpretation of magnetic fields from action currents in a single nerve axon  
  Wikswo, J.P., J.O. Palmer, and J.A. Freeman, Biophysical J., 1/1/1982
• A new, accurate method for quantitating synaptic number  
  Norden, J.A., and J.A. Freeman, Anat. Record, 1/1/1982
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Books/Book Chapters

• Recovery from Neural Trauma 
  Chapter: Axonal and glial proteins associated with development and response to injury in the rat and goldfish optic nerve. 
  Page 26 - 38Freeman, J.A., S. Bock, M. Deaton, B. McGuire, J.J. Norden, and G.J. SnipesEditors: G. Gilad and M.Schwartz.Springer- Verlag1985
• Comparative Neurology of the Optic Tectum 
  Chapter: Neurotransmitters in the optic tectum of nonmammalians. 
  Page 469 - 546Freeman, J.A., and J.J. NordenEditors: H. Vanegas.Plenum Press, New York1984
• Contemporary Stereology, Third European Stereology Symposium 
  Chapter: Methods and correction factors for quantitating the number of synapses present in a given volume of brain tissue. 
  Page 519 - 523Norden, J.J., and J.A. FreemanEditors: W. DeHoff.1981
• Specificity in Retinotectal Connections 
  Chapter: Cholinergic mechanisms in the formation and maintenance of retinotectal connections. 
  Page 321 - 327Freeman, J.A.Editors: M.V. Edds, R.M. Gaze, G.E. Schneider, and L.N. Irwin.1979
• Proc. Third International Congress of Eye Research, Osaka, Japan 
  Chapter: In quest of the optic nerve transmitter. 
  Page 253 - 260Freeman, J.A. and R.E. Oswald1978
• Third International Congress of Eye Research, Osaka, Japan 
  Chapter: A quantitative EM study of degeneration in the optic tectum of Xenopus following enucleation. 
  Page 320 - 326Norden, J.J., A.J.C. Ostberg, and J.A. Freeman1978
• Advances in Electrophoresis 
  Chapter: Quantitation of brain proteins by computer analyzed two-dimensional electrophoresis. 
  Page 93 - 106Lutin, W.A., C.F. Kyle, and J.A. FreemanEditors: N. Catsimpoolas.Elsevier1978
• Cholinergic Receptor Mechanisms 
  Chapter: A comparison of the binding properties of muscarinic receptor in the brain of the rat and frog. 
  Page 103 - 112Birdsall, N.J.M., S.H. Chung, J.A. Freeman, and E.G. HulmeEditors: .A. Raftery.Calif. Inst. Tech. Press1977
• Neurobiology of Cerebellar Evolution and Development 
  Chapter: The cerebellum as a timing device: An experimental study in the frog. 
  Page 397 - 420Freeman, J.A.Editors: R. Llinas.American Medical Association/ERF, Chicago1969
• Neurobiology of Cerebellar Evolution and Development 
  Chapter: A technique for current density analysis of field potentials and its application to the frog cerebellum. 
  Page 421 - 430Freeman, J.A., and J. StoneEditors: R. Llinas.American Medical Association/ERF, Chicago1969
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Abstracts/Posters

• Regulation and phosphorylation of the growth-associated protein, GAP-43, in NGF-stimulated PC12 cells.
  Costello, B., G.J. Snipes, J.J. Norden, S.S. Bock and J.A. Freeman, Soc. Neurosci., 1/1/1986
• Regenerating optic nerve tips generate steady calcium currents.
  Freeman, J.A. and J.J. Norden, Investig. Ophthal. Visual Sci., 1/1/1986
• Apolipoproteins serve as markers in the CSF for demyelinating neuropathy.
  Bock, S.S., G.J. Snipes, J.J. Norden, and J.A. Freeman, Soc. for Neurosci., 1/1/1985
• Immunocytochemical localization of a neuronal growth-associated protein (GAP-43) in the neonatal rat brain.
  McGuire, C.B., J.J. Norden, S.S. Bock, and J.A. Freeman, Soc. For Neurosci., 1/1/1985
• Nerve injury stimulates apolipoprotein secretion by non-neuronal cells.
  Snipes, G.J., and J.A. Freeman, Soc. for Neurosci., 1/1/1985
• Regenerating optic nerves produce steady currents at their tips.
  Freeman, J.A., Soc. for Neurosci., 1/1/1985
• In vitro assessment of proposed nicotinic mechanisms in goldfish optic tectum.
  Langdon, R.B., J.S. Andrews, and J.A. Freeman, Invest. Ophthal., 1/1/1985
• Characterization of the 37 Kd protein associated with development and injury of the optic nerve.
  Snipes, G.J., C.B. McGuire, J.J. Norden, and J.A. Freeman, Invest. Ophthal., 1/1/1985
• Optical recordings of neural activity in the goldfish optic tectum.
  Manis, P.B., and J.A. Freeman, Invest. Ophthal., 1/1/1985
• Production of a specific antiserum that binds to degenerating fiber tracts in the rat CNS.
  McGuire, C.B., G.J. Snipes, J.J. Norden, and J.A. Freeman, Soc. for Neurosci., 1/1/1984
• Developmental program of protein expression in rat retinal ganglion cells.
  Bock, S., G.J. Snipes, J.J. Norden, J.A. Freeman, Soc. for Neurosci., 1/1/1984
• Voltage-sensitive dyes signal synaptic potentials in goldfish optic tectum in vitro.
  Manis, P.B., and J.A. Freeman, Soc. for Neurosci., 1/1/1984
• Characterization of the 37 Kd protein associated with nerve development and injury.
  Snipes, G.J., and J.A. Freeman, Soc. for Neurosci., 1/1/1984
• Electric fields affect active transport of proteins in neurons.
  Mayes, B.N., and J.A. Freeman, Soc. for Neurosci., 1/1/1984
• Glial cells secrete specific proteins during regeneration of the goldfish optic nerve which may play a role in axon growth.
  Deaton, M.A., and J.A. Freeman, Soc. for Neurosci., 1/1/1983
• Optical monitoring, of neuronal activity from the intact frog tectum using a photodiode array.
  Grinvald, A., L. Anglister, R. Hildesheim, and J.A. Freeman, Soc. for Neurosci., 1/1/1983
• Developing rat opt Li-nerves synthesize a specific set of growth-associated proteins.
  Bock, S., J.J. Norden, G.J. Snipes, and J.A. Freeman, Soc. for Neurosci., 1/1/1983
• Analysis of proteins released by nerve sheath cells during development.
  Snipes, G.J., J.H.P. Skene, and J.A. Freeman, Soc. for Neurosci., 1/1/1983
• Optimization of methods to measure biological currents using a circularly vibrating microprobe.
  Manis, P.B., P.C. Samson, and J.A. Freeman, Soc. for Neurosci., 1/1/1983
• Fine-structural analysis of retinal growth cones and retinotectal synaptogenesis in vivo and in vitro.
  Norden, J.J., G.J. Snipes, B.M. Mayes, and J.A. Freeman, Intl. Soc. for Develop. Neurosci., 1/1/1982
• Effects of substrate charge on neurite growth, orientation, and adhesion.
  Snipes, G.J., B.N. Mayes, and J.A. Freeman, Soc. for Neurosci., 1/1/1982
• Modification of an axonallv transported protein in toad retinotectal terminals.
  Skene, J.P.H., M. Willard, and J.A. Freeman, Soc. for Neurosci., 1/1/1982
• Fine-structural analysis of retinal growth cones and retinotectal synaptogenesis .in vivo and in vitro.
  Norden, J.J., G.J. Snipes, B.M. Mayes, and J.A. Freeman, Intl. Soc. for Develop. Neurosci., 1/1/1982
• Cultured retinal neurite growth cones generate steady currents that might play a role in development.
  Freeman, J.A., G.J. Snipes, B.N. Mayes, J. Weiss, J.J. Norden, Intl. Soc. for Develop. Neurosci., 1/1/1982
• Real-time measurements of minute neuronal currents with a circularly vibrating microprobe.
  Freeman, J.A., B.M. Mayes, G.J. Snipes, and J.P. Wikswo, Soc. for Neurosci., 1/1/1982
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Other

• AChE activity and ACh synthesis in the optic tectum of the toad B. marinus: probable identification of and optic nerve neurotransmitter. 
  Gruberg, E.R., and Freeman, J.A., M.I.T. Quarterly Progress Report
  1/1/1975
• Optic projections of the toad (Bufo Marinus) as seen with autoradiography. 
  Gruberg, E.R., and J.A. Freeman, M.I.T. Quarterly Progress Report
  1/1/1975
• Plot D, a pseudo 3-dimensional perspective display for the PDP-12. 
  Lubozynski, M., and J.A. Freeman, Digital Equipment Corp. Program Library
  1/1/1972
• Analysis of sensory information by the cerebellum. 
  Freeman, J.A., Massachusetts Institute of Technology
  8/1/1967
• "Psychiatrist's Personal Assistant" (Extensive Psychiatric EMR computer program) 
  John A. Freeman, MD, PhD
  http://www.soundlabs.com/PsychiatristsPersonalAssistant.htm
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