John C Edwards MD Ph.D.

PubMed

• Clinical Significance of Immune Deposits and Complement System Activation in FSGS: Findings from the CureGN Study.
  Yasar Caliskan, Virginie Royal, Stéphan Troyanov, Arnaud Bonnefoy, Clémence Merlen
  Kidney360. 2025-04-01
• 1 citations
  Renin angiotensin system-induced muscle wasting: putative mechanisms and implications for clinicians.
  Baris Afsar, Rengin Elsurer Afsar, Yasar Caliskan, Krista L Lentine, John C Edwards
  Molecular and Cellular Biochemistry. 2025-04-01
• LIM Zinc Finger Domain Containing 1 Risk Genotype of Recipient Is Associated with Renal Tubular Inflammation in Kidney Transplantation.
  Yasar Caliskan, Yasemin Ozluk, Kento Kurashima, Safak Mirioglu, Ahmet Burak Dirim
  Genes. 2024-06-13

Journal Articles

• Data supporting characterization of CLIC1, CLIC4, CLIC5 and DmCLIC antibodies and localization of CLICs in endoplasmic reticulum of cardiomyocytes  
  Ponnalagu D, Rao SG, Farber J, Xin W, Hussain AT, Shah K, Tanda S, Berryman MA, Edwards JC, Singh H, Data Brief., 1/26/2016
• Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice  
  Padmakumar VC, Speer K, Pal-Ghosh S, Masiuk KE, Ryscavage A, Dengler SL, Hwang S, Edwards JC, Coppola V, Tessarollo L, Stepp MA, Yuspa SH, Am J Pathol, 1/1/2012
• Chloride Transport  
  Edwards JC, Comprehensive Physiology, 1/1/2012
• What’s a CLIC doing in the podocyte?  
  Edwards, JC, Kidney Int, 1/1/2010
• Chloride intracellular channel-4 is a determinant of native collateral formation in skeletal muscle and brain  
  Chalothorn D, Zhang H, Smith JE, Edwards JC, and Faber JE, Circ. Res., 1/1/2009
• CLIC4 Functions in Angiogenesis by Supporting Acidification of Vacuoles Along the Intracellular Tubulogenic Pathway  
  Ulmasov B, Bruno J, Gordon N, Hartnett ME, and Edwards JC, Am. J. Path, 1/1/2009
• Isolation of peptide transport system-6 from brain endothelial cells: therapeutic effects with antisense inhibition in Alzheimer and stroke models  
  Dogrukol-Ak D, Kumar VB, Ryerse JS, Farr SA, Verma S, Nonaka N, Nakamachi T, Ohtaki H, Niehoff ML, Edwards JC, Shioda S, Morley JE, and Banks WA, J. Cereb. Blood Flow Metab, 1/1/2009
• The CLIC1 chloride channel is regulated by the cystic fibrosis transmembrane conductance regulator when expressed in Xenopus oocytes  
  Edwards JC, J. Membrane Biol, 1/1/2006
• Chloride Channel and c-Src Control of Osteoclast HCl Transport and Bone Resorption  
  Edwards JC, Cohen C, Xu CW, and Schlesinger PH, J. Biol. Chem., 1/1/2006
• Vascular Biology in uremia: insights into novel mechanisms of vascular injury  
  Al-Aly Z., and Edwards J, Adv. Chronic Kidney Disease, 1/1/2004
• CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo  
  Berryman M, Bruno J, Price J, and Edwards JC, J. Biol. Chem, 1/1/2004
• AKAP350 at the golgi apparatus II: association of AKAP350 with a novel chloride intracellular channel (CLIC) family member  
  Shanks RA, Larocca MC, Berryman M, Edwards JC, Urushidani T, Navarre J, and Goldenring JR, J. Biol. Chem., 1/1/2002
• Differential Expression of a chloride intracellular channel gene, CLIC4, in TGF-beta 1 mediated conversion of fibroblasts to myofibroblasts  
  Roonov-Jessen L, Villadsen R, Edwards JC, and Petersen OW, Am. J. Pathol, 1/1/2002
• CLIC-1 Directly Inserts From the Aqueous Phase Into Phospholipid Membranes Where it Functions as a Chloride Channel  
  Tulk BM, Kapadia S, and Edwards JC, Am. J. Physiol.: Cell Physiol, 1/1/2002
• The bovine kidney microsomal chloride channel p64 is regulated by p59-fyn, a src family tryosine kinase  
  Edwards JC, and Kapadia S, J. Biol. Chem., 1/1/2000
• CLIC-1 Functions as a Chloride Channel when Expressed and Purified from Bacteria  
  Tulk BM, Schlesinger, PH, and Edwards, JC, J. Biol. Chem., 1/1/2000
• A novel p64-related Cl channel: subcellular distribution and nephron segment-specific expresssion  
  Edwards JC, Am. J. Physiol. (Renal), 1/1/1999
• Functional expression of p64, an intracellular chloride channel  
  Edwards JC, Tulk BM, and Schlesinger P, J. Mem. Biol., 1/1/1998
• NCC27, a homolog of intracellular chloride channel p64, is expressed in the brush border of renal proximal tubule  
  Tulk BM, and Edwards JC, Am. J. Physiol. (Renal), 1/1/1998
• Characterization of the osteoclast ruffled border chloride channel and its role in bone resorption  
  Schlesinger PH, Blair HC, Teitelbaum SL, and Edwards JC, J. Biol. Chem, 1/1/1997
• Subcellular distribution and targeting of the intracellular chloride channel, p64  
  Redhead C, Sullivan SK, Kosecki C, Fugiwara K, and Edwards JC, Mol. Biol. Cell, 1/1/1997
• Cellular distribution and regulation of NHE -1 isoform of the Na-H exchanger in the avian osteoclast  
  Gupta A, Edwards JC and Hruska KA, Bone, 1/1/1996
• Avian cathepsin B cDNA: sequence and demonstration that mRNAs of two sizes produced in cell types producing large quantities of enzyme  
  Dong SS, Stransky GI, Whitaker CH, Jordan SE, Schlesinger PH, Edwards JC and Blair HC, Biochim. Biophy. Acta., 1/1/1995
• The apical Cl/HCO3 exchanges of ß intercalated cells is band 3  
  Van Adelsberg J, Edwards JC, Al-Awqati Q, J. Biol. Chem., 1/1/1993
• Molecular cloning and characterization of p64, a chloride channel protein from kidney microsomes  
  Landry D, Sullivan S, Nicolaides M, Redhead C, Edelman A, Field M, Al-Awqati Q, Edwards JC, J. Biol. Chem., 1/1/1993
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Abstracts/Posters

• The chloride channel activity of ApoL1
  Edwards, JC, Am. Soc. Of Nephrol Annual Meeting, 1/1/2014
• Chloride Channels CLIC1 and CLIC4 Function in Proximal Tubule Endocytosis
  Edwards, JC and Cheng, Y-W, Am. Soc. Of Nephrol. Annual Meeting, 1/1/2011
• CLIC1 Potentiates Acute Toxic Injury
  Ulmasov BV, Bruno, J, and Edwards JC, Am. Soc. of Nephrol. Annual Meeting, 1/1/2010
• CLIC4 and Acute Toxic Kidney Injury
  Kahl CR and Edwards JC, Am. Soc. of Nephrol. Annual Meeting, 1/1/2010
• Chloride Channel CLIC4 Functions in Angiogenesis by Supporting Acidification of Vacuoles along the Endothelial Tubulogenesis Pathway.
  Edwards, JC, Bruno, J., J. Am. Soc. Nephrol, 1/1/2008
• CLIC4 Knockout mice show defective endothelial tubulogenesis
  Edwards, JC, Ulmasov, B., and Bruno, J., J. Am. Soc. Nephrol., 1/1/2007
• Generation and phenotypic characterization of CLIC-family chloride channel knockout mice
  Edwards, JC, Bruno, J., and Ulmasov, B., J. Am. Soc. Nephrol., 1/1/2006
• Mapping membrane association domains in the CLIC-1 chloride channel
  Edwards, JC, J. Am. Soc. Nephrol., 1/1/2004
• Oxidation Regulates CLIC-1 Chloride Channel Activity and Membrane Association
  Edwards, JC, and Bruno, J, American Society for Cell Biology Annual Meeting, 1/1/2004
• CLIC-1 chloride channel is expressed in the apical domain of proximal tubule and other absorptive epithelia where it resides in vesicles along the endocytic pathway
  Edwards, JC, J. Am. Soc. Nephrol., 1/1/2003
• Recruitment of CLIC1 Chloride Channel into phospholipid membranesis enhanced by presence of a receptor cytoplasmic domain
  Edwards, JC, and Tulk, BM, J. Am. Soc. Nephrol., 1/1/2002
• Purified Recombinant CLIC-4 functions as a unique chloride selective channel when reconstituted in phsopholipid vesicles
  Edwards, JC, Tulk, BM, and Kapadia, S, J. Am. Soc. Nephrol., 1/1/2001
• CLIC-1 forms choride selective channels when inserted into membranes from the aqueous phase
  Tulk, BM, Kapadia, SA, and Edwards, JC, Biophys, 1/1/2001
• Functional CLIC1 directly inserts into membranes from the aqueous phase
  Edwards, JC, Tulk, BM, and Kapadia, S, J. Am. Soc. Nephrol, 1/1/2000
• The CLIC-1 chloride channel is regulated by CFTR in Xenopus oocytes
  Edwards, JC, Tulk, BM, Nichols, C, Sha, Q, and Schlesinger, P., J. Am. Soc. Nephrol., 1/1/1999
• CFTR Modulates the Activity of CLIC1 in Xenopus oocytes
  Tulk, BM, Sha, Q, Nichols, C., Schlesinger, P., and Edwards, JC, Pediatric Pulmonology, 1/1/1999
• Expression, purification and characterization of NCC27, a novel intracellular chloride channel
  Tulk, BM, Schlesinger, P, and Edwards, JC, Biophys. J., 1/1/1999
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Other

• Analysis of yeast mitochondrial RNA synthesis using a homologous in vitro transcription system (Doctoral Dissertation) 
  Edwards JC, University of Chicago
  1/1/1983