JohnFDipersioMD

Oncology • Saint Louis, MO

Hematologic Oncology

Division Chief, Oncologist

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Office
4921 Parkview Pl
# Dv
Saint Louis, MO 63110
Phone+1 314-454-8304

Fax+1 314-454-5902

Education & Training

UCLA David Geffen School of Medicine/UCLA Medical CenterFellowship, Hematology and Medical Oncology, 1984 - 1985
University of Texas Southwestern Medical CenterResidency, Internal Medicine, 1980 - 1984
University of Rochester School of Medicine and DentistryClass of 1980

Certifications & Licensure

CA State Medical License 1984 - Present
IL State Medical License 2021 - 2026
MO State Medical License 1994 - 2026
NY State Medical License 1990 - 1994
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Legacy Award Leukemia and Lymphoma Society of America, 2016
America's Top Doctors Castle Connolly, 2002-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
Fellow (FACP) American College of Physicians, 2012
CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2012
St. Louis Magazine: Top Doctors Castle Connolly, 2001
Elected Member The American Society for Clinical Investigation, 1996
Whos Who in Medicine and Healthcare Marquis Whos Who
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Clinical Trials

Arsenic Trioxide in Treating Patients With Refractory or Recurrent Acute Promyelocytic Leukemia Start of enrollment: 1998 Nov 01
Completed
Phase 1, Phase 2
Dosing Study of Ara-C/EL625/Idarubicin in Refractory and Relapsed AML Start of enrollment: 2004 Apr 01
Completed
Phase 2
Comparison of Fluconazole vs Voriconazole to Treat Fungal Infections for Blood and Marrow Transplants (BMT CTN 0101) Start of enrollment: 2003 Nov 01
Completed
Phase 3
Peripheral Blood Stem Cell Transplant vs Bone Marrow Transplant in Individuals With Hematologic Cancers (BMT CTN 0201) Start of enrollment: 2004 Jan 01
Completed
Phase 3
Stem Cell Transplantation in Individuals With Multiple Myeloma (BMT CTN 0102) Start of enrollment: 2003 Dec 01
Completed
Phase 3
Autologous or Donor Stem Cell Transplantation in Treating Patients With Recurrent Non-Hodgkin's Lymphoma (BMT CTN 0202) Start of enrollment: 2004 Aug 01
Terminated
Phase 2, Phase 3
Acute Myeloid Leukemia T Cell Depletion to Improve Transplants in Adults With Acute Myeloid Leukemia (BMT CTN 0303) Start of enrollment: 2005 Jun 01
Completed
Phase 2
Treatment for Acute Graft-Versus-Host Disease (BMT CTN 0302) Start of enrollment: 2005 Sep 01
Completed
Phase 2
Study Evaluating AMD3100 for Transplantation of Sibling Donor Stem Cells in Patients With Hematological Malignancies Start of enrollment: 2004 May 01
Completed
Phase 1, Phase 2
Efficacy & Safety of the Oral Neurokinin-1 Antagonist, Aprepitant, in Combo With Ondansetron & Dexamethasone in Patients Undergoing Auto Peripheral Blood Stem Cell Transplantation Start of enrollment: 2005 Oct 01
Completed
Early Phase 1
Rituxan/BEAM vs Bexxar/BEAM in Autologous Hematopoietic Stem Cell Transplant for Non-Hodgkin's Lymphoma (BMTCTN0401) Start of enrollment: 2005 Dec 01
Completed
Phase 3
Sirolimus/Tacrolimus Versus Tacrolimus/Methotrexate for Preventing Graft-Versus-Host Disease (GVHD) (BMT CTN 0402) Start of enrollment: 2006 Nov 01
Completed
Phase 3
A Study of Active Immunotherapy With GRNVAC1 in Patients With Acute Myelogenous Leukemia (AML) Start of enrollment: 2007 Jul 01
Completed
Phase 2
CC-4047 (Pomalidomide) for Graft vs. Host Disease Start of enrollment: 2009 Feb 01
Completed
Phase 2
Vorinostat to Prevent Graft Versus Host Disease Following Reduced Intensity, Related Donor Stem Cell Transplant Start of enrollment: 2009 Jan 01
Completed
Phase 1, Phase 2
Infusion of Genetically Modified T Cell for Post Transplant Patients With Relapsed Disease Start of enrollment: 2010 Oct 01
Completed
Phase 1
Tandem Stem Cell Transplantation for Non-Hodgkin's Lymphoma Start of enrollment: 2009 May 05
Active, not recruiting
Phase 2
Intravenous (IV) AMD3100 for Mobilization and Matched Related Transplant for Advanced Hematological Malignancies Start of enrollment: 2009 Aug 01
Completed
Phase 2
Decitabine Maintenance for Acute Myelogenous Leukemia (AML) and Myelodysplastic Syndrome (MDS) Post Transplant Start of enrollment: 2009 Dec 01
Completed
Phase 1
Granulocyte Colony-stimulating Factor (G-CSF) Plus or Minus AMD3100 for Engraftment Post Allogeneic Transplant Start of enrollment: 2010 Apr 29
Completed
Phase 1
Stem Cell Transplant With Lenalidomide Maintenance in Patients With Multiple Myeloma (BMT CTN 0702) Start of enrollment: 2010 May 01
Completed
Phase 3
Carfilzomib, Pegylated Liposomal Doxorubicin Hydrochloride, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma Start of enrollment: 2012 May 14
Completed
Phase 1, Phase 2
NK Cell Based Non-Myeloablative Transplantation in Acute Myeloid Diseases Start of enrollment: 2011 Sep 01
Completed
Phase 2
Safety and Efficacy of POL6326 for Mobilization/Transplant of Sibling Donor in Patients With Hematologic Malignancies Start of enrollment: 2012 Apr 01
Completed
Phase 1, Phase 2
Brentuximab Vedotin Prevention of (GVHD) After Unrelated Allogeneic Stem Cell Transplantation Start of enrollment: 2013 Feb 25
Completed
Phase 1
Geriatric Assessments in Senior Adults With Multiple Myeloma Start of enrollment: 2012 Sep 01
Completed
Azacitidine in Patients Undergoing Matched Unrelated Stem Cell Transplantation Start of enrollment: 2013 Apr 15
Terminated
Phase 1, Phase 2
Cytokine-induced Memory-like NK Cells in Patients With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) Start of enrollment: 2014 Aug 11
Terminated
Phase 1, Phase 2
Study of Melphalan HCl for Injection (Propylene Glycol-free), Carmustine, Etoposide, Cytarabine (BEAM Regimen) and Autologous Stem Cell Transplantation for Lymphoma Start of enrollment: 2014 Mar 19
Completed
Phase 2
Allogeneic or Haploidentical Stem Cell Transplant Followed By High-Dose Cyclophosphamide in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Start of enrollment: 2014 Feb 28
Terminated
Phase 1
Non-inferiority Study of XM02 Filgrastim (Granix) and Filgrastim (Neupogen) in Combination With Plerixafor for Autologous Stem Cell Mobilization in Patients With Multiple Myeloma or Non-Hodgkin Lymphoma Start of enrollment: 2014 Aug 20
Completed
Phase 2
A Study of Granix to Disrupt the Bone Marrow Microenvironment in Patients With Multiple Myeloma Undergoing Autologous Transplantation Start of enrollment: 2015 Jan 20
Terminated
Phase 2
Flotetuzumab in Primary Induction Failure (PIF) or Early Relapse (ER) Acute Myeloid Leukemia (AML) Start of enrollment: 2014 Jun 09
Terminated
Phase 1, Phase 2
Phase I Study of Bortezomib With G-CSF for Stem Cell Mobilization in Patients With Multiple Myeloma Start of enrollment: 2015 Feb 20
Completed
Phase 1
Allogeneic Stem Cell Transplantation for Patients With Multiple Myeloma Start of enrollment: 2015 Dec 01
Withdrawn
Early Phase 1
Multi-Ctr PII Cmb.Modality Tx Ruxolitinib, Decitabine, and DLI for Post HSCT in AML/MDS Start of enrollment: 2020 Feb 17
Completed
Phase 2
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Publications & Presentations

PubMed

Integration of Clinical Trial Development in Hematology-Oncology Fellowship Training.
Christine Auberle, Ningying Wu, John F Dipersio, Saiama N Waqar, Lee Ratner
Academic Medicine. 2025-01-01
5 citations
Menin Inhibition With Revumenib for-Rearranged Relapsed or Refractory Acute Leukemia (AUGMENT-101).
Ghayas C Issa, Ibrahim Aldoss, Michael J Thirman, John DiPersio, Martha Arellano
Journal of Clinical Oncology. 2025-01-01
Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors.
Ju-Fang Chang, Jack H Landmann, Tien-Ching Chang, Mehmet Emrah Selli, Yangdon Tenzin
Cancer Discovery. 2024-11-01

Journal Articles

Secondary Acute Lymphoblastic Leukemia, a Retrospective Analysis from Washington University and Meta-Analysis of Published Data
Francesca Ferraro, Peter Westervelt, John F Dipersio, Armin Ghobadi, Leukemia Research
Single Institution Experience with G-CSF Mobilized T-cell Replete Haploidentical Hematopoietic Cell Transplantation
M A Schroeder, R Romee, J F DiPersio, T A Fehniger, F Gao, G L Uy, C N Abboud, P Westervelt, R Vij, Nature

Abstracts/Posters

CXCR4 Inhibition with BL-8040 in Combination with Nelarabine in Patients with Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia / Lymphoblastic Lymphoma
John F. DiPersio, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Increased Early Mortality after Fludarabine and Melphalan Conditioning with Peripheral Blood Grafts in Haploidentical SCT with Post-Transplant Cyclophosphamide
John F. DiPersio, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Single-Cell Pathway Enrichment and Regulatory Profiling of Multiple Myeloma across Disease Stages
John F. DiPersio, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Updated Study Results of CX-01, an Inhibitor of CXCL12/CXCR4, and Azacitidine for the Treatment of Hypomethylating Agent Refractory AML and MDSClinically Relevant Abst...
John F. DiPersio, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
CD45-ADC Plus Janus Kinase (JAK) Inhibitors As Conditioning for MHC-Mismatched Murine Hematopoietic Stem Cell Transplantation Is Associated with Minimal Toxicity and G...
John F. DiPersio, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Identification of Small Molecule Kinase Inhibitors That Potently and Reversibly Block Chimeric Antigen Receptor T Cell Proliferation and Cytotoxicity
John F. DiPersio, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Flotetuzumab, an Investigational CD123 x CD3 Bispecific Dart¬ Protein, in Salvage Therapy for Primary Refractory and Early Relapsed Acute Myeloid Leukemia (AML) Patients
John F. DiPersio, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Blocking JAK1/JAK2 While Sparing JAK3 Not Only Prevents GvHD but Also Promotes Damaged Tissue Repair
John F. DiPersio, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Targeting CXCR4, VLA4, and CXCR2 for Hematopoietic Stem Cell Mobilization
John F. DiPersio, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/2019
Dramatic Resolution of HLH after Treatment with the JAK 1/2 Inhibitor, Ruxolitinib
John F. DiPersio, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Immune Landscapes Predict Chemotherapy Resistance and Anti-Leukemic Activity of Flotetuzumab, an Investigational CD123_CD3 Bispecific Dart¬ Molecule, in Patients with ...
John F. DiPersio, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
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Lectures

Rapid and Robust Mobilization of CD34+ HSCs without G-CSF Following Administration of Mgta-145 Alone or in Combination with Plerixafor
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
A Long-Acting Pharmacological Grade Interleukin-7 Molecule Logarithmically Accelerates Ucart Proliferation, Differentiation, and Tumor Killing
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Conditioning for Hematopoietic Stem Cell Transplantation Using Antibody-Drug Conjugate Targeting CD45 Permits Engraftment across Immunologic Barriers
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Phase II Study Evaluating the Safety and Efficacy of BL-8040 for the Mobilization of Donor Hematopoietic Stem and Progenitor Cells for Allogeneic Hematopoietic Cell Tr...
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Chimeric Antigen Receptor T Cells Specific for CLL-1 for Treatment of Acute Myeloid Leukemia
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Investigating the Effects of Clonal Hematopoiesis in Healthy Marrow and Blood Donors on the Outcomes of Recipients Following Hematopoietic Stem Cell Transplantation
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Comprehensive Multi-Omics Analysis of Gene Fusions in a Large Multiple Myeloma Cohort
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Phase 1 First-in-Human Trial of AMV564, a Bivalent Bispecific (2x2) CD33/CD3 T-Cell Engager, in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML)Clinicall...
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Advancing Care for Patients With GvHD: Making Sense of Recent Approvals and Late-Stage Compounds
60th American Society of Hematology Annual Meeting - 11/30/2018
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Authored Content

Secondary Acute Lymphoblastic Leukemia, a Retrospective Analysis from Washington University and Meta-Analysis of Published DataAugust 2018

Press Mentions

$10.8 Million Grant Supports Cutting-Edge Leukemia ResearchDecember 16th, 2024
Itacitinib Helps Prevent Graft Versus Host Disease in Stem Cell Transplant RecipientsDecember 10th, 2024
HMN 2024: New Drug Tested to Reduce Side Effect of ‘Half-Matched’ Stem Cell TransplantsDecember 6th, 2024
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Grant Support

Washington University PAUL Calabresi Career Development Award For Clinical OncoloNational Cancer Institute2012
Targeting Aml-Stromal InteractionsNational Cancer Institute2011–2012
Genomics Of Acute Myelogenous Leukemia (Aml): Relapse And Resistance FactorsNational Cancer Institute2008–2012
RES Proj 4: PET Imaging Of GVHD &Gvl Modulation Using Genetically-Modified...National Cancer Institute2007–2011
Targeting The Cxcr4-Sdf1 Axis As Therapy For Relapsed/Refractory AMLNational Cancer Institute2009–2010
Optimizing Allogeneic Transplantation Using CXCR4 BlockadeNational Cancer Institute2009–2010
DLI Using Genetically Modified T Cells: Phase 1 TrialNational Cancer Institute2004–2005
Genetic Manipulation Of T Cells--Preclinical ModelsNational Cancer Institute2001–2005
Progenitor Mobilization In Breast CancerNational Cancer Institute1994–1996
Progenitor Mobilization In Breast CancerNational Cancer Institute1993
The NA+/H+ Exchanger In Human Granulocytic CellsNational Institute Of General Medical Sciences1990–1991