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Office
231 Albert Sabin Way, ML 0551, Room 6065 Cincinnati OH 45267-0551
Cincinnati, OH 45267Phone+1 513-558-0858
Summary
- I am currently Chair, Department of Internal Medicine at the University of Cincinnati and also a physician scientist who has done translational and clinical drug development for two decades. Closest to me professional being is performing as an exceptional, empathetic board certified hematologist in care of patients with blood cancers. My laboratory and clinical research has directly resulted in 7 drugs getting FDA approval. This experience bridges close interaction with industry as a consultant to develop and implement a successful development plan (Calistoga, Idelalisib) to performing pre-clinical and clinical work in my University role focused on a single class of drugs that transformed the care of CLL (Ibrutinib, Acalabrutinib) and other B-cell malignancies. My role in the current Leukemia and Lymphoma Society Beat AML Study as Principal and Chief Medical Officer has offered an even larger extension of this by planning, implementing, and running a multi-center umbrella study in AML that brings together academic clinical investigators, diagnostic companies, pharmaceutical companies, clinical research organizations and the FDA to effectively move new therapies forward to the clinic.
Education & Training
- National Capital ConsortiumFellowship, Hematology and Medical Oncology, 1994 - 1997
- National Capital Consortium (Walter Reed)Residency, Internal Medicine, 1991 - 1994
- University of Arkansas For Medical Sciences College of MedicineClass of 1991
- Hendrix CollegeB.A., Chemistry, With distinction, 1987
Certifications & Licensure
- OH State Medical License 2001 - 2025
- VA State Medical License 1993 - 2020
- American Board of Internal Medicine Hematology
Awards, Honors, & Recognition
- Return of the Child Award Leukemia and Lymphoma Society, 2017
- Fellow American College of Physicians, 2017
- Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research AACR, 2016
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Clinical Trials
- Fludarabine and Monoclonal Antibody Therapy in Treating Patients With Untreated B-cell Chronic Lymphocytic Leukemia Start of enrollment: 1998 Mar 01
- Monoclonal Antibody Therapy in Treating Patients With Chronic Lymphocytic Leukemia, Lymphocytic Lymphoma, Acute Lymphoblastic Leukemia, or Acute Myeloid Leukemia Start of enrollment: 2001 Apr 01
- Alvocidib, Fludarabine Phosphate, and Rituximab in Treating Patients With Lymphoproliferative Disorders or Mantle Cell Lymphoma Start of enrollment: 2003 Apr 01
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Publications & Presentations
PubMed
- Outcomes of patients with Richter transformation who received no prior chemoimmunotherapy for their CLL.Adam S Kittai, Ying Huang, Sarah Miller, John N Allan, Seema A Bhat
Blood Cancer Journal. 2025-02-20 - Correction: Efficacy and safety in a 4-year follow-up of the ELEVATE-TN study comparing acalabrutinib with or without obinutuzumab versus obinutuzumab plus chlorambuci...Jeff P Sharman, Miklos Egyed, Wojciech Jurczak, Alan Skarbnik, John M Pagel
Leukemia. 2025-02-01 - CD37 in acute myeloid leukemia: a novel surface target for drug delivery.Erin Jeremy, Esthela Artiga, Sara Elgamal, Carolyn Cheney, Dalen Eicher
Blood Advances. 2025-01-14
Journal Articles
- Non-Hodgkin’s lymphomasZelenetz AD, Abramson JS, Advani RH, Andreadis B, Bartlett N, Bellam N, Byrd JC, Czuczman MS, Fayad LE, Glenn MJ, Gockerman JP, Gordon LI, Harris NL, Hoppe RT, Horwitz..., J Natl Compr Canc Netw, 1/1/2011
- Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitorsLu Q, Yang YT, Chen CS, Davis M, Byrd JC, Etherton MR, Umar A, Chen CS, J Med Chemistry, 1/15/2004
- Enhanced pneumocystis carinii activity of new primaquine analoguesGoodwin TE, Boylan CJ, Current WL, Byrd JC, Edwards CB, Fuller DA, Green JL, Larocca CD, Raney KD, Ross AS, Tucker WA, Bioorg Med Chem Lett, 1/2/2000
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Press Mentions
- Ohio State's Novel DHODH Inhibitor Enters First Human TrialsSeptember 16th, 2024
- Meet the OSU Cancer Center Doctor Who Calls His CLL Leukemia a 'Silver Lining'August 28th, 2024
- Next, Now Campaign Closes with $2.19 Billion in GiftsAugust 27th, 2024
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Grant Support
- Lenalidomide As An Immune Modulating Agent For Chronic Lymphocytic LeukemiaNational Cancer Institute2009–2011
- Experimental Therapeutics Of LeukemiaNational Cancer Institute2009–2011
- Administration And OperationsNational Cancer Institute2009–2011
- Translational Training Grant In Experimental TherapeuticsNational Cancer Institute2008–2011
- Innate Immune Therapies In B Cell MalignanciesNational Cancer Institute2007–2011
- 2010 Clinical Research Training Institute Summer WorkshopNational Heart, Lung, And Blood Institute2010
- Clinical Investigation Of Epigenetic TherapyNational Cancer Institute2006–2010
- Clinical Trial OfficeNational Cancer Institute2005–2009
- Hu1d10 In CLL: Clinical And Laboratory StudiesNational Cancer Institute2003–2006
- Molecular Markers: Response To Chemo-Immunotherapy In C*National Cancer Institute2005
- Epigenetic Targeted Therapy For Chronic Lymphocytic Leu*National Cancer Institute2005
- Molecular Markers: Response To Chemo-Immunotherapy In CLNational Cancer Institute2004
- Chronic Lymphocytic Leukemia:Epigenetic Targeted TherapyNational Cancer Institute2004
- Depsipeptide: A Novel Histone Deacytlase Inhibitor In LNational Cancer Institute2002–2003
- Clinical Investigation Of The Innate Immune SystemNational Cancer Institute2002
- A Phase 1 Study Of Hud10 In Cll/Sll PatientsNational Cancer Institute2001–2002
- Cancer And Leukemia Group BNational Cancer Institute1999
Professional Memberships
- Member
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