JohnPattersonAtkinsonMD

PubMed

• Multiorgan involvement and circulating IgG1 predict hypocomplementaemia in IgG4-related disease.
  Guy Katz, Cory Perugino, Zachary S Wallace, Bohang Jiang, Thomas Guy
  Annals of the Rheumatic Diseases. 2024-11-14
• 5 citations
  Engineering human pluripotent stem cell lines to evade xenogeneic transplantation barriers.
  Hannah A Pizzato, Paula Alonso-Guallart, James Woods, Jon P Connelly, Todd A Fehniger
  Stem Cell Reports. 2024-02-13
• 2 citations
  Complement receptor 1 is the human erythrocyte receptor forerythrocyte binding protein.
  Seong-Kyun Lee, Cécile Crosnier, Paola Carolina Valenzuela-Leon, Brian L P Dizon, John P Atkinson
  Proceedings of the National Academy of Sciences of the United States of America. 2024-01-30

Journal Articles

• Blood Concentrations of Complement Split Product iC3b and Serum C3 Associate with SLE Disease Activity  
  Deepali P Sen, John P Atkinson, Vibeke Strand, Arthritis & Rheumatology
• TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia  
  Kothari P, Kolar G, Jen J, Hajj-ali R, Bertram P, Schmidt R, Atkinson J, Brain Pathol, 1/1/2018
• Timing and mechanism of conceptus demise in a complement regulatory membrane protein deficient mouse  
  Triebwasser MP, Wu, X, Bertram P, Hourcade DE, Nelson DM, Atkinson JP, Am J Reprod Immunol, 1/1/2018
• Transcriptional profiling of synovial macrophages using minimally invasive ultrasound-guided synovial biopsies in rheumatoid arthritis  
  Mandelin AM, Homan PJ, Shaffer AM, Cuda CM, Dominguez ST, Bacalao E, Carns M, Hinchcliff M, Lee J, Aren K, Thakrar A, Montgomery AB, Bridges L, Bathon JM, Atkinson JP,..., Arthritis Rheumatol, 1/1/2018
• The complement system in the airway epithelium: An overlooked host defense mechanism and therapeutic target?  
  Kulkarni, HS, Liszewski MK, Brody SL, Atkinson JP, J Allergy Clin.Immunol, 1/1/2018
• Contribution of adipose-derived factor D/adipsin to alternative complement activation: Lessons from lipodystrophy  
  Wu X, Hutson I, Akk A, Marcharak S, Pham CTN, Hourcade DE, Brown R, Atkinson JP, Harris C, J Immunol, 1/1/2018
• Complement dysregulation and disease: Insights from contemporary genetics  
  Liszewski, M.K., Java, A., Schramm, E.C., and Atkinson, J.P., Annual Rev Pathol: Mechanisms of Disease, 1/1/2017
• A 55-year-old man with periorbital and inguinal masses, pericarditis and pleuritis (cover)  
  Vu K, Gupta R, Frater J, Atkinson J, Ranganathan P, Arthritis Care Res, 1/1/2017
• Protective low frequency variants for preeclampsia in the FLT1 gene in the Finnish population  
  Lokki AI, Daly E, Triebwasser M, Kurki MI, Roberson EO, Happola P, Auro K, Perola M, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Salmon JE, Meri S, Daly M, Atk..., Hypertension, 1/1/2017
• DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice  
  Sakai T, Miyazaki T, Shin D-M, Kim Y-S, Qi C-F, Fariss R, Munasinghe J, Wang H, Kovalchuk AL, Kothari PH, Fermaintt CS, Atkinson JP, Ferrino FW, Yan N, Morse HC, J Autoimmunity, 1/1/2017
• A C3(H2O) recycling pathway of the intracellular complement system  
  Elvington, M, Liszewski MK, Kulkarni HS, Atkinson JP, J Clin Invest, 1/1/2017
• The complement regulatory protein CD46 deficient mouse spontaneously develops dry-type age-related macular degeneration-like phenotype  
  Lyzogubov VV, Bora PS, Wu X, Horn LE, de Roque R, Rudolf XV, Atkinson JP, Bora NS, Am J Path, 1/1/2016
• Bone lesions, lymphadenopathy and hepatic granulomas in a patient with psoriasis (cover)  
  Vu K, Atkinson J, Ranganathan P, Arthritis Care Res, 1/1/2016
• Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S)  
  Stam AH, Kothari PH, Shaikh A, Gschwendter A, Jen JC, Hodgkinson S, Hardy TA, Hayes M, Kempster PA, Kotschet KE, Bajema IM, van Duinen SG, Maat-Schieman MLC, de Jong P..., Brain, 1/1/2016
• Regulators of complement activity mediate host protection mechanisms through common C3b-binding mode  
  Forneris F, Wu J, Xue X, Ricklin D, Lin Z, Sfyroera G, Tzekou A, Volokhina E, Granneman JCM, Hauhart R, Bertram P, Liszewski MK, Atkinson JP, Lambris JD, Gros P, EMBO J, 1/1/2016
• Early components of complement classical activation pathway in human systemic autoimmune diseases  
  Lintner K, Wu YL, Yang Y, Spencer C, Hauptmann G, Hebert L, Atkinson J, Yung Yu C (Carroll MC, editor), Frontiers in Immunology, 1/1/2016
• Evolution of the complement system: from defense of the single cell to guardian of the intravascular space  
  Elvington M, Liszewski MK, Atkinson JP, Immunological Reviews, 1/1/2016
• Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells  
  Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B, J Clin Invest, 1/1/2016
• Secreted NA1 protects dengue virus from mannose binding lectin-mediated neutralization  
  Thiemmeca S, Tamdej C, Punyadee N, Prommool T, Songjaeng A, Noisakran S, Puttikhunt C, Atkinson JP, Diamond MS, Ponlawat A, Avirutnan P, J Immunol, 1/1/2016
• Von Willebrand factor regulates complement on endothelial cells  
  Noone DG, Riedl M, Pluthero FG, Bowman ML, Liszewski MK, Lu L, Quan Y, Balgobin S, Schneppenheim R, Schneppenheim S, Budde U, James P, Atkinson JP, Palaniyar N, Kahr W..., Kidney Int, 1/1/2016
• Complement�s hidden arsenal: new insight and novel functions inside the cell  
  Liszewski MK, Elvington M, Kulkarni HS, Atkinson JP, Molecular Immunology, 1/1/2016
• Analysis of the putative role of CR1 in Alzheimer�s disease: Genetic association, expression and function  
  Fonseca MI, Chu S, Pierce AL, Brubaker WD, Hauhart RE, Mastroeni D, Clarke EV, Rogers J, Atkinson JP, Tenner AJ, PLoS One, 1/1/2016
• Mapping rare, deleterious mutations in Factor H: Association with early onset, drusen burden, and lower antigenic levels in familial AMD  
  Wagner E, Raychaudhuri S, Villalonga M, Java A, Triebwasser M, Daly M, Atkinson J, Seddon J, Scientific Rep, 1/1/2016
• A quantitative lateral flow assay to detect complement activation in blood  
  Schramm EC, Staten NR, Zhang Z, Bruce SS, Kellner C, Atkinson JP, Kyttaris VC, Tsokos GC, Petri M, Connolly ES, Olson PK, Analytical Biochem, 1/1/2015
• Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome  
  Schramm E, Roumenina LT, Rybkine T, Chauvet S, Vierira-Martins P, Hue C, Maga T, Valoti E, Wilson V, Jokiranta S, Smith RJH, Noris M, Goodship T, Atkinson JP, Fremeaux..., Blood, 1/1/2015
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Books/Book Chapters

• Complement FactsBook 
  Chapter: CD46, Membrane cofactor protein regulatory proteins. 
  Page 271 - 278Liszewski MK, Atkinson JPEditors: Barnum S, Schein T.Edition 2nd,2018
• Encyclopedia of Medical Immunology. 
  Chapter: Complement deficiencies associated with atypical hemolytic uremic syndrome. 
  Page 1 - 9Schramm EC, Java A, Liszewski MK, Atkinson JPEditors: Mackay I, Rose, NR.Springer Science + Business Media LLC2017
• Systemic Lupus Erythematosus, Basic, Applied and Clinical Aspects. 
  Chapter: The complement system in systemic lupus erythematosus. 
  Page 81 - 112Atkinson JP, Yung Yu CEditors: Tsokos GC.2016
• Cecil Medicine, Volume I 
  Chapter: Complement system in disease. 
  Page 240 - 246Atkinson JPEdition 25th,2015
• Washington Manual Subspecialty Consult Series, Rheumatology Subspecialty Consult 
  Chapter: Vasculitis, Takayasu’s Arteritis 
  Atkinson, J.P. (Faculty co-author)Department of Medicine, Washington University School of MedicineEdition 2nd,2012
• Washington Manual Subspecialty Consult Series, Rheumatology Subspecialty Consult 
  Chapter: Giant Cell Arteritis and Polymyalgia Rheumatica 
  Atkinson, J.P. (Faculty co-author)Department of Medicine, Washington University School of MedicineEdition 2nd,2012
• Washington Manual Subspecialty Consult Series, Rheumatology Subspecialty Consult 
  Chapter: Polyarteritis Nodosa 
  Atkinson, J.P. (Faculty co-author)Department of Medicine, Washington University School of MedicineEdition 2nd,2012
• Washington Manual Subspecialty Consult Series, Rheumatology Subspecialty Consult 
  Chapter: Wegener’s Granulomatosis 
  Atkinson, J.P. (Faculty co-author)Department of Medicine, Washington University School of MedicineEdition 2nd,2012
• Washington Manual Subspecialty Consult Series, Rheumatology Subspecialty Consult 
  Chapter: Churg-Strauss Syndrome 
  Atkinson, J.P. (Faculty co-author)Department of Medicine, Washington University School of MedicineEdition 2nd,2012
• Washington Manual Subspecialty Consult Series, Rheumatology Subspecialty Consult 
  Chapter: Microscopic Polyangiitis 
  Atkinson, J.P. (Faculty co-author)Department of Medicine, Washington University School of MedicineEdition 2nd,2012
• Washington Manual Subspecialty Consult Series, Rheumatology Subspecialty Consult 
  Chapter: Henoch-Schonlein Purpura 
  Atkinson, J.P. (Faculty co-author)Department of Medicine, Washington University School of MedicineEdition 2nd,2012
• Washington Manual Subspecialty Consult Series, Rheumatology Subspecialty Consult 
  Chapter: Cryoglobulinemia and Cryglobulinemic Vasculitis 
  Atkinson, J.P. (Faculty co-author)Department of Medicine, Washington University School of MedicineEdition 2nd,2012
• Washington Manual Subspecialty Consult Series, Rheumatology Subspecialty Consult 
  Chapter: Cutaneous Vasculitis 
  Atkinson, J.P. (Faculty co-author)Department of Medicine, Washington University School of MedicineEdition 2nd,2012
• Washington Manual Subspecialty Consult Series, Rheumatology Subspecialty Consult 
  Chapter: Thromboangiitis Obliterans 
  Atkinson, J.P. (Faculty co-author)Department of Medicine, Washington University School of MedicineEdition 2nd,2012
• Washington Manual Subspecialty Consult Series, Rheumatology Subspecialty Consult 
  Chapter: Behcet’s Disease 
  Atkinson, J.P. (Faculty co-author)Department of Medicine, Washington University School of MedicineEdition 2nd,2012
• American Society of Hematology Education Program Book 
  Chapter: Too much of a good thing at the site of tissue injury: The instructive example of the complement system predisposing to thrombotic microangiopathy. 
  Page 9 - 14Liszewski, M.K., and Atkinson, J.P.2011
• Systemic Lupus Erythematosus. 
  Chapter: Genetic susceptibility and class III complement genes. 
  Page 21 - 45Atkinson JP, Yung Yu CEditors: Lahita RG, Tsokos G, Buyon J, Koike T.Elsevier Academic PressEdition 5th,2010
• Current Topics in Microbiology and Immunology; Measles: History and Basic Biology 
  Chapter: Measles virus and CD46. 
  Page 31 - 57Kemper, C., and Atkinson, J.P.Editors: Griffen, D.E., Oldstone, M.B.A..Springer-Verlag, Berlin Heidelberg2009
• Kelley’s Textbook of Rheumatology 
  Chapter: Complement system. 
  Page 323 - 337Atkinson, J.P.Editors: Firestein, G.S., Budd, R.C., Harris, E.D., McInnes, I.B., Ruddy, S., and Sergent, J.S..Saunders ElsevierEdition Eigh,2009
• Kelley�s Textbook of Rheumatology 
  Chapter: Complement system. 
  Page 323 - 337Atkinson JPEditors: Firestein GS, Budd RC, Harris ED, McInnes IB, Ruddy S, Sergent JS.Saunders ElsevierEdition 8th,2009
• Current Topics in Microbiology and Immunology; Measles: History and Basic Biology. 
  Chapter: Measles virus and CD46. 
  Page 31 - 57Kemper C, Atkinson JPEditors: Griffen DE, Oldstone MBA.Springer-Verlag, Berlin Heidelberg2009
• Complement and Kidney Diseases 
  Chapter: Genetic testing in atypical HUS and the role of membrane cofactor protein (MCP; CD46) and factor I. 
  Page 111 - 127Goodship, T.H.J., Fremeaux-Bacchi, V., and Atkinson, J.P.Editors: Peter Zipfel.Birkhauser Verlag, Basel, Switzerland2006
• ACP Medicine 
  Chapter: Sensing a role for innate immunity in chronic disease. 
  Page 1 - 2Atkinson, J.P.WebMD, Inc.2006
• ACP Medicine 
  Chapter: Debris, inflammatory reactions, and ills of old age. 
  Page 1 - 2Atkinson, J.P.WebMD, Inc.2006
• ACP Medicine. 
  Chapter: Sensing a role for innate immunity in chronic disease. 
  Atkinson JPWebMD, Inc.2006
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Abstracts/Posters

• A new mouse model of Dengue shock syndrome identifies complement activation as a novel target for pharmacological intervention.
  Pinto, A.K., Brien, J.D., Wu, X., Tang, W., Eddy, W.E., Atkinson, J.P., Shresta, S., and Diamond, M.S., Fourth Panamerican Dengue Research Network Meeting, Belem, Brazil, 10/20/2014
• A loss of type I IFN signaling in myeloid cells results in a MAVS-dependent induction of cytokine storm, complement activation, and sepsis after viral infection.
  Pinto, A.K., Ramos, H.J., Wu, X., Aggarwal, S., Shrestha, B., Gorman, M., Kim, K.Y., Suthar, M.S., Atkinson, JP., Gale, Jr., M., and Diamond, M.S., Keystone Meeting on Viral Infection, Breckenridge, CO, 3/30/2014
• Whole exome sequencing identifies rare, functional CFH variants in families with macular degeneration.
  Yu, Y., Triebwasser, M.P., Wong, E.K.S., Schramm, E.C., Thomas, B., Mardis, E., Atkinson, J.P., Daly, M., Raychaudhuri, S., Kavanagh, D., and Seddon, J.M., American Society of Human Genetics Meeting, San Diego, CA, 1/1/2014
• Cd46-/- mouse as a model of dry-type age-related macular degeneration.
  Bora, N.S., Lyzogubov, V.V., Wu, X., Kolar, G., Bora, P.S. and Atkinson, J.P., ARVO Meeting, Seattle, WA, 5/1/2013
• Regulatory T cells in acute severe RSV bronchiolitis.
  Bacharier, L.B., Coverstone, A., Schweiger, T., Gregory, G., Yin-DeClue, H.Y., Sajol, G., Giri, T., Sierra, O., Atkinson, J., Wilson, B., Zheng, J., Schechtman, K., an..., Amer. Thoracic Society Meeting, 1/1/2013
• An innate-like CD4+ T cell expressing complement receptor 1.
  Reilly, B., Rasberry, K., and Atkinson, J.P., Frontiers of Immunology, 1/1/2013
• Regulatory T cells in acute severe RSV bronchiolitis.
  Bacharier, L.B., Coverstone, A., Schweiger, T., Gregory, G., Yin-DeClue, H.Y., Sajol, G., Giri, T., Atkinson, J., Sierra, O., Zheng, J., Schechtman, K., Castro, M., Am. J. Respir. Crit. Care Med., 1/1/2013
• Rare functional variants in complement genes mitigate C3 inactivation and confer high risk of advanced age-related macular degeneration.
  Raychaudhuri, S., Yu, Y., Miller, E.C., Reynolds, R., Tan, P.l., Gowrisankar, S., Goldstein, J.I., Triebwasser, M., Anderson, H.E., Zerbib, J., Kavanagh, D., Souied, E..., American Society of Human Genetics, 1/1/2013
• Cleavage of intracellular C3 into C3a and C3b by cathepsin L is required for human TH1 induction.
  Liszewski, M.D., Kolev, M., Bertram, P., Yamamoto, H., Leung, M.K., Fara, A., Atkinson, J.P., and Kemper. C., Immunobiology, 1/1/2012
• In vivo dissection of the contribution of fB, fD and properdin to alternative pathway activation on membranes.
  Wu, X., Bertram, P., Xu, T., Hourcade, D., Stover, C., and Atkinson, J.P., Immunobiology, 1/1/2012
• Pinpointing the time and cause of fetal demise in the Crry-/- embryo.
  Triebwasser, M.P. Wu, X., Hourcade, D., and Atkinson, J.P., Immunobiology, 1/1/2012
• Targeted deep sequencing of the complement system in complementopathies.
  Triebwasser, M.P., Bertram, P.B., Laivouri, H., Kimberly, R. Salmon, J.E., Atkinson, J.P., Immunobiology, 1/1/2012
• Analysis of genes coding for CD46, CD55 and C4b-binding protein in patients with idiopathic, recurrent, spontaneous pregnancy loss.
  Mohlin, F.C., Mercier, E., Fremeaux-Bacchi, V., Liszewski, M.K., Atkinson J.P., Gris, J.-C., and Blom. A.M., Immunobiology, 1/1/2012
• MCP (CD46) autoantibodies are associated with atypical hemolytic uremic syndrome.
  Bennaceur, K., Hunze, E.-M., Liszewski, M.K., Bertram, P., Staniforth, S.J., Strain, L., Wilson, V., Atkinson. J.P., Goodship, T.H.G., and Marchbank, K.J., Immunobiology, 1/1/2012
• Role of CD46 in laser induced choroidal neovascularization.
  Lyzoguvov, V.V., Tytarenko, R.G., Jha, P., Wu, X., Kolar, G., Atkinson, J.P., Bora, P.S., and Bora, N.S., Invest. Ophthalmol. Vis. Sci., 1/1/2011
• Identification of sites within complement receptor 1 important for plasmodium falciparum invasion into human erythrocytes.
  Tham, W.-H., Schmidt, C.Q., Hauhart, R.E., Guariento, M., Tetteh-Quarcoo, P.B., Lopaticki, S., Atkinson, J.P., Barlow, P.N., and Cowman, A.F., Australian Society for Parasitology Annual Conference, 1/1/2011
• The malaria parasite plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes.
  Tham, W.-H., Schmidt, C.Q., Hauhart, R.E., Guariento, M., Tettoh-Quarcoo, P.B., Lopaticki, S., Atkinson, J.P., Barlow, P.N., and Cowman, A.F., ComBio2011, 1/1/2011
• Interrogation of the contribution of fB and fD to alternative complement pathway activation and homeostasis.
  Wu, X., Bertram, P., Xu, T.Q., Bruce, C., Gupta, R., and Atkinson, J.P., 14th International Congress of Immunology, 1/1/2010
• Human peripheral CD4+ T-cells expressing complement receptor 1 (CR1, CD35).
  Reilly, B.D., Pfeiffer, A., Petney, K., and Atkinson, J.P., Amer. Assoc. Immunol., 1/1/2010
• Expression of CD35 on subsets of human peripheral CD8+ T-cells.
  Reilly, B.D., Ketron, S., Hempstead, S., and Atkinson, J.P., Amer. Assoc. Immunol., 1/1/2010
• The complement system as a regulator of osteoclasts and bone loss.
  Fang, C.J., Wu, X., Atkinson, J.P., and Nakamura, M.C., 3rd International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems, 1/1/2010
• Mutations in complement regulatory proteins predispose to preeclampsia.
  Salmon, J.E., Liszewski, M.K., Kavanagh, D., Heuser, C., Triebwasser, M., Roumenina, L., Branch, W., Goodship, T., Fremeaux-Bacchi, V., and Atkinson, J.P., Molec. Immunol., 1/1/2010
• Characterization of the interactions between C3b and complement regulators.
  Wu, J., Ricklin, D., Sfyroera, G., Tzekou, A., Atkinson, J.P., Lambris, J.D., and Gros, P., Molec. Immunol., 1/1/2010
• Inhibition of the human complement component C4 by flavivirus non-structural protein NS1.
  Avirutnan, P., Fuchs, A., Hauhart, R.E., Somnuke, P., Youn, S., Diamond, M.S., and Atkinson, J.P., Molec. Immunol., 1/1/2010
• Functional characterization of mutations in complement C3 that predispose to aHUS.
  Miller, E.C., Roumenina, L., Fremeaux-Bacchi, V., and Atkinson, J.P., Molec. Immunol., 1/1/2010
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Other

• Ss-Slp/C4 and the recognition of a linkage between complement and the major histocompatibility complex. 
  Hauptmann, G., Atkinson, J., Demant, P., and Ogata, R., The Complement Bulletin
  1/1/2008
• Complement: A renaissance of interest in an ancient immune system. 
  Liszewski, M.K., and Atkinson, J.P., The Scientist
  1/1/2006
• “Cells Expressing a Modified Regulator of Complement Activation" 
  John P. Atkinson, Dennis Hourcade, Malgorzata Krych, United States Patent No. 6,521,450
  2/18/2003
• The complications of complement. 
  Atkinson, J.P., Lupus Now
  1/1/2003
• Complement pathways. 
  Liszewski MK, Atkinson JP (Rose, B, editor), Up to Date CD ROM
  1/1/2003
• Inherited complement deficiencies. 
  Liszewski MK, Atkinson JP (Rose, B, editor), Up to Date CD ROM
  1/1/2003
• Regulators and receptors of the complement systems. 
  Liszewski MK, Atkinson JP (Rose, B, editor), Up to Date CD ROM
  1/1/2001
• The complement system. 
  Liszewski MK, Atkinson JP (Rose, B, editor), Up to Date CD ROM
  1/1/2001
• “Complement System Regulators" 
  John P. Atkinson, Dennis Hourcade, Malgorzata Krych, United States Patent No. 5,719,127
  2/17/1998
• “Treatment Method Using Recombinantly Produced Human Membrane Cofactor Protein (MCP)" 
  John P. Atkinson, United States Patent No. 5,703,046
  12/30/1997
• “Recombinantly Produced Human Membrane Cofactor Protein (MCP): Pharmaceutical Compositions and Methods of Inhibiting Complement Activity" 
  John P. Atkinson, United States Patent No. 5,552,381
  9/3/1996
• “Modified Complement System Regulators" 
  John P. Atkinson, Dennis Hourcade, Malgorzata Krych, United States Patent No. 5,545,619
  8/13/1996
• “DNA Sequences Encoding Human Membrane Cofactor Protein (MCP)" 
  John P. Atkinson, United States Patent No. 5,514,787
  5/7/1996
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