Jeffrey Allan Zonder MD

Hematology•Detroit, MI

Hematologic Oncology

Professor of Oncology (Multiple Myeloma and Amyloidosis Specialist)

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Karmanos Cancer Center4100 John R Hwcrc 4th FlDetroit, MI 48201
Phone+1 800-527-6266
Fax+1 313-576-8767

Education & Training

Detroit Medical Center/Wayne State UniversityFellowship, Hematology and Medical Oncology, 1998 - 2001
University of Rochester Medical CenterResidency, Internal Medicine, 1995 - 1998
Wayne State University School of MedicineClass of 1995
Duke UniversityBA, Biological Anthropology, Art-Design (Double Major), 1987 - 1991

Certifications & Licensure

MI State Medical License 1998 - 2026
American Board of Internal Medicine Hematology

Awards, Honors, & Recognition

Accelerator Award Multiple Myeloma Research Foundation, 2015
School of Medicine Teaching Award Wayne State University, 2005, 2012, 2015
Fellows' Hematology Teaching Award Division of Hematology-Oncology, 2007, 2012

Clinical Trials

Arsenic Trioxide and Ascorbic Acid Combined With Bortezomib, Thalidomide, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma or Plasma Cell Leukemia Start of enrollment: 2005 May 01
Completed
Phase 1
Phase I, Multi-Center, Open-Label, Dose Escalation Study of HuLuc63 in Subjects With Advanced Multiple Myeloma Start of enrollment: 2006 Dec 01
Completed
Phase 1
Bortezomib, Melphalan, and Dexamethasone in Treating Patients With Primary Amyloidosis or Light Chain Deposition Disease Start of enrollment: 2007 Sep 01
Completed
Phase 2
Phase 1/2 Study of Anti GM-2 Monoclonal Antibody To Treat Multiple Myeloma Start of enrollment: 2008 Oct 01
Terminated
Phase 1
Treated T Cells Followed by a Stem Cell Transplant in Treating Patients With Multiple Myeloma Start of enrollment: 2009 Oct 01
Completed
Phase 1
Green Tea Extract in Treating Patients With Monoclonal Gammopathy of Undetermined Significance and/or Smoldering Multiple Myeloma Start of enrollment: 2009 Nov 01
Terminated
Phase 2
Randomized Trial of Lenalidomide, Bortezomib, Dexamethasone vs High-Dose Treatment With SCT in MM Patients up to Age 65
ACTIVE_NOT_RECRUITING
PHASE3
Bendamustine and Dexamethasone in Patients With Relapsed AL Amyloidosis Start of enrollment: 2013 Jan 01
Completed
Phase 2
Phase 1/2, Open Label, Dose Escalation Study of NEOD001 in Subjects With Light Chain (AL) Amyloidosis Start of enrollment: 2013 Apr 01
Completed
Phase 1, Phase 2
First-line Pomalidomide, Bortezomib, and Dexamethasone For AL Amyloidosis or LCDD Start of enrollment: 2013 Mar 01
Terminated
Phase 1
Combination Study of Pomalidomide, Marizomib, and Low-Dose Dexamethasone in Relapsed and Refractory Multiple Myeloma Start of enrollment: 2014 Jun 05
Completed
Phase 1
The PRONTO Study, a Global Phase 2b Study of NEOD001 in Previously Treated Subjects With Light Chain (AL) Amyloidosis Start of enrollment: 2016 Mar 01
Completed
Phase 2
A Study of Melphalan Flufenamide (Melflufen) Plus Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma Start of enrollment: 2016 Dec 28
Completed
Phase 2
Lenalidomide, Dexamethasone, and Elotuzumab With or Without Cyclophosphamide in Treating Patients With Relapsed Primary Amyloidosis Start of enrollment: 2017 Aug 25
Active, not recruiting
Phase 2
Antigen-specific T Cell Therapy for Patients With Relapsed Refractory Multiple Myeloma Start of enrollment: 2020 Aug 17
Suspended
Phase 1, Phase 2
Isatuximab As Upfront Therapy for the Treatment of High Risk AL Amyloidosis Start of enrollment: 2021 Apr 28
ACTIVE_NOT_RECRUITING
PHASE1
Myeloma-Developing Regimens Using Genomics (MyDRUG) Start of enrollment: 2019 Apr 01
COMPLETED
PHASE1, PHASE2
Roles: Contact
Phase 1/2 Study of REGN5458 in Adult Patients With Relapsed or Refractory Multiple Myeloma Start of enrollment: 2019 Jan 23
RECRUITING
PHASE1, PHASE2
Roles: Contact
COVID-19 VAX Booster Dosing in Patients With Hematologic Malignancies Start of enrollment: 2021 Aug 17
Completed
Phase 2
Roles: Contact, Principal Investigator
Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma in African-American and European-American Patients Start of enrollment: 2022 Mar 07
RECRUITING
PHASE2
Roles: Principal Investigator, Contact
Phase 1/2 Study of ISB 1442 in Relapsed/Refractory Multiple Myeloma Start of enrollment: 2022 Sep 27
TERMINATED
PHASE1, PHASE2
Roles: Contact
A Study of Modakafusp Alfa in Adult Participants With Multiple Myeloma Start of enrollment: 2022 Oct 27
COMPLETED
PHASE1
Roles: Principal Investigator
Iberdomide and Daratumumab As Maintenance Therapy After an Autologous Stem Cell Transplant for Multiple Myeloma Start of enrollment: 2023 Dec 21
RECRUITING
PHASE2
Roles: Principal Investigator
Dietary Reporting in the Amyloidoses Start of enrollment: 2023 Mar 02
RECRUITING
NA
Roles: Contact, Principal Investigator
DapagliFLOzin in Renal AL Amyloidosis (FLORAL) Start of enrollment: 2024 Jul 11
RECRUITING
PHASE2
Roles: Sponsor-Investigator
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Publications & Presentations

PubMed

A model for predicting day-100 stem cell transplant-related mortality in AL amyloidosis.
Eli Muchtar, Angela Dispenzieri, Vaishali Sanchorawala, Hamza Hassan, Raphael Mwangi
Bone Marrow Transplantation. 2025-02-24
Phase 1 first-in-human study of MEDI2228, a BCMA-targeted ADC, in patients with relapsed refractory multiple myeloma.
Meletios A Dimopoulos, Magdalini Migkou, Manisha Bhutani, Sikander Ailawadhi, Anna Kalff
Leukemia & Lymphoma. 2024-12-01
11 citations
Linvoseltamab for Treatment of Relapsed/Refractory Multiple Myeloma.
Naresh Bumma, Joshua Richter, Sundar Jagannath, Hans C Lee, James E Hoffman
Journal of Clinical Oncology. 2024-08-01

Abstracts/Posters

Randomized Phase 2 Study of Subcutaneous Daratumumab Plus Carfilzomib/Dexamethasone Versus Carfilzomib/Dexamethasone Alone in Patients with Multiple Myeloma Who Have B...
Jeffrey A. Zonder, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Results from Phase 1/2 Trial of Tagraxofusp in Combination with Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma
Jeffrey A. Zonder, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Translational and Clinical Evidence of a Differentiated Profile for the Novel CELMoD, Iberdomide (CC-220)
Jeffrey A. Zonder, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Real-World (RW) Multiple Myeloma (MM) Patients (Pts) Remain Under-Represented in Clinical Trials Based on Standard Laboratory Parameters and Baseline Characteristics: ...
Jeffrey A. Zonder, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Closing the Efficacy and Effectiveness Gap: Outcomes in Relapsed/Refractory Multiple Myeloma (RRMM) Patients (Pts) Treated with Ixazomib-Lenalidomide-Dexamethasone (IR...
Jeffrey A. Zonder, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Results of the Phase 3 VITAL Study of NEOD001 (Birtamimab) Plus Standard of Care in Patients with Light Chain (AL) Amyloidosis Suggest Survival Benefit for Mayo Stage ...
Jeffrey A. Zonder, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Comprehensive Investigation of White Blood Cell and Gene Expression Profiles As Risk Factors for Multiple Myeloma in African Americans
Jeffrey A. Zonder, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
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Lectures

Untangling Amyloidosis 2019
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
Untangling Amyloidosis 2019
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
Ixazomib Plus Lenalidomide-Dexamethasone (IRd) in Relapsed/Refractory Multiple Myeloma (MM) Patients (Pts) – Effectiveness in Routine Clinical Practice Is Similar to t...
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Phase II Trial of Combination of Elotuzumab, Lenalidomide, and Dexamethasone in High-Risk Smoldering Multiple Myeloma
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Untangling Amyloidosis 2018
60th American Society of Hematology Annual Meeting - 11/30/2018
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Press Mentions

The Uncanny Symptoms That Led to a Detroit Filmmaker’s Multiple Myeloma DiagnosisMay 3rd, 2023
Triple-Drug Therapy for Post-Transplant Management of Multiple MyelomaJanuary 13th, 2023
Expanded Cancer CareNovember 21st, 2022
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