JeffreyLiebermanMD

Neuropsychiatry, Psychopharmacology

Psychiatrist in Chief, NewYork-Presbyterian/Columbia University Irving Medical Center; Director, New York State Psychiatric Institute; Chair, Department of Psychiatry, Columbia University

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Office
1155 Park Ave
New York, NY 10128
Phone+1 646-288-1535

Summary

Jeffrey A. Lieberman, M.D. is Professor and the Constance and Stephen Lieber Chair of Psychiatry at the Columbia University College of Physicians and Surgeons. Throughout his 40 year career he has focused on research, clinical care of patients with serious mental illness, influencing government and social policy, educating health care providers and the general public and reducing stigma. Dr. Lieberman's research on the neurobiology, pharmacology and treatment of schizophrenia and psychotic disorders has transformed our understanding of the causes and advanced the treatment of mental illness. He has authored or co-authored over 800 articles published in scientific literature and wrote or edited 17 books on mental illness and psychiatry and is the recipient of many awards including the Lieber Prize for Schizophrenia Research from NARSAD, the Adolph Meyer Award from the APA the Research Award from the NAMI among many others. Dr. Lieberman has been a member of the Advisory committee for Neuropharmacologic and Psychopharmacologic Drugs of the FDA, the Planning Board for the Surgeon General's Report on Mental Health, the Committee on Research on Psychiatric Treatments of the APA, and the APA Work Group for the Development of Schizophrenia Treatment Guidelines.
In 2000 he was elected to the National Academy of Medicine, in 2010 fellowship in the AAAS and in 2021 named to the New York Power 50 in Mental Health. He served as President of the APA in 2013 and 2014.
His work extended beyond biomedical research and clinical psychiatry to public policy for mental health care and diminishing the stigma of mental illness. This motivated him to write the critically acclaimed book Shrinks: The Untold Story of Psychiatry. A 4 part series, Mysteries of Mental Illness, based on his book was nationally broadcast on PBS June 22 and 24, 2022.
His new book, Malady of the Mind: Schizophrenia and the Path to Prevention was published by Scribner's of Simon and Shuster in February 2023.

Proud to rank #6 of all Columbia faculty on Best Scientists

Impact and replication of research are the metrics of good research

Education & Training

New York Medical College at St Vincent's Hospital and Medical Center of New YorkChief Residency, Psychiatry, 1979 - 1980
New York Medical College at St Vincent's Hospital and Medical Center of New YorkResidency, Psychiatry, 1975 - 1978
George Washington University School of Medicine and Health SciencesClass of 1975
Miami UniversityBS, Biology, 1970

Certifications & Licensure

NY State Medical License 1976 - 2028
NC State Medical License 1996 - 2005
American Board of Psychiatry and Neurology Psychiatry

Awards, Honors, & Recognition

Ed Hornick Award New York Academy of Medicine, 2012
Scientific Research Award National Alliance on Mental Illness, 2011
C. Charles Burlingame Award The Institute of Living, Hartford Hospital, 2011
Elected Fellow American Association for the Advancement of Science, 2010
Adolph Meyer Award American Psychiatric Association, 2007
Distinguished Alumni Scholar Award George Washington University, 2007
Eugene A. Hargrove Mental Health Research Award North Carolina Foundation for Mental Health Research, Inc., North Carolina Psychiatric Association, 2006
Lieber Prize for Schizophrenia Research NARSAD, 2006
Best Doctors in America 2003
Lilly Neuroscience Award The Collegium Internationale Neuro-Psychopharmacologicum, 2002
Ziskind-Somerfield Award Society of Biological Psychiatry, 2000
Stanley Dean Award, Schizophrenia Research American College of Psychiatry, 2000
Exemplary Psychiatrist National Alliance for the Mentally Ill, NAMI, 2000-2001
Kempf Fund Award, Research in Psychobiological Psychiatry American Psychiatric Association, 1994, 2000
Edward A. Strecker Award for Psychiatric Research University of Pennsylvania Hospital, 1998
Research Award American Psychiatric Association, 1998
Gralnick Award, Schizophrenia Research National Association of Private Psychiatric Hospitals, 1992, 1998
Exemplary Psychiatrist National Alliance for the Mentally Ill, 1994, 1997
Thad & Alice Eure Award, Distinguished Professor in Psychiatry UNC School of Medicine, 1996
Independent Scientitst Award National Institute of Mental Health, 1995
Presidential Award, Research National Association of Psychiatric Health Systems, 1993
MERIT Award National Institute of Mental Health, 1990
Research Scientist Development Award, Levels I, II and Independent Scientist Award National Institute of Mental Health, 1985
Sandoz Award George Washington University School of Medicine, 1975
William S. Schafirt Award George Washington University School of Medicine, 1975
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Clinical Trials

TC-5619 as Augmentation Therapy to Improve Cognition in Outpatients With Cognitive Dysfunction in Schizophrenia Start of enrollment: 2009 Oct 01
Completed
Phase 2
Efficacy of Cognitive Remediation in Patients With Schizophrenia or Schizoaffective Disorder Stabilized on Lurasidone Start of enrollment: 2010 Jul 01
Completed
Phase 3
Effects of Eltoprazine on Cognitive Impairment Associated With Schizophrenia (CIAS) in Adults Start of enrollment: 2011 Aug 01
Completed
Phase 2
A Clinical Trial That Will Study the Efficacy and Safety of an Investigational Drug in Acutely Psychotic People With Schizophrenia Start of enrollment: 2019 Sep 30
Completed
Phase 3
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Publications & Presentations

PubMed

18 citations
Brain volumes in psychotic youth with schizophrenia and mood disorders
Mohamed El-Sayed, R. Grant Steen, Michele D. Poe, T. Carter Bethea, Guido Gerig
Journal of Psychiatry & Neuroscience. 2010-07-01
576 citations
Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies.
R. Grant Steen, Courtney Mull, Robert K. McClure, Robert M. Hamer, Jeffrey A. Lieberman
The British Journal of Psychiatry. 2006-06-01
1017 citations
Mapping genomic loci implicates genes and synaptic biology in schizophrenia.
Vassily Trubetskoy, Antonio F Pardiñas, Ting Qi, Georgia Panagiotaropoulou, Swapnil Awasthi
Nature. 2022-04-01

Journal Articles

A Multicenter Study of Ketamine Effects on Functional Connectivity: Large Scale Network Relationships, Hubs and Symptom Mechanisms
Ragy R Girgis, Richard J Maddock, John D Ragland, Daniel C Javitt, Cameron S Carter, Joshua T Kantrowitz, Jeffrey Lieberman, John H Krystal, Lawrence S Kegeles, Willia..., ScienceDirect
Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci
Andreassen OA, Harbo HF, Wang Y, Thompson WK, Schork AJ, Mattingsdal M, Zuber V, Bettella F, Ripke S, Kelsoe JR, Kendler KS, O'Donovan MC, Sklar P; The Psychiatric Gen..., Mol Psychiatry, 1/1/2014
Genetic variation in the GCG and in the GLP1R genes and antipsychotic-induced weight gain
Brandl EJ, Lieberman JA, et al, Pharmacogenomics, 1/1/2014
Investigation of melancortico system gene variants in antipsychotic-induced weight gain
Chowdhury NI, Souza RP, Tiwari AK, Brandl EJ, Sicard M, Meltzer HY, Lieberman JA, Kennedy JL, Muller DJ, World J Biol Psychiatry, 1/1/2014
Young brains on drugs
DuPont RF, Lieberman JA, Science, 1/1/2014
Protein kinase cAMP-dependent regulatory type II beta (PRKAR2B) gene variants in antipsychotic-induced weight gain
Gagliano SA, Tiwari AK, Freeman N, Lieberman JA, Meltzer HY, Kennedy JL, Knight J, Muller DJ, Hum Psychopharmacol, 1/1/2014
A Hypothesis Driven Association Study of 28 Nuclear-Encoded Mitochondrial Genes With Antipsychotic-Induced Weight Gain in Schizophrenia
Goncalves VF, Zai CC, Tiwari AK, Brandl EJ, Derkach A, Meltzer HY, Lieberman JA, Muller DJ, Sun L, Kennedy JL, Neuropsychopharmacology, 1/1/2014
Methylenetetrahydrofolate reductase gene variants and antipsychotic-induced weight gain and metabolic disturbances
Kao AC, Rojnic Kuzman M, Tiwari AK, Zivkovic MV, Chowdhury NI, Medved V, Kekin I, Zai CC, Lieberman JA, Meltzer HY, Bozina T, Bozina N, Kennedy JL, Sertic J, Muller DJ, J psychiatry Res, 1/1/2014
Imaging glutamate in schizophrenia: review of findings and implications for drug discovery
Poels EM, Kegeles LS, Kantrowitz JT, Slifstein M, Javitt DC, Lieberman JA, Abi-Dargham A, Girgis RR, Mol Psychiatry, 1/1/2014
Glutamatergic abnormalities in schizophrenia: a review of proton MRG findings
Poels EM, Kegeles LS, Kantrowitz JT, Javitt DC, Lieberman JA, Abi-Dargham A, Girgis RR, Schizophr Res, 1/1/2014
Fat mass- and obesity-associated (FTO) gene and antipsychotic-induced weight gain: an association study
Shing EC, Tiwari AK, Brandl EJ, Zai CC, Lieberman JA, Meltzer HY, Kennedy JL, Muller DJ, Neuropsychobiology, 1/1/2014
Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors
Andreassen OA, Djurovic S, Thompson WK, Schork AJ, Kendler KS, O'Donovan MC, Rujescu D, Werge T, van de Bunt M, Morris AP, McCarthy MI; International Consortium for Bl..., Am J Hum Gent, 1/1/2013
Exploratory study on association of genetic variation in TBC1D1 with antipsychotic-induced weight gain
Brandl EJ, Tiwari AK, Lett TA, Shaikh SA, Lieberman JA, Meltzer HY, Kennedy JL, Muller DJ, Human Psychopharmacol, 1/1/2013
Anatomical abnormalities in gray and white matter of the cortical surface in persons with schizophrenia
Colibazzi T, Wexler B, Bansal R, Hao X, Liu J, Sanchez-Peña J, Corcoran, C, Lieberman JA, Peterson BS, PLoS One, 1/1/2013
Deep resequencing and association analysis of schizophrenia candidate genes
Crowley JJ, Hilliard CE, Kim Y, Morgan MB, Lewis LR, Muzny DM, Hawes AC, Sabo A, Wheeler DA, Lieberman JA, Sullivan PF, Gibbs RA, Mol Psychiatry, 1/1/2013
Getting the facts straight about gun violence and mental illness: putting compassion before fear
Fisher CE, Lieberman JA, Ann Intern Med, 1/1/2013
Metformin for weight loss and metabolic control in overweight outpatients with schizophrenia and schizoaffective disorder
Jarskog LF, Hamer RM, Catellier DJ, Stewart DD, Lavange L, Ray N, Golden LH, Lieberman JA, Stroup TS, METS Investigators, Am J Psychiatry, 1/1/2013
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, A..., Nat Genet, 1/1/2013
Response to the presidential address
Lieberman JA, Am J Psychiatry, 1/1/2013
A randomized exploratory trial of an alpha-7 nicotinic receptor agonist (TC-5619) for cognitive enhancement in schizophrenia
Lieberman JA, Dunbar G, Segreti AC, Girgis RR, Seoane F, Beaver JS, Duan N, Hosford DA, Neuropsychopharmacology, 1/1/2013
Localized differences in caudate and hippocampal shape are associated with schizophrenia but not antipsychotic type
McClure RK, Styner MA, Maltbie E, Lieberman JA, Gouttard S, Gerig G, Shi X, Zhu H, Psychiatry Res, 1/1/2013
Genetic schizophrenia risk variants jointly modulate total brain and white matter volume
Terwisscha van Scheltinga AF, Bakker SC, van Haren NE, Derks EM, Buizer-Voskamp JE, Boos HB, Cahn W, Hulshoff Pol HE, Ripke S, Ophoff RA, Kahn RS; Psychiatric Genome-w..., Biol Psychiatry, 1/1/2013
Association study of the vesicular monoamine transporter gene SLC18A2 with tardive dyskinesia
Zai CC, Tiwari AK, Mazzoco M, de Luca V, Muller DJ, Shaikh SA, Lohoff FW, Freeman N, Voineskos AN, Potkin SG, Lieberman JA, Meltzer HY, Remington G, Kennedy JL, J psychiatry Res, 1/1/2013
Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain
Brandl EJ, Frydrychowicz C, Tiwari AK, Lett TA, Kitzrow W, Büttner S, Erlich S, Meltzer HY, Lieberman JA, Kennedy JL, Muller DJ, Puls I, Prog Neuropsychopharmacol Biol Psychiatry, 1/1/2012
Neurocognitive outcomes in the treatment of early-onset schizophrenia spectrum disorders study
Frazier JA, Guiliano AJ, Johnson JL, Yakutis L, Youngstrom EA, Breiger D, Sikich L, Findling RL, McClellan J, Hamer RM, Vitiello B, Lieberman JA, Hooper SR, J Am Acad Child Adolesc Psychiatry, 1/1/2012
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