JeffMichaelSandsMD

PubMed

• Thick Ascending Limb Specific Inactivation of Myh9 and Myh10 Myosin Motors Results in Progressive Kidney Disease and Drives Sex-specific Cellular Adaptation in the Dis...
  Karla L Otterpohl, Brook W Busselman, Jenna L Zimmerman, Malini Mukherjee, Claire Evans
  Function. 2025-02-12
• 1 citations
  Longitudinal Renal Function Degradation Among Florida Agricultural Workers.
  Roxana C Chicas, Lisa Elon, Nezahualcoyotl Xiuhtecutli, Donghai Liang, Madelyn C Houser
  Journal of Occupational and Environmental Medicine. 2024-09-01
• Renoprotective Effects of Daprodustat in Patients with Chronic Kidney Disease and Renal Anemia.
  Yoshitaka Shimada, Yuichiro Izumi, Yukiko Yasuoka, Tomomi Oshima, Yasushi Nagaba
  International Journal of Molecular Sciences. 2024-08-30

Journal Articles

• ENaC activity is increased in isolated, split-open cortical collecting ducts from protein kinase Calpha knockout mice  
  Bao H-F, Thai TL, Yue Q, Ma H-P, Eaton AF, Cai H, Klein JD, Sands JM, Eaton DC, Am. J. Physiol. Renal Physiol, 1/1/2014
• Advances in understanding the urine-concentrating mechanism  
  Sands JM, Layton HE, Annu. Rev. Physiol, 1/1/2014
• Defining kidney biology to understand renal disease  
  Little MH, Brown D, Humphreys B, McMahon A, Miner JH, Sands JM, Weisz OA, Mullins C, Hoshizaki D, Clin. J. Am. Soc, 1/1/2014
• Gottschalk Distinguished Lecturer of the American Physiological Society Renal Section  
  Sands JM, Am. J. Physiol. Renal Physiol, 1/1/2014
• Urine concentration in the diabetic mouse requires both water and urea transporters  
  Ilori TO, Blount MA, Martin CF, Sands JM, Klein JD, Am. J. Physiol. Renal Physiol, 1/1/2013
• Role of protein kinase C alpha in hypertonicity-stimulated urea permeability in mouse inner medullary collecting ducts  
  Wang Y, Klein JD, Frohlich O, Sands JM, Am. J. Physiol. Renal Physiol, 1/1/2013
• Small GTPase Rab14 down-regulates UT-A1 urea transport activity through enhanced clathrin-dependent endocytosis  
  Su H, Liu B, Frohlich O, Ma H, Sands JM, Chen G, FASEB J, 1/1/2013
• Activation of the cAMP/PKA pathway induces UT-A1 urea transporter monoubiquitination and targets it for lysosomal degradation  
  Su H, Chen M, Sands JM, Chen G, Am. J. Physiol. Renal Physiol, 1/1/2013
• Urea transporter inhibitors: en route to new diuretics  
  Sands JM, Chem. Biol, 1/1/2013
• Acute calcineurin inhibition with tacrolimus increases phosphorylated UT-A1  
  Ilori TO, Wang Y, Blount MA, Martin CF, Sands JM, Klein JD, Am. J. Physiol. Renal Physiol, 1/1/2012
• Protein kinase C-alpha mediates hypertonicity-stimulated increase in urea transporter phosphorylation in the inner medullary collecting duct  
  Klein JD, Martin CF, Kent KJ, Sands JM, Am. J. Physiol. Renal Physiol, 1/1/2012
• Protein abundance of urea transporters and aquaporin 2 change differently in nephrotic pair-fed versus non-pair-fed rats  
  Bou Matar RN, Malik B, Wang XH, Martin CF, Eaton DC, Sands JM, Klein JD, Am. J. Physiol. Renal Physiol, 1/1/2012
• Monitoring urea transport in rat kidney in vivo using hyperpolarized 13C magnetic resonance imaging  
  Von Morze C, Bok RA, Sands JM, Kurhanewicz J, Vigneron DB, Am. J. Physiol. Renal Physiol, 1/1/2012
• Lack of protein kinase C-alpha leads to impaired urine concentrating ability and decreased aquaporin-2 in angiotensin II-induced hypertension  
  Thai TL, Blount MA, Klein JD, Sands JM, Am. J. Physiol. Renal Physiol, 1/1/2012
• Forskolin stimulation promotes urea transporter UT-A1 ubiquitination, endocytosis and degradation in MDCK cells  
  Su H, Carter CB, Laur O, Sands JM, Chen G, Am. J. Physiol. Renal Physiol, 1/1/2012
• Aquaporin 2: not just for moving water  
  Sands JM, J. Am. Soc. Nephrol., 1/1/2012
• The thick ascending limb and water channels: half-full or half-empty  
  Sands JM, Am. J. Physiol. Renal Physiol, 1/1/2012
• Urine concentrating and diluting ability during aging  
  Sands JM, J Gerontol A Biol Sci Med Sci, 1/1/2012
• Molecular mechanisms of urea transport in health and disease  
  Klein JD, Blount MA, Sands JM, Pflügers Archiv. European J. Physiol, 1/1/2012
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  Huang L, Zhang R, Wu J, Chen J, Grosjean F, Satlin LH, Klein JD, Sands JM, Striker GE, Tan J, Zheng F, Kidney Int, 1/1/2011
• N-methyl-D-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct  
  Sproul AD, Steele SL, Thai TL, Yu SP, Klein JD, Sands JM, Bell PD, Am. J. Physiol. Renal Physiol, 1/1/2011
• Geriatric nephrology: a missing area of nephrology’s expertise  
  Schlanger LE, Bailey JL, Sands JM, NephSAP, 1/1/2011
• Benos 1950-2010: scientist, teacher, colleague  
  Sands JM. Dale J, ASN Kidney News, 1/1/2011
• Urea transport in the kidney  
  Klein JD, Blount MA, Sands JM, Comprehensive Physiology, 1/1/2011
• Regulation of renal urea transport by vasopressin  
  Sands JM, Blount MA, Klein JD, Trans. Am. Clin. Climatol Assoc, 1/1/2011
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Books/Book Chapters

• Chronic Renal Disease 
  Chapter: Aging and the kidney: clinical and pathophysiological issues 
  Page 126 - 135Schlanger LE, Bailey JL, Sands JMEditors: Kimmel PL and Rosenberg ME.Elsevier2014
• Modern Nutrition in Health and Disease 
  Chapter: Water, electrolytes, and acid-base metabolism 
  Page 102 - 132Bailey JL, Sands JM, Franch HAEditors: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR.Lippincott, Williams & WilkinsEdition 11th,2014
• Core Concepts in Disorders of Fluid, Electrolytes and Acid-Base Balance. 
  Chapter: The physiology of water homeostasis 
  Page 1 - 28Sands JM, Mount DB, Layton HEEditors: Mount DB, Sayegh MH, Singh AK.Springer, New York2013
• Encyclopedia of Signaling Molecules. 
  Chapter: UT (Urea transporter) 
  Page 1945 - 1953Blount MA, Klein JD, Sands JMEditors: Choi S.Springer, New York2012
• Dietary sodium intake in heart failure. 
  Gupta D, Georgiopoulou VV, Kalogeropoulos AP, Dunbar SB, Reilly CM, Sands JM, Fonarow GC, Jessup M, Gheorghiade M, Yancy C, Butler J2012
• Brenner and Rector’s The Kidney 
  Chapter: Urine concentration and dilution 
  Page 326 - 352Sands JM, Layton HE, Fenton RAEditors: Taal MW, Chertow GM, Marsden PA, Skorecki K, Yu ASL, Brenner, BM.Elsevier, PhiladelphiaEdition 9th,2011
• Comprehensive Toxicology; Volume 7: Renal Toxicology 
  Chapter: Functional anatomy of the kidney 
  Page 1 - 22Sands JM, Verlander JWEditors: McQueen C; Schnellman, R (volume ed).Elsevier, Oxford, EnglandEdition 2nd,2010
• Principals of Geriatric Medicine and Gerontology 
  Chapter: Semin. Nephrol 
  Page 1017 - 1034Schlanger LE, Sands JM, Bailey JLEditors: Hazzard WR, Blass JP, Halter JB, Ouslander JG, Tinetti ME.McGraw-Hill, New YorkEdition 6th,2009
• Textbook of Nephro-Endocrinology 
  Chapter: Anti-diuretic hormone - introduction and historical overview 
  Page 205 - 223Schlanger LE, Sands JMEditors: Singh AK, Williams GH.Elsevier, San Diego, CA2009
• The Kidney: Physiology and Pathophysiology 
  Chapter: The urine-concentrating mechanism and urea transporters 
  Page 1143 - 1178Sands JM, Layton HEEditors: Alpern RJ, Hebert SC.Academic Press, San Diego, CAEdition 4th,2008
• Principals of Molecular Medicine 
  Chapter: Nephrogenic diabetes insipidus: water and urea transport 
  Page 622 - 628Editors: Runge MS, Patterson C.Humana Press, Totowa, NJEdition 2nd,2006
• Ruminant physiology: digestion, metabolism and impact of nutrition on gene expression, immunology and stress. 
  Chapter: Urea transporters and urea metabolism in ruminants 
  Page 155 - 171Marini JC, Sands JM, Van Amburgh MEEditors: Sejrsen K, Hvelplund T, Nielsen MO.Wageningen Academic Publishers, The Netherlands2006
• Toxicology of the Kidney; Target Organ Toxicology Series. 
  Chapter: Anatomy and physiology of the kidneys 
  Page 3 - 56Sands JM, Verlander JWEditors: Tarloff JB and Lash LH; Hayes AW, Thomas JA, Gradner DE (series eds).CRC Press, Boca Raton, FLEdition 3rd,2005
• Membrane Transport and Renal Physiology; The IMA Volumes in Mathematics and its Applications, Volume 129 
  Chapter: Urine concentrating mechanism: measured permeability values in medullary nephron segments and urea transport processes 
  Page 193 - 210Sands JMEditors: Layton HE, Weinstein AM; Arnold DN, Santosa F (series eds).Springer-Verlag, New York2002
• The Kidney: Physiology and Pathophysiology 
  Chapter: Urine concentrating mechanism and its regulation 
  Page 1175 - 1216Sands JM, Layton HEEditors: Seldin DW, Giebisch G.Lippincott Williams and Wilkins, Philadelphia, PAEdition 3rd,2000
• The Emory University Comprehensive Board Review in Internal Medicine. 
  Chapter: Disturbances of water balance 
  Page 635 - 639Sands JMEditors: Stein SF, Kokko JP.McGraw-Hill, New York2000
• Handbook of Physiology - Section 7: The Endocrine System. Volume 3 
  Chapter: Renal actions of vasopressin 
  Page 496 - 529Knepper MA, Valtin H, Sands JMEditors: Fray J.Oxford University Press, New York2000
• Principals of Geriatric Medicine and Gerontology 
  Chapter: Renal disease 
  Page 777 - 796Sands JM, Vega SREditors: Hazzard WR, Blass JP, Ettinger WH, Halter JB, Ouslander JG.McGraw-Hill, New YorkEdition 4th,1999
• Comprehensive Toxicology; Volume 7: Renal Toxicology. 
  Chapter: Functional anatomy of the kidney 
  Page 21 - 48Sands JM, Verlander JWEditors: Sipes G, McQueen C, and Gandolfi J; Goldstein RS (volume ed).Pergamon Press, Cambridge, England1997
• Fluids and Electrolytes 
  Chapter: Fluid and electrolyte disorders in transplantation 
  Page 581 - 591Tumlin JA, Sands JMTumlin JA, Sands JMEditors: Kokko JP, Tannen RL.W.B. Saunders Co., Philadelphia, PAEdition 3rd,1996
• Textbook of Nephrology 
  Chapter: Urinary concentration and dilution 
  Page 108 - 113Sands JMEditors: Massry SG, Glassock RJ.Williams and Wilkins Co., Baltimore, MDEdition 3rd,1995
• Neurohypophysis: Recent Progress of Vasopressin and Oxytocin Research 
  Chapter: Regulation of kidney urea transporters by vasopressin and dietary protein 
  Page 525 - 534Sands JM, Isozaki T, Ashkar ZM, Martial S, and Price SREditors: Saito T, Kurokawa K, Yoshida S.Elsevier Science, Amsterdam1995
• Cellular and Molecular Physiology of Cell Volume Regulation. 
  Chapter: Regulation of intracellular polyols and sugars in response to osmotic stress 
  Page 133 - 144Sands JMEditors: Strange K.CRC Press, Boca Raton, FL1994
• The Kidney: Physiology and Pathophysiology 
  Chapter: Intrarenal Heterogeneity: Vascular and Tubular 
  Page 1087 - 1155Sands JM, Kokko JP, Jacobson HREditors: Seldin DW, Giebisch G.Raven Press, New YorkEdition 2ns,1992
• Cellular and Molecular Biology of the Kidney. 
  Chapter: Coordinated response of aldose reductase and sorbitol dehydrogenase regulates net sorbitol production in the renal inner medulla 
  Page 272 - 278Sands JM, Schrader DCEditors: Koide H, Endou H, Kurokawa K.Basel, Karger1991
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Abstracts/Posters

• High resolution hyperpolarized 13C urea MRI renography.
  Reed GD, von Morze C, Koelsch BL, Chaumeil MM, Bok RA, Sands JM, Verkman AS, Larson PEZ, Ardenkjaer-Larsen JH, Kurhanewicz J, Vigneron DB, ISMRM abstract, 1/1/2014
• Localization of urea transporters UT-A1 and UT-B in human eccrine clear cell.
  Keller RW, Sands JM, FASEB J, 1/1/2014
• Increased UT-A1 ubiquitination is partially due to decreased deubiquitination activity in streptozotocin-induced diabetic rat kidney inner medulla.
  Su H, Ilori TO, Klein JD, Sands JM, Chen G, FASEB J, 1/1/2013
• Transgenic mice expressing UT-A1, but lacking UT-A3, have intact urine concentrating ability.
  Klein JD, Frohlich O, Mistry AC, Kent KJ, Martin CF, Sands JM, FASEB J, 1/1/2013
• Transgenic mice that express UT-A1 but lack UT-A3 have increased AQP3 and normal urine concentrating ability.
  Klein JD, Mistry AC, Molina PA, Datta P, Rogers RT, Blount MA, Sands JM, J. Am. Soc. Nephrol, 1/1/2013
• Protein kinase C (PKC) increases UT-A1 urea transporter glycan sialylation, membrane expression and urea transport activity.
  Li X, Klein JD, Sands JM, Chen G, J. Am. Soc. Nephrol, 1/1/2013
• Chronic kidney disease diagnosis and referral patterns by (ICD-9) codes.
  Oommen A, Schlanger LE, Bailey JL, Sands JM, Lea JP, J. Am. Soc. Nephrol, 1/1/2013
• The urea transporter UT-A1 is directly phosphorylated by PKC.
  Redd SK, Cipriani P, Ordas RJ, Klein JD, Blount MA, Sands JM, FASEB J, 1/1/2011
• Quality improvement project: improving cardiovascular risk factor modification in chronic kidney disease patients in nephrology fellow continuity clinic.
  Cobb J, Sarolia S, Ilori T, Sands J, Bailey J, Am J. Kidney Dis, 1/1/2011
• Familial azotemia is caused by a duplication of urea transporter-B gene.
  Bokenkamp A, Sands JM, Wigman L, van Zwleten R, Verhoeven AJ, Klein JD, Thai TL, Knegt LAC, Groothoff JW, Linthorst GE, J. Am. Soc. Nephrol, 1/1/2011
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Lectures

• Renal Research Seminar 
  Vanderbilt University - 7/1/2014
• Physiology Seminar and Renal Grand Rounds 
  Yale University (Feb 2004) - 12/1/2013
• Carl W. Gottschalk Distinguished Lecture entitled: “Regulation of Renal Urea Transport by Vasopressin”. 
  Boston, MA - 4/1/2013
• Family Medicine Board Review Course 
  Educational Testing Consultants, Atlanta, Georgia - 2/28/2013
• MRI Research Seminar and Renal Grand Rounds 
  Univ. CA San Francisco - 2/1/2013
• Physiology Seminar 
  Louisiana State University New Orleans - 2/1/2013
• Renal Grand Rounds 
  Drexel University - 10/1/2012
• Hypertension and Renal Center Conference 
  Tulane University (Feb 2008) - 2/1/2012
• "Renal Concentrating Defects in Elderly Patients". 
  Atlanta, GA - 11/1/2011
• O’Brien Center 4th Annual Symposium 
  Univ. of Texas -Southwestern - 5/1/2011
• Renal Grand Rounds and Medicine Grand Rounds 
  University of Florida - 5/1/2011
• Medicine Grand Rounds 
  University of Tennessee at Chattanooga - 12/1/2010
• Keynote lecture: “Regulation of Renal Urea Transport by Vasopressin”. 
  Tucson, AZ - 11/1/2009
• "Urinary concentration and dilution in the aging kidney". 
  Philadelphia, PA - 11/1/2008
• “Regulation of renal urea transport by vasopressin”. 
  Queenstown, New Zealand - 9/1/2008
• “Hypertonicity stimulates urea permeability and the accumulation of the urea transporters UT-A1 and UT-A3 in the IMCD plasma membrane”. 
  Amelia Island, FL - 9/1/2008
• Renal Grand Rounds & Research Seminar 
  University of Otago at Dunedin - 8/1/2008
• Renal Grand Rounds & Medicine Grand Rounds 
  Univ. of California at Irvine - 8/1/2007
• Renal Grand Rounds and Renal Research Seminar 
  University of Florida; Henry Ford Hospital (Feb 2002); Vanderbilt University & University of Florida - 2/1/2007
• “Vasopressin regulation of the UT-A1 urea transporter”. 
  Chicago, IL - 2/1/2007
• Renal Research Seminar and Physiology Seminar 
  University of Colorado - 9/1/2006
• Research Seminar 
  University of New England - 5/1/2006
• “The renal concentrating and diluting mechanism: role of vasopressin and water channels”. 
  Chicago, IL - 4/1/2006
• “Hormonal regulation of urea transporters”. 
  San Diego, CA - 4/1/2005
• Renal Grand Rounds & Medical Grand Rounds 
  Univ. of California - Irvine; Univ. of California at Irvine (Jan 2002) - 11/1/2004
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Other

• Kidney polycation-sensing receptor and methods of use thereof. 
  Harris HW, Baum M, Brown, E, Hebert S, Sands JM, Patent: CMCC-484p
  9/13/1995
• A study of the transmembrane potentials of papillary epithelial cells. Undergraduate Honors Thesis 
  Sands JM, Committee on Applied Mathematics, Harvard College, Cambridge, MA
  1/1/1977