Jayakrishna Ambati MD
Retinal Disease
Professor, Ophthalmology & Visual Sciences, University of Kentucky College of Medicine
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1300 Jefferson Park AveCharlottesville, VA 22903
Phone+1 434-924-5485
Fax+1 434-244-9436
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Education & Training
Massachusetts Eye and Ear Infirmary/Harvard Medical SchoolFellowship, Surgical Retina and Vitreous, 1998 - 2001
University of Rochester Medical CenterResidency, Ophthalmology, 1995 - 1998
Zucker School of Medicine at Hofstra/NorthwellInternship, Internal Medicine, 1994 - 1995
State University of New York Downstate Medical Center College of MedicineClass of 1994
Certifications & Licensure
KY State Medical License 2001 - 2026
VA State Medical License 2016 - 2026
MA State Medical License 1999 - 2002
NY State Medical License 1996 - 1999
American Board of Ophthalmology Ophthalmology
Awards, Honors, & Recognition
- Fellow, National Academy of Inventors National Academy of Inventors, 2015
- NIH Director's Pioneer Award National Institutes of Health, 2014
- Chanchlani Global Vision Research Award CNIB, 2014
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Clinical Trials
- A Phase I Open Label Dose Escalation Trial of RNA-144101 in the Treatment of Geographic Atrophy Start of enrollment: 2011 Mar 01
Publications & Presentations
PubMed
- TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis.Jing Li, Yosuke Nagasaka, Hongtao Shen, Xinyu Zhou, Jianjie Ma
Molecular Therapy. Nucleic Acids. 2025-03-11 - NLRP3 Activation With Bisphosphonate Use and the Risk of Incident Age-Related Macular Degeneration.Joseph Magagnoli, Tammy Cummings, James W Hardin, S Scott Sutton, Jayakrishna Ambati
Investigative Ophthalmology & Visual Science. 2025-03-03 - Targeting the cholinergic anti-inflammatory pathway for type 2 diabetes prevention: A retrospective cohort study.Joseph Magagnoli, Tammy H Cummings, James W Hardin, Jayakrishna Ambati, S Scott Sutton
Diabetes, Obesity & Metabolism. 2025-02-01
Press Mentions
New Way to Prevent AMD, a Common Cause of Vision LossFebruary 26th, 2023- Link Found Between Lupus, Macular DegenerationDecember 7th, 2021
- Inhibiting Inflammation Blocks Retinal Death in Animal Models of an Untreatable BlindnessSeptember 30th, 2021
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Grant Support
- Cytosolic SINE retrotransposable element cDNA and mitochondrial DNA in aging retinaUNIVERSITY OF VIRGINIA2023–2028
- Defining the role of SINE retrotransposons and inflammasome activation in Alzheimer's diseaseUNIVERSITY OF VIRGINIA2022–2027
- Nlrp3 inflammasome activation in early diabetic retinopathyUNIVERSITY OF VIRGINIA2020–2025
- Nlrp3 inflammasome activation in early diabetic retinopathyUNIVERSITY OF VIRGINIA2020–2025
- Nlrp3 inflammasome activation in early diabetic retinopathyUNIVERSITY OF VIRGINIA2020–2025
- Functional Studies Of DICER1 And ALU RNA In Geographic AtrophyNational Eye Institute2012
- Endogenous Specific Inhibitor Of Corneal LymphangiogenesisNational Eye Institute2010–2012
- Intrinsic Anti-Angiogenic Activity Of SirnaNational Eye Institute2008–2011
- Pro-And Anti-Angiogenic Effects Of Vascular Endothelial Growth Factor-ANational Eye Institute2007–2011
- Novel TLR3 Inhibitors For Geographic Atrophy Of Age-Related Macular DegenerationNational Eye Institute2009–2010
- CCR3: A Molecular Marker For Neovascular AMDNational Eye Institute2009–2010
- Novel Mouse Models Of Age-Related Macular DegenerationNational Eye Institute2004–2007
Professional Memberships
- Fellow
External Links
- Laboratoryhttp://www.ambatilab.com/
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