Jason Ciril Kovacic MD PhD FRACP FAHA FACC FSCAI

PubMed

• The Australian-New Zealand SCAD observational cohort study: major adverse cardiovascular events are associated with ticagrelor combined with aspirin, FMD, and history ...
  Marysia S Tweet, Jason C Kovacic
  European Heart Journal. 2025-03-25
• Plasma proteins are integral to gene-regulatory networks acting within and across blood cells, the arterial wall and major metabolic organs.
  Sean Bankier, Husain Talukdar, Mariyam Khan, Giuseppe Mocci, Katyayani Sukhavasi
  Medrxiv. 2025-01-25
• Machine learning cluster analysis identifies increased 12-month mortality risk in transcatheter aortic valve replacement recipients.
  Thomas Meredith, Farhan Mohammed, Amy Pomeroy, Sebastiano Barbieri, Erik Meijering
  Frontiers in Cardiovascular Medicine. 2025-01-01

Journal Articles

• JACC Focus Seminar: Macrophage in CVD Series JACC Focus Seminar Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CV...  
  Amanda C Doran, Jason C Kovacic, Edward A Fisher, Ira Tabas, ScienceDirect
• The Macrophage in Cardiac Homeostasis and Disease  
  Jason C Kovacic, Kory J Lavine, ScienceDirect
• JACC Focus Seminar: Macrophage in CVD Series JACC Focus Seminar Macrophage Biology, Classification, and Phenotype in Cardiovascular Disease: JACC Macrophage in CVD Ser...  
  Jason Kovacic, MD, ScienceDirect
• Monocyte and Macrophage Dynamics in the Cardiovascular System  
  Jason Kovacic, MD, ScienceDirect
• Temporal Trends, Determinants, and Impact of High-Intensity Statin Prescriptions After Percutaneous Coronary Intervention  
  George Dangas, Serdar Farhan, Samin Sharma, Jason C Kovacic, Nitin Barman, Pedro Moreno, Joseph Sweeny, Birgit Vogel, Usman Baber, Roxana Mehran, ScienceDirect
• Oxidative stress and cardiovascular risk factors: obesity, diabetes, smoking and pollution  
  Niemann B, Rohrbach S, Miller MR, Newby DE, Fuster V, Kovacic JC, J Am Coll Cardiol, 1/1/2017
• Intracoronary Imaging, Cholesterol Efflux, and Transcriptomes after Intensive Statin Treatment: The YELLOW II study  
  Kini AS, Vengrenyuk Y, Shameer K, Maehara A, Purushothaman M, Yoshimura T, Matsumura M, Aquino M, Haider N, Johnson KW, Readhead B, Kidd BA, Feig JE, Krishnan P, Sween..., J Am Coll Cardiol, 1/1/2017
• Increased Lipid Length, Macrophage Infiltration, and Neovascularization in Coronary Atheroma from Patients with Chronic Kidney Disease  
  Pena J, Vengrenyuk Y, Kezbor S, Yoshimura T, Kovacic JC, Sharma SK, Baber U, Kini AS, Narula J, Moreno PR, JACC Imaging, 1/1/2017
• Impact Of Diabetes Mellitus On Ischemic Events In Men And Women After Percutaneous Coronary Intervention  
  Farhan S, Baber U, Aquino M, Vogel B, Chandrasekhar J, Faggioni M, Giustino G, Kautzky-Willer A, Sweeny J, Shah S, Vijay P, Barman N, Moreno P, Kovacic J, Dangas G, Ki..., Am J Cardiol, 1/1/2017
• Coronary Artery PET/MR Imaging: Feasibility, Limitations, and Solutions  
  Robson PM, Dweck MR, Trivieri MG, Abgral R, Karakatsanis NA, Contreras J, Gidwani U, Narula JP, Fuster V, Kovacic JC, Fayad ZA, JACC Imaging, 1/1/2017
• Hybrid MR/PET Imaging with FDG to Diagnose Active Cardiac Sarcoidosis  
  Dweck MR, Abgral R, Trivieri MG, Robson PM, Karakatsanis N, Mani V, Palmisano A, Miller M, Lala A, Chang HL, Sanz J, Contreras J, Narula J, Fuster V, Padilla M, Fayad ..., JACC Imaging, 1/1/2017
• Rationale and Design of Family-Based Approach in a Minority Community Integrating Systems-Biology for Promotion of Health (FAMILIA)  
  Bansilal S, Vedanthan R, Kovacic JC, Soto AV, Latina J, Björkegren JLM, Jaslow R, Santana M, Sartori S, Giannarelli C, Mani V, Hajjar R, Schadt E, Kasarskis A, Fayad Z..., Am Heart J, 1/1/2017
• Basic Biology of Oxidative Stress and the Cardiovascular System  
  Sack MN, Fyhrquist FY, Saijonmaa OJ, Fuster V, Kovacic JC, J Am Coll Cardiol, 1/1/2017
• Impact of oxidative stress on the heart and vasculature  
  Munzel T, Camici GC, Maack C, Bonetti NR, Fuster V, Kovacic JC, J Am Coll Cardiol, 1/1/2017
• Prevalence, Correlates, and Impact of Coronary Calcification on Adverse Events Following PCI with Newer-Generation DES: Findings from a Large Multi-Ethnic Registry  
  Copeland-Halperin RS, Baber U, Aquino M, Rajamanickam A, Roy S, Hasan C, Barman N, Kovacic JC, Moreno P, Krishnan P, Sweeny JM, Mehran R, Dangas G, Kini AS, Sharma SK, Catheter Cardiovasc Interv, 1/1/2017
• Unraveling the complex genetics of coronary artery disease  
  Kovacic JC, J Am Coll Cardiol, 1/1/2017
• Enabling Precision Cardiology through Disease Networks and Systems Pharmacotherapy  
  Johnson KW, Shameer K, Glicksberg BS, Readhead B, Sengupta PP, Björkegren JLM, Kovacic JC, Dudley JT, JACC: Basic to Translational Science, 1/1/2016
• Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease  
  Talukdar HA, Asl HF, Jain RK, Ermel R, Ruusalepp A, Franzén O, Kidd BA, Readhead B, Giannarelli C, Kovacic JC, Ivert T, Dudley JT, Civelek M, Lusis AJ, Schadt EE, Skog..., Cell Systems, 1/1/2016
• Intraprocedural Transcatheter Aortic Valve Replacement (TAVR) Annulus Sizing Using Three-Dimensional Transesophageal Echocardiology And “The Turnaround Rule”  
  Wiley B, Kovacic JC, Basnet S, Makoto A, Kini A, Sharma S, Sengupta P, JACC Cardiovasc Imaging, 1/1/2016
• Family-Based Approaches to Cardiovascular Health Promotion  
  Vedanthan R, Bansilal S, Soto AV, Kovacic JC, Latina J, Jaslow R, Santana M, Gorga E, Kasarskis A, Hajjar R, Schadt EE, Bjorkegren JL, Fayad ZA, Fuster V, J Am Coll Cardiol, 1/1/2016
• Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis  
  Jeong D, Lee MA, Li Y, Yang DK, Kho C, Oh JG, Hong G, Lee A, Song MH, LaRocca TJ, Chen J, Liang L, Mitsuyama S, D'Escamard V, Kovacic JC, Kwak TH, Hajjar RJ, Park WJ, J Am Coll Cardiol, 1/1/2016
• Developmental origin and lineage plasticity of endogenous cardiac stem cells  
  Santini MP, Forte E, Harvey RP, Kovacic JC, Development, 1/1/2016
• Management of complete iliofemoral artery avulsion with a hybrid technique  
  Mosley GE, Beckerman W, Kovacic JC, Kini AS, Sharma SK, Tadros RO, J Vasc Surg Cases, 1/1/2016
• Endothelial-To-Mesenchymal Transition Is Common In Advanced Atherosclerotic Lesions And Is Associated With Plaque Instability  
  Evrard SM*, Lecce L*, Michelis KC, Nomura-Kitabayashi A, Pandey G, Purushothaman KR, d’Escamard V, Li JR, Hadri L, Fujitani K, Moreno PR, Benard L, Rimmele P, Cohain A..., Nat Commun, 1/1/2016
• Cardiometabolic Risk Loci Share Downstream Cis- and Trans-Gene Regulation Across Tissues and Diseases: The Stockholm-Tartu Atherosclerosis Reverse Network Engineering ...  
  Franzen O,* Ermel R,* Cohain A,* Akers NK, Di Narzo A, Talukdar HA, Asl HF, Giambartolomei C, Fullard JF, Sukhavasi K, Köks S, Gan LM, Gianarelli C, Kovacic JC, Betsho..., Science, 1/1/2016
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Books/Book Chapters

• Interventional Cardiology: Principles and Practice 
  Chapter: Aortic Valvuloplasty and Large-Bore Percutaneous Arterial Access 
  Page 546 - 557Tomey M, Kini AS, Sharma SK, Kovacic JCEditors: George Dangas, Carlo Di-Mario, Nicholas Kipshidze.Wiley Blackwell Publishing, Oxford, United KingdomEdition 2nd,2017
• Interventional Cardiology: Principles and Practice 
  Chapter: Genetics and Pharmacogenetics in Interventional Cardiology 
  Page 459 - 468Johnston-Cox H, Bjorkegren JLM, Kovacic JCEditors: George Dangas, Carlo Di-Mario, Nicholas Kipshidze.Wiley Blackwell Publishing, Oxford, United KingdomEdition 2nd,2017
• Hurst’s the Heart 
  Chapter: Biology of the vessel wall 
  Page 144 - 160Johnston-Cox H, Fuster V, Kovacic JCEditors: Valentin Fuster, Robert Harrington, Jagat Narula, Zubin Eapen.The McGraw-Hill Companies Publishing, Columbus, OHEdition 14th,2017
• Cardiovascular Medicine - Reducing the Disease Burden 
  Chapter: The Pathogenesis of Atherothrombosis 
  Page 375 - 406Rocha VZ, Tomey M, Libby P, Fuster V, Kovacic JCEditors: Roberto Kalil and Valentin Fuster.Atheneu Publishing, Brazil2016
• Panvascular Medicine 
  Chapter: Atherothrombosis 
  Page 245 - 271Castellano JM, Kovacic JC and Fuster VEditors: Peter Lanzer.Springer-Verlag, Berlin & Heidelberg, Germany2015
• Atherosclerosis: The 21st Century Epidemic 
  Chapter: Cardiovascular Disease: From treatment to promoting health; a challenge for the next decade 
  Page 108 - 116Kovacic JC and Fuster VEditors: Conrado J. Estol and Marcelo Sanchez Sorondo.Pontificiae Academiae Scientiarvm, Vatican City2011
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Lectures

• Post Discharge Care: It's Not Over Yet What Do I Tell my Patient? 
  2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019
• Defining the cause of the "rare" vascular disease fibromuscular dysplasia using systems genetics and leveraging CAD genetics datasets 
  Paris, France - 1/1/2017
• Endothelial to Mesenchymal Transition Contributes to Plaque Formation and Correlates with Instability 
  Sunday River, Newry, ME - 1/1/2017
• Mount Sinai DEFINE- FMD Study Update 
  Cleveland Clinic Foundation, Cleveland, OH - 1/1/2017
• Atherectomy for calcified lesions – Rotational Atherectomy 
  New Orleans, LA - 1/1/2017
• Defining the cause of fibromuscular dysplasia; and redefining our understanding of spontaneous arterial dissection 
  1/1/2017
• History of TAVR 
  New York, NY - 1/1/2016
• EndMT, CAD and FMD – intersecting vascular biology and disease states 
  Bethesda, MD - 1/1/2016
• LV support during PCI 
  Mount Sinai, New York, NY - 1/1/2016
• Indications for TAVR and the Role of Risk Assessment 
  Medellin, Colombia - 1/1/2016
• Minimally Invasive Devices for Cardiac Failure and LV support 
  Medellin, Colombia - 1/1/2016
• Low Coronary Height and TAVR 
  New York, NY - 1/1/2016
• Coronary Evaluation and Treatment Timing 
  New York, NY - 1/1/2016
• The High-Risk STEMI Patient. Elderly, CKD, Diabetics 
  New Orleans, LA - 1/1/2016
• Leveraging Systems Genetics to Understand Fibromuscular Dysplasia and Coronary Artery Disease 
  Washington University School of Medicine, St. Louis, MO - 1/1/2015
• ACS: Recent and Evolving Aspects, Definitions and Diagnostics, Acquired and Genetic Factors, Ischemic and Reperfusion Injury 
  New York, NY - 1/1/2015
• Atherosclerosis and Vascular Disease: Inflammation, Genetics, and Cell Biology 
  Bethesda, MD - 1/1/2015
• The Integration of Genomics into Computerized Systems Biology: An Evolution in the Understanding of CV Disease by the Clinician 
  San Diego, CA - 1/1/2015
• Becoming a successful researcher: How to secure funding and ramp-up your publications 
  Washington, DC - 1/1/2014
• Valvular Heart Disease: Aortic Valvuloplasty and TAVR 
  Washington, DC - 1/1/2014
• Endothelial to Mesenchymal Transition and Beyond 
  New York, NY - 1/1/2014
• Left Main Intervention – Difficult Delivery 
  Las Vegas, NV - 1/1/2014
• The DEFINE FMD Study – defining the molecular and cellular basis of FMD using patient-derived fibroblasts 
  Cleveland, OH - 1/1/2014
• Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia: time to DEFINE the cause! 
  Golden Jubilee National Hospital, Glasgow, Scotland - 1/1/2014
• Endothelial to Mesenchymal Transition: From Cardiovascular Development to Disease 
  Glasgow, Scotland - 1/1/2014
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