JanetLKwiatkowskiMD

Pediatric Hematology & Oncology • Philadelphia, PA

Professor, Pediatrics, Perelman School of Medicine

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Office
3401 Civic Center Blvd
# Children
Philadelphia, PA 19104
Phone+1 215-590-3535

Fax+1 215-590-3992

Summary

Dr. Janet Kwiatkowski is a pediatric hematologist/oncologist in Philadelphia, PA and is affiliated with multiple hospitals in the area, including Hospital of the University of Pennsylvania, Pennsylvania Hospital, and Children's Hospital of Philadelphia (CHOP). She received her medical degree from Columbia University Vagelos College of Physicians and Surgeons and has been in practice 25 years. She is the Director of the Thalassemia Program at CHOP and she also is the Clinical Director of the Sickle Cell and Red Cell Disorders Curative Therapies Center at CHOP. She is experienced in stroke, hemochromatosis, thalassemias, sickle-cell anemia, and iron deficiency anemia. She has more than 100 publications and over 500 citings.

Education & Training

Children's Hospital of PhiladelphiaFellowship, Pediatric Hematology/Oncology, 1995 - 1998
Johns Hopkins UniversityResidency, Pediatrics, 1992 - 1995
Columbia University Vagelos College of Physicians and SurgeonsClass of 1992

Certifications & Licensure

PA State Medical License 1995 - 2024
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

Super Doctor SuperDoctors.com

Clinical Trials

Evaluating People With Thalassemia: The Thalassemia Longitudinal Cohort (TLC) Study Start of enrollment: 2007 May 01
Completed
Sildenafil to Improve Exercise Capacity in People With Thalassemia and Pulmonary Hypertension Start of enrollment: 2009 Mar 01
Completed
Phase 2, Phase 3
Assessment of Pain in People With Thalassemia Start of enrollment: 2009 Mar 01
Completed
Assessment of Pain in People With Thalassemia Who Are Treated With Regular Blood Transfusions Start of enrollment: 2009 Jul 01
Completed
Hydroxyurea to Prevent Brain Injury in Sickle Cell Disease Start of enrollment: 2012 Aug 16
Completed
Phase 2
Combination Deferasirox and Deferiprone for Severe Iron Overload in Thalassemia Start of enrollment: 2012 Sep 01
Completed
Phase 1, Phase 2
Efficacy and Safety of Ferriprox® in Patients With Sickle Cell Disease or Other Anemias Start of enrollment: 2014 Apr 17
Terminated
Phase 4
Phase II Study to Investigate the Benefits of an Improved Deferasirox Formulation (Film-coated Tablet) Start of enrollment: 2014 Jul 08
Completed
Phase 2
A Study of AG-348 in Adult Participants With Pyruvate Kinase (PK) Deficiency Start of enrollment: 2015 Jun 26
Active, not recruiting
Phase 2
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Publications & Presentations

PubMed

244 citations
American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support.
Stella T. Chou, Mouaz Alsawas, Ross M. Fasano, Joshua J. Field, Jeanne E. Hendrickson
Blood Advances. 2020-01-28
133 citations
Silent infarcts in young children with sickle cell disease
Janet L. Kwiatkowski, Robert A. Zimmerman, Avrum N. Pollock, Wendy Seto, Kim Smith-Whitley
British Journal of Haematology. 2009-08-01
58 citations
International survey of T2* cardiovascular magnetic resonance in β-thalassemia major
John Paul Carpenter, Michael Roughton, Dudley J. Pennell, Taigang He, Paul D. W. Kirk
Haematologica. 2013-09-01

Journal Articles

The Phenotypic Spectrum of Germline YARS2 Variants: From Isolated Sideroblastic Anemia to Mitochondrial Myopathy, Lactic Acidosis and Sideroblastic Anemia 2
Matthew M Heeney, Gregory A Hale, David P Steensma, Mark D Fleming, Colin A Sieff, Lee M Hilliard, Sylvia S Bottomley, Janet L Kwiatkowski, Haematologica

Abstracts/Posters

Pyruvate Kinase (PK) Protein and Enzyme Levels in the Diagnosis and Clinical Phenotype of PK Deficiency
Janet L. Kwiatkowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Preliminary Results of a Phase 1/2 Clinical Study of Zinc Finger Nuclease-Mediated Editing of BCL11A in Autologous Hematopoietic Stem Cells for Transfusion-Dependent B...
Janet L. Kwiatkowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Northstar-3: Interim Results from a Phase 3 Study Evaluating Lentiglobin Gene Therapy in Patients with Transfusion-Dependent _-Thalassemia and Either a _0 or IVS-I-110...
Janet L. Kwiatkowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Comorbidities and Complications in Adults with Pyruvate Kinase Deficiency
Janet L. Kwiatkowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Exploring the Drivers of Potential Clinical Benefit in Initial Patients Treated in the Hgb-206 Study of Lentiglobin for Sickle Cell Disease (SCD) Gene Therapy
Janet L. Kwiatkowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Preclinical Evaluation of ALS20, a New and Improved Lentiviral Vector for Beta-Globinopathies
Janet L. Kwiatkowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Resolution of Sickle Cell Disease Manifestations in Patients Treated with Lentiglobin Gene Therapy: Updated Results from the Phase 1/2 Hgb-206 Group C Study
Janet L. Kwiatkowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Long-Term Clinical Outcomes of Lentiglobin Gene Therapy for Transfusion-Dependent _-Thalassemia in the Northstar (HGB-204) Study
Janet L. Kwiatkowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Characterization of the Severe Phenotype of Pyruvate Kinase Deficiency
Janet L. Kwiatkowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Long-Term Clinical Outcomes of Lentiglobin Gene Therapy for Transfusion-Dependent _-Thalassemia in the Northstar (HGB-204) Study
Janet L. Kwiatkowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Northstar-2: Updated Safety and Efficacy Analysis of Lentiglobin Gene Therapy in Patients with Transfusion-Dependent _-Thalassemia and Non-_0/_0 Genotypes
Janet L. Kwiatkowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
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Lectures

¤-Thalassemia: Expert Insights on New Therapies for an Old Disease
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
Long-Term Clinical Outcomes of Lentiglobin Gene Therapy for Transfusion-Dependent _-Thalassemia in the Northstar (HGB-204) Study
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
Outcomes for Initial Patient Cohorts with up to 33 Months of Follow-up in the Hgb-206 Phase 1 Trial
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Clinical Outcomes of Lentiglobin Gene Therapy for Transfusion-Dependent β-Thalassemia Following Completion of the Northstar Hgb-204 Study
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Thalassemia Management Checklists: Quick Reference Guides to Reduce Disparities in the Care of Patients with Transfusion-Dependent Thalassemia
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
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Press Mentions

FDA Approves First Potentially Curative Gene Therapy for Beta ThalassemiaAugust 24th, 2022
Bluebird Bio to Present New Data from Gene and Cell Therapy Programs at 61st American Society of Hematology Annual Meeting and ExpositionNovember 6th, 2019
Physicians’ Education Resource® to Present Six Satellite Symposia at Annual American Society of Hematology Meeting and ExpositionNovember 21st, 2018
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Grant Support

Comparative Effectiveness Of Strategies To Improve Iron Chelation In ThalassemiaNational Heart, Lung, And Blood Institute2011
Thalassemia Clinical Research NetworkNational Heart, Lung, And Blood Institute2006–2009