JanSchwabMDPhD

Medical Director, Belford Center for Spinal Cord Injury, The Ohio State University, William E. Hunt and Charlotte M. Curtis Chair

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Office
2050 Kenny Rd
Ste 3300
Columbus, OH 43221
Phone+1 614-293-4969

Fax+1 614-293-6111

Education & Training

Berlin Trauma Hospital - Spinal Cord Injury DivisionFellowship, 2013 - 2014
Residency, Charite - Universtätsmedizin BerlinBoard Certification, Neurology, 2006 - 2012
Harvard Medical SchoolPost-Doctoral Fellowship, 2005 - 2006
Universite Pierre et Marie CurieFellowship, 2004 - 2005
Max Planck Research SchoolPhD, Neurobiology, 2000 - 2003
Eberhard Karls University TuebingenHabilitation (Venia Legendi), Neuropathology, 1999 - 2003
Eberhard Karls University Faculty of MedicineClass of 1998

Certifications & Licensure

OH State Medical License 2017 - 2026
Neurology (Physician Chamber Berlin, Germany)Board Certification in Neurology

Awards, Honors, & Recognition

Apple Award American Spinal Injury Association (ASIA), 2020
Chair of the Spine Section American Academy of Neurology, 2018
Tator and Turnbull Lecturer University of Toronto, Canada, 2015
Novartis Award German Society for Pharmacology and Toxicology (DGPT), 2011
Sir Ludwig Guttmann Award German Medical Society for Paraplegia, 2006
Fellowship (Boston USA) German Research Council (DFG), 2005
Hannelore Kohl Award in Neurotraumatology Hannelore Kohl Foundation, Germany, 2005
German Pain Award German Pain Association (DGSS), 2005
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Clinical Trials

Safety Study of Ibuprofen to Treat Acute Traumatic Spinal Cord Injury Start of enrollment: 2013 Jun 01
Completed
Phase 1
Biomarkers of Spontaneous Recovery From Traumatic Spinal Cord Injury Start of enrollment: 2015 Oct 01
Completed
A Study of Autonomic Dynamic Dysfunction to Predict Infections After Spinal Cord Injury. Start of enrollment: 2017 Sep 29
Recruiting
AXER-204 in Participants With Chronic Spinal Cord Injury Start of enrollment: 2019 Jul 16
Completed
Phase 1, Phase 2
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Publications & Presentations

PubMed

Enhancing data standards to advance translation in spinal cord injury.
Vanessa K Noonan, Suzanne Humphreys, Fin Biering-Sørensen, Susan Charlifue, Yuying Chen
Experimental Neurology. 2025-02-01
Targeting Nerve Fiber Outgrowth Inhibition After Experimental Spinal Cord Injury: A Systematic Review and Meta-analysis of Chondroitinase ABC.
Alireza Khanteymoori, Clayton Peterson, Roza Atamny, Marc Hohenhaus, Jürgen Beck
Neurorehabilitation and Neural Repair. 2025-01-07
Hospital-Acquired Pressure Ulcers and Long-Term Motor Score Recovery in Patients With Acute Cervical Spinal Cord Injury.
Marcel A Kopp, Felix W Finkenstaedt, Oliver Schweizerhof, Ulrike Grittner, Peter Martus
JAMA Network Open. 2024-12-02

Journal Articles

Lesion level-dependent systemic muscle wasting after spinal cord injury is mediated by glucocorticoid signaling in mice
Harrigan ME, Filous AR, Vadala CP, Webb A, Pietrzak M, Sahenk Z, Prüss H, Reiser PJ, Popovich PG, Arnold WD, Schwab JM, Sci Transl Med, 12/20/2023
The spinal cord injury-induced immune deficiency syndrome: results of the SCIentinel study.
Kopp MA, Meisel C, Liebscher T, Watzlawick R, Cinelli P, Schweizerhof O, Blex C, Lübstorf T, Prilipp E, Niedeggen A, Druschel C, Schaser KD, Wanner GA, Curt A, Lindema..., Brain, 8/1/2023
Soluble Nogo-Receptor-Fc decoy (AXER-204) in patients with chronic cervical spinal cord injury in the USA: a first-in-human and randomised clinical trial
George Maynard, Ramakrishnan Kannan, Jian Liu, Weiwei Wang, Tu Kiet T Lam, Xingxing Wang, Crista Adamson, Craig Hackett, Jan M Schwab, Charles Liu, Donald P Leslie, Da..., Lancet Neurol, 8/22/2023
Lesional Antibody Synthesis and Complement Deposition Associate With De Novo Antineuronal Antibody Synthesis After Spinal Cord Injury.
Schwab JM, Haider C, Kopp MA, Zrzavy T, Endmayr V, Ricken G, Kubista H, Haider T, Liebscher T, Lübstorf T, Blex C, Serdani-Neuhaus L, Curt A, Cinelli P, Scivoletto G, ..., Neurol Neuroimmunol Neuroinflamm, 4/5/2023
Acute and non-resolving inflammation associate with oxidative injury after human spinal cord injury
Zrzavy T, Schwaiger C, Wimmer I, Berger T, Bauer J, Butovsky O, Schwab JM, Lassmann H, Höftberger R, Brain, 2/12/2021
Resolvin E1 and protectin D1 activate inflammation-resolution programmes
Schwab JM, Chiang N, Arita M, Serhan CN., Nature, 6/6/2007
Central nervous system injury-induced immune deficiency syndrome.
Meisel C, Schwab JM, Prass K, Meisel A, Dirnagl U., Nat Rev Neurosci, 10/6/2005
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Press Mentions

Bed Sores Can Slow Neurological Recovery After Spinal Cord InjuryDecember 10th, 2024
Outcomes Worse for Patients Who Develop Pressure Sores After Acute Spinal Cord InjuryDecember 9th, 2024
Pressure Sores Worsen Outcomes Post-Spinal InjuryDecember 6th, 2024
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Grant Support

Protecting endogenous recovery from the ‘infectious insult’ in Spinal Cord InjuryNIH/NINDS2024–2029
Reducing Infection Susceptibility by Immune Function Restoration in Spinal Cord InjuryNIH/NINDS2020–2025
Interrogating adrenal dysfunction to prevent muscle wasting after acute spinal cord injuryNIH/NINDS2020–2022
Exofocal Injury after Spinal Cord InjuryCraig H Neilsen Foundation2019–2021
Central Ohio Spinal Cord Injury Model SystemNational Institute for Diasability, Independent Living and Rehabilitation Research (NIDILRR)2016–2021

Committees

Rooster Member, NIH/NINDS SCI Common Data Element (CDE) Oversight Committee 2015 - Present

Other Languages

German

External Links

Schwab Labhttps://u.osu.edu/schwablab/
Spinal Cord Injury Lab (Berlin, Germany)https://expneuro.charite.de/en/research/spinal_cord_injury/
The Ohio State University - SCI Medical and Research Servicehttps://wexnermedical.osu.edu/neurological-institute/departments-and-centers/research-centers/spinal-cord-injury-model-systems