JanLewisBrandesMDMS, FAAN, FAHS

Neurology • Nashville, TN

Headache

Founder and Director, Nashville Neuroscience Group; Assistant Clinical Professor of Neurology, Vanderbilt University

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Office
2315 GOLF CLUB LN
Nashville, TN 37215
Phone+1 615-516-0711

Summary

As the founder and director of Nashville Neuroscience Group, Jan Lewis Brandes, MD, MS, also holds an appointment as an Assistant Clinical Professor in the Department of Neurology at Vanderbilt University School of Medicine, Nashville, Tennessee. Prior to attending Vanderbilt University School of Medicine, where she subsequently earned her medical degree, Dr. Brandes attended the Robert Koch Institute of Virology, Free University in Berlin, Federal Republic of Germany, as a Fulbright Scholar. Her postgraduate medical training was completed at Vanderbilt University Medical Center where she served as chief resident in neurology. She also holds a Master of Science degree in microbiology from the University of Tennessee in Knoxville. She is certified by the National Board of Medical Examiners, The American Board of Psychiatry and Neurology and the National Board for Certification in Headache Management.

Dr. Brandes has been active in clinical trials for more than two decades. She has served as the principal or co-principal investigator in more than st100 studies, primarily examining issues in migraine including acute treatment, prophylaxis and menstrual migraine. She has published extensively in peer-reviewed journals including JAMA, Cephalalgia, Headache, and Mayo Clinic Proceedings.

Dr. Brandes is the immediate past chairman of Nashville Metro General Hospital Authority, a fellow of the American Headache Society and the American Academy of Neurology, and serves on the National Headache Foundation Board. She is a former member of the board of directors of the American Headache Society and is a past president of the American Council for Headache Education. In recognition of her professional endeavors, she has been named to Best Doctors in the Americas from 1996 to present.

Education & Training

Vanderbilt University Medical CenterResidency, Neurology, 1990 - 1993
Vanderbilt University Medical CenterInternship, Internal Medicine, 1989 - 1990
Vanderbilt University School of MedicineClass of 1989
Robert Koch Institute of VirologyFulbright Scholarship, Molecular Virology, 1982 - 1983
University of TennesseeMS, Microbiology, subspecialty, herpes virology, 1977 - 1980
Mississippi University for WomenBS, Biology, Cum Laude, 1975

Certifications & Licensure

TN State Medical License 1991 - 2026
American Board of Psychiatry and Neurology Neurology
United Council for Neurologic SubspecialtiesCertification in Headache Medicine

Awards, Honors, & Recognition

Lifetime Achievement Award National Headache Foundation, 2022
Fulbright Scholar Robert Koch Institute of Virology
Best Doctors in the Americas 1995-2018
Health Care Heroes Award Recipient: Clinical Research Nashville Business Journal, 2012
2010 Top Women to Watch Nashville Medical News, 2010
Regional Top Doctor Castle Connolly, 2014
Health Care Heroes Award Nashville Business Journal, 2012
Top 10 Women to Watch Nashville Medical News, 2010
Best Doctors in the America 1996
Fulbright Scholar Robert Koch Institute of Virology, Free University, 1982
Award in Microbiology University of Tennessee, 1980
George Cameron Award University of Tennessee, 1980
Dean’s List Mississippi University of Women
Hall of Fame Mississippi University of Women
Who’s Who in American Colleges and Universities Mississippi University of Women
Top MD Consumers Checkbook
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Clinical Trials

A Study on the Usability of the Needle-free Intraject® System in Adult Patients During Acute Migraine Attack Start of enrollment: 2007 Sep 01
Completed
Phase 2

Publications & Presentations

PubMed

361 citations
ARISE: A Phase 3 randomized trial of erenumab for episodic migraine:
David W. Dodick, Messoud Ashina, Jan Lewis Brandes, David Kudrow, Michel Lanteri-Minet
Cephalalgia. 2018-02-22
451 citations
Safety and efficacy of erenumab for preventive treatment of chronic migraine: a randomised, double-blind, placebo-controlled phase 2 trial
Stewart J. Tepper, Messoud Ashina, Uwe Reuter, Jan Lewis Brandes, David Doležil
The Lancet. Neurology. 2017-06-01
335 citations
Efficacy and safety of topiramate for the treatment of chronic migraine: a randomized, double-blind, placebo-controlled trial.
Stephen D. Silberstein, Richard B. Lipton, David W. Dodick, Frederick G. Freitag, Nabih M. Ramadan
Headache. 2007-02-01

Journal Articles

ARISE: A Phase 3 Randomised Trial of Erenumab for Episodic Migraine
Dodick, D, Ashina, M., Brandes, J, Kudrow, D, Lanteri-Minet, M, Osipova, V, Palmer K, Picard, H, Mikol, D, Lenz R, Lancet Neurology
Safety and Efficacy of Erenumab for Preventive Treatment of Chronic Migraine: A Randomused, Double-Blind, Plecebo-Controlled Phase 2 Trial
Brandes JL, Tepper S, Ashina M, Reuter U, Lenz R, The Lancet Neurology, 1/1/2017
Sex Differences in the Study of Neurological Illnesses
Attarian H, Brandes JL, Dafer R, Giesser B, Behavioral Neurology, 1/1/2015
Migraine in Women
Brandes JL, Continuum: Lifelong Learning in Neurology, 1/1/2012
Randomized, Controlled Study of Telcagepant in Patients with Migraine and Coronary Artery Disease
Brandes JL, Lines C, Ho T, Ho A, Chaitman B, Ninan M, Aurora S, Beebe LA, Krucoff M, Kost JT, Headache: The Jouranl of Head and Face Pain, 1/1/2012
Satisfaction With and Confidence in Needle-Free Subcutaneous Sumatriptan in Patients Currently Treated with Triptans
Brandes JL, Cady R, Aurora S, Rothrock J, Myers J, Fox AW, Farr SJ, Headache: The Journal of Head and Face Pain, 1/1/2011
Depression Has a Greater Influence than Migraine Frequency on Comorbidity Prevalence
Brandes JL, Tietjen G, Utley C, Peterlin L, Dager R, Aurora S, Headache: The Journal of Head and Face Pain, 1/1/2011
The Influence of Childhood Trauma on Clinical Phenotype in Depressed Migraineurs
Brandes JL, Tietjen G, Utley C, Peterlin L, Headache: The Journal of Head and Face Pain, 1/1/2011
Randomized Controlled Trial of Telcagepant Combined with Ibuprofen or Acetaminophen in the Acute Treatment of Migraine
Brandes JL, Hewitt D, Martin V, Ho T, Lipton R, Headache: The Journal of Head and Face Pain, 1/1/2010
Evaluation of the Relationship between Body Mass Index (BMI) to Response and Tolerability after Treatment with Sumatriptan 85mg RT/Naproxen Sodium 500mg for the Early ...
Brandes J, International Headache Congress, 1/1/2009
Headache Related to Pregnancy: Management of Migraine and Migraine Headache in Pregnancy
JL Brandes, Current Treatment Options in Neurology, 1/1/2008
In-Office Discussions of Migraine: results from the American Migraine Communication Study
Lipton RB, Hahn SR, Cady RK, Brandes JL, Simons SE, Bain, PA, Nelson MR, J Gen Int Med, 1/1/2008
Efficacy and Safety of Topiramate for the Treatment of Chronic Migraine: A Randomized, Double-Blind, Placebo Controlled Trial
S.D. Silberstein, R.B. Lipton, D.W. Dodick, F.G. Freitag, N. Ramadan, N. Mathew, J.L. Brandes, M. Bigal, J. Saper, S. Ascher, D. M. Jordan, S.J. Greenburg, J. Hulihan, Headache, 1/1/2007
C-Reactive Protein Increased in Migraine
KMA Welch, AW Brandes, L Salerno, JL Brandes, Headache, 1/1/2006
The Influence of Estrogen on Migraine: Current Understanding and Future Direction
JL Brandes, JAMA, 1/1/2006
Assessing the Ability of Topiramate to Improve the Daily Activities of Patients with Migraine
J.L. Brandes, D.B. Kudrow, J.F. Rothrock, M.F.T. Rupnow, D.L. Fairclough, S.J. Greenberg, Mayo Clinic Proceedings, 1/1/2006
Mismatch in How Oestrogen Modulates Molecular and Neuronal Function May Explain Menstrual Migraine
K.M.A. Welch, J.L. Brandes, N. Berman, Neurological Sciences, 1/1/2006
Strategies for Optimizing Management of Menstrual Migraine
Martin, Vincent, Brandes, Jan L, The Journal of Family Practice, 1/1/2005
Two Replicate Randomized, Double-Blind, Placebo-Controlled Trials of the Time to Onset of Pain Relief in the Acute Treatment of Migraine with a Fast-Disintegrating/Rap...
Fred D. Sheftell, MD, Carl G.H. Dahlof, MD, Jan Lewis Brandes, MD, Reto Agosti, MD, Martin W.Jones, PhD, and Pamela S. Barrett, PharmD, Clinical Therapeutics, 1/1/2005
Migraine Treatment Strategies: the Global Migraine and Zolmitriptan Evaluation (MAZE) Survey – Phase IV
Brandes J, Curr Med Res Opin, 1/1/2004
Topiramate for Migraine Prevention
Brandes JL, Saper JR, Diamond M, Couch JR, Lewis DW, Schmitt J, Neto W, Schwabe S, Jacobs D, JAMA, 1/1/2004
Making the Case for Early Intervention
Jan L. Brandes, MD, The Migraine Monitor, 1/1/2004
Migraine Matters: The Role of Triptans in Relieving the Burden in Managed Care
Jan L. Brandes, MD, Diana I. Brixner, RPh, PhD, Journal of Managed Care Pharmacy, 1/1/2004
Speed of Onset and Efficacy of Sumatriptan Fast-Disintegrating/Rapid-Release Tablets: Pooled Results of Two Replicate, Randomized, Placebo-Controlled Studies
C. Dahlof, R. Cady, A.C. Poole, J. Brandes, C. Few and M. Jones, Headache Care, 1/1/2004
The Migraine Disability Assessment (MIDAS) Questionnaire in the primary-care setting
Dowson, AJ, Sakai F, Brandes J, Int J Pharm Med, 1/1/2004
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Books/Book Chapters

Handbook of Clinical Neurology
Chapter: Acute treatment of migraine
Brandes JL, Buchanan TM, Welch KMAEditors: G Nappi and MA Moskowitz.Elsevier Publishing Company, London, EnglandEdition 3rd,2011
Menstrual Migraine: Oxford American Pain Library
Chapter: Comorbidities in Migraine
Page 33.0 - 44.0Brandes, Jan LEditors: Susan Hutchinson, B. Lee Peterlin.Oxford University Press, New York2008
Topiramate for Migraine Prevention
Chapter: Topiramate for Migraine Prevention
Page 11.0 - 12.0Brandes,JL, et al2004
Migraine in Women
Chapter: Migraine Management During Pregnancy
Jan Lewis Brandes, MD and Dawn A. Marcus, MD2004
Headache and Migraine Biology and Management
Chapter: Cranial Neuralgia, Sinus Headache, and Vestibular Migraine
Brandes JEditors: S Diamond.Edition 1st,2015
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Abstracts/Posters

Multiple-Attack Efficacy and Tolerability of Sumavel DosePro (needle-free subcutaneous sumatriptan) Among Current Triptan Users
Brandes JL, Rothrock J, Cady R, Aurora S, Fox AW, Farr SJ, AAN Scientific Meeting, 1/1/2011
Randomized, Controlled Trial of Telcagepant in Acute Treatment of Migraine in Patients with Stable Coronary Artery Disease
Ho TW, Ho AP, Chaitman BR, Johnson C, Mathew NT, Kost J, Fan X, Aurora S, Brandes JL, Fei K, Beebe L, Lines C, Krucoff M, Merck Research Laboratories, 1/1/2010
Migrainous Vertigo Presenting in the Perimenopause
Brandes JL, Roberson S, Bennett M, Haynes D, 63nd Annual Meeting of the American Academy of Neurology, Toronto, 1/1/2010
Evaluation of Safety and Efficacy of MAP0004 in Treating Acute Menstrual Migraine
Schreiber C, Kori SH, Lucas S, Borland SW, Wang M, Hu B, Brandes JL, 62nd Annual Meeting of the American Academy of Neurology, Toronto, 1/1/2010
Body Mass Index (BMI), Responsiveness, and Tolerability of a Fixed-Dose Single Tablet of Sumatriptan 85mg Formulated with RT Technology and Naproxen Sodium 500mg
Brandes JL, Winner PK, Lener SI, Derosier F, White J, McDonald S, European Headache and Migraine Trust Scientific Meeting, 1/1/2008
Over-the-Counter Medication in Migraine: A Questionnaire-Based Analysis in Migraineurs in Spain
Macgregor A, Giammarco R, Brandes JL, Gendolla A, 2008 Migraine Trust, London, England, 1/1/2008
The Importance of Initial Drug Choice When Treating Migraine: A Questionnaire-Based Analysis in Migraineurs in Spain
Macgregor A, Giammarco, Brandes JL, Gendolla A, 2008 Migraine Trust, London, England, 1/1/2008
Pain Free with Sumatriptan Rapid Release Tablets: Results from Two Double-Blind, Placebo-Controlled Trials
Dr. Fred Sheftell, Dr. Jean Shoenen, Dr. Jan L. Brandes, Dr. Reto Agosti, Mr. Christopher J. Webster, American Academy of Neurology 7th Annual Meeting, Miami Beach, FL, 1/1/2005
Patient Strategies for the Management of Migraine: Interim Results from an Online Market Research Study (MAZE study Phase IV)
MacGregor E., Brandes J., Eikermann A., Giammarco R, American Headache Society’s 46th Annual Scientific Meeting, Vancouver, BC, 1/1/2004
The Speed of Onset, Efficacy and Tolerability of Zolmitriptan Nasal Spray in the Management of Acute Migraine
Dodick D., Brandes J., Elkind A., Mathew N., Rodichok L, American Headache Society’s 46th Annual Scientific Meeting, Vancouver, BC, 1/1/2004
Intermittent Prophylaxis of Menstrually-Related Migraines: Evaluating Recent Clinical Data
Jan L. Brandes, MD, American Headache Society’s 46th Annual Scientific Meeting, Vancouver, BC, 1/1/2004
C-Reactive Protein Increased in Migraine
KMA Welch, AW Brandes, L Salerno, JL Brandes, American Headache Society’s 46th Annual Scientific Meeting, Vancouver, BC, 1/1/2004
Study of Eletriptan (20 and 40 mg) versus Placebo in Early Treatment of Migraine
Jan L. Brandes, MD, American Headache Society’s 46th Annual Scientific Meeting, Vancouver, BC, 1/1/2004
Migraine Pain and Women
Brandes J, Monograph, SynerMed Communications, 1/1/2001
Determinants of Patient Preference for Either Rizatriptan Orally Disintegrating Tablet (ODT) 10 mg or Sumatriptan Tablet 50 mg for the Acute Treatment of Migraine
J. Brandes, MD, E. Loder, MD, D. Boyle, MD, L. Wang, MD, N. Bohidar, MD, A. Kolodny, MD, N. Santanello, MD, L. Johnson-Pratt, MD, American Academy of Neurology, Philadelphia, PA, 1/1/2001
MAZE (Migraine and Zomig Evaluation) Survey
J. Brandes, A. Eikermann, A. MacGregor, Headache World, London, England, 1/1/2000
Migraine A Predictor for the Presence of Other Serotonergic Disorders
Jan Lewis Brandes and Elizabeth Loder, Headache World, London, England, 1/1/2000
A comparison of Common Antigenic Determinants for the gA/gB Glycoprotein in BHV and HSV-1,2 Using Monoclonal Antibodies
J. Lewis, George Pauli, and Hanns Ludwig, European Conference on Herpes-viruses, Mainz, Germany, 1/1/1986
Effects of Vitamin E on the ability of Penicillamine to Protect Against Allozan-Induced Diabetes
J. Lewis Brandes, Edward Smith, and J. H. Park, Vanderbilt University Summer Research on Diabetes Symposium, Nashville, Tennessee, 1/1/1985
Identification of Specific Herpes Simplex Virus Type 2 (HSV-2) Glycoproteins Expressed in HSV-2 Transformed Cells
J. Lewis, L.Kucera, R. Eberle, and R. Courtney, 5th Cole Spring Harbor meeting on Herpes Viruses, 1/1/1980
Quetiapine for Migraine Prophylaxis
Brandes, Jan Lewis, Roberson, Susan C., Pearlman, Starr H., and Abu-Shakra, Susan, 54th Annual Meeting of the American Academy of Neurology/American Society of Headache Meeting, Denver, CO, 2002; Seattle, WA, 2002, 1/21/2002
Impact of Co-morbid Depression on Migraine Disability in Clinical Practice: Preliminary Observations
Jan L. Brandes, 54th Annual Meeting of the American Academy of Neurology, Denver, CO, 1/11/2002
Neuromodulation of Late Life Migrainous Accompaniments with Topiramate Therapy
Susan Roberson, CFNP, Rita Hatfield, LPN, Bryce Dixon, MD, Jan Brandes, MD, American Academy of Neurology/10th Congress of the International Headache Society IHC, Philadelphia, PA, 2001; New York, NY, 2001, 1/29/2001
Early Efficacy and Excellent Tolerability of Zolmitriptan Nasal Spray in Acute Migraine
David Dodick, Jan Brandes, Arthur Elkind, Ninan Mathew, Larry Rodichok, 56th American Academy of Neurology Annual Meeting, San Francisco, CA, 1/27/2004
Impact of Co-morbid Depression on Migraine Disability in Clinical Practice: Preliminary Observations
Jan L. Brandes, American Society of Headache Meeting, Seattle, WA, 1/21/2002
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Lectures

The Neurological Examination
Vanderbilt University School of Medicine, Nashville, TN - 1/1/2017
Vestibular Headache/ Dysautonomia
Lake Buena Vista, FL - 1/1/2016
25th Annual Practicing Physicians Approach to the Difficult Headache Patient
Diamond Headache Clinic Reseach and Educational Foundation, Rancho Mirage, California
Acing Migraine Pain with Monica Seles
New York, NY - 1/1/2004
Hormonal Aspects of Migraine, Part 1
Cadiz, Spain - 1/1/2001
Management of Headache
Palmetto Baptist Medical Center, Columbia, SC - 1/1/2000
Migraine Diagnosis and Treatment Options
Medical University of South Carolina, Charleston, SC - 1/1/1999
New Acute Therapies in Migraine Management
Wake Forest University Medical School, NC - 1/1/1998
Migraines
Gatlinburg Convention Center, Gatlinburg, TN - 1/1/1998
Cost Effective Management of Headache
Nashville, TN - 1/1/1998
The Difficult Headache Patient
Destin, FL - 1/1/1998
The Impact of Migraine
Chicago, IL - 1/1/1998
Clinical Impact of Migraines
Boston, MA - 1/1/1998
Take Charge – Migraine Awareness
Rockefeller University, New York, NY - 1/1/1998
Update in Migraine
New Orleans, LA - 1/20/2017
Menstrual Migraine
Carlsbad, California, 2017; Orlando, Florida, 2017 - 1/15/2017
Vestibular Migraine
Orlando, Florida - 1/15/2017
The Dizzy Headache Patient
Carlsbad, California - 1/19/2017
Perimenopausal Issues in Headache
Lake Buena Vista, FL - 1/19/2014
Diagnosis and Management of Headache
1/6./2014
Vestibular Migraine: Diagnosis and Treatment
Department of Otolaryngology, Vanderbilt University Medical Center - 1/19/2014
Perimenopausal and Menopausal Issues In Migraine
Palm Springs, CA, 2012; Newport Beach, CA, 2014 - 1/16/2014
The ‘Dizzy’ Headache, POTS Syndrome, and Vestibular Migraine
Newport Beach, CA - 1/16/2014
Headache: When to Refer
New Orleans, LA - 1/30/2014
Migraine, Vertigo and Postural Orthostatic Tachycardia Syndrome (POTS)
Palm Springs, CA - 1/18/2012
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Other

Infertile Women Significantly More Likely To Have Migraines
Brandes J, Pain Medicine News – Headache and Migraine
1/1/2005
Headache Medication Interactions: Focus on the Triptans
Brandes JL and Tepper S, CNS News Special Edition
1/1/2003
Perspectives on Managed Care – Managing with Managed Care
Jan Lewis Brandes, M.D., HEADACHE – Newsletter of the American Council for Headache Education
1/1/1998
Migraine, It’s All in Your Head
Jan Lewis Brandes M.D., Washington Woman
1/1/1998
Detection of Virus-Specific Glycoproteins Within Herpes Simplex Virus Transformed Cells
Brandes J, Thesis
Migraines 101
Brandes J, Medical Mondays, NewsChannel 5
www.newschannel5.com/+/medical-monday/medical-monday-migraines-101
1/19/2017
Why Women Suffer More Migraines Than Men
Brandes J, Morning Edition, National Public Radio
http://www.npr.org/blogs/health/2012/04/16/150525391/why-women-suffer-more-migraines-than-men
1/16/2012
Dr. Jan Lewis Brandes Talks about Migraine Research Trials
Brandes J, Talk of the Town, NewsChannel 5
http://www.newschannel5.com/global/video/flash/popupplayer.asp?ClipID1=6688448&h1=Doctor%20Talks%20About%20Migraine%20Research%20Trials&vt1=v&at1=Community&d1=291800&LaunchPageAdTag=Search%20Results&activePane=info&rnd=84517299
1/30/2012
Coming Home: Veterans face long waits for medical care
Brandes J, The Tennessean, Tom Wilemon
http://www.tennessean.com/article/20111125/NEWS/311250050/Coming-Home-Veterans-face-long-waits-medical-care
1/25/2011
How to Treat Your Migraines
Brandes J, Talk of the Town, NewsChannel 5
http://www.newschannel5.com/global/video/flash/popupplayer.asp?ClipID1=6455703&h1=How%20To%20Treat%20Your%20Migraines&vt1=v&at1=Community&d1=245233&LaunchPageAdTag=Search%20Results&activePane=info&rnd=50262386
1/10/2011
Migraines and Women
Brandes J, Medical Mondays, NewsChannel 5
http://www.wtvf.com/story/15712643/migraines-and-women-october-17-2011-dr
1/17/2011
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Press Mentions

5 of the Most Common Migraine TriggersJuly 13th, 2021
Nashville General Hospital Seeks $20M Boost to Annual City SubsidyMarch 17th, 2017
FDA Approves ReyvowOctober 13th, 2019